DE69524871D1 - Benzopyrans und deren verwendung als therapeutische mittel - Google Patents

Benzopyrans und deren verwendung als therapeutische mittel

Info

Publication number
DE69524871D1
DE69524871D1 DE69524871T DE69524871T DE69524871D1 DE 69524871 D1 DE69524871 D1 DE 69524871D1 DE 69524871 T DE69524871 T DE 69524871T DE 69524871 T DE69524871 T DE 69524871T DE 69524871 D1 DE69524871 D1 DE 69524871D1
Authority
DE
Germany
Prior art keywords
benzopyrans
therapeutic agents
therapeutic
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69524871T
Other languages
English (en)
Other versions
DE69524871T2 (de
Inventor
Ngor Chan
Kate Morgan
Mervyn Thompson
Morris Evans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9411632A external-priority patent/GB9411632D0/en
Priority claimed from GB9411798A external-priority patent/GB9411798D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of DE69524871D1 publication Critical patent/DE69524871D1/de
Application granted granted Critical
Publication of DE69524871T2 publication Critical patent/DE69524871T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
DE69524871T 1994-06-10 1995-05-31 Benzopyrans und deren verwendung als therapeutische mittel Expired - Lifetime DE69524871T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9411632A GB9411632D0 (en) 1994-06-10 1994-06-10 Novel treatment
GB9411798A GB9411798D0 (en) 1994-06-13 1994-06-13 Novel treatment
PCT/EP1995/002076 WO1995034545A1 (en) 1994-06-10 1995-05-31 Benzopyrans and their use as therapeutic agents

Publications (2)

Publication Number Publication Date
DE69524871D1 true DE69524871D1 (de) 2002-02-07
DE69524871T2 DE69524871T2 (de) 2002-08-22

Family

ID=26305044

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69531801T Expired - Lifetime DE69531801T2 (de) 1994-06-10 1995-05-31 Benzopyrane und deren Verwendung als Heilmittel
DE69524871T Expired - Lifetime DE69524871T2 (de) 1994-06-10 1995-05-31 Benzopyrans und deren verwendung als therapeutische mittel

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69531801T Expired - Lifetime DE69531801T2 (de) 1994-06-10 1995-05-31 Benzopyrane und deren Verwendung als Heilmittel

Country Status (29)

Country Link
US (1) US5760074A (de)
EP (2) EP1114821B1 (de)
JP (2) JP3575767B2 (de)
KR (1) KR100397721B1 (de)
CN (2) CN1234702C (de)
AP (1) AP714A (de)
AT (2) ATE250052T1 (de)
AU (1) AU701060B2 (de)
BG (1) BG63339B1 (de)
BR (1) BR9507980A (de)
CA (1) CA2192480C (de)
CY (1) CY2508B1 (de)
CZ (1) CZ286081B6 (de)
DE (2) DE69531801T2 (de)
DK (2) DK0764157T3 (de)
ES (2) ES2170798T3 (de)
FI (1) FI120686B (de)
HK (2) HK1001286A1 (de)
HU (1) HUT76136A (de)
NO (1) NO315651B1 (de)
NZ (1) NZ287872A (de)
OA (1) OA10593A (de)
PL (1) PL188134B1 (de)
PT (2) PT764157E (de)
RO (1) RO113463B1 (de)
SG (1) SG67930A1 (de)
SI (2) SI1114821T1 (de)
SK (1) SK281456B6 (de)
WO (1) WO1995034545A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010021780A1 (en) * 1992-12-11 2001-09-13 Smithkline Beecham P.L.C. Pharmaceutical composition containing bicyclic type compounds
GB9411635D0 (en) * 1994-06-10 1994-08-03 Smithkline Beecham Plc Novel treatment
GB9619492D0 (en) * 1996-09-18 1996-10-30 Smithkline Beecham Plc Novel treatment
US6492415B2 (en) * 1996-09-18 2002-12-10 Smithkline Beecham P.L.C. Use of benzopyranols to treat neurological disorders
GB9726543D0 (en) * 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel compositions
GB9813949D0 (en) * 1998-06-29 1998-08-26 Smithkline Beecham Plc Novel compounds
GB0028697D0 (en) * 2000-11-23 2001-01-10 S P A Novel process
PE20061355A1 (es) * 2005-04-04 2007-01-15 Takeda Pharmaceutical Composicion farmaceutica que comprende ramelteon
CA2726878A1 (en) * 2008-06-05 2009-12-10 Minster Research Limited Novel treatments
MX2010013312A (es) * 2008-06-05 2011-05-30 Minster Res Ltd Tratamientos novedoos.
CN102770134A (zh) 2009-12-03 2012-11-07 普罗克西梅根有限公司 传染性失调的治疗
CA2782625A1 (en) 2009-12-03 2011-06-09 Proximagen Ltd Treatment of allodynia and hyperalgesia
AU2013285164A1 (en) 2012-07-03 2015-01-22 Proximagen Limited Pro-drug compounds
GB201304814D0 (en) * 2013-03-15 2013-05-01 Proximagen Ltd Pro-drug compounds
GB201322932D0 (en) * 2013-12-23 2014-02-12 Proximagen Ltd Pro-drug compounds
GB201322934D0 (en) 2013-12-23 2014-02-12 Proximagen Ltd Prodrug compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0126311B1 (de) * 1983-05-18 1989-09-13 Beecham Group Plc Benzopyran-Derivate.
GB9112721D0 (en) * 1991-06-13 1991-07-31 Smithkline Beecham Plc Novel treatment
ES2143541T3 (es) * 1992-12-11 2000-05-16 Smithkline Beecham Plc Composicion farmaceutica que contiene compuestos de tipo biciclico.
KR100326968B1 (ko) * 1992-12-11 2002-07-27 스미스클라인비이참피이엘시이 약학적 활성을 가진 이환식 화합물
US5536718A (en) * 1995-01-17 1996-07-16 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists

