NO985039L - Alkyl-4-silyl-fenoler og estere derav som antiatherosklerotiske midler - Google Patents

Alkyl-4-silyl-fenoler og estere derav som antiatherosklerotiske midler

Info

Publication number
NO985039L
NO985039L NO985039A NO985039A NO985039L NO 985039 L NO985039 L NO 985039L NO 985039 A NO985039 A NO 985039A NO 985039 A NO985039 A NO 985039A NO 985039 L NO985039 L NO 985039L
Authority
NO
Norway
Prior art keywords
alkyl
hydrogen
independently
nr8r1
trifluoromethyl
Prior art date
Application number
NO985039A
Other languages
English (en)
Norwegian (no)
Other versions
NO985039D0 (no
Inventor
Steven Jeffrey Busch
Kim Seng Chen
Michael Louis Edwards
Jr James Edward Matt
Roger Alan Parker
Mark Joseph Vaal
Paul Steven Wright
Mark Thirston Yates
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of NO985039D0 publication Critical patent/NO985039D0/no
Publication of NO985039L publication Critical patent/NO985039L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO985039A 1996-04-30 1998-10-29 Alkyl-4-silyl-fenoler og estere derav som antiatherosklerotiske midler NO985039L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/637,968 US5608095A (en) 1996-04-30 1996-04-30 Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
PCT/US1997/003335 WO1997041129A1 (en) 1996-04-30 1997-03-03 Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents

Publications (2)

Publication Number Publication Date
NO985039D0 NO985039D0 (no) 1998-10-29
NO985039L true NO985039L (no) 1998-12-21

Family

ID=24558107

Family Applications (1)

Application Number Title Priority Date Filing Date
NO985039A NO985039L (no) 1996-04-30 1998-10-29 Alkyl-4-silyl-fenoler og estere derav som antiatherosklerotiske midler

Country Status (19)

Country Link
US (1) US5608095A (enExample)
EP (1) EP0900225B1 (enExample)
JP (1) JP4309473B2 (enExample)
KR (1) KR100503181B1 (enExample)
CN (1) CN1216993A (enExample)
AR (1) AR006890A1 (enExample)
AT (1) ATE212639T1 (enExample)
AU (1) AU711322B2 (enExample)
BR (1) BR9709190A (enExample)
CA (1) CA2251991C (enExample)
DE (1) DE69710191T2 (enExample)
DK (1) DK0900225T3 (enExample)
ES (1) ES2167716T3 (enExample)
IL (1) IL126758A0 (enExample)
NO (1) NO985039L (enExample)
PT (1) PT900225E (enExample)
TW (1) TW474940B (enExample)
WO (1) WO1997041129A1 (enExample)
ZA (1) ZA973503B (enExample)

