EP0934287A4 - Heterocyclic esters and amides - Google Patents
Heterocyclic esters and amidesInfo
- Publication number
- EP0934287A4 EP0934287A4 EP97938449A EP97938449A EP0934287A4 EP 0934287 A4 EP0934287 A4 EP 0934287A4 EP 97938449 A EP97938449 A EP 97938449A EP 97938449 A EP97938449 A EP 97938449A EP 0934287 A4 EP0934287 A4 EP 0934287A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- amides
- heterocyclic esters
- heterocyclic
- esters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/719,947 US5801187A (en) | 1996-09-25 | 1996-09-25 | Heterocyclic esters and amides |
US719947 | 1996-09-25 | ||
PCT/US1997/014624 WO1998013355A1 (en) | 1996-09-25 | 1997-08-20 | Heterocyclic esters and amides |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0934287A1 EP0934287A1 (en) | 1999-08-11 |
EP0934287A4 true EP0934287A4 (en) | 2000-01-12 |
EP0934287B1 EP0934287B1 (en) | 2009-05-27 |
Family
ID=24892040
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97938449A Expired - Lifetime EP0934287B1 (en) | 1996-09-25 | 1997-08-20 | Heterocyclic esters and amides |
Country Status (24)
Country | Link |
---|---|
US (4) | US5801187A (en) |
EP (1) | EP0934287B1 (en) |
JP (1) | JP2001502668A (en) |
KR (1) | KR20000048589A (en) |
CN (1) | CN1234795A (en) |
AR (1) | AR009749A1 (en) |
AT (1) | ATE432266T1 (en) |
AU (1) | AU732194C (en) |
BG (1) | BG103232A (en) |
BR (1) | BR9712834A (en) |
CA (1) | CA2263925A1 (en) |
CZ (1) | CZ66099A3 (en) |
DE (1) | DE69739422D1 (en) |
EA (1) | EA199900140A1 (en) |
HU (1) | HUP0000969A3 (en) |
ID (1) | ID19588A (en) |
IL (1) | IL128675A (en) |
NO (1) | NO991433L (en) |
NZ (1) | NZ334186A (en) |
PA (1) | PA8438501A1 (en) |
PL (1) | PL332183A1 (en) |
SK (1) | SK26699A3 (en) |
WO (1) | WO1998013355A1 (en) |
ZA (1) | ZA977901B (en) |
Families Citing this family (47)
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US6291510B1 (en) | 1995-06-07 | 2001-09-18 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US6509477B1 (en) | 1998-11-12 | 2003-01-21 | Guilford Pharmaceuticals Inc. | Small molecule inhibitors of rotamase enzyme activity |
US5859031A (en) * | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US5801187A (en) | 1996-09-25 | 1998-09-01 | Gpi-Nil Holdings, Inc. | Heterocyclic esters and amides |
US6218424B1 (en) * | 1996-09-25 | 2001-04-17 | Gpi Nil Holdings, Inc. | Heterocyclic ketone and thioester compounds and uses |
US5935989A (en) | 1996-12-31 | 1999-08-10 | Gpi Nil Holdings Inc. | N-linked ureas and carbamates of heterocyclic thioesters |
JP2002515050A (en) | 1996-12-31 | 2002-05-21 | ジーピーアイ エヌアイエル ホールディングス インコーポレイテッド | N-linked ureas and carbamates of heterocyclic thioesters |
US5721256A (en) * | 1997-02-12 | 1998-02-24 | Gpi Nil Holdings, Inc. | Method of using neurotrophic sulfonamide compounds |
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CA2333997A1 (en) | 1998-06-02 | 1999-12-09 | Bristol-Myers Squibb Company | Neurotrophic difluoroamide agents |
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US6331537B1 (en) | 1998-06-03 | 2001-12-18 | Gpi Nil Holdings, Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
AU1708099A (en) | 1998-06-03 | 1999-12-20 | Amgen, Inc. | N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres |
HUP0200637A3 (en) | 1998-07-17 | 2003-05-28 | Agouron Pharmaceuticals Inc La | Compounds, compositions, and their use for stimulating neuronal growth and elongation |
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WO2000009108A2 (en) * | 1998-08-14 | 2000-02-24 | Gpi Nil Holdings, Inc. | Compositions and uses for vision and memory disorders |
US7338976B1 (en) * | 1998-08-14 | 2008-03-04 | Gpi Nil Holdings, Inc. | Heterocyclic esters or amides for vision and memory disorders |
US6337340B1 (en) * | 1998-08-14 | 2002-01-08 | Gpi Nil Holdings, Inc. | Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders |
US6399648B1 (en) * | 1998-08-14 | 2002-06-04 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders |
US6462072B1 (en) | 1998-09-21 | 2002-10-08 | Gpi Nil Holdings, Inc. | Cyclic ester or amide derivatives |
US6307049B1 (en) | 1998-09-30 | 2001-10-23 | The Procter & Gamble Co. | Heterocyclic 2-substituted ketoamides |
US6300341B1 (en) | 1998-09-30 | 2001-10-09 | The Procter & Gamble Co. | 2-substituted heterocyclic sulfonamides |
US6228872B1 (en) | 1998-11-12 | 2001-05-08 | Bristol-Myers Squibb Company | Neurotrophic diamide and carbamate agents |
MXPA02000330A (en) * | 1999-07-09 | 2004-05-21 | Johnson & Johnson | Neurotrophic pyrrolidines and piperidines, and related compositions and methods. |
WO2001004091A1 (en) | 1999-07-09 | 2001-01-18 | Ortho-Mcneil Pharmaceutical, Inc. | Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods |
WO2001004090A2 (en) * | 1999-07-09 | 2001-01-18 | Ortho-Mcneil Pharmaceutical, Inc. | Neurotrophic tetrahydroisoquinolines and tetrahydrothienopyridines, and related compositions and methods |
JP2003508512A (en) | 1999-09-08 | 2003-03-04 | ギルフォード ファーマシュウティカルズ インコーポレイテッド | Non-peptidic cyclophilin binding compounds and their uses |
ATE335524T1 (en) * | 1999-11-12 | 2006-09-15 | Alcon Inc | USE OF NEUROPHILIN LIGANDS TO TREAT EYE DISEASES |
US6417189B1 (en) | 1999-11-12 | 2002-07-09 | Gpi Nil Holdings, Inc. | AZA compounds, pharmaceutical compositions and methods of use |
US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
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US20030185754A1 (en) * | 2001-01-16 | 2003-10-02 | Genset, S.A. | Treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase antagonists |
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CN1240691C (en) | 2001-12-06 | 2006-02-08 | 中国人民解放军军事医学科学院毒物药物研究所 | Substituted penta azacylo compounds and their use for preventing and treating nervous retrogression disease |
US20060089400A1 (en) * | 2002-05-03 | 2006-04-27 | The Vernalis Group Of Companies | Novel spiro ketone and carboxylic acid derivatives as specific inhibitors for (po3h2) ser/(po3h2)thr-pro-specific peptidyl-prolylcis/trans-isomerases |
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- 1997-08-20 CA CA002263925A patent/CA2263925A1/en not_active Abandoned
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- 1997-08-20 NZ NZ334186A patent/NZ334186A/en not_active IP Right Cessation
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1999
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Non-Patent Citations (5)
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EP0934287A1 (en) | 1999-08-11 |
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AU4076997A (en) | 1998-04-17 |
US6218544B1 (en) | 2001-04-17 |
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KR20000048589A (en) | 2000-07-25 |
EP0934287B1 (en) | 2009-05-27 |
WO1998013355A1 (en) | 1998-04-02 |
PL332183A1 (en) | 1999-08-30 |
HUP0000969A2 (en) | 2000-10-28 |
DE69739422D1 (en) | 2009-07-09 |
BR9712834A (en) | 1999-11-16 |
US5801187A (en) | 1998-09-01 |
ID19588A (en) | 1998-07-23 |
BG103232A (en) | 2000-05-31 |
ATE432266T1 (en) | 2009-06-15 |
EA199900140A1 (en) | 1999-10-28 |
ZA977901B (en) | 1998-03-25 |
AU732194B2 (en) | 2001-04-12 |
CN1234795A (en) | 1999-11-10 |
CA2263925A1 (en) | 1998-04-02 |
IL128675A0 (en) | 2000-01-31 |
IL128675A (en) | 2002-08-14 |
NO991433L (en) | 1999-05-25 |
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