NO951072L - Polyjoderte forbindelser, fremgangsmåte for deres fremstilling og diagnostisk preparat - Google Patents

Polyjoderte forbindelser, fremgangsmåte for deres fremstilling og diagnostisk preparat

Info

Publication number
NO951072L
NO951072L NO951072A NO951072A NO951072L NO 951072 L NO951072 L NO 951072L NO 951072 A NO951072 A NO 951072A NO 951072 A NO951072 A NO 951072A NO 951072 L NO951072 L NO 951072L
Authority
NO
Norway
Prior art keywords
ch2oh
preparation
substd
formula
opt
Prior art date
Application number
NO951072A
Other languages
English (en)
Other versions
NO951072D0 (no
Inventor
Myriam Petta
Dominique Meyer
Original Assignee
Guerbet Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet Sa filed Critical Guerbet Sa
Publication of NO951072D0 publication Critical patent/NO951072D0/no
Publication of NO951072L publication Critical patent/NO951072L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/12—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic the nitrogen atom of the amino group being further bound to hydrocarbon groups substituted by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/22—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/69—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cephalosporin Compounds (AREA)
  • Detergent Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

Oppfinnelsen vedrører forbindelser av formel: hvori Rlf R2, R3, R4, R5 og R6 er valgt uavhengig fra jodatom og gruppene: hvori: A representerer ingenting eller (C1-C4)alkylen. som eventuelt er hydroksylert, R7« Re» Rg» Rio« Rn °9 Ri2' som er identiske eller for- skjellige, representerer H, (C^-CujJalkyl, som eventuelt er hydroksylert eller bærer en eller flere (C1-C3)alkoksygrupper, som eventuelt er hydroksylert eller R7 og R8, R9 og R10 eller Rn °ST Ri2 kan, med nitrogenatomet hvortil de er bundet, uavhengig danne en 5- til 8-leddet mettet heterosyklus, som eventuelt er hydroksylert. med den betingelse at minst 4 grupper blant RI( R2, R3/ R4. R5 og R6 representerer et jodatom og at forbindelsene av formel I inneholder 10 til 24 hydroksylgrupper, idet alkyl. alkoksy og alkylen kan være lineær eller forgrenet. Forbindelsene kan anvendes som kontrastmidler i diagnostisk røntgenfotografering.
NO951072A 1994-03-22 1995-03-21 Polyjoderte forbindelser, fremgangsmåte for deres fremstilling og diagnostisk preparat NO951072L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9403356A FR2717799B1 (fr) 1994-03-22 1994-03-22 Composés polyiodes : procédé de préparation ; composition de diagnostic.

Publications (2)

Publication Number Publication Date
NO951072D0 NO951072D0 (no) 1995-03-21
NO951072L true NO951072L (no) 1995-09-25

Family

ID=9461306

Family Applications (1)

Application Number Title Priority Date Filing Date
NO951072A NO951072L (no) 1994-03-22 1995-03-21 Polyjoderte forbindelser, fremgangsmåte for deres fremstilling og diagnostisk preparat

Country Status (19)

Country Link
US (1) US5693311A (no)
EP (1) EP0675105B1 (no)
JP (1) JPH07316112A (no)
KR (1) KR950032116A (no)
CN (1) CN1112548A (no)
AT (1) ATE174902T1 (no)
AU (1) AU694164B2 (no)
BR (1) BR9501157A (no)
CA (1) CA2145035A1 (no)
CZ (1) CZ69595A3 (no)
DE (1) DE69506760T2 (no)
ES (1) ES2126224T3 (no)
FI (1) FI951323A (no)
FR (1) FR2717799B1 (no)
HU (1) HUT71893A (no)
IL (1) IL112985A (no)
NO (1) NO951072L (no)
NZ (1) NZ270750A (no)
ZA (1) ZA952265B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2780287B3 (fr) * 1998-06-30 2000-09-08 Guerbet Sa Derive polyhydroxyle du tetraiodoterephtalamide, son procede de preparation, son utilisation en radiologie et amino alcool intermediaire
US20060100127A1 (en) * 2004-11-11 2006-05-11 Meier Ingrid K N,N-dialkylpolyhydroxyalkylamines
EP2200656B1 (en) 2007-10-12 2012-12-05 GE Healthcare AS Contrast agents
DE102007058220A1 (de) 2007-12-03 2009-06-04 Bayer Schering Pharma Aktiengesellschaft Dimere macrocyclisch substituierte Benzolderivate
CN103086915A (zh) * 2011-10-31 2013-05-08 上海海神化学生物科技有限公司 制备3,5-二取代-2,4,6-三碘代芳香胺类化合物的碘化方法
US10918742B2 (en) 2016-03-25 2021-02-16 Nanoprobes, Inc. Iodine-based particles
US10342232B1 (en) 2018-10-24 2019-07-09 The United States Of America As Represented By The Secretary Of The Navy Iodinated polymers for biological agent defeat
CN114262279B (zh) * 2021-12-30 2022-12-16 上海汇禾医疗科技有限公司 一种x射线可显影分子、栓塞微球及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH385423A (de) * 1958-12-03 1964-12-15 Chemie Linz Ag Verwendung polyjodierter Benzoesäureabkömmlinge als Röntgenkontrastmittel
DE2909439A1 (de) * 1979-03-08 1980-09-18 Schering Ag Neue nichtionische roentgenkontrastmittel
IT1245853B (it) * 1990-11-16 1994-10-25 Bracco Spa 1,3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliidrossi-alchil) aminocarbonil-2,4,6-triiodo-benzoil-amino)-idrossi- o idrossi-alchil- propani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono
FR2687669B1 (fr) * 1992-02-24 1997-12-19 Guerbet Sa Composes utilisables dans des produits de contraste pour la radiographie.

Also Published As

Publication number Publication date
NO951072D0 (no) 1995-03-21
DE69506760T2 (de) 1999-09-02
DE69506760D1 (de) 1999-02-04
HU9500823D0 (en) 1995-05-29
HUT71893A (en) 1996-02-28
FR2717799A1 (fr) 1995-09-29
FR2717799B1 (fr) 1996-07-19
AU1499095A (en) 1995-09-28
EP0675105A1 (fr) 1995-10-04
ZA952265B (en) 1996-09-20
ATE174902T1 (de) 1999-01-15
AU694164B2 (en) 1998-07-16
CZ69595A3 (en) 1995-11-15
CA2145035A1 (en) 1995-09-23
ES2126224T3 (es) 1999-03-16
NZ270750A (en) 1996-05-28
JPH07316112A (ja) 1995-12-05
KR950032116A (ko) 1995-12-20
IL112985A (en) 1999-10-28
US5693311A (en) 1997-12-02
FI951323A (fi) 1995-09-23
FI951323A0 (fi) 1995-03-21
EP0675105B1 (fr) 1998-12-23
BR9501157A (pt) 1996-06-04
IL112985A0 (en) 1995-06-29
CN1112548A (zh) 1995-11-29

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Legal Events

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