NO980919L - 8-azabicyklo(3.2.1)okt-2-ene derivater, og deres anvendelse til fremstilling av et legemiddel - Google Patents
8-azabicyklo(3.2.1)okt-2-ene derivater, og deres anvendelse til fremstilling av et legemiddelInfo
- Publication number
- NO980919L NO980919L NO19980919A NO980919A NO980919L NO 980919 L NO980919 L NO 980919L NO 19980919 A NO19980919 A NO 19980919A NO 980919 A NO980919 A NO 980919A NO 980919 L NO980919 L NO 980919L
- Authority
- NO
- Norway
- Prior art keywords
- heteroaryl
- alkynyl
- cycloalkyl
- alkenyl
- alkyl
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000000304 alkynyl group Chemical group 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
- -1 3,4-methylenedioxyphenyl Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 230000001561 neurotransmitter reuptake Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK115695 | 1995-10-13 | ||
| PCT/EP1996/004449 WO1997013770A1 (en) | 1995-10-13 | 1996-10-11 | 8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO980919D0 NO980919D0 (no) | 1998-03-03 |
| NO980919L true NO980919L (no) | 1998-06-08 |
Family
ID=8101642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19980919A NO980919L (no) | 1995-10-13 | 1998-03-03 | 8-azabicyklo(3.2.1)okt-2-ene derivater, og deres anvendelse til fremstilling av et legemiddel |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6100275A (cs) |
| EP (1) | EP0859777B1 (cs) |
| JP (1) | JP3462505B2 (cs) |
| KR (1) | KR100274829B1 (cs) |
| CN (1) | CN1083840C (cs) |
| AT (1) | ATE362931T1 (cs) |
| AU (1) | AU709327B2 (cs) |
| BR (1) | BR9610960A (cs) |
| CA (1) | CA2233541C (cs) |
| CZ (1) | CZ285093B6 (cs) |
| DE (1) | DE69637097T2 (cs) |
| DK (1) | DK0859777T3 (cs) |
| EE (1) | EE03446B1 (cs) |
| HU (1) | HUP9802433A3 (cs) |
| IL (1) | IL123583A (cs) |
| IS (1) | IS4681A (cs) |
| NO (1) | NO980919L (cs) |
| NZ (1) | NZ320216A (cs) |
| PL (1) | PL185357B1 (cs) |
| RU (1) | RU2157372C2 (cs) |
| SK (1) | SK283425B6 (cs) |
| TR (1) | TR199800628T2 (cs) |
| UA (1) | UA63894C2 (cs) |
| WO (1) | WO1997013770A1 (cs) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9510459D0 (en) * | 1995-05-24 | 1995-07-19 | Zeneca Ltd | Bicyclic amines |
| WO1997043286A1 (en) * | 1996-05-13 | 1997-11-20 | Zeneca Limited | Bicyclic amines as insecticides |
| GB9623944D0 (en) * | 1996-11-15 | 1997-01-08 | Zeneca Ltd | Bicyclic amine derivatives |
| GB9624114D0 (en) * | 1996-11-20 | 1997-01-08 | Zeneca Ltd | Pesticidal bicyclic amine derivatives |
| KR20000069122A (ko) | 1996-11-26 | 2000-11-25 | 돈 리사 로얄 | 8-아자비시클로[3.2.1]옥탄-, 8-아자비시클로[3.2.1]옥-6-텐-,9-아자비시클로[3.3.1]노난-, 9-아자비시클로[3.3.1]노난- 및9-아자-3-티아비시클로[3.3.1]노난 유도체, 그의 제조방법 및살충제로서의 용도 |
| GB9624611D0 (en) * | 1996-11-26 | 1997-01-15 | Zeneca Ltd | Bicyclic amine compounds |
| GB9706222D0 (en) * | 1997-03-26 | 1997-05-14 | Zeneca Ltd | Bicyclic amine derivatives |
| TR199902942T2 (xx) | 1997-05-30 | 2000-04-21 | Neurosearch A/S | Nikotinik ACh Resept�rlerinde kolinerjik ligandlar olarak 8-Azabisiklo(3.2.1)okt-ene ve okstan t�revleri. |
| GB9726033D0 (en) | 1997-12-09 | 1998-02-04 | Zeneca Ltd | Chemical process |
| TWI221842B (en) | 1997-12-11 | 2004-10-11 | Syngenta Ltd | Process for the preparation of 8-azabicyclo(3.2.1)octane derivatives |
| AU2609999A (en) * | 1998-01-28 | 1999-08-16 | Neurosearch A/S | 8-azabicyclo(3.2.1)oct-2-ene derivatives in labelled and use of 8-azabicyclo(3.2.1)oct-2-ene derivatives in labelled and unlabelled form |
| US6403605B1 (en) * | 1998-05-29 | 2002-06-11 | Queen's University At Kingston | Methods for the normalization of sexual response and amelioration of long term genital tissue degradation |
| WO1999065492A1 (en) * | 1998-06-19 | 1999-12-23 | Eli Lilly And Company | Inhibition of serotonin reuptake |
| AU761055B2 (en) | 1998-11-27 | 2003-05-29 | Neurosearch A/S | 8-azabicyclo(3.2.1)oct-2-ene and -octane derivatives |
| RU2211216C2 (ru) * | 1998-12-22 | 2003-08-27 | Мерк Патент Гмбх | Производные амидов и мочевины в качестве ингибиторов вторичного поглощения 5-ht и лигандов 5-ht1b/1d |
| AU2278700A (en) * | 1999-01-28 | 2000-08-18 | Neurosearch A/S | Novel azabicyclo derivatives and their use |
| WO2000051972A1 (en) * | 1999-03-01 | 2000-09-08 | Pfizer Limited | 1,2,3,4-tetrahydro-1-naphthalenamine compounds useful in therapy |
| DE60026146T2 (de) | 1999-09-03 | 2006-08-17 | Apbi Holdings, Llc | Verwendung von Dapoxetin, A selektiver Serotonin Aufnahme Inhibitor mit schnellem Wirkungseintritt, zur Behandlung von sexueller Disfunktion |
| AU2049501A (en) * | 1999-12-20 | 2001-07-03 | Eli Lilly And Company | Benzofuran derivatives |
| BR0110956A (pt) | 2000-05-25 | 2003-06-10 | Targacept Inc | Heteroarildiazabicicloalcanos como ligantes do receptor colinérgico nicotìnico |
| US6667314B2 (en) | 2000-05-26 | 2003-12-23 | Pfizer, Inc. | Tropane derivatives useful in therapy |
| US6579878B1 (en) | 2000-07-07 | 2003-06-17 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| US6624167B1 (en) | 2000-08-04 | 2003-09-23 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| WO2002030405A2 (en) | 2000-10-13 | 2002-04-18 | Neurosearch A/S | Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance |
| EP1379269B1 (en) | 2001-04-09 | 2009-03-04 | Neurosearch A/S | Adenosine a2a receptor antagonists combined with neurotrophic activity compounds in the treatment of parkinson's disease |
| TW589312B (en) | 2001-05-25 | 2004-06-01 | Wyeth Corp | Aryl-8-azabicyclo[3.2.1]octanes for the treatment of depression |
| RU2203044C1 (ru) * | 2001-12-27 | 2003-04-27 | Закрытое акционерное общество "Брынцалов-А" | Антидепрессант амитриптилин-ферейн |
| DE60322212D1 (de) * | 2002-05-07 | 2008-08-28 | Neurosearch As | Neue azacyclische ethinylderivate |
| CN100368409C (zh) * | 2003-06-24 | 2008-02-13 | 神经研究公司 | 8-氮杂双环[3.2.1]辛烷衍生物及其用于制备单胺神经递质再摄取抑制剂的用途 |
| ATE494286T1 (de) * | 2004-09-30 | 2011-01-15 | Neurosearch As | Neue chromen-2-one derivate und ihre verwendung als monoamineneurotransmitter- wiederaufnahmeinhibitoren |
| EP2272847A1 (en) | 2005-04-08 | 2011-01-12 | NeuroSearch A/S | Enantiomers and their use as monoamine neurotransmitter re-uptake inhibitors |
| TW200744590A (en) * | 2005-09-01 | 2007-12-16 | Neurosearch As | Novel compounds |
| RU2315047C1 (ru) * | 2006-09-04 | 2008-01-20 | Институт нефтехимии и катализа РАН | Способ получения 8-этил-6,7-фуллеро[60]-3-окса-8-азабицикло[3.2.1]октана |
| KR100812499B1 (ko) * | 2006-10-16 | 2008-03-11 | 이도훈 | 항경련제 |
| TWI415850B (zh) * | 2007-07-20 | 2013-11-21 | Theravance Inc | 製備ｍｕ類鴉片受體拮抗劑之中間物的方法 |
| AU2009221310A1 (en) * | 2008-03-05 | 2009-09-11 | Neurosearch A/S | Novel 4-benzhydryl-tetrahydro-pyridine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB247886A (en) * | 1925-11-02 | 1926-02-25 | Thomas Stewart Hamilton | Improvements in attachments for leaf springs |
| US3133073A (en) * | 1959-12-10 | 1964-05-12 | Sterling Drug Inc | 3-aryl-1, 5-iminocycloalkanes and preparation thereof |
| US3657257A (en) * | 1970-08-31 | 1972-04-18 | Robins Co Inc A H | 3-aryl-8-carbamoyl nortropanes |
| US4180669A (en) * | 1976-12-13 | 1979-12-25 | Abbott Laboratories | 2-(N-phenethyl-4-piperidino)-5-pentyl resorcinol |
