DE69527839T2 - Tropan-2-aldoximderivate als neurotransmitter "reuptake" inhibitoren - Google Patents

Tropan-2-aldoximderivate als neurotransmitter "reuptake" inhibitoren

Info

Publication number
DE69527839T2
DE69527839T2 DE69527839T DE69527839T DE69527839T2 DE 69527839 T2 DE69527839 T2 DE 69527839T2 DE 69527839 T DE69527839 T DE 69527839T DE 69527839 T DE69527839 T DE 69527839T DE 69527839 T2 DE69527839 T2 DE 69527839T2
Authority
DE
Germany
Prior art keywords
pct
reuptake
inhibitors
tropan
red transmitter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69527839T
Other languages
English (en)
Other versions
DE69527839D1 (en
Inventor
Peter Moldt
Frank Waetjen
Jorgen Scheel-Krueger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch AS filed Critical Neurosearch AS
Application granted granted Critical
Publication of DE69527839D1 publication Critical patent/DE69527839D1/de
Publication of DE69527839T2 publication Critical patent/DE69527839T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
DE69527839T 1994-04-19 1995-04-12 Tropan-2-aldoximderivate als neurotransmitter "reuptake" inhibitoren Expired - Lifetime DE69527839T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK44794 1994-04-19
DK133894 1994-11-24
PCT/EP1995/001358 WO1995028401A1 (en) 1994-04-19 1995-04-12 Tropane-2-aldoxine derivatives as neurotransmitter reuptake inhibitors

Publications (2)

Publication Number Publication Date
DE69527839D1 DE69527839D1 (en) 2002-09-26
DE69527839T2 true DE69527839T2 (de) 2003-01-02

Family

ID=26064021

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69527839T Expired - Lifetime DE69527839T2 (de) 1994-04-19 1995-04-12 Tropan-2-aldoximderivate als neurotransmitter "reuptake" inhibitoren

Country Status (25)

Country Link
US (1) US5736556A (de)
EP (1) EP0756596B1 (de)
JP (1) JP2899418B2 (de)
KR (1) KR100210417B1 (de)
CN (1) CN1043763C (de)
AT (1) ATE222587T1 (de)
AU (1) AU690257B2 (de)
BG (1) BG63259B1 (de)
BR (1) BR9507489A (de)
CA (1) CA2187309C (de)
CZ (1) CZ284379B6 (de)
DE (1) DE69527839T2 (de)
DK (1) DK0756596T3 (de)
EE (1) EE03877B1 (de)
FI (1) FI965074A (de)
GE (1) GEP19991749B (de)
HU (1) HU215830B (de)
LV (1) LV11738B (de)
NO (1) NO964180L (de)
NZ (1) NZ284075A (de)
PL (1) PL183025B1 (de)
RU (1) RU2134264C1 (de)
SK (1) SK280875B6 (de)
UA (1) UA49801C2 (de)
WO (1) WO1995028401A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK283425B6 (sk) * 1995-10-13 2003-07-01 Neurosearch A/S Deriváty 8-azabicyklo[3,2,1]okt-2-énu, spôsob ich prípravy a použitia
US6241963B1 (en) * 1995-10-19 2001-06-05 The Trustees Of The University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents
SK282944B6 (sk) * 1995-11-02 2003-01-09 Neurosearch A/S Tavené tropánové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie
US5948933A (en) 1997-07-11 1999-09-07 Organix, Inc. Tropane analogs and methods for inhibition of monoamine transport
RU2167876C2 (ru) 1996-02-22 2001-05-27 Ньюросерч А/С 2,3-трансдизамещенное тропановое производное, способ его получения, фармацевтическая композиция
US6232326B1 (en) 1998-07-14 2001-05-15 Jodi A. Nelson Treatment for schizophrenia and other dopamine system dysfunctions
US20040229908A1 (en) * 1999-07-13 2004-11-18 Jodi Nelson Compositions and methods for the treatment of Parkinson's disease and tardive dyskinesias
WO2001003649A2 (en) 1999-07-13 2001-01-18 Alpha Research Group, Llc Compositions and methods for the treatment of parkinson's disease
IL152531A0 (en) * 2000-05-26 2003-05-29 Pfizer Tropane derivatives useful in therapy
US6667314B2 (en) 2000-05-26 2003-12-23 Pfizer, Inc. Tropane derivatives useful in therapy
EP1397358A1 (de) * 2001-05-23 2004-03-17 Neurosearch A/S Tropanderivate und deren verwendung als monoamin-neurotransmitter-wiederaufnahmehemmer
US6610849B2 (en) * 2001-06-28 2003-08-26 Boehringer Ingelheim Pharma Kg Process for the manufacture of tropenol
ATE345135T1 (de) * 2001-11-30 2006-12-15 Neurosearch As Tropan-derivate mit dopamin-wiederaufnahme-hemmer-wirkung für die behandlung von ischämischen erkrankungen
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
AU2003265233B2 (en) * 2002-03-28 2008-05-08 Organix, Inc. Tropane compounds
CA2540834C (en) 2003-10-03 2010-06-22 Pfizer Inc. Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activity for the treatment of hiv and inflammation
MXPA06003762A (es) * 2003-10-16 2006-06-14 Boehringer Ingelheim Int Composicion farmaceutica que comprende un inhibidor de recaptacion de neurotransmisor monoamina y un inhibidor de acetilcolinesterasa.
EP1727547A1 (de) * 2004-01-22 2006-12-06 Neurosearch A/S Verbindungen für die anhaltende verringerung des körpergewichts
WO2005070429A1 (en) * 2004-01-22 2005-08-04 Neurosearch A/S Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist
WO2006075976A1 (fr) * 2005-01-14 2006-07-20 Private Enterprise 'slavyanskaya Klinika' Utilisation d'un anesthesique local pour corriger un comportement alimentaire humain, et procede d'utilisation associe
EP1779851A1 (de) 2005-10-31 2007-05-02 Boehringer Ingelheim Pharma GmbH & Co.KG Behandlung von Diabetes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU672052B2 (en) * 1992-12-23 1996-09-19 Neurosearch A/S Antidepressant and antiparkinsonian compounds
AU671163B2 (en) * 1992-12-23 1996-08-15 Neurosearch A/S Alkyl substituted heterocyclic compounds

Also Published As

Publication number Publication date
PL183025B1 (pl) 2002-05-31
DK0756596T3 (da) 2002-12-23
CA2187309A1 (en) 1995-10-26
HU215830B (hu) 2001-05-28
JP2899418B2 (ja) 1999-06-02
GEP19991749B (en) 1999-09-10
NZ284075A (en) 1998-01-26
SK128896A3 (en) 1997-04-09
MX9604966A (es) 1998-05-31
UA49801C2 (uk) 2002-10-15
WO1995028401A1 (en) 1995-10-26
CA2187309C (en) 2000-11-21
CN1043763C (zh) 1999-06-23
KR100210417B1 (ko) 1999-07-15
BG100883A (en) 1998-03-31
BR9507489A (pt) 1997-08-12
EP0756596A1 (de) 1997-02-05
US5736556A (en) 1998-04-07
BG63259B1 (bg) 2001-07-31
CZ284379B6 (cs) 1998-11-11
CN1148854A (zh) 1997-04-30
RU2134264C1 (ru) 1999-08-10
FI965074A0 (fi) 1996-12-17
EP0756596B1 (de) 2002-08-21
CZ298296A3 (en) 1997-06-11
NO964180L (no) 1996-12-16
FI965074A (fi) 1996-12-17
EE9600132A (et) 1997-04-15
ATE222587T1 (de) 2002-09-15
DE69527839D1 (en) 2002-09-26
EE03877B1 (et) 2002-10-15
HUT75865A (en) 1997-05-28
AU2257595A (en) 1995-11-10
NO964180D0 (no) 1996-10-02
HU9602707D0 (en) 1996-11-28
PL316876A1 (en) 1997-02-17
LV11738A (lv) 1997-04-20
AU690257B2 (en) 1998-04-23
SK280875B6 (sk) 2000-08-14
LV11738B (en) 1997-12-20
JPH09505607A (ja) 1997-06-03

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Legal Events

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