NO964180L - Tropan-2-aldoksimderivater som neurotransmitter-gjenopptaksinhibitorer - Google Patents
Tropan-2-aldoksimderivater som neurotransmitter-gjenopptaksinhibitorerInfo
- Publication number
- NO964180L NO964180L NO964180A NO964180A NO964180L NO 964180 L NO964180 L NO 964180L NO 964180 A NO964180 A NO 964180A NO 964180 A NO964180 A NO 964180A NO 964180 L NO964180 L NO 964180L
- Authority
- NO
- Norway
- Prior art keywords
- pct
- reuptake inhibitors
- tropan
- date oct
- neurotransmitter reuptake
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Addiction (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Den foreliggende oppfinnelse beskriver forbindelser med formel (I), (II), (IH)eller (IV) en hver blanding derav eller et farmasøytisk akseptabelt salt derav: hvori R er hydrogen, alkyl, alkenyl, alkynyl, cykloalkyl, cykloalkylalkyl eller 2-hydroksyetyl; R3 er CH=NOR', hvori R' er hydrogen eller alkenyl, alkynyl, cykloalkyl, cyklalkyalkyl, aryl eller alkyl, hvor alle kan substitueres med COOH, COO-alkyl, COO- cykloalkyl, eller fenyl som kan være substituert en eller flere ganger med substituenter valgt fra gruppen som består av halogen, CF3, CN, alkoksy, cykloalkoksy, alkyl, cykloalkyl, alkenyl, alkynyl, amino, nitro; og R4 er fenyl som kan være substituert en eller flere ganger med substituenter valgt fra grupper som består av halogen, CF3, CN, alkoksy, cykloalkoksy, alkyl, cykloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl og aryl; 3,4- metylendioksyfenyl; benzyl som kan være substituert en eller flere ganger med substituenter valgt fra gruppen som består av halogen, CF3, CN, alkoksy, cykloalkoksy, alkyl, cykloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl og aryl; heteroaryl som kan substitueres en eller flere ganger med substituenter valgt fra gruppen som består av halogen, CF3, CN, alkoksy cykloalkoksy, alkenyl, amino, nitro, heteroaryl og aryl; eller naftyl som kan være substituert en eller flere ganger med substituenter valgt fra gruppen som består av halogen, CF3, CN, alkoksy, cykloalkoksy, alkyl, cykloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl og aryl. Forbindelsene innehar verdifulle farmasøytiske egenskaper som monoamin- neurotransmitter-, dvs. dopamin, serotonin, noradrenalin, gjenopptaks-inhibitorer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK44794 | 1994-04-19 | ||
| DK133894 | 1994-11-24 | ||
| PCT/EP1995/001358 WO1995028401A1 (en) | 1994-04-19 | 1995-04-12 | Tropane-2-aldoxine derivatives as neurotransmitter reuptake inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO964180D0 NO964180D0 (no) | 1996-10-02 |
| NO964180L true NO964180L (no) | 1996-12-16 |
Family
ID=26064021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO964180A NO964180L (no) | 1994-04-19 | 1996-10-02 | Tropan-2-aldoksimderivater som neurotransmitter-gjenopptaksinhibitorer |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5736556A (no) |
| EP (1) | EP0756596B1 (no) |
| JP (1) | JP2899418B2 (no) |
| KR (1) | KR100210417B1 (no) |
| CN (1) | CN1043763C (no) |
| AT (1) | ATE222587T1 (no) |
| AU (1) | AU690257B2 (no) |
| BG (1) | BG63259B1 (no) |
| BR (1) | BR9507489A (no) |
| CA (1) | CA2187309C (no) |
| CZ (1) | CZ284379B6 (no) |
| DE (1) | DE69527839T2 (no) |
| DK (1) | DK0756596T3 (no) |
| EE (1) | EE03877B1 (no) |
| FI (1) | FI965074A (no) |
| GE (1) | GEP19991749B (no) |
| HU (1) | HU215830B (no) |
| LV (1) | LV11738B (no) |
| NO (1) | NO964180L (no) |
| NZ (1) | NZ284075A (no) |
| PL (1) | PL183025B1 (no) |
| RU (1) | RU2134264C1 (no) |
| SK (1) | SK280875B6 (no) |
| UA (1) | UA49801C2 (no) |
| WO (1) | WO1995028401A1 (no) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0859777B1 (en) * | 1995-10-13 | 2007-05-23 | Neurosearch A/S | 8-azabicyclo(3.2.1)oct-2-ene derivatives, their preparation and use |
| US6241963B1 (en) * | 1995-10-19 | 2001-06-05 | The Trustees Of The University Of Pennsylvania | Dopamine and serotonin transporter ligands and imaging agents |
| IL123898A (en) * | 1995-11-02 | 2001-08-08 | Neurosearch As | The history of compressed tropane, their preparation and the pharmaceutical preparations containing them |
| US5948933A (en) * | 1997-07-11 | 1999-09-07 | Organix, Inc. | Tropane analogs and methods for inhibition of monoamine transport |