| US4132710A (en) | 1976-12-20 | 1979-01-02 | Ayerst, Mckenna And Harrison, Ltd. | [2]Benzopyrano[3,4-c]pyridines and process therefor |
| ES488803A0 (es) * | 1979-02-22 | 1981-02-16 | Wellcome Found | Un procedimiento para la preparacion de un imidazol susti- tuido en la posicion 1 |
| DK198590D0 (da) * | 1990-08-21 | 1990-08-21 | Novo Nordisk As | Heterocykliske forbindelser, deres fremstilling og anvendelse |
| US5418240A (en) * | 1990-08-21 | 1995-05-23 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
| GB9019973D0 (en) * | 1990-09-12 | 1990-10-24 | Wyeth John & Brother Ltd | Azabicyclic derivatives |
| FI111367B (fi) * | 1991-02-04 | 2003-07-15 | Aventis Pharma Inc | Menetelmä terapeuttisesti käyttökelpoisten N-(aryylioksialkyyli)heteroaryyli-8-atsabisyklo[3.2.1]oktaanijohdannaisten valmistamiseksi ja menetelmässä käytetyt välituotteet |
| NZ243065A (en) * | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
| DE4200145A1 (de) * | 1992-01-07 | 1993-07-08 | Kali Chemie Pharma Gmbh | 7,10-epoxy-oxacyclododecan-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| AU672052B2 (en) * | 1992-12-23 | 1996-09-19 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
| DK154192D0 (da) * | 1992-12-23 | 1992-12-23 | Neurosearch As | Heterocycliske forbindelser |
| WO1994026274A1 (en) * | 1993-05-18 | 1994-11-24 | Wake Forest University | Treatment process with biologically active tropane derivatives |
| UA49801C2 (uk) * | 1994-04-19 | 2002-10-15 | Нейросерч А/С | Похідні тропан-2-альдоксиму, спосіб їх отримання, фармацевтична композиція, спосіб лікування |
| US5731317A (en) * | 1995-03-10 | 1998-03-24 | Merck & Co., Inc. | Bridged piperidines promote release of growth hormone |
-
1996
- 1996-10-11 DE DE69637097T patent/DE69637097T2/de not_active Expired - Lifetime
- 1996-10-11 SK SK287-98A patent/SK283425B6/sk unknown
- 1996-10-11 WO PCT/EP1996/004449 patent/WO1997013770A1/en not_active Ceased
- 1996-10-11 CA CA002233541A patent/CA2233541C/en not_active Expired - Fee Related
- 1996-10-11 TR TR1998/00628T patent/TR199800628T2/xx unknown
- 1996-10-11 JP JP51472697A patent/JP3462505B2/ja not_active Expired - Fee Related
- 1996-10-11 DK DK96934662T patent/DK0859777T3/da active
- 1996-10-11 CN CN96197566A patent/CN1083840C/zh not_active Expired - Fee Related
- 1996-10-11 AT AT96934662T patent/ATE362931T1/de active
- 1996-10-11 NZ NZ320216A patent/NZ320216A/xx not_active IP Right Cessation
- 1996-10-11 US US09/043,294 patent/US6100275A/en not_active Expired - Fee Related
- 1996-10-11 PL PL96326195A patent/PL185357B1/pl not_active IP Right Cessation
- 1996-10-11 AU AU72917/96A patent/AU709327B2/en not_active Ceased
- 1996-10-11 HU HU9802433A patent/HUP9802433A3/hu unknown
- 1996-10-11 CZ CZ98758A patent/CZ285093B6/cs not_active IP Right Cessation
- 1996-10-11 RU RU98105169/04A patent/RU2157372C2/ru not_active IP Right Cessation
- 1996-10-11 EE EE9800062A patent/EE03446B1/xx not_active IP Right Cessation
- 1996-10-11 BR BR9610960A patent/BR9610960A/pt not_active Application Discontinuation
- 1996-10-11 IL IL12358396A patent/IL123583A/xx not_active IP Right Cessation
- 1996-10-11 EP EP96934662A patent/EP0859777B1/en not_active Expired - Lifetime
- 1996-10-11 KR KR1019980702103A patent/KR100274829B1/ko not_active Expired - Fee Related
- 1996-11-10 UA UA98031543A patent/UA63894C2/uk unknown
-
1998
- 1998-03-03 NO NO19980919A patent/NO980919L/no not_active Application Discontinuation
- 1998-03-04 IS IS4681A patent/IS4681A/is unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |