NO964180L - Tropan-2-aldoksimderivater som neurotransmitter-gjenopptaksinhibitorer - Google Patents
Tropan-2-aldoksimderivater som neurotransmitter-gjenopptaksinhibitorerInfo
- Publication number
- NO964180L NO964180L NO964180A NO964180A NO964180L NO 964180 L NO964180 L NO 964180L NO 964180 A NO964180 A NO 964180A NO 964180 A NO964180 A NO 964180A NO 964180 L NO964180 L NO 964180L
- Authority
- NO
- Norway
- Prior art keywords
- pct
- reuptake inhibitors
- tropan
- date oct
- neurotransmitter reuptake
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Den foreliggende oppfinnelse beskriver forbindelser med formel (I), (II), (IH)eller (IV) en hver blanding derav eller et farmasøytisk akseptabelt salt derav: hvori R er hydrogen, alkyl, alkenyl, alkynyl, cykloalkyl, cykloalkylalkyl eller 2-hydroksyetyl; R3 er CH=NOR', hvori R' er hydrogen eller alkenyl, alkynyl, cykloalkyl, cyklalkyalkyl, aryl eller alkyl, hvor alle kan substitueres med COOH, COO-alkyl, COO- cykloalkyl, eller fenyl som kan være substituert en eller flere ganger med substituenter valgt fra gruppen som består av halogen, CF3, CN, alkoksy, cykloalkoksy, alkyl, cykloalkyl, alkenyl, alkynyl, amino, nitro; og R4 er fenyl som kan være substituert en eller flere ganger med substituenter valgt fra grupper som består av halogen, CF3, CN, alkoksy, cykloalkoksy, alkyl, cykloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl og aryl; 3,4- metylendioksyfenyl; benzyl som kan være substituert en eller flere ganger med substituenter valgt fra gruppen som består av halogen, CF3, CN, alkoksy, cykloalkoksy, alkyl, cykloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl og aryl; heteroaryl som kan substitueres en eller flere ganger med substituenter valgt fra gruppen som består av halogen, CF3, CN, alkoksy cykloalkoksy, alkenyl, amino, nitro, heteroaryl og aryl; eller naftyl som kan være substituert en eller flere ganger med substituenter valgt fra gruppen som består av halogen, CF3, CN, alkoksy, cykloalkoksy, alkyl, cykloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl og aryl. Forbindelsene innehar verdifulle farmasøytiske egenskaper som monoamin- neurotransmitter-, dvs. dopamin, serotonin, noradrenalin, gjenopptaks-inhibitorer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK44794 | 1994-04-19 | ||
DK133894 | 1994-11-24 | ||
PCT/EP1995/001358 WO1995028401A1 (en) | 1994-04-19 | 1995-04-12 | Tropane-2-aldoxine derivatives as neurotransmitter reuptake inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
NO964180D0 NO964180D0 (no) | 1996-10-02 |
NO964180L true NO964180L (no) | 1996-12-16 |
Family
ID=26064021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO964180A NO964180L (no) | 1994-04-19 | 1996-10-02 | Tropan-2-aldoksimderivater som neurotransmitter-gjenopptaksinhibitorer |
Country Status (25)
Country | Link |
---|---|
US (1) | US5736556A (no) |
EP (1) | EP0756596B1 (no) |
JP (1) | JP2899418B2 (no) |
KR (1) | KR100210417B1 (no) |
CN (1) | CN1043763C (no) |
AT (1) | ATE222587T1 (no) |
AU (1) | AU690257B2 (no) |
BG (1) | BG63259B1 (no) |
BR (1) | BR9507489A (no) |
CA (1) | CA2187309C (no) |
CZ (1) | CZ284379B6 (no) |
DE (1) | DE69527839T2 (no) |
DK (1) | DK0756596T3 (no) |
EE (1) | EE03877B1 (no) |
FI (1) | FI965074A (no) |
GE (1) | GEP19991749B (no) |
HU (1) | HU215830B (no) |
LV (1) | LV11738B (no) |
NO (1) | NO964180L (no) |
NZ (1) | NZ284075A (no) |
PL (1) | PL183025B1 (no) |
RU (1) | RU2134264C1 (no) |
SK (1) | SK280875B6 (no) |
UA (1) | UA49801C2 (no) |
WO (1) | WO1995028401A1 (no) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK283425B6 (sk) * | 1995-10-13 | 2003-07-01 | Neurosearch A/S | Deriváty 8-azabicyklo[3,2,1]okt-2-énu, spôsob ich prípravy a použitia |
US6241963B1 (en) * | 1995-10-19 | 2001-06-05 | The Trustees Of The University Of Pennsylvania | Dopamine and serotonin transporter ligands and imaging agents |
SK282944B6 (sk) * | 1995-11-02 | 2003-01-09 | Neurosearch A/S | Tavené tropánové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie |
US5948933A (en) | 1997-07-11 | 1999-09-07 | Organix, Inc. | Tropane analogs and methods for inhibition of monoamine transport |
RU2167876C2 (ru) | 1996-02-22 | 2001-05-27 | Ньюросерч А/С | 2,3-трансдизамещенное тропановое производное, способ его получения, фармацевтическая композиция |
US6232326B1 (en) | 1998-07-14 | 2001-05-15 | Jodi A. Nelson | Treatment for schizophrenia and other dopamine system dysfunctions |
US20040229908A1 (en) * | 1999-07-13 | 2004-11-18 | Jodi Nelson | Compositions and methods for the treatment of Parkinson's disease and tardive dyskinesias |
WO2001003649A2 (en) | 1999-07-13 | 2001-01-18 | Alpha Research Group, Llc | Compositions and methods for the treatment of parkinson's disease |
IL152531A0 (en) * | 2000-05-26 | 2003-05-29 | Pfizer | Tropane derivatives useful in therapy |
US6667314B2 (en) | 2000-05-26 | 2003-12-23 | Pfizer, Inc. | Tropane derivatives useful in therapy |
EP1397358A1 (en) * | 2001-05-23 | 2004-03-17 | Neurosearch A/S | Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
US6610849B2 (en) * | 2001-06-28 | 2003-08-26 | Boehringer Ingelheim Pharma Kg | Process for the manufacture of tropenol |
ATE345135T1 (de) * | 2001-11-30 | 2006-12-15 | Neurosearch As | Tropan-derivate mit dopamin-wiederaufnahme-hemmer-wirkung für die behandlung von ischämischen erkrankungen |
DE10200943A1 (de) * | 2002-01-12 | 2003-07-24 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Scopinestern |
AU2003265233B2 (en) * | 2002-03-28 | 2008-05-08 | Organix, Inc. | Tropane compounds |
CA2540834C (en) | 2003-10-03 | 2010-06-22 | Pfizer Inc. | Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activity for the treatment of hiv and inflammation |
MXPA06003762A (es) * | 2003-10-16 | 2006-06-14 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un inhibidor de recaptacion de neurotransmisor monoamina y un inhibidor de acetilcolinesterasa. |
EP1727547A1 (en) * | 2004-01-22 | 2006-12-06 | Neurosearch A/S | Compounds for the sustained reduction of body weight |
WO2005070429A1 (en) * | 2004-01-22 | 2005-08-04 | Neurosearch A/S | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist |
WO2006075976A1 (fr) * | 2005-01-14 | 2006-07-20 | Private Enterprise 'slavyanskaya Klinika' | Utilisation d'un anesthesique local pour corriger un comportement alimentaire humain, et procede d'utilisation associe |
EP1779851A1 (en) | 2005-10-31 | 2007-05-02 | Boehringer Ingelheim Pharma GmbH & Co.KG | Treatment of diabetes |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU672052B2 (en) * | 1992-12-23 | 1996-09-19 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
AU671163B2 (en) * | 1992-12-23 | 1996-08-15 | Neurosearch A/S | Alkyl substituted heterocyclic compounds |
-
1995
- 1995-04-12 AU AU22575/95A patent/AU690257B2/en not_active Ceased
- 1995-04-12 NZ NZ284075A patent/NZ284075A/en unknown
- 1995-04-12 WO PCT/EP1995/001358 patent/WO1995028401A1/en active IP Right Grant
- 1995-04-12 BR BR9507489A patent/BR9507489A/pt not_active Application Discontinuation
- 1995-04-12 US US08/722,010 patent/US5736556A/en not_active Expired - Lifetime
- 1995-04-12 JP JP7526700A patent/JP2899418B2/ja not_active Expired - Fee Related
- 1995-04-12 SK SK1288-96A patent/SK280875B6/sk unknown
- 1995-04-12 CZ CZ962982A patent/CZ284379B6/cs not_active IP Right Cessation
- 1995-04-12 CA CA002187309A patent/CA2187309C/en not_active Expired - Fee Related
- 1995-04-12 PL PL95316876A patent/PL183025B1/pl unknown
- 1995-04-12 UA UA96103884A patent/UA49801C2/uk unknown
- 1995-04-12 KR KR1019960705823A patent/KR100210417B1/ko not_active IP Right Cessation
- 1995-04-12 EE EE9600132A patent/EE03877B1/xx not_active IP Right Cessation
- 1995-04-12 EP EP95915869A patent/EP0756596B1/en not_active Expired - Lifetime
- 1995-04-12 DK DK95915869T patent/DK0756596T3/da active
- 1995-04-12 DE DE69527839T patent/DE69527839T2/de not_active Expired - Lifetime
- 1995-04-12 CN CN95193151A patent/CN1043763C/zh not_active Expired - Fee Related
- 1995-04-12 RU RU96121937A patent/RU2134264C1/ru active
- 1995-04-12 GE GEAP19953459A patent/GEP19991749B/en unknown
- 1995-04-12 AT AT95915869T patent/ATE222587T1/de not_active IP Right Cessation
- 1995-04-12 HU HU9602707A patent/HU215830B/hu not_active IP Right Cessation
-
1996
- 1996-10-02 NO NO964180A patent/NO964180L/no not_active Application Discontinuation
- 1996-10-02 BG BG100883A patent/BG63259B1/bg unknown
- 1996-11-11 LV LVP-96-428A patent/LV11738B/en unknown
- 1996-12-17 FI FI965074A patent/FI965074A/fi active IP Right Revival
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |