AU711322B2 - Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents - Google Patents

Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents Download PDF

Info

Publication number
AU711322B2
AU711322B2 AU19854/97A AU1985497A AU711322B2 AU 711322 B2 AU711322 B2 AU 711322B2 AU 19854/97 A AU19854/97 A AU 19854/97A AU 1985497 A AU1985497 A AU 1985497A AU 711322 B2 AU711322 B2 AU 711322B2
Authority
AU
Australia
Prior art keywords
compound
butyl
phenol
methyl
methyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU19854/97A
Other languages
English (en)
Other versions
AU1985497A (en
Inventor
Steven J Busch
Kim S. Chen
Michael J. Edwards
James E. Matt Jr.
Roger A. Parker
Mark J. Vaal
Paul S Wright
Mark T. Yates
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of AU1985497A publication Critical patent/AU1985497A/en
Application granted granted Critical
Publication of AU711322B2 publication Critical patent/AU711322B2/en
Assigned to AVENTIS PHARMACEUTICALS INC. reassignment AVENTIS PHARMACEUTICALS INC. Alteration of Name(s) in Register under S187 Assignors: HOECHST MARION ROUSSEL, INC.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU19854/97A 1996-04-30 1997-03-03 Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents Ceased AU711322B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/637968 1996-04-30
US08/637,968 US5608095A (en) 1996-04-30 1996-04-30 Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
PCT/US1997/003335 WO1997041129A1 (en) 1996-04-30 1997-03-03 Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents

Publications (2)

Publication Number Publication Date
AU1985497A AU1985497A (en) 1997-11-19
AU711322B2 true AU711322B2 (en) 1999-10-14

Family

ID=24558107

Family Applications (1)

Application Number Title Priority Date Filing Date
AU19854/97A Ceased AU711322B2 (en) 1996-04-30 1997-03-03 Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents

Country Status (19)

Country Link
US (1) US5608095A (enExample)
EP (1) EP0900225B1 (enExample)
JP (1) JP4309473B2 (enExample)
KR (1) KR100503181B1 (enExample)
CN (1) CN1216993A (enExample)
AR (1) AR006890A1 (enExample)
AT (1) ATE212639T1 (enExample)
AU (1) AU711322B2 (enExample)
BR (1) BR9709190A (enExample)
CA (1) CA2251991C (enExample)
DE (1) DE69710191T2 (enExample)
DK (1) DK0900225T3 (enExample)
ES (1) ES2167716T3 (enExample)
IL (1) IL126758A0 (enExample)
NO (1) NO985039L (enExample)
PT (1) PT900225E (enExample)
TW (1) TW474940B (enExample)
WO (1) WO1997041129A1 (enExample)
ZA (1) ZA973503B (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2252869A1 (en) * 1996-04-30 1997-11-06 Hoechst Marion Roussel, Inc. Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2,6-di-alkyl-4-silyl-phenols
US5795876A (en) * 1996-04-30 1998-08-18 Hoechst Marion Rousssel, Inc. Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
PL194329B1 (pl) 1997-05-14 2007-05-31 Atherogenics Inc Zastosowanie monoestru probukolu kwasu bursztynowego lub jego farmaceutycznie dopuszczalnej soli dowytwarzania leku do leczenia choroby, której mediatorem jest VCAM-1
US6121463A (en) * 1997-06-24 2000-09-19 Hoechst Marion Roussel, Inc. Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents
WO1998058937A1 (en) * 1997-06-25 1998-12-30 Hoechst Marion Roussel, Inc. 2,6-DI-t-BUTYL-4-[ (DIMETHYL-4-METHOXYPHENYLSILYL) -METHYLOXY]PHENOL AND 2,6-DI-t-BUTYL-4-[ (DIMETHYL-2-METHOXY-PHENYLSILYL) -METHYLOXY]PHENOL
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
EA200000087A1 (ru) * 1997-07-01 2000-08-28 Атеродженикс, Инк. Повышение эффективности терапии гиперпролиферативных состояний с помощью антиоксиданта
DE69931279T2 (de) * 1998-11-09 2007-04-12 Atherogenics, Inc. Methode und zusammensetzungen zum vermindern des cholesterolspiegels im plasma
US6887712B1 (en) 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
US6020383A (en) * 1999-01-11 2000-02-01 Eastman Chemicals Company Method for reducing blood cholesterol and/or blood triglycerides
EP1343502A2 (en) 2000-11-17 2003-09-17 Idenix (Cayman) Limited Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines
WO2002087556A2 (en) * 2001-04-11 2002-11-07 Atherogenics, Inc. Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality
CN100415227C (zh) * 2001-10-25 2008-09-03 阿特罗吉尼克斯公司 化合物在制备用于治疗移植排斥的药物中的应用
WO2003039352A2 (en) * 2001-11-09 2003-05-15 Atherogenics, Inc. Methods of reversing and preventing cardiovascular pathologies
MXPA04005864A (es) * 2001-12-19 2004-10-29 Atherogenics Inc Derivados de charcona y su uso para tratar enfermedades.
US6960683B2 (en) * 2002-07-12 2005-11-01 Atherogenics, Inc. Salt forms of poorly soluble probucol esters and ethers
WO2004024094A2 (en) * 2002-09-13 2004-03-25 Samford University Methods and compositons for the use of d-malic acid to decrease serum triglyceride, cholesterol, and lipoprotein levels
WO2004056727A2 (en) * 2002-12-19 2004-07-08 Atherogenics, Inc. Process of making chalcone derivatives
CN100548950C (zh) * 2003-01-13 2009-10-14 阿特罗吉尼克斯公司 制备普罗布考及其衍生物的酯和醚的方法
US7173129B2 (en) * 2003-06-06 2007-02-06 Athero Genics, Inc. Sulfonamide-substituted chalcone derivatives and their use to treat diseases
EP1677804A1 (en) * 2003-10-17 2006-07-12 Amylin Pharmaceuticals, Inc. Silyl phenols for promoting vascular health
WO2005112914A2 (en) 2004-04-20 2005-12-01 Atherogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
US20070260087A1 (en) 2004-04-20 2007-11-08 Atherogenics, Inc. Process of Preparing Esters and Ethers of Probucol and Derivatives Thereof
WO2006004903A2 (en) * 2004-06-28 2006-01-12 Atherogenics, Inc. 1,2-bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof
WO2006007508A2 (en) * 2004-07-01 2006-01-19 Atherogenics, Inc. Compounds and methods for treating diabetic vascular diseases
AU2008230861A1 (en) * 2007-03-26 2008-10-02 Salutria Pharmaceuticals, Llc Methods and compositions of derivatives of probucol for the treatment of diabetes
WO2008118946A1 (en) * 2007-03-27 2008-10-02 Atherogenics, Inc. Methods and compositions using certain phenolic derivatives for the treatment of diabetes
ES2496093T3 (es) * 2010-04-15 2014-09-18 Merck Patent Gmbh Proceso para la preparación de hidroquinonas
WO2018008761A1 (ja) * 2016-07-08 2018-01-11 Ｙａｎｃｈｅｒｓ株式会社 固形癌治療剤

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3129262A (en) * 1962-10-08 1964-04-14 Consolidation Coal Co Reduction of organic thiocyanates
US3862332A (en) * 1967-05-11 1975-01-21 Dow Chemical Co Method of lowering serum cholesterol
US3576883A (en) * 1969-06-30 1971-04-27 Consolidation Coal Co Alkylidenedithiobisphenols
US3897500A (en) * 1971-12-10 1975-07-29 Continental Oil Co Alkylidenedithiobisphenols
US3786100A (en) * 1971-12-10 1974-01-15 Continental Oil Co Keto substituted alkylidenedithiobisphenols
JPS61263988A (ja) * 1985-05-16 1986-11-21 Shionogi & Co Ltd シリル置換エ−テル類および殺虫・殺ダニ剤
US5356917A (en) * 1985-08-09 1994-10-18 Eli Lilly And Company Aryl-substituted rhodanine derivatives
US4719237A (en) * 1986-01-28 1988-01-12 Merrell Dow Pharmaceuticals Inc. Cardiac antiarrythmic method employing probucol
US4734527A (en) * 1986-10-17 1988-03-29 Merrell Dow Pharmaceuticals Inc. Process for preparing 2,6-di-tertiarybutyl-4-mercaptophenol
US4772363A (en) * 1987-01-14 1988-09-20 Merrell Dow Pharmaceuticals Inc. Process for preparing 2,6-di-tertiarybutyl-4-mercaptophenol by electrocatalysis
US4861443A (en) * 1987-01-14 1989-08-29 Merrell Dow Pharmaceuticals Inc. Process for preparing 4,4'-isopropylidenedithio-bis-(2,6-di-tertiarybutylphenol) by electrocatalysis
US5401883A (en) * 1987-01-20 1995-03-28 Merrell Dow Pharmaceuticals Inc. Process for preparing 2,6-di-tertiarybutyl-4-mercaptophenol and 4,4'-isopropylidenedithio-bis-(2,6-di-tertiarybutylphenol)
US4975467A (en) * 1987-03-17 1990-12-04 Merrell Dow Pharmaceuticals Inc. Method of inhibiting interleukin-1 release and alleviating interleukin-1 mediated conditions
JPH0813824B2 (ja) * 1988-10-27 1996-02-14 北興化学工業株式会社 有機ケイ素化合物
US4900757A (en) * 1988-12-08 1990-02-13 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane
US5047555A (en) * 1988-12-13 1991-09-10 Tanabe Seiyaku Co., Ltd. 4-aminophenol derivatives and processes for preparing the same
US5272263A (en) * 1989-04-28 1993-12-21 Biogen, Inc. DNA sequences encoding vascular cell adhesion molecules (VCAMS)
US5217870A (en) * 1989-04-28 1993-06-08 Biogen, Inc. Monoclonal antibodies against CDX
US5008421A (en) * 1989-07-05 1991-04-16 Aristech Chemical Corporation Silyl derivatives of 2,6-dimethyl-4-allyl phenol
DE3935638A1 (de) * 1989-10-26 1991-05-02 Consortium Elektrochem Ind Organosilylalkylaromaten
US5112870A (en) * 1990-05-09 1992-05-12 Merrell Dow Pharmaceuticals Inc. Bis(alkyl-substituted-4-hydroxyphenylthio)alkane analogs as inhibitors of cataractogenesis
US5061734A (en) * 1990-05-09 1991-10-29 Merrell Dow Pharmaceuticals Inc. Bis(alkyl-substituted-4-hydroxyphenylthio)alkane analogs as inhibitors of cataractogenesis
JP2899064B2 (ja) * 1990-05-23 1999-06-02 キヤノン株式会社 液晶性化合物、これを含む液晶組成物およびこれを使用した液晶素子
NZ238807A (en) * 1990-07-05 1994-03-25 Merrell Dow Pharma Bis[4-(2,6-dialkyl)phenol]silane derivatives and antiatherosclerotic compositions
US5304668A (en) * 1990-07-05 1994-04-19 Merrell Dow Pharmaceuticals Bis-[4-(2,6-di-alkyl)phenolisilane derivatives as antiatherosclerotic agents
US5155250A (en) * 1990-07-05 1992-10-13 Merrell Dow Pharmaceuticals Inc. 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents
US5254549A (en) * 1991-12-19 1993-10-19 Merz & Co. Gmbh & Co. New BHT ether compounds and their use as hypolipidemic and antiatherosclerotic drugs
US5262439A (en) * 1992-04-30 1993-11-16 The Regents Of The University Of California Soluble analogs of probucol
AU673193B2 (en) * 1992-09-02 1996-10-31 Isis Pharmaceuticals, Inc. Oligonucleotide modulation of cell adhesion
US5380747A (en) * 1992-10-30 1995-01-10 Emory University Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
DE69309487T2 (de) * 1992-11-13 1997-10-23 Univ Washington Peripheralisierung hämatopoietischer stammzellen
CA2152394A1 (en) * 1992-12-22 1994-07-07 Ronald Joseph King Piperidine derivatives as calcium channel antagonists
SG44845A1 (en) * 1993-01-12 1997-12-19 Biogen Inc Recombitant anti-vla4 antibody molecules
AU687790B2 (en) * 1993-02-09 1998-03-05 Biogen Idec Ma Inc. Treatment for insulin dependent diabetes
WO1995004749A1 (en) * 1993-08-05 1995-02-16 Isis Pharmaceuticals, Inc. Oligomers for modulating metabolic function
JP3650144B2 (ja) * 1994-06-08 2005-05-18 花王株式会社 細胞接着抑制剤

Also Published As

Publication number Publication date
ES2167716T3 (es) 2002-05-16
EP0900225B1 (en) 2002-01-30
WO1997041129A1 (en) 1997-11-06
DK0900225T3 (da) 2002-05-13
CN1216993A (zh) 1999-05-19
AU1985497A (en) 1997-11-19
CA2251991C (en) 2002-05-14
JP2001509782A (ja) 2001-07-24
BR9709190A (pt) 1999-08-10
NO985039L (no) 1998-12-21
US5608095A (en) 1997-03-04
DE69710191D1 (de) 2002-03-14
JP4309473B2 (ja) 2009-08-05
ATE212639T1 (de) 2002-02-15
IL126758A0 (en) 1999-08-17
NO985039D0 (no) 1998-10-29
PT900225E (pt) 2002-06-28
DE69710191T2 (de) 2002-07-25
EP0900225A1 (en) 1999-03-10
KR20000065101A (ko) 2000-11-06
TW474940B (en) 2002-02-01
AR006890A1 (es) 1999-09-29
ZA973503B (en) 1997-10-30
CA2251991A1 (en) 1997-11-06
KR100503181B1 (ko) 2006-03-03

Similar Documents

Publication Publication Date Title
AU711322B2 (en) Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
JP2009132710A (ja) 抗酸化剤として有用な置換フェノールおよびチオフェノール
KR20000065102A (ko) 2,6-디-알킬-4-실릴-페놀을사용한혈관세포흡착분자-1의억제방법및만성염증성질병의치료방법
US6114572A (en) Substituted phenols and thiophenols useful as antioxidant agents
US6121463A (en) Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents
CA2293461C (en) Alkyl-4-silylheterocyclic phenols and thiophenols as antioxidant agents
MXPA98009012A (en) Rent-4-silil-phenoles and esters of the same as agents antiateroscleroti
HK1027815B (en) Alkyl-4-silylheterocyclic phenols and thiophenols as antioxidant agents
HK1021970B (en) Substituted phenols and thiophenols useful as antioxidant agents
HUP9903447A2 (hu) Arteroszklerózis-ellenes hatású alkil-4-szilil-fenolok és észtereik
MXPA99011872A (en) Alkyl-4-silylheterocyclic phenols and thiophenols as antioxidant agents
MXPA99004653A (en) Substituted phenols and thiophenols useful as antioxidant agents