Also Published As

Publication number Publication date
EP1114821A1 (de) 2001-07-11
US5760074A (en) 1998-06-02
HK1001286A1 (en) 1998-06-12
KR100397721B1 (ko) 2004-04-28
RO113463B1 (ro) 1998-07-30
SG67930A1 (en) 1999-10-19
BG101040A (en) 1997-08-29
ES2170798T3 (es) 2002-08-16
HK1039115A1 (en) 2002-04-12
NO965260L (no) 1997-02-06
NO965260D0 (no) 1996-12-09
SK281456B6 (sk) 2001-03-12
CN1336369A (zh) 2002-02-20
HUT76136A (en) 1997-06-30
FI120686B (fi) 2010-01-29
PL188134B1 (pl) 2004-12-31
ATE211469T1 (de) 2002-01-15
FI964936A (fi) 1997-02-06
HU9603415D0 (en) 1997-02-28
EP0764157A1 (de) 1997-03-26
BG63339B1 (bg) 2001-10-31
SI0764157T1 (en) 2002-06-30
HK1039115B (zh) 2004-08-13
AP9600889A0 (en) 1997-01-31
EP1114821B1 (de) 2003-09-17
ATE250052T1 (de) 2003-10-15
JP2003238554A (ja) 2003-08-27
PT1114821E (pt) 2004-02-27
AU701060B2 (en) 1999-01-21
CZ361796A3 (en) 1997-08-13
CY2508B1 (en) 2005-12-23
DK0764157T3 (da) 2002-04-22
AU2672795A (en) 1996-01-05
CN1154698A (zh) 1997-07-16
CA2192480C (en) 2007-07-24
AP714A (en) 1998-12-23
EP0764157B1 (de) 2002-01-02
NO315651B1 (no) 2003-10-06
PL317579A1 (en) 1997-04-14
DE69524871T2 (de) 2002-08-22
DE69531801D1 (de) 2003-10-23
DK1114821T3 (da) 2004-02-02
OA10593A (en) 2002-07-10
WO1995034545A1 (en) 1995-12-21
ES2207590T3 (es) 2004-06-01
SI1114821T1 (en) 2004-02-29
FI964936A0 (fi) 1996-12-10
CZ286081B6 (cs) 2000-01-12
CA2192480A1 (en) 1995-12-21
JPH10501251A (ja) 1998-02-03
BR9507980A (pt) 1997-08-12
CN1174975C (zh) 2004-11-10
DE69531801T2 (de) 2004-07-01
CN1234702C (zh) 2006-01-04
NZ287872A (en) 1998-05-27
PT764157E (pt) 2002-06-28
JP3575767B2 (ja) 2004-10-13
SK158796A3 (en) 1997-07-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition