NO964180L - Tropan-2-aldoksimderivater som neurotransmitter-gjenopptaksinhibitorer - Google Patents
Tropan-2-aldoksimderivater som neurotransmitter-gjenopptaksinhibitorerInfo
- Publication number
- NO964180L NO964180L NO964180A NO964180A NO964180L NO 964180 L NO964180 L NO 964180L NO 964180 A NO964180 A NO 964180A NO 964180 A NO964180 A NO 964180A NO 964180 L NO964180 L NO 964180L
- Authority
- NO
- Norway
- Prior art keywords
- alkenyl
- cycloalkyl
- alkyl
- alkynyl
- substituted
- Prior art date
Links
- 239000003901 neurotransmitter uptake inhibitor Substances 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 7
- 125000000304 alkynyl group Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical group 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 5
- 125000001424 substituent group Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
- -1 3,4-methylenedioxyphenyl Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 239000002858 neurotransmitter agent Substances 0.000 abstract 1
- 229960002748 norepinephrine Drugs 0.000 abstract 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK44794 | 1994-04-19 | ||
| DK133894 | 1994-11-24 | ||
| PCT/EP1995/001358 WO1995028401A1 (en) | 1994-04-19 | 1995-04-12 | Tropane-2-aldoxine derivatives as neurotransmitter reuptake inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO964180D0 NO964180D0 (no) | 1996-10-02 |
| NO964180L true NO964180L (no) | 1996-12-16 |
Family
ID=26064021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO964180A NO964180L (no) | 1994-04-19 | 1996-10-02 | Tropan-2-aldoksimderivater som neurotransmitter-gjenopptaksinhibitorer |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5736556A (cs) |
| EP (1) | EP0756596B1 (cs) |
| JP (1) | JP2899418B2 (cs) |
| KR (1) | KR100210417B1 (cs) |
| CN (1) | CN1043763C (cs) |
| AT (1) | ATE222587T1 (cs) |
| AU (1) | AU690257B2 (cs) |
| BG (1) | BG63259B1 (cs) |
| BR (1) | BR9507489A (cs) |
| CA (1) | CA2187309C (cs) |
| CZ (1) | CZ284379B6 (cs) |
| DE (1) | DE69527839T2 (cs) |
| DK (1) | DK0756596T3 (cs) |
| EE (1) | EE03877B1 (cs) |
| FI (1) | FI965074A0 (cs) |
| GE (1) | GEP19991749B (cs) |
| HU (1) | HU215830B (cs) |
| LV (1) | LV11738B (cs) |
| NO (1) | NO964180L (cs) |
| NZ (1) | NZ284075A (cs) |
| PL (1) | PL183025B1 (cs) |
| RU (1) | RU2134264C1 (cs) |
| SK (1) | SK280875B6 (cs) |
| UA (1) | UA49801C2 (cs) |
| WO (1) | WO1995028401A1 (cs) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100274829B1 (ko) * | 1995-10-13 | 2000-12-15 | 페더 벨링 | 8-아자바이사이클로[3,2,1]-옥트-2-엔 유도체의 제조방법 및 용도 |
| US6241963B1 (en) * | 1995-10-19 | 2001-06-05 | The Trustees Of The University Of Pennsylvania | Dopamine and serotonin transporter ligands and imaging agents |
| IL123898A (en) * | 1995-11-02 | 2001-08-08 | Neurosearch As | The history of compressed tropane, their preparation and the pharmaceutical preparations containing them |
| US5948933A (en) | 1997-07-11 | 1999-09-07 | Organix, Inc. | Tropane analogs and methods for inhibition of monoamine transport |
| SI0885220T1 (en) * | 1996-02-22 | 2001-12-31 | Neurosearch As | Tropane-derivatives, their preparation and use |
| US6232326B1 (en) | 1998-07-14 | 2001-05-15 | Jodi A. Nelson | Treatment for schizophrenia and other dopamine system dysfunctions |
| JP2004500331A (ja) | 1999-07-13 | 2004-01-08 | アルファ リサーチ グループ， エルエルシー | パーキンソン病の処置のための組成物および方法 |
| US20040229908A1 (en) * | 1999-07-13 | 2004-11-18 | Jodi Nelson | Compositions and methods for the treatment of Parkinson's disease and tardive dyskinesias |
| US6667314B2 (en) | 2000-05-26 | 2003-12-23 | Pfizer, Inc. | Tropane derivatives useful in therapy |
| ME00555B (me) * | 2000-05-26 | 2011-12-20 | Pfizer | Derivati tropana i njihova primj ena |
| US20040106643A1 (en) * | 2001-05-23 | 2004-06-03 | Gouliaev Alex Haarh | Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| US6610849B2 (en) * | 2001-06-28 | 2003-08-26 | Boehringer Ingelheim Pharma Kg | Process for the manufacture of tropenol |
| EP1453511B1 (en) * | 2001-11-30 | 2006-11-15 | Neurosearch A/S | Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases |
| DE10200943A1 (de) * | 2002-01-12 | 2003-07-24 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Scopinestern |
| WO2003099783A2 (en) * | 2002-03-28 | 2003-12-04 | President And Fellows Of Harvard College | Tropane compounds |
| ATE380813T1 (de) | 2003-10-03 | 2007-12-15 | Pfizer | Imidazopyridinsubstituierte tropanderivate mit ccr5-rezeptorantagonistischer wirkung zur behandlung von hiv und entzündungen |
| CA2542442C (en) * | 2003-10-16 | 2012-08-21 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor |
| EP1708707A1 (en) * | 2004-01-22 | 2006-10-11 | Neurosearch A/S | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist |
| WO2005070427A1 (en) * | 2004-01-22 | 2005-08-04 | Neurosearch A/S | Compounds for the sustained reduction of body weight |
| WO2006075976A1 (fr) * | 2005-01-14 | 2006-07-20 | Private Enterprise 'slavyanskaya Klinika' | Utilisation d'un anesthesique local pour corriger un comportement alimentaire humain, et procede d'utilisation associe |
| EP1779851A1 (en) | 2005-10-31 | 2007-05-02 | Boehringer Ingelheim Pharma GmbH & Co.KG | Treatment of diabetes |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3813404A (en) * | 1972-11-15 | 1974-05-28 | Sterling Drug Inc | Tropane-2-carboxylates and derivatives |
| SU941369A1 (ru) * | 1978-12-29 | 1982-07-07 | Научно-исследовательский институт фармакологии АМН СССР | Хлоргидраты W-аминоацильных эфиров тропан-3-ола как стимул торы центральной нервной системы |
| AT397962B (de) * | 1985-12-27 | 1994-08-25 | Madaus & Co Dr | Verfahren zur herstellung von azoniaspironortropanolestern |
| AU672052B2 (en) * | 1992-12-23 | 1996-09-19 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
| AU671163B2 (en) * | 1992-12-23 | 1996-08-15 | Neurosearch A/S | Alkyl substituted heterocyclic compounds |
-
1995
- 1995-04-12 CZ CZ962982A patent/CZ284379B6/cs not_active IP Right Cessation
- 1995-04-12 DE DE69527839T patent/DE69527839T2/de not_active Expired - Lifetime
- 1995-04-12 NZ NZ284075A patent/NZ284075A/en unknown
- 1995-04-12 EE EE9600132A patent/EE03877B1/xx not_active IP Right Cessation
- 1995-04-12 BR BR9507489A patent/BR9507489A/pt not_active Application Discontinuation
- 1995-04-12 US US08/722,010 patent/US5736556A/en not_active Expired - Lifetime
- 1995-04-12 UA UA96103884A patent/UA49801C2/uk unknown
- 1995-04-12 PL PL95316876A patent/PL183025B1/pl unknown
- 1995-04-12 RU RU96121937A patent/RU2134264C1/ru active
- 1995-04-12 KR KR1019960705823A patent/KR100210417B1/ko not_active Expired - Fee Related
- 1995-04-12 WO PCT/EP1995/001358 patent/WO1995028401A1/en active IP Right Grant
- 1995-04-12 GE GEAP19953459A patent/GEP19991749B/en unknown
- 1995-04-12 SK SK1288-96A patent/SK280875B6/sk unknown
- 1995-04-12 CN CN95193151A patent/CN1043763C/zh not_active Expired - Fee Related
- 1995-04-12 AT AT95915869T patent/ATE222587T1/de not_active IP Right Cessation
- 1995-04-12 DK DK95915869T patent/DK0756596T3/da active
- 1995-04-12 AU AU22575/95A patent/AU690257B2/en not_active Ceased
- 1995-04-12 JP JP7526700A patent/JP2899418B2/ja not_active Expired - Fee Related
- 1995-04-12 EP EP95915869A patent/EP0756596B1/en not_active Expired - Lifetime
- 1995-04-12 HU HU9602707A patent/HU215830B/hu not_active IP Right Cessation
- 1995-04-12 CA CA002187309A patent/CA2187309C/en not_active Expired - Fee Related
-
1996
- 1996-10-02 NO NO964180A patent/NO964180L/no not_active Application Discontinuation
- 1996-10-02 BG BG100883A patent/BG63259B1/bg unknown
- 1996-11-11 LV LVP-96-428A patent/LV11738B/en unknown
- 1996-12-17 FI FI965074A patent/FI965074A0/fi active IP Right Revival
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |