ATE212639T1 - Alkyl-4-silyl-phenole und deren ester als antiatherosclerotische mittel - Google Patents

Alkyl-4-silyl-phenole und deren ester als antiatherosclerotische mittel

Info

Publication number
ATE212639T1
ATE212639T1 AT97907998T AT97907998T ATE212639T1 AT E212639 T1 ATE212639 T1 AT E212639T1 AT 97907998 T AT97907998 T AT 97907998T AT 97907998 T AT97907998 T AT 97907998T AT E212639 T1 ATE212639 T1 AT E212639T1
Authority
AT
Austria
Prior art keywords
silyl
phenols
esters
alkyl
antiatherosclerotic agents
Prior art date
Application number
AT97907998T
Other languages
German (de)
English (en)
Inventor
Steven J Busch
Kim S Chen
Michael J Edwards
James E Matt Jr
Roger A Parker
Mark J Vaal
Paul S Wright
Mark T Yates
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of ATE212639T1 publication Critical patent/ATE212639T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT97907998T 1996-04-30 1997-03-03 Alkyl-4-silyl-phenole und deren ester als antiatherosclerotische mittel ATE212639T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/637,968 US5608095A (en) 1996-04-30 1996-04-30 Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
PCT/US1997/003335 WO1997041129A1 (en) 1996-04-30 1997-03-03 Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents

Publications (1)

Publication Number Publication Date
ATE212639T1 true ATE212639T1 (de) 2002-02-15

Family

ID=24558107

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97907998T ATE212639T1 (de) 1996-04-30 1997-03-03 Alkyl-4-silyl-phenole und deren ester als antiatherosclerotische mittel

Country Status (19)

Country Link
US (1) US5608095A (enExample)
EP (1) EP0900225B1 (enExample)
JP (1) JP4309473B2 (enExample)
KR (1) KR100503181B1 (enExample)
CN (1) CN1216993A (enExample)
AR (1) AR006890A1 (enExample)
AT (1) ATE212639T1 (enExample)
AU (1) AU711322B2 (enExample)
BR (1) BR9709190A (enExample)
CA (1) CA2251991C (enExample)
DE (1) DE69710191T2 (enExample)
DK (1) DK0900225T3 (enExample)
ES (1) ES2167716T3 (enExample)
IL (1) IL126758A0 (enExample)
NO (1) NO985039L (enExample)
PT (1) PT900225E (enExample)
TW (1) TW474940B (enExample)
WO (1) WO1997041129A1 (enExample)
ZA (1) ZA973503B (enExample)

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WO1997040837A1 (en) * 1996-04-30 1997-11-06 Hoechst Marion Roussel, Inc. Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2,6-di-alkyl-4-silyl-phenols
CN1287783C (zh) * 1997-05-14 2006-12-06 阿特罗吉尼克斯公司 普罗布考单酯在制备用于治疗心血管疾病和炎性疾病的药物中的应用
US6670398B2 (en) * 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
US6121463A (en) * 1997-06-24 2000-09-19 Hoechst Marion Roussel, Inc. Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
CA2295232A1 (en) * 1997-06-25 1998-12-30 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[ (dimethyl-4-methoxyphenylsilyl) -methyloxy]phenol and 2,6-di-t-butyl-4-[ (dimethyl-2-methoxy-phenylsilyl) -methyloxy]phenol
CA2294247C (en) * 1997-07-01 2004-10-26 Atherogenics, Inc. Antioxidant enhancement of therapy for hyperproliferative conditions
US6887712B1 (en) 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
CN1332849A (zh) * 1998-11-09 2002-01-23 埃瑟若詹尼克斯公司 降低血浆胆固醇水平的方法和组合物
US6020383A (en) * 1999-01-11 2000-02-01 Eastman Chemicals Company Method for reducing blood cholesterol and/or blood triglycerides
WO2002040021A2 (en) 2000-11-17 2002-05-23 Idenix (Cayman) Limited Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines
WO2002087556A2 (en) * 2001-04-11 2002-11-07 Atherogenics, Inc. Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality
CN100512809C (zh) * 2001-10-25 2009-07-15 阿特罗吉尼克斯公司 化合物在制备用于慢性移植排斥的药物中的用途
IL161741A0 (en) * 2001-11-09 2005-11-20 Atherogenics Inc Methods of reversing and preventingcardiovascular pathologies
BR0215240A (pt) * 2001-12-19 2004-10-26 Atherogenics Inc Derivados de calcona e seu uso no tratamento de doenças
US6960683B2 (en) * 2002-07-12 2005-11-01 Atherogenics, Inc. Salt forms of poorly soluble probucol esters and ethers
US20040110803A1 (en) * 2002-09-13 2004-06-10 Hossein Dovlatabadi Methods and compositions for the use of D-malic acid to decrease serum triglyceride, cholesterol and lipoprotein levels
WO2004056727A2 (en) * 2002-12-19 2004-07-08 Atherogenics, Inc. Process of making chalcone derivatives
WO2004062622A2 (en) * 2003-01-13 2004-07-29 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
WO2004108094A2 (en) * 2003-06-06 2004-12-16 Atherogenics, Inc. Sulfonamide-substituted chalcone derivatives and their use to treat diseases
WO2005039596A1 (en) * 2003-10-17 2005-05-06 Amylin Pharmaceuticals, Inc. Silyl phenols for promoting vascular health
US7294737B2 (en) 2004-04-20 2007-11-13 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
WO2005112914A2 (en) 2004-04-20 2005-12-01 Atherogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
US20060063828A1 (en) * 2004-06-28 2006-03-23 Weingarten M D 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof
CA2571589A1 (en) * 2004-07-01 2006-01-19 Atherogenics, Inc. Compounds and methods for treating diabetic vascular diseases
CA2682258A1 (en) * 2007-03-26 2008-10-02 Salutria Pharmaceuticals Llc Methods and compositions of derivatives of probucol for the treatment of diabetes
US20080280985A1 (en) * 2007-03-27 2008-11-13 Scott Robert A D Methods and Compositions Using Certain Phenolic Derivatives for the Treatment of Diabetes
EP2558433B1 (en) * 2010-04-15 2014-06-18 Merck Patent GmbH Process for the preparation of hydroquinones
CN109641004A (zh) 2016-07-08 2019-04-16 燕财成有限公司 实体癌治疗剂

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Also Published As

Publication number Publication date
TW474940B (en) 2002-02-01
JP2001509782A (ja) 2001-07-24
AU711322B2 (en) 1999-10-14
KR100503181B1 (ko) 2006-03-03
CA2251991A1 (en) 1997-11-06
NO985039D0 (no) 1998-10-29
EP0900225A1 (en) 1999-03-10
ES2167716T3 (es) 2002-05-16
EP0900225B1 (en) 2002-01-30
AU1985497A (en) 1997-11-19
DK0900225T3 (da) 2002-05-13
JP4309473B2 (ja) 2009-08-05
AR006890A1 (es) 1999-09-29
WO1997041129A1 (en) 1997-11-06
ZA973503B (en) 1997-10-30
DE69710191D1 (de) 2002-03-14
NO985039L (no) 1998-12-21
CA2251991C (en) 2002-05-14
CN1216993A (zh) 1999-05-19
IL126758A0 (en) 1999-08-17
KR20000065101A (ko) 2000-11-06
BR9709190A (pt) 1999-08-10
US5608095A (en) 1997-03-04
PT900225E (pt) 2002-06-28
DE69710191T2 (de) 2002-07-25

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