ATE494286T1 - Neue chromen-2-one derivate und ihre verwendung als monoamineneurotransmitter- wiederaufnahmeinhibitoren - Google Patents

Neue chromen-2-one derivate und ihre verwendung als monoamineneurotransmitter- wiederaufnahmeinhibitoren

Info

Publication number
ATE494286T1
ATE494286T1 AT05792113T AT05792113T ATE494286T1 AT E494286 T1 ATE494286 T1 AT E494286T1 AT 05792113 T AT05792113 T AT 05792113T AT 05792113 T AT05792113 T AT 05792113T AT E494286 T1 ATE494286 T1 AT E494286T1
Authority
AT
Austria
Prior art keywords
monoamine
inhibitors
derivatives
reuppost
eurotransmitter
Prior art date
Application number
AT05792113T
Other languages
English (en)
Inventor
Dan Peters
Gunnar Olsen
Jorgen Scheel-Krueger
Elsebet Nielsen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of ATE494286T1 publication Critical patent/ATE494286T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Developing Agents For Electrophotography (AREA)
AT05792113T 2004-09-30 2005-09-28 Neue chromen-2-one derivate und ihre verwendung als monoamineneurotransmitter- wiederaufnahmeinhibitoren ATE494286T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61405204P 2004-09-30 2004-09-30
DKPA200401491 2004-09-30
PCT/EP2005/054861 WO2006035034A1 (en) 2004-09-30 2005-09-28 Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Publications (1)

Publication Number Publication Date
ATE494286T1 true ATE494286T1 (de) 2011-01-15

Family

ID=43448525

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05792113T ATE494286T1 (de) 2004-09-30 2005-09-28 Neue chromen-2-one derivate und ihre verwendung als monoamineneurotransmitter- wiederaufnahmeinhibitoren

Country Status (14)

Country Link
US (1) US7696350B2 (de)
EP (2) EP1797088B1 (de)
JP (1) JP5001156B2 (de)
CN (1) CN101023081A (de)
AT (1) ATE494286T1 (de)
AU (1) AU2005288914B2 (de)
BR (1) BRPI0515261A (de)
CA (1) CA2582297A1 (de)
DE (1) DE602005025785D1 (de)
DK (1) DK1797088T3 (de)
NZ (1) NZ552919A (de)
PL (1) PL1797088T3 (de)
RU (1) RU2382040C2 (de)
WO (1) WO2006035034A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007002384A (es) * 2004-09-30 2007-05-11 Neurosearch As Nuevos derivados de cromen-2-ona y su uso como inhibidores de la reabsorcion del neurotransmisor de monoamina.
TW200800980A (en) * 2006-02-17 2008-01-01 Neurosearch As Novel compounds
PL2121677T3 (pl) * 2006-12-20 2011-04-29 Neurosearch As Nowe pochodne chromen-2-onu i ich zastosowanie jako inhibitorów wychwytu zwrotnego neurotransmiteru monoaminowego
JP2010513392A (ja) * 2006-12-20 2010-04-30 ノイロサーチ アクティーゼルスカブ 新規クロメン−２−オン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのそれらの使用
TW200836732A (en) * 2006-12-20 2008-09-16 Neurosearch As Novel compounds
TW200904815A (en) * 2007-05-09 2009-02-01 Neurosearch As Novel compounds
WO2009034043A1 (en) * 2007-09-10 2009-03-19 Neurosearch A/S Novel phenoxazin-3-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US20100286195A1 (en) * 2007-09-10 2010-11-11 Neurosearch A/S Novel benzooxazol-and benzooxathiol-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US20110136854A1 (en) * 2008-02-05 2011-06-09 Neurosearch A/S Novel 9-aza-bicyclo[3.3.1]non-3-yloxy chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
KR20110053356A (ko) 2008-08-21 2011-05-20 뉴로서치 에이/에스 불안 장애의 치료
RU2011143972A (ru) 2009-05-15 2013-06-20 НьюроСёрч А/С Производные хромен-2-она и их применение в качестве ингибиторов обратного захвата моноаминовых нейромедиаторов
US20130040985A1 (en) 2010-01-29 2013-02-14 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2011117289A1 (en) 2010-03-25 2011-09-29 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neuro-transmitter re-uptake inhibitors
WO2012000881A1 (en) 2010-07-02 2012-01-05 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
BR112022002169A2 (pt) * 2019-08-06 2022-06-07 Initiator Pharma As Composto, composição farmacêutica, e, métodos para tratamento, prevenção ou alívio de uma combinação de: disfunção erétil e depressão, disfunção erétil e disfunção sexual, disfunção erétil e ansiedade, disfunção erétil e distúrbio de ejaculação, disfunção sexual e depressão, disfunção sexual e ansiedade, disfunção sexual e distúrbio de ejaculação, depressão e ansiedade, depressão e distúrbio de ejaculação e/ou ansiedade e distúrbio de ejaculação, para aumentar a magnitude da resposta erétil, para aumentar a duração de uma resposta erétil, para aumentar a frequência de respostas eréteis, para induzir relaxamento do corpo cavernoso e para aumentar o fluxo sanguíneo peniano
TW202440106A (zh) * 2023-01-03 2024-10-16 丹麥商創始人製藥股份有限公司 用於治療勃起障礙之化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2189027B1 (de) * 1972-06-21 1976-03-05 Leurquin Laboratoires Fr
EP0861242B1 (de) * 1995-10-13 2001-05-30 Aventis CropScience UK Limited Heterozyclische fungizide
SG99853A1 (en) 1996-02-22 2003-11-27 Neurosearch As Tropane-derivatives, their preparation and use
EP1397358A1 (de) 2001-05-23 2004-03-17 Neurosearch A/S Tropanderivate und deren verwendung als monoamin-neurotransmitter-wiederaufnahmehemmer
CA2488635C (en) 2002-06-12 2012-10-23 Abbott Laboratories Antagonists of melanin concentrating hormone receptor
US7538233B2 (en) * 2003-09-05 2009-05-26 Aventis Pharmaceuticals Inc. Coumarins as iNOS inhibitors

Also Published As

Publication number Publication date
EP1797088B1 (de) 2011-01-05
CN101023081A (zh) 2007-08-22
US20070232666A1 (en) 2007-10-04
EP2284170A1 (de) 2011-02-16
JP2008514676A (ja) 2008-05-08
CA2582297A1 (en) 2006-04-06
JP5001156B2 (ja) 2012-08-15
BRPI0515261A (pt) 2008-07-15
WO2006035034A1 (en) 2006-04-06
RU2007106970A (ru) 2008-11-10
RU2382040C2 (ru) 2010-02-20
US7696350B2 (en) 2010-04-13
DK1797088T3 (da) 2011-04-04
AU2005288914A1 (en) 2006-04-06
AU2005288914B2 (en) 2011-05-19
PL1797088T3 (pl) 2011-06-30
DE602005025785D1 (de) 2011-02-17
EP1797088A1 (de) 2007-06-20
NZ552919A (en) 2010-06-25

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