NO985039L - Alkyl-4-silyl-fenoler og estere derav som antiatherosklerotiske midler - Google Patents

Alkyl-4-silyl-fenoler og estere derav som antiatherosklerotiske midler

Info

Publication number
NO985039L
NO985039L NO985039A NO985039A NO985039L NO 985039 L NO985039 L NO 985039L NO 985039 A NO985039 A NO 985039A NO 985039 A NO985039 A NO 985039A NO 985039 L NO985039 L NO 985039L
Authority
NO
Norway
Prior art keywords
alkyl
hydrogen
independently
nr8r1
trifluoromethyl
Prior art date
Application number
NO985039A
Other languages
English (en)
Norwegian (no)
Other versions
NO985039D0 (no
Inventor
Steven Jeffrey Busch
Kim Seng Chen
Michael Louis Edwards
Jr James Edward Matt
Roger Alan Parker
Mark Joseph Vaal
Paul Steven Wright
Mark Thirston Yates
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of NO985039D0 publication Critical patent/NO985039D0/no
Publication of NO985039L publication Critical patent/NO985039L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO985039A 1996-04-30 1998-10-29 Alkyl-4-silyl-fenoler og estere derav som antiatherosklerotiske midler NO985039L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/637,968 US5608095A (en) 1996-04-30 1996-04-30 Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
PCT/US1997/003335 WO1997041129A1 (en) 1996-04-30 1997-03-03 Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents

Publications (2)

Publication Number Publication Date
NO985039D0 NO985039D0 (no) 1998-10-29
NO985039L true NO985039L (no) 1998-12-21

Family

ID=24558107

Family Applications (1)

Application Number Title Priority Date Filing Date
NO985039A NO985039L (no) 1996-04-30 1998-10-29 Alkyl-4-silyl-fenoler og estere derav som antiatherosklerotiske midler

Country Status (19)

Country Link
US (1) US5608095A (enExample)
EP (1) EP0900225B1 (enExample)
JP (1) JP4309473B2 (enExample)
KR (1) KR100503181B1 (enExample)
CN (1) CN1216993A (enExample)
AR (1) AR006890A1 (enExample)
AT (1) ATE212639T1 (enExample)
AU (1) AU711322B2 (enExample)
BR (1) BR9709190A (enExample)
CA (1) CA2251991C (enExample)
DE (1) DE69710191T2 (enExample)
DK (1) DK0900225T3 (enExample)
ES (1) ES2167716T3 (enExample)
IL (1) IL126758A0 (enExample)
NO (1) NO985039L (enExample)
PT (1) PT900225E (enExample)
TW (1) TW474940B (enExample)
WO (1) WO1997041129A1 (enExample)
ZA (1) ZA973503B (enExample)

