HUP9900679A2 - Simaizom sejtburjánzást gátló benzimidazolszármazékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Simaizom sejtburjánzást gátló benzimidazolszármazékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP9900679A2
HUP9900679A2 HU9900679A HUP9900679A HUP9900679A2 HU P9900679 A2 HUP9900679 A2 HU P9900679A2 HU 9900679 A HU9900679 A HU 9900679A HU P9900679 A HUP9900679 A HU P9900679A HU P9900679 A2 HUP9900679 A2 HU P9900679A2
Authority
HU
Hungary
Prior art keywords
cell proliferation
inhibitors
producing
pharmaceutical compositions
compositions containing
Prior art date
Application number
HU9900679A
Other languages
English (en)
Inventor
Hassan Mahmoud Elokdah
Chai Sie-Yearl
Theodore Sylvester Sulkowski
Original Assignee
American Home Products Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corporation filed Critical American Home Products Corporation
Publication of HUP9900679A2 publication Critical patent/HUP9900679A2/hu
Publication of HUP9900679A3 publication Critical patent/HUP9900679A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány (I) vagy (II) általánős képletű vegyületekre ésgyógyászatilag elfőgadható sóira vőnatkőzik, ahől R jelentése alkil-, fenil- vagy szűbsztitűált fenilcsőpőrt; R2 jelentése hidrőgén- vagy halőgénatőm, alkőxi- vagy alkilcsőpőrt; R1 jelentése hidrőgénatőm, alkil-, aril-, aril-alkil- vagyszűbsztitűált benzilcsőpőrt, mely vegyületek simaizőm sejtbűrjánzástgátlóként hasznősak. ŕ
HU9900679A 1995-06-06 1996-06-03 Benzimidazole derivatives as inhibitors of smooth muscle cell proliferation, process for producing them and pharmaceutical compositions containing them HUP9900679A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/468,271 US6444694B1 (en) 1995-06-06 1995-06-06 Styryl benzimidazole derivatives

Publications (2)

Publication Number Publication Date
HUP9900679A2 true HUP9900679A2 (hu) 1999-09-28
HUP9900679A3 HUP9900679A3 (en) 2001-07-30

Family

ID=23859136

Family Applications (2)

Application Number Title Priority Date Filing Date
HU9900679A HUP9900679A3 (en) 1995-06-06 1996-06-03 Benzimidazole derivatives as inhibitors of smooth muscle cell proliferation, process for producing them and pharmaceutical compositions containing them
HU9900914A HUP9900914A2 (hu) 1995-06-06 1996-06-03 Simaizom sejtburjánzást gátló sztiril-benzimidazol-származékok

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU9900914A HUP9900914A2 (hu) 1995-06-06 1996-06-03 Simaizom sejtburjánzást gátló sztiril-benzimidazol-származékok

Country Status (19)

Country Link
US (1) US6444694B1 (hu)
EP (1) EP0830345B1 (hu)
JP (1) JPH11506753A (hu)
KR (1) KR19990022266A (hu)
CN (1) CN1192206A (hu)
AR (1) AR002749A1 (hu)
AT (1) ATE205196T1 (hu)
AU (1) AU711965B2 (hu)
BR (1) BR9609153A (hu)
CA (1) CA2223585A1 (hu)
DE (1) DE69615023T2 (hu)
DK (1) DK0830345T3 (hu)
ES (1) ES2162063T3 (hu)
HU (2) HUP9900679A3 (hu)
IL (1) IL118385A0 (hu)
NZ (1) NZ309499A (hu)
PT (1) PT830345E (hu)
WO (1) WO1996039391A1 (hu)
ZA (1) ZA964693B (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
EP2335700A1 (en) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
US7223785B2 (en) 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7098231B2 (en) 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
EA200901463A1 (ru) 2004-02-20 2010-08-30 Бёрингер Ингельхайм Интернациональ Гмбх Ингибиторы вирусной полимеразы
WO2007019674A1 (en) 2005-08-12 2007-02-22 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
KR101565271B1 (ko) 2006-07-05 2015-11-02 피브로테크 세라퓨틱 피티와이 엘티디 치료 화합물
EP2491030B1 (en) * 2009-10-22 2015-07-15 Fibrotech Therapeutics PTY LTD Fused ring analogues of anti-fibrotic agents
WO2018144620A1 (en) 2017-02-03 2018-08-09 Shire Human Genetic Therapies, Inc. Anti-fibrotic compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3575956A (en) * 1967-07-24 1971-04-20 Sterling Drug Inc 2-substituted-benz-x-azol-6-ylazo-aminonaphthalene compounds
DE1670908A1 (de) * 1967-08-16 1971-04-29 Hoechst Ag Neue Benzimidazolverbindungen,Verfahren zu ihrer Herstellung und ihre Verwendung als optische Aufhellungsmittel
FR2104717A1 (en) * 1970-09-28 1972-04-21 Dynachim Sarl Organophosphorus pesticides stabilised with benzimidazole derivs - - for controlling insects and internal parasites of animals
DE3505609A1 (de) 1985-02-19 1986-08-21 Merck Patent Gmbh, 6100 Darmstadt Benzimidazolyl-pyridazinone
CA2080582A1 (en) 1990-04-16 1991-10-17 Alfred P. Spada Heterocyclicethenediyl compounds which inhibit egf receptor tyrosine kinase
US5196446A (en) 1990-04-16 1993-03-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Certain indole compounds which inhibit EGF receptor tyrosine kinase
DE4212748A1 (de) 1992-04-16 1993-10-21 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5387600A (en) 1992-07-30 1995-02-07 Fuji Photo Film Co., Ltd. Treating arteriosclerosis using benzimidazole compositions

Also Published As

Publication number Publication date
DK0830345T3 (da) 2001-11-19
ES2162063T3 (es) 2001-12-16
MX9709647A (es) 1998-07-31
HUP9900914A2 (hu) 1999-07-28
EP0830345B1 (en) 2001-09-05
CN1192206A (zh) 1998-09-02
IL118385A0 (en) 1996-09-12
US6444694B1 (en) 2002-09-03
HUP9900679A3 (en) 2001-07-30
WO1996039391A1 (en) 1996-12-12
ZA964693B (en) 1997-12-05
AR002749A1 (es) 1998-04-29
NZ309499A (en) 2000-08-25
AU711965B2 (en) 1999-10-28
BR9609153A (pt) 1999-05-04
DE69615023D1 (de) 2001-10-11
KR19990022266A (ko) 1999-03-25
DE69615023T2 (de) 2002-06-06
EP0830345A1 (en) 1998-03-25
PT830345E (pt) 2002-01-30
JPH11506753A (ja) 1999-06-15
AU5968496A (en) 1996-12-24
CA2223585A1 (en) 1996-12-12
ATE205196T1 (de) 2001-09-15

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