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KR20000065102A (ko) * 1996-04-30 2000-11-06 게리 디. 스트리트, 스티븐 엘. 네스비트 2,6-디-알킬-4-실릴-페놀을사용한혈관세포흡착분자-1의억제방법및만성염증성질병의치료방법
US6670398B2 (en) * 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
EA200800375A1 (ru) * 1997-05-14 2008-06-30 Атеродженикс, Инк. Соединения и способы ингибирования экспрессии vcam-1
US6121463A (en) * 1997-06-24 2000-09-19 Hoechst Marion Roussel, Inc. Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
JP2002506443A (ja) * 1997-06-25 2002-02-26 アベンティス・ファーマスーティカルズ・インコーポレイテッド 2,6−ジ−t−ブチル−4−[(ジメチル−4−メトキシフェニルシリル)メチルオキシ]フェノール及び2,6−ジ−t−ブチル−4−[(ジメチル−2−メトキシフェニルシリル)メチルオキシ]フェノール
KR20010020611A (ko) * 1997-07-01 2001-03-15 아테로제닉스, 인코포레이티드 항산화제에 의한 과증식질병 치료의 향상
US6887712B1 (en) 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
CA2350316A1 (en) * 1998-11-09 2000-05-18 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
US6020383A (en) * 1999-01-11 2000-02-01 Eastman Chemicals Company Method for reducing blood cholesterol and/or blood triglycerides
WO2002040021A2 (en) 2000-11-17 2002-05-23 Idenix (Cayman) Limited Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines
WO2002087556A2 (en) * 2001-04-11 2002-11-07 Atherogenics, Inc. Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality
WO2003039231A2 (en) * 2001-10-25 2003-05-15 Atherogenics, Inc. Compounds and methods for treating transplant rejection
IL161741A0 (en) * 2001-11-09 2005-11-20 Atherogenics Inc Methods of reversing and preventingcardiovascular pathologies
CN1596240A (zh) * 2001-12-19 2005-03-16 阿特罗吉尼克斯公司 查耳酮衍生物及其治疗疾病的用途
AU2003253887A1 (en) * 2002-07-12 2004-02-02 Atherogenics, Inc. Novel salt forms of poorly soluble probucol esters and ethers
US20040110803A1 (en) * 2002-09-13 2004-06-10 Hossein Dovlatabadi Methods and compositions for the use of D-malic acid to decrease serum triglyceride, cholesterol and lipoprotein levels
WO2004056727A2 (en) * 2002-12-19 2004-07-08 Atherogenics, Inc. Process of making chalcone derivatives
BRPI0406738A (pt) * 2003-01-13 2005-12-20 Atherogenics Inc Processo de preparação de ésteres e éteres de probucol e derivados desse
WO2004108094A2 (en) * 2003-06-06 2004-12-16 Atherogenics, Inc. Sulfonamide-substituted chalcone derivatives and their use to treat diseases
WO2005039596A1 (en) * 2003-10-17 2005-05-06 Amylin Pharmaceuticals, Inc. Silyl phenols for promoting vascular health
US7294737B2 (en) 2004-04-20 2007-11-13 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
WO2005112914A2 (en) 2004-04-20 2005-12-01 Atherogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
US20060063828A1 (en) * 2004-06-28 2006-03-23 Weingarten M D 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof
AU2005262390B2 (en) * 2004-07-01 2011-09-22 Atherogenics, Inc. Compounds and methods for treating diabetic vascular diseases
JP2010522762A (ja) * 2007-03-26 2010-07-08 サルトリア・フアーマシユーテイカルズ・エル・エル・シー 糖尿病の治療のための方法及びプロブコール誘導体の組成物
US20080280985A1 (en) * 2007-03-27 2008-11-13 Scott Robert A D Methods and Compositions Using Certain Phenolic Derivatives for the Treatment of Diabetes
JP5778755B2 (ja) * 2010-04-15 2015-09-16 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung ヒドロキノンの製造方法
JP6447858B2 (ja) * 2016-07-08 2019-01-09 Yanchers株式会社 固形癌治療剤

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Also Published As

Publication number Publication date
PT900225E (pt) 2002-06-28
IL126758A0 (en) 1999-08-17
KR100503181B1 (ko) 2006-03-03
DK0900225T3 (da) 2002-05-13
JP2001509782A (ja) 2001-07-24
CA2251991C (en) 2002-05-14
EP0900225A1 (en) 1999-03-10
US5608095A (en) 1997-03-04
BR9709190A (pt) 1999-08-10
DE69710191T2 (de) 2002-07-25
NO985039D0 (no) 1998-10-29
AU711322B2 (en) 1999-10-14
AU1985497A (en) 1997-11-19
KR20000065101A (ko) 2000-11-06
WO1997041129A1 (en) 1997-11-06
ES2167716T3 (es) 2002-05-16
ZA973503B (en) 1997-10-30
CN1216993A (zh) 1999-05-19
CA2251991A1 (en) 1997-11-06
DE69710191D1 (de) 2002-03-14
EP0900225B1 (en) 2002-01-30
TW474940B (en) 2002-02-01
AR006890A1 (es) 1999-09-29
JP4309473B2 (ja) 2009-08-05
ATE212639T1 (de) 2002-02-15

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