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US5795876A (en) * 1996-04-30 1998-08-18 Hoechst Marion Rousssel, Inc. Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
PL194329B1 (pl) 1997-05-14 2007-05-31 Atherogenics Inc Zastosowanie monoestru probukolu kwasu bursztynowego lub jego farmaceutycznie dopuszczalnej soli dowytwarzania leku do leczenia choroby, której mediatorem jest VCAM-1
US6121463A (en) * 1997-06-24 2000-09-19 Hoechst Marion Roussel, Inc. Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents
WO1998058937A1 (en) * 1997-06-25 1998-12-30 Hoechst Marion Roussel, Inc. 2,6-DI-t-BUTYL-4-[ (DIMETHYL-4-METHOXYPHENYLSILYL) -METHYLOXY]PHENOL AND 2,6-DI-t-BUTYL-4-[ (DIMETHYL-2-METHOXY-PHENYLSILYL) -METHYLOXY]PHENOL
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
EA200000087A1 (ru) * 1997-07-01 2000-08-28 Атеродженикс, Инк. Повышение эффективности терапии гиперпролиферативных состояний с помощью антиоксиданта
DE69931279T2 (de) * 1998-11-09 2007-04-12 Atherogenics, Inc. Methode und zusammensetzungen zum vermindern des cholesterolspiegels im plasma
US6887712B1 (en) 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
US6020383A (en) * 1999-01-11 2000-02-01 Eastman Chemicals Company Method for reducing blood cholesterol and/or blood triglycerides
EP1343502A2 (en) 2000-11-17 2003-09-17 Idenix (Cayman) Limited Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines
WO2002087556A2 (en) * 2001-04-11 2002-11-07 Atherogenics, Inc. Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality
CN100415227C (zh) * 2001-10-25 2008-09-03 阿特罗吉尼克斯公司 化合物在制备用于治疗移植排斥的药物中的应用
WO2003039352A2 (en) * 2001-11-09 2003-05-15 Atherogenics, Inc. Methods of reversing and preventing cardiovascular pathologies
MXPA04005864A (es) * 2001-12-19 2004-10-29 Atherogenics Inc Derivados de charcona y su uso para tratar enfermedades.
US6960683B2 (en) * 2002-07-12 2005-11-01 Atherogenics, Inc. Salt forms of poorly soluble probucol esters and ethers
WO2004024094A2 (en) * 2002-09-13 2004-03-25 Samford University Methods and compositons for the use of d-malic acid to decrease serum triglyceride, cholesterol, and lipoprotein levels
WO2004056727A2 (en) * 2002-12-19 2004-07-08 Atherogenics, Inc. Process of making chalcone derivatives
CN100548950C (zh) * 2003-01-13 2009-10-14 阿特罗吉尼克斯公司 制备普罗布考及其衍生物的酯和醚的方法
US7173129B2 (en) * 2003-06-06 2007-02-06 Athero Genics, Inc. Sulfonamide-substituted chalcone derivatives and their use to treat diseases
EP1677804A1 (en) * 2003-10-17 2006-07-12 Amylin Pharmaceuticals, Inc. Silyl phenols for promoting vascular health
WO2005112914A2 (en) 2004-04-20 2005-12-01 Atherogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
US20070260087A1 (en) 2004-04-20 2007-11-08 Atherogenics, Inc. Process of Preparing Esters and Ethers of Probucol and Derivatives Thereof
WO2006004903A2 (en) * 2004-06-28 2006-01-12 Atherogenics, Inc. 1,2-bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof
WO2006007508A2 (en) * 2004-07-01 2006-01-19 Atherogenics, Inc. Compounds and methods for treating diabetic vascular diseases
AU2008230861A1 (en) * 2007-03-26 2008-10-02 Salutria Pharmaceuticals, Llc Methods and compositions of derivatives of probucol for the treatment of diabetes
WO2008118946A1 (en) * 2007-03-27 2008-10-02 Atherogenics, Inc. Methods and compositions using certain phenolic derivatives for the treatment of diabetes
ES2496093T3 (es) * 2010-04-15 2014-09-18 Merck Patent Gmbh Proceso para la preparación de hidroquinonas
WO2018008761A1 (ja) * 2016-07-08 2018-01-11 Ｙａｎｃｈｅｒｓ株式会社 固形癌治療剤

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Also Published As

Publication number Publication date
ES2167716T3 (es) 2002-05-16
EP0900225B1 (en) 2002-01-30
WO1997041129A1 (en) 1997-11-06
DK0900225T3 (da) 2002-05-13
CN1216993A (zh) 1999-05-19
AU1985497A (en) 1997-11-19
CA2251991C (en) 2002-05-14
JP2001509782A (ja) 2001-07-24
BR9709190A (pt) 1999-08-10
US5608095A (en) 1997-03-04
AU711322B2 (en) 1999-10-14
DE69710191D1 (de) 2002-03-14
JP4309473B2 (ja) 2009-08-05
ATE212639T1 (de) 2002-02-15
IL126758A0 (en) 1999-08-17
NO985039D0 (no) 1998-10-29
PT900225E (pt) 2002-06-28
DE69710191T2 (de) 2002-07-25
EP0900225A1 (en) 1999-03-10
KR20000065101A (ko) 2000-11-06
TW474940B (en) 2002-02-01
AR006890A1 (es) 1999-09-29
ZA973503B (en) 1997-10-30
CA2251991A1 (en) 1997-11-06
KR100503181B1 (ko) 2006-03-03

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