NO990012L - Nye erytromyciner og fremgangsmÕte for deres fremstilling - Google Patents

Nye erytromyciner og fremgangsmÕte for deres fremstilling

Info

Publication number
NO990012L
NO990012L NO990012A NO990012A NO990012L NO 990012 L NO990012 L NO 990012L NO 990012 A NO990012 A NO 990012A NO 990012 A NO990012 A NO 990012A NO 990012 L NO990012 L NO 990012L
Authority
NO
Norway
Prior art keywords
preparation
methods
erythromycins
new
new erythromycins
Prior art date
Application number
NO990012A
Other languages
English (en)
Norwegian (no)
Other versions
NO990012D0 (no
Inventor
Peter Francis Leadlay
James Staunton
Jesus Cortes
Michael Stephen Pacey
Original Assignee
Biotica Tech Ltd
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9614189.0A external-priority patent/GB9614189D0/en
Priority claimed from GBGB9710962.3A external-priority patent/GB9710962D0/en
Application filed by Biotica Tech Ltd, Pfizer filed Critical Biotica Tech Ltd
Publication of NO990012D0 publication Critical patent/NO990012D0/no
Publication of NO990012L publication Critical patent/NO990012L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO990012A 1996-07-05 1999-01-04 Nye erytromyciner og fremgangsmÕte for deres fremstilling NO990012L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9614189.0A GB9614189D0 (en) 1996-07-05 1996-07-05 Polyketides and their synthesis
US2418896P 1996-08-19 1996-08-19
GBGB9710962.3A GB9710962D0 (en) 1997-05-28 1997-05-28 Polyketides and their synthesis
PCT/GB1997/001810 WO1998001571A2 (fr) 1996-07-05 1997-07-04 Erythromycines et leur procede de preparation

Publications (2)

Publication Number Publication Date
NO990012D0 NO990012D0 (no) 1999-01-04
NO990012L true NO990012L (no) 1999-02-23

Family

ID=27268361

Family Applications (1)

Application Number Title Priority Date Filing Date
NO990012A NO990012L (no) 1996-07-05 1999-01-04 Nye erytromyciner og fremgangsmÕte for deres fremstilling

Country Status (28)

Country Link
EP (3) EP0909327B1 (fr)
JP (2) JP2000511063A (fr)
KR (1) KR20000023579A (fr)
CN (1) CN1179046C (fr)
AP (1) AP1029A (fr)
AT (2) ATE451455T1 (fr)
AU (2) AU731654B2 (fr)
BG (1) BG103133A (fr)
BR (1) BR9710209A (fr)
CA (2) CA2259420C (fr)
DE (2) DE69739688D1 (fr)
DK (2) DK0910633T3 (fr)
EA (1) EA001744B1 (fr)
EE (1) EE03976B1 (fr)
ES (2) ES2337424T3 (fr)
GB (1) GB2331518B (fr)
GE (1) GEP20012348B (fr)
IL (1) IL127916A0 (fr)
IS (1) IS4940A (fr)
NO (1) NO990012L (fr)
NZ (1) NZ333861A (fr)
OA (1) OA10952A (fr)
PL (1) PL331285A1 (fr)
PT (1) PT909327E (fr)
SI (1) SI0910633T1 (fr)
SK (1) SK182498A3 (fr)
TR (1) TR199900006T2 (fr)
WO (2) WO1998001571A2 (fr)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063561A (en) * 1991-01-17 2000-05-16 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US6060234A (en) * 1991-01-17 2000-05-09 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US20030170725A1 (en) 1993-09-20 2003-09-11 Chaitan Khosla Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US6927057B2 (en) 1993-09-20 2005-08-09 Kosan Biosciences Macrolide analogs
US6500960B1 (en) 1995-07-06 2002-12-31 Stanford University (Board Of Trustees Of The Leland Stanford Junior University) Method to produce novel polyketides
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US6558942B1 (en) 1994-05-06 2003-05-06 The Leland Stanford Junior University Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
IL122859A0 (en) 1995-07-06 1998-08-16 Univ Leland Stanford Junior Cell-free synthesis of polyketides
EP0870053A4 (fr) 1995-12-19 2002-09-11 Univ Minnesota Procede metabolique de fabrication de synthases monomeres de polyhydroxyalcanoates
US6271255B1 (en) 1996-07-05 2001-08-07 Biotica Technology Limited Erythromycins and process for their preparation
US6399789B1 (en) 1996-12-18 2002-06-04 Kosan Biosciences, Inc. Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
US6117659A (en) 1997-04-30 2000-09-12 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
AU732909B2 (en) 1997-04-30 2001-05-03 Board Of Trustees Of The Leland Stanford Junior University Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US6902913B2 (en) 1997-04-30 2005-06-07 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
JP2008169226A (ja) * 1997-04-30 2008-07-24 Kosan Biosciences Inc 足場としてモジュラー性ｐｋｓ遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー
US6503741B1 (en) 1998-05-28 2003-01-07 Kosan Biosciences, Inc. Polyketide synthase genes from Streptomyces venezuelae
US6262340B1 (en) 1997-07-10 2001-07-17 Kosan Biosciences, Inc. Production of polyketides in plants
AP1060A (en) 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
JP2002508968A (ja) * 1998-01-14 2002-03-26 グラクソ グループ リミテッド ポリケチドおよびその合成
NZ509006A (en) * 1998-05-28 2003-09-26 Kosan Biosciences Inc Recombinant narbonolide polyketide synthase
US6265202B1 (en) 1998-06-26 2001-07-24 Regents Of The University Of Minnesota DNA encoding methymycin and pikromycin
GB9814006D0 (en) * 1998-06-29 1998-08-26 Biotica Tech Ltd Polyketides and their synthesis
AU765821B2 (en) * 1998-07-02 2003-10-02 Board Of Regents Of The Leland Stanford Junior University, The Methods for making polyketides
GB9814622D0 (en) * 1998-07-06 1998-09-02 Biotica Tech Ltd Polyketides,their preparation,and materials for use therein
WO2000024907A2 (fr) 1998-10-28 2000-05-04 Kosan Biosciences, Inc. Banque de nouveaux produits naturels « non naturels »
OA11670A (en) 1998-11-03 2005-01-12 Pfizer Prod Inc Novel macrolide antibiotics.
US6358712B1 (en) 1999-01-05 2002-03-19 Trustee Of Boston University Ordered gene assembly
DK1147121T3 (da) 1999-01-27 2004-04-13 Pfizer Prod Inc Ketolidantibiotika
WO2000047724A2 (fr) * 1999-02-09 2000-08-17 Board Of Trustees Of The Leland Stanford Junior University Procedes de modulation de l'efficacite de modules de polyketide-synthases
US7001748B2 (en) 1999-02-09 2006-02-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of making polyketides using hybrid polyketide synthases
US6458771B1 (en) 1999-04-16 2002-10-01 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
WO2000063224A2 (fr) 1999-04-16 2000-10-26 Kosan Biosciences, Inc. ipcNTS ANTI-INFECTIEUX MACROLIDES
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
SK15162001A3 (sk) 1999-05-24 2003-02-04 Pfizer Products Inc. Deriváty 13-metylerytromycínu
GB9912563D0 (en) * 1999-05-28 1999-07-28 Biotica Tech Ltd Polyketides and their synthesis
ES2283344T3 (es) * 1999-10-29 2007-11-01 Kosan Biosciences, Inc. Analogos de la rapamicina.
EP1101769A3 (fr) 1999-11-18 2001-10-24 Pfizer Products Inc. Dérivés de l'érythromycine contenant de l'azote
EP1255763A2 (fr) 2000-02-18 2002-11-13 Kosan Biosciences, Inc. Composes motilides
EP1146051A3 (fr) * 2000-04-10 2001-10-31 Pfizer Products Inc. Dérivées de l' érythromycine A
AU2001248588B2 (en) 2000-04-13 2006-02-02 Biotica Technology Limited Hybrid glycosylated products and their production and use
US20030225006A1 (en) * 2002-02-19 2003-12-04 Burns Lesley S Novel spinosyn-producing polyketide synthases
DE60315723T2 (de) 2002-07-16 2008-06-19 Biotica Technology Ltd. Herstellung von Polyketiden und anderen natürlichen Produkten
DK200201957A (da) 2002-12-20 2003-01-20 Alpharma Aps 10-substituted erythromycin ketolides and methods of making
GB0230217D0 (en) * 2002-12-27 2003-02-05 Biotica Tech Ltd Borrelidin-producing polyketide synthase and its uses
EP2535042A1 (fr) 2003-06-16 2012-12-19 ANDRX Pharmaceuticals LLC. Composition à libération prolongée orale comprenant a macrolide
GB0327720D0 (en) 2003-11-28 2003-12-31 Biotica Tech Ltd Erythromycins and process for their preparation
GB0417852D0 (en) 2004-08-11 2004-09-15 Biotica Tech Ltd Production of polyketides and other natural products
US7582611B2 (en) * 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
CN102224242B (zh) 2008-09-24 2014-09-24 中国科学院上海有机化学研究所 新基因簇
GB0904540D0 (en) 2009-03-17 2009-04-29 Biotica Tech Ltd Novel compounds and methods for their production
CN101519637B (zh) * 2009-04-07 2011-06-15 华东理工大学 一种红色糖多孢菌及其发酵生产红霉素的方法
GB0914589D0 (en) 2009-08-20 2009-09-30 Biotica Tech Ltd Novel compounds and methods for their production
WO2011098805A1 (fr) 2010-02-09 2011-08-18 Biotica Technology Limited Composés à base de sangliféhrine
WO2011098808A1 (fr) 2010-02-09 2011-08-18 Biotica Technology Limited Composés à base de sangliféhrine
BR112012019866A8 (pt) 2010-02-09 2017-12-26 Biotica Tech Limited Composto, uso do mesmo, composição farmacêutica, e, processo para preparar um composto
GB201118334D0 (en) 2011-10-24 2011-12-07 Biotica Tech Ltd Novel dosage form
WO2013172782A1 (fr) * 2012-05-16 2013-11-21 Nanyang Technological University Construction de polycétide synthase et son utilisation dans la préparation de polycétides
EP4289950A3 (fr) 2015-01-09 2024-01-24 Revolution Medicines, Inc. Composés macrocycliques participant à une liaison coopérative et leurs utilisations médicales
ES2921056T3 (es) 2016-04-12 2022-08-17 Warp Drive Bio Inc Composiciones y métodos para la producción de compuestos
EP3960857A1 (fr) 2016-07-29 2022-03-02 Isomerase Therapeutics Limited Nouveaux procédés
AU2017350898A1 (en) * 2016-10-28 2019-06-13 Ginkgo Bioworks, Inc. Compositions and methods for the production of compounds
WO2018081592A2 (fr) 2016-10-28 2018-05-03 Warp Drive Bio, Inc. Compositions et procédés pour la production de composés
EP3585795B1 (fr) 2017-02-22 2021-06-09 ISR Immune System Regulation Holding AB (publ) Nouveaux macrolides stimulateurs de l'immunité
EP3585796B1 (fr) 2017-02-22 2021-06-16 ISR Immune System Regulation Holding AB (publ) Nouveaux macrolides stimulateurs de l'immunité
JP2021523930A (ja) 2018-03-23 2021-09-09 アイエスアール イミューン システム レギュレイション ホールディング アクチエボラグ（パブル） マクロライド化合物と免疫チェックポイント阻害剤との組み合わせ
EA202191983A1 (ru) 2019-01-22 2021-12-01 Аеовиан Фармасьютикалз, Инк. МОДУЛЯТОРЫ mTORC И ИХ ПРИМЕНЕНИЕ
AU2020379734A1 (en) 2019-11-04 2022-05-05 Revolution Medicines, Inc. Ras inhibitors
US11739074B2 (en) 2019-11-04 2023-08-29 Revolution Medicines, Inc. Ras inhibitors
TW202132314A (zh) 2019-11-04 2021-09-01 美商銳新醫藥公司 Ｒａｓ抑制劑
AU2021345111A1 (en) 2020-09-15 2023-04-06 Revolution Medicines, Inc. Indole derivatives as Ras inhibitors in the treatment of cancer
KR20240014756A (ko) 2022-07-26 2024-02-02 강원대학교산학협력단 에리트로마이신으로 로딩된 키토산 결합 닭뼈유래 수산화인회석 나노입자 및 그 제조방법
CN117288869B (zh) * 2023-11-24 2024-02-09 中国医学科学院医药生物技术研究所 一种原料药中对甲苯磺酸酯类杂质的检测方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013663A1 (fr) * 1992-01-17 1993-07-22 Abbott Laboratories Procede permettant d'effectuer la biosynthese de polycetides specifiques
US6060234A (en) * 1991-01-17 2000-05-09 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
ATE297992T1 (de) * 1993-09-20 2005-07-15 Univ Leland Stanford Junior Recombinante herstellung aromatischer polyketiden

Also Published As

Publication number Publication date
EP2182067A3 (fr) 2010-07-14
SK182498A3 (en) 2000-05-16
AP9901444A0 (en) 1999-03-31
ATE451455T1 (de) 2009-12-15
BG103133A (en) 2000-04-28
BR9710209A (pt) 2000-01-11
WO1998001546A2 (fr) 1998-01-15
WO1998001571A2 (fr) 1998-01-15
WO1998001571A3 (fr) 1998-02-19
AU731654B2 (en) 2001-04-05
JP2000516450A (ja) 2000-12-12
DE69733416T2 (de) 2006-04-27
GB9900156D0 (en) 1999-02-24
EP0909327B1 (fr) 2005-06-01
KR20000023579A (ko) 2000-04-25
DE69733416D1 (de) 2005-07-07
DE69739688D1 (de) 2010-01-21
CA2259420C (fr) 2007-09-18
IL127916A0 (en) 1999-11-30
EE03976B1 (et) 2003-02-17
DK0910633T3 (da) 2010-03-29
IS4940A (is) 1999-01-04
CA2259420A1 (fr) 1998-01-15
AP1029A (en) 2001-12-11
CN1229438A (zh) 1999-09-22
EP2182067A2 (fr) 2010-05-05
CN1179046C (zh) 2004-12-08
CA2259463A1 (fr) 1998-01-15
AU731301B2 (en) 2001-03-29
EP0910633B1 (fr) 2009-12-09
GB2331518B (en) 2001-03-14
EA199900087A1 (ru) 1999-08-26
AU3450997A (en) 1998-02-02
ES2337424T3 (es) 2010-04-23
PT909327E (pt) 2005-10-31
GB2331518A (en) 1999-05-26
NZ333861A (en) 2000-08-25
SI0910633T1 (sl) 2010-04-30
ATE296893T1 (de) 2005-06-15
NO990012D0 (no) 1999-01-04
ES2244001T3 (es) 2005-12-01
EE9900014A (et) 1999-08-16
EA001744B1 (ru) 2001-08-27
WO1998001546A3 (fr) 1998-04-09
DK0909327T3 (da) 2005-09-26
GEP20012348B (en) 2001-01-25
EP0909327A2 (fr) 1999-04-21
JP4173551B2 (ja) 2008-10-29
JP2000511063A (ja) 2000-08-29
PL331285A1 (en) 1999-07-05
AU3451497A (en) 1998-02-02
EP0910633A2 (fr) 1999-04-28
OA10952A (en) 2002-02-25
TR199900006T2 (xx) 1999-04-21

Similar Documents

Publication Publication Date Title
NO990012L (no) Nye erytromyciner og fremgangsmÕte for deres fremstilling
NO992297D0 (no) FremgangsmÕte og nye forbindelser
NO975710D0 (no) Nye Dolastatinderivater, deres fremstilling og anvendelse
NO984695L (no) Nye isoflavonanrikede soyaproteinprodukter og deres fremstilling
NO944187D0 (no) Isokinoliner, fremgangsmåte for deres fremstilling og anvendelse
NO20000627D0 (no) ForhÕndsbelagte kontrollert - frigjørings - gjødningsmidler og fremgangsmÕter for deres fremstilling
NO983965D0 (no) Polymer-organoleire-kompositter og deres fremstilling
DK0811006T3 (da) Benzopyranholdige forbindelser og fremgangsmåde til deres anvendelse
NO976072L (no) Propiofenonderivater og fremgangsmÕte for fremstilling derav
DK0869126T3 (da) Dithiolanderivater, deres fremstilling og deres terapeutiske virkning
DK0836615T3 (da) Nye thrombininhibitorer, deres fremstilling og anvendelse
NO20003067L (no) Antipicornavirus-forbindelser og fremgangsmÕter for deres anvendelse og fremstilling
NO991761D0 (no) Nye piperidin-kotokarbonsyre-derivater, deres fremstilling og anvendelse
NO20005266D0 (no) Nye substituerte amider, deres fremstilling og anvendelse
NO952677D0 (no) Nye dihydropyrrolopyridinon- og oksazolopyridinonforbindelser, deres fremstilling og farmasöytiske preparater
NO984717L (no) Nye hydroksamsyre-derivater, deres fremstilling og anvendelse
NO995909L (no) Krystallinske makrolider og fremgangsmåte for deres fremstilling
NO914288D0 (no) Nye 2-sakkarinylmetylarylkarboksylater og fremgangsmaater for deres fremstilling
NO941517L (no) 2-amino-4-kinolin-dihydropyridiner, fremgangsmåter for deres fremstilling og deres anvendelse
NO954763D0 (no) Piperidinderivater, deres fremstilling og anvendelse
NO984624D0 (no) Nye furan-diarylmetyliden-derivater, fremgangsmÕte for deres fremstilling og terapeutiske anvendelser derav
NO973230D0 (no) Nye peptider, deres fremstilling og anvendelse
NO984921D0 (no) Tienopyridinderivater og deres anvendelse
NO955242D0 (no) Piperidinderivater, fremgangsmåte for fremstilling derav og deres terapeutiske anvendelse
NO972821D0 (no) 1-C-perfluoralkylglycosider, deres fremstilling og anvendelse

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application