| CA2244773C (en) | 1996-02-22 | 2006-01-03 | Neurosearch A/S | Tropane-derivatives, their preparation and use |
| US6232326B1 (en) | 1998-07-14 | 2001-05-15 | Jodi A. Nelson | Treatment for schizophrenia and other dopamine system dysfunctions |
| US6417177B1 (en) | 1999-07-13 | 2002-07-09 | Alpha Research Group, Llc | Chloroquine derivatives for the treatment of Parkinson's disease |
| US20040229908A1 (en) * | 1999-07-13 | 2004-11-18 | Jodi Nelson | Compositions and methods for the treatment of Parkinson's disease and tardive dyskinesias |
| US6667314B2 (en) | 2000-05-26 | 2003-12-23 | Pfizer, Inc. | Tropane derivatives useful in therapy |
| JP3693957B2 (ja) * | 2000-05-26 | 2005-09-14 | ファイザー・インク | 療法において有用なトロパン誘導体 |
| US20040106643A1 (en) * | 2001-05-23 | 2004-06-03 | Gouliaev Alex Haarh | Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| US6610849B2 (en) * | 2001-06-28 | 2003-08-26 | Boehringer Ingelheim Pharma Kg | Process for the manufacture of tropenol |
| WO2003045388A1 (en) * | 2001-11-30 | 2003-06-05 | Neurosearch A/S | Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases |
| DE10200943A1 (de) * | 2002-01-12 | 2003-07-24 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Scopinestern |
| CA2480742A1 (en) * | 2002-03-28 | 2003-12-04 | President And Fellows Of Harvard College | Tropane compounds |
| US7309790B2 (en) | 2003-10-03 | 2007-12-18 | Pfizer Inc | Chemical compounds |
| JP2007508336A (ja) * | 2003-10-16 | 2007-04-05 | ニューロサーチ、アクティーゼルスカブ | モノアミン神経伝達物質再取り込みインヒビター及びアセチルコリンエステラーゼインヒビターを含む医薬組成物 |
| CA2554617A1 (en) * | 2004-01-22 | 2005-08-04 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist |
| NZ547919A (en) * | 2004-01-22 | 2009-12-24 | Neurosearch As | Compounds for the sustained reduction of body weight |
| WO2006075976A1 (fr) * | 2005-01-14 | 2006-07-20 | Private Enterprise 'slavyanskaya Klinika' | Utilisation d'un anesthesique local pour corriger un comportement alimentaire humain, et procede d'utilisation associe |
| EP1779851A1 (en) | 2005-10-31 | 2007-05-02 | Boehringer Ingelheim Pharma GmbH & Co.KG | Treatment of diabetes |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU672052B2 (en) * | 1992-12-23 | 1996-09-19 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
| AU671163B2 (en) * | 1992-12-23 | 1996-08-15 | Neurosearch A/S | Alkyl substituted heterocyclic compounds |
-
1995
- 1995-04-12 EP EP95915869A patent/EP0756596B1/en not_active Expired - Lifetime
- 1995-04-12 RU RU96121937A patent/RU2134264C1/ru active
- 1995-04-12 GE GEAP19953459A patent/GEP19991749B/en unknown
- 1995-04-12 CN CN95193151A patent/CN1043763C/zh not_active Expired - Fee Related
- 1995-04-12 US US08/722,010 patent/US5736556A/en not_active Expired - Lifetime
- 1995-04-12 SK SK1288-96A patent/SK280875B6/sk unknown
- 1995-04-12 DE DE69527839T patent/DE69527839T2/de not_active Expired - Lifetime
- 1995-04-12 BR BR9507489A patent/BR9507489A/pt not_active Application Discontinuation
- 1995-04-12 PL PL95316876A patent/PL183025B1/pl unknown
- 1995-04-12 UA UA96103884A patent/UA49801C2/uk unknown
- 1995-04-12 EE EE9600132A patent/EE03877B1/xx not_active IP Right Cessation
- 1995-04-12 WO PCT/EP1995/001358 patent/WO1995028401A1/en active IP Right Grant
- 1995-04-12 CZ CZ962982A patent/CZ284379B6/cs not_active IP Right Cessation
- 1995-04-12 JP JP7526700A patent/JP2899418B2/ja not_active Expired - Fee Related
- 1995-04-12 KR KR1019960705823A patent/KR100210417B1/ko not_active IP Right Cessation
- 1995-04-12 DK DK95915869T patent/DK0756596T3/da active
- 1995-04-12 CA CA002187309A patent/CA2187309C/en not_active Expired - Fee Related
- 1995-04-12 NZ NZ284075A patent/NZ284075A/en unknown
- 1995-04-12 AU AU22575/95A patent/AU690257B2/en not_active Ceased
- 1995-04-12 AT AT95915869T patent/ATE222587T1/de not_active IP Right Cessation
- 1995-04-12 HU HU9602707A patent/HU215830B/hu not_active IP Right Cessation
-
1996
- 1996-10-02 BG BG100883A patent/BG63259B1/bg unknown
- 1996-10-02 NO NO964180A patent/NO964180L/no not_active Application Discontinuation
- 1996-11-11 LV LVP-96-428A patent/LV11738B/en unknown
- 1996-12-17 FI FI965074A patent/FI965074A/fi active IP Right Revival
Also Published As
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| DK0756596T3 (da) | Tropan-2-aldoximderivater som neurotransmitter-genoptagelsesinhibitorer | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |