JP4309473B2 - 抗アテローム性動脈硬化剤としてのアルキル―４―シリル―フェノールおよびそのエステル - Google Patents
抗アテローム性動脈硬化剤としてのアルキル―４―シリル―フェノールおよびそのエステル Download PDFInfo
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- JP4309473B2 JP4309473B2 JP53886297A JP53886297A JP4309473B2 JP 4309473 B2 JP4309473 B2 JP 4309473B2 JP 53886297 A JP53886297 A JP 53886297A JP 53886297 A JP53886297 A JP 53886297A JP 4309473 B2 JP4309473 B2 JP 4309473B2
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- Prior art keywords
- phenol
- butyl
- methyloxy
- methyl
- dimethylphenylsilyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- CBCWILDIHQQQMU-UHFFFAOYSA-N [2,5-ditert-butyl-4-[[dimethyl(phenyl)silyl]methoxy]phenyl] acetate Chemical compound C1=C(C(C)(C)C)C(OC(=O)C)=CC(C(C)(C)C)=C1OC[Si](C)(C)C1=CC=CC=C1 CBCWILDIHQQQMU-UHFFFAOYSA-N 0.000 claims description 2
- LCRVOORFFQBAPA-UHFFFAOYSA-N [2-tert-butyl-4-[[dimethyl(phenyl)silyl]methoxy]phenyl] acetate Chemical compound C1=C(C(C)(C)C)C(OC(=O)C)=CC=C1OC[Si](C)(C)C1=CC=CC=C1 LCRVOORFFQBAPA-UHFFFAOYSA-N 0.000 claims description 2
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- DYUMLJSJISTVPV-UHFFFAOYSA-N phenyl propanoate Chemical compound CCC(=O)OC1=CC=CC=C1 DYUMLJSJISTVPV-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/637,968 US5608095A (en) | 1996-04-30 | 1996-04-30 | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents |
| US08/637,968 | 1996-04-30 | ||
| PCT/US1997/003335 WO1997041129A1 (en) | 1996-04-30 | 1997-03-03 | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001509782A JP2001509782A (ja) | 2001-07-24 |
| JP2001509782A5 JP2001509782A5 (enExample) | 2004-12-02 |
| JP4309473B2 true JP4309473B2 (ja) | 2009-08-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP53886297A Expired - Fee Related JP4309473B2 (ja) | 1996-04-30 | 1997-03-03 | 抗アテローム性動脈硬化剤としてのアルキル―４―シリル―フェノールおよびそのエステル |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5608095A (enExample) |
| EP (1) | EP0900225B1 (enExample) |
| JP (1) | JP4309473B2 (enExample) |
| KR (1) | KR100503181B1 (enExample) |
| CN (1) | CN1216993A (enExample) |
| AR (1) | AR006890A1 (enExample) |
| AT (1) | ATE212639T1 (enExample) |
| AU (1) | AU711322B2 (enExample) |
| BR (1) | BR9709190A (enExample) |
| CA (1) | CA2251991C (enExample) |
| DE (1) | DE69710191T2 (enExample) |
| DK (1) | DK0900225T3 (enExample) |
| ES (1) | ES2167716T3 (enExample) |
| IL (1) | IL126758A0 (enExample) |
| NO (1) | NO985039L (enExample) |
| PT (1) | PT900225E (enExample) |
| TW (1) | TW474940B (enExample) |
| WO (1) | WO1997041129A1 (enExample) |
| ZA (1) | ZA973503B (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5795876A (en) * | 1996-04-30 | 1998-08-18 | Hoechst Marion Rousssel, Inc. | Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols |
| WO1997040837A1 (en) * | 1996-04-30 | 1997-11-06 | Hoechst Marion Roussel, Inc. | Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2,6-di-alkyl-4-silyl-phenols |
| CN1287783C (zh) * | 1997-05-14 | 2006-12-06 | 阿特罗吉尼克斯公司 | 普罗布考单酯在制备用于治疗心血管疾病和炎性疾病的药物中的应用 |
| US6670398B2 (en) * | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
| US6121463A (en) * | 1997-06-24 | 2000-09-19 | Hoechst Marion Roussel, Inc. | Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents |
| US6133467A (en) * | 1997-06-25 | 2000-10-17 | Hoechst Marion Roussel, Inc. | 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol |
| CA2295232A1 (en) * | 1997-06-25 | 1998-12-30 | Hoechst Marion Roussel, Inc. | 2,6-di-t-butyl-4-[ (dimethyl-4-methoxyphenylsilyl) -methyloxy]phenol and 2,6-di-t-butyl-4-[ (dimethyl-2-methoxy-phenylsilyl) -methyloxy]phenol |
| CA2294247C (en) * | 1997-07-01 | 2004-10-26 | Atherogenics, Inc. | Antioxidant enhancement of therapy for hyperproliferative conditions |
| US6887712B1 (en) | 1998-11-09 | 2005-05-03 | Atherogenics, Inc. | Methods and compositions to lower plasma cholesterol levels |
| CN1332849A (zh) * | 1998-11-09 | 2002-01-23 | 埃瑟若詹尼克斯公司 | 降低血浆胆固醇水平的方法和组合物 |
| US6020383A (en) * | 1999-01-11 | 2000-02-01 | Eastman Chemicals Company | Method for reducing blood cholesterol and/or blood triglycerides |
| WO2002040021A2 (en) | 2000-11-17 | 2002-05-23 | Idenix (Cayman) Limited | Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines |
| WO2002087556A2 (en) * | 2001-04-11 | 2002-11-07 | Atherogenics, Inc. | Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality |
| CN100512809C (zh) * | 2001-10-25 | 2009-07-15 | 阿特罗吉尼克斯公司 | 化合物在制备用于慢性移植排斥的药物中的用途 |
| IL161741A0 (en) * | 2001-11-09 | 2005-11-20 | Atherogenics Inc | Methods of reversing and preventingcardiovascular pathologies |
| BR0215240A (pt) * | 2001-12-19 | 2004-10-26 | Atherogenics Inc | Derivados de calcona e seu uso no tratamento de doenças |
| US6960683B2 (en) * | 2002-07-12 | 2005-11-01 | Atherogenics, Inc. | Salt forms of poorly soluble probucol esters and ethers |
| US20040110803A1 (en) * | 2002-09-13 | 2004-06-10 | Hossein Dovlatabadi | Methods and compositions for the use of D-malic acid to decrease serum triglyceride, cholesterol and lipoprotein levels |
| WO2004056727A2 (en) * | 2002-12-19 | 2004-07-08 | Atherogenics, Inc. | Process of making chalcone derivatives |
| WO2004062622A2 (en) * | 2003-01-13 | 2004-07-29 | Atherogenics, Inc. | Process of preparing esters and ethers of probucol and derivatives thereof |
| WO2004108094A2 (en) * | 2003-06-06 | 2004-12-16 | Atherogenics, Inc. | Sulfonamide-substituted chalcone derivatives and their use to treat diseases |
| WO2005039596A1 (en) * | 2003-10-17 | 2005-05-06 | Amylin Pharmaceuticals, Inc. | Silyl phenols for promoting vascular health |
| US7294737B2 (en) | 2004-04-20 | 2007-11-13 | Atherogenics, Inc. | Process of preparing esters and ethers of probucol and derivatives thereof |
| WO2005112914A2 (en) | 2004-04-20 | 2005-12-01 | Atherogenics, Inc. | Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease |
| US20060063828A1 (en) * | 2004-06-28 | 2006-03-23 | Weingarten M D | 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof |
| CA2571589A1 (en) * | 2004-07-01 | 2006-01-19 | Atherogenics, Inc. | Compounds and methods for treating diabetic vascular diseases |
| CA2682258A1 (en) * | 2007-03-26 | 2008-10-02 | Salutria Pharmaceuticals Llc | Methods and compositions of derivatives of probucol for the treatment of diabetes |
| US20080280985A1 (en) * | 2007-03-27 | 2008-11-13 | Scott Robert A D | Methods and Compositions Using Certain Phenolic Derivatives for the Treatment of Diabetes |
| EP2558433B1 (en) * | 2010-04-15 | 2014-06-18 | Merck Patent GmbH | Process for the preparation of hydroquinones |
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1996
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- 1997-03-03 JP JP53886297A patent/JP4309473B2/ja not_active Expired - Fee Related
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- 1997-03-03 EP EP97907998A patent/EP0900225B1/en not_active Expired - Lifetime
- 1997-03-03 AU AU19854/97A patent/AU711322B2/en not_active Ceased
- 1997-03-03 CN CN97194267A patent/CN1216993A/zh active Pending
- 1997-03-03 KR KR1019980708692A patent/KR100503181B1/ko not_active Expired - Fee Related
- 1997-03-03 PT PT97907998T patent/PT900225E/pt unknown
- 1997-03-03 DK DK97907998T patent/DK0900225T3/da active
- 1997-03-03 AT AT97907998T patent/ATE212639T1/de not_active IP Right Cessation
- 1997-03-03 IL IL12675897A patent/IL126758A0/xx unknown
- 1997-03-03 DE DE69710191T patent/DE69710191T2/de not_active Expired - Fee Related
- 1997-03-03 BR BR9709190A patent/BR9709190A/pt active Search and Examination
- 1997-04-23 TW TW086105269A patent/TW474940B/zh active
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Also Published As
| Publication number | Publication date |
|---|---|
| TW474940B (en) | 2002-02-01 |
| JP2001509782A (ja) | 2001-07-24 |
| AU711322B2 (en) | 1999-10-14 |
| KR100503181B1 (ko) | 2006-03-03 |
| CA2251991A1 (en) | 1997-11-06 |
| NO985039D0 (no) | 1998-10-29 |
| EP0900225A1 (en) | 1999-03-10 |
| ES2167716T3 (es) | 2002-05-16 |
| EP0900225B1 (en) | 2002-01-30 |
| AU1985497A (en) | 1997-11-19 |
| DK0900225T3 (da) | 2002-05-13 |
| ATE212639T1 (de) | 2002-02-15 |
| AR006890A1 (es) | 1999-09-29 |
| WO1997041129A1 (en) | 1997-11-06 |
| ZA973503B (en) | 1997-10-30 |
| DE69710191D1 (de) | 2002-03-14 |
| NO985039L (no) | 1998-12-21 |
| CA2251991C (en) | 2002-05-14 |
| CN1216993A (zh) | 1999-05-19 |
| IL126758A0 (en) | 1999-08-17 |
| KR20000065101A (ko) | 2000-11-06 |
| BR9709190A (pt) | 1999-08-10 |
| US5608095A (en) | 1997-03-04 |
| PT900225E (pt) | 2002-06-28 |
| DE69710191T2 (de) | 2002-07-25 |
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