SK280875B6 - Tropánové deriváty, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a použitie týchto derivátov na výrobu liečiv - Google Patents

Tropánové deriváty, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a použitie týchto derivátov na výrobu liečiv Download PDF

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Publication number
SK280875B6
SK280875B6 SK1288-96A SK128896A SK280875B6 SK 280875 B6 SK280875 B6 SK 280875B6 SK 128896 A SK128896 A SK 128896A SK 280875 B6 SK280875 B6 SK 280875B6
Authority
SK
Slovakia
Prior art keywords
tropane
dichlorophenyl
carbon atoms
cycloalkyl
alkyl
Prior art date
Application number
SK1288-96A
Other languages
English (en)
Slovak (sk)
Other versions
SK128896A3 (en
Inventor
Peter Moldt
Frank W�Tjen
Jorgen Scheel-Kr�Ger
Original Assignee
Neurosearch A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch A/S filed Critical Neurosearch A/S
Publication of SK128896A3 publication Critical patent/SK128896A3/sk
Publication of SK280875B6 publication Critical patent/SK280875B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Addiction (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
SK1288-96A 1994-04-19 1995-04-12 Tropánové deriváty, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a použitie týchto derivátov na výrobu liečiv SK280875B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK44794 1994-04-19
DK133894 1994-11-24
PCT/EP1995/001358 WO1995028401A1 (en) 1994-04-19 1995-04-12 Tropane-2-aldoxine derivatives as neurotransmitter reuptake inhibitors

Publications (2)

Publication Number Publication Date
SK128896A3 SK128896A3 (en) 1997-04-09
SK280875B6 true SK280875B6 (sk) 2000-08-14

Family

ID=26064021

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1288-96A SK280875B6 (sk) 1994-04-19 1995-04-12 Tropánové deriváty, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a použitie týchto derivátov na výrobu liečiv

Country Status (25)

Country Link
US (1) US5736556A (no)
EP (1) EP0756596B1 (no)
JP (1) JP2899418B2 (no)
KR (1) KR100210417B1 (no)
CN (1) CN1043763C (no)
AT (1) ATE222587T1 (no)
AU (1) AU690257B2 (no)
BG (1) BG63259B1 (no)
BR (1) BR9507489A (no)
CA (1) CA2187309C (no)
CZ (1) CZ284379B6 (no)
DE (1) DE69527839T2 (no)
DK (1) DK0756596T3 (no)
EE (1) EE03877B1 (no)
FI (1) FI965074A0 (no)
GE (1) GEP19991749B (no)
HU (1) HU215830B (no)
LV (1) LV11738B (no)
NO (1) NO964180L (no)
NZ (1) NZ284075A (no)
PL (1) PL183025B1 (no)
RU (1) RU2134264C1 (no)
SK (1) SK280875B6 (no)
UA (1) UA49801C2 (no)
WO (1) WO1995028401A1 (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9610960A (pt) * 1995-10-13 1999-03-02 Neurosearch As Derivados de 8-azabiciclo [3.2.1] oct -2- eno sua preparação e uso
US6241963B1 (en) * 1995-10-19 2001-06-05 The Trustees Of The University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents
DE69623799T2 (de) * 1995-11-02 2003-01-30 Neurosearch A/S, Ballerup Kondensierte tropanderivate als neurotransmitter-reuptake-inhibitoren
US5948933A (en) * 1997-07-11 1999-09-07 Organix, Inc. Tropane analogs and methods for inhibition of monoamine transport
SK281813B6 (sk) 1996-02-22 2001-08-06 Neurosearch A/S Tropánové deriváty, spôsob ich prípravy, použitie a farmaceutická kompozícia s ich obsahom
US6232326B1 (en) 1998-07-14 2001-05-15 Jodi A. Nelson Treatment for schizophrenia and other dopamine system dysfunctions
US20040229908A1 (en) * 1999-07-13 2004-11-18 Jodi Nelson Compositions and methods for the treatment of Parkinson's disease and tardive dyskinesias
JP2004500331A (ja) 1999-07-13 2004-01-08 アルファ　リサーチ　グループ，　エルエルシー パーキンソン病の処置のための組成物および方法
DE60135685D1 (de) * 2000-05-26 2008-10-16 Pfizer Triazolyltropanderivate als ccr5-modulatoren
US6667314B2 (en) 2000-05-26 2003-12-23 Pfizer, Inc. Tropane derivatives useful in therapy
JP2005508872A (ja) * 2001-05-23 2005-04-07 ニューロサーチ、アクティーゼルスカブ トロパン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害剤として使用する方法
US6610849B2 (en) * 2001-06-28 2003-08-26 Boehringer Ingelheim Pharma Kg Process for the manufacture of tropenol
JP2005511639A (ja) * 2001-11-30 2005-04-28 ニューロサーチ、アクティーゼルスカブ 虚血性疾患の治療用ドパミン再取り込み阻害活性を有するトロパン誘導体
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
AU2003265233B2 (en) * 2002-03-28 2008-05-08 Organix, Inc. Tropane compounds
RS20060198A (en) 2003-10-03 2008-09-29 Pfizer Limited, Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activ ity for the treatment of hiv and inflammation
DK1675591T3 (da) 2003-10-16 2011-11-14 Neurosearch As Farmaceutisk sammensætning omfattende en monoamin-neurotransmitter-genoptagelseshæmmer og en acetylcholinesterase-hæmmer
CA2553649A1 (en) * 2004-01-22 2005-08-04 Neurosearch A/S Compounds for the sustained reduction of body weight
JP2007518755A (ja) * 2004-01-22 2007-07-12 ノイロサーチ アクティーゼルスカブ モノアミン神経伝達物質再取り込み阻害剤及びｎ−メチル−ｄ−アスパラギン酸（ｎｍｄａ）受容体アンタゴニストを含む医薬組成物
RU2352332C1 (ru) * 2005-01-14 2009-04-20 Частное Предприятие "Славянская Клиника" Применение местного анестетика для коррекции пищевого поведения человека и способ применения
EP1779851A1 (en) 2005-10-31 2007-05-02 Boehringer Ingelheim Pharma GmbH & Co.KG Treatment of diabetes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU672052B2 (en) * 1992-12-23 1996-09-19 Neurosearch A/S Antidepressant and antiparkinsonian compounds
AU671163B2 (en) * 1992-12-23 1996-08-15 Neurosearch A/S Alkyl substituted heterocyclic compounds

Also Published As

Publication number Publication date
CZ284379B6 (cs) 1998-11-11
DE69527839D1 (en) 2002-09-26
SK128896A3 (en) 1997-04-09
WO1995028401A1 (en) 1995-10-26
FI965074A (fi) 1996-12-17
HU215830B (hu) 2001-05-28
CZ298296A3 (en) 1997-06-11
PL316876A1 (en) 1997-02-17
EP0756596A1 (en) 1997-02-05
HUT75865A (en) 1997-05-28
FI965074A0 (fi) 1996-12-17
ATE222587T1 (de) 2002-09-15
EE9600132A (et) 1997-04-15
CA2187309A1 (en) 1995-10-26
AU2257595A (en) 1995-11-10
LV11738B (en) 1997-12-20
HU9602707D0 (en) 1996-11-28
AU690257B2 (en) 1998-04-23
NZ284075A (en) 1998-01-26
LV11738A (lv) 1997-04-20
EE03877B1 (et) 2002-10-15
BG100883A (en) 1998-03-31
GEP19991749B (en) 1999-09-10
BR9507489A (pt) 1997-08-12
DE69527839T2 (de) 2003-01-02
NO964180D0 (no) 1996-10-02
NO964180L (no) 1996-12-16
CN1043763C (zh) 1999-06-23
EP0756596B1 (en) 2002-08-21
PL183025B1 (pl) 2002-05-31
CN1148854A (zh) 1997-04-30
UA49801C2 (uk) 2002-10-15
CA2187309C (en) 2000-11-21
BG63259B1 (bg) 2001-07-31
MX9604966A (es) 1998-05-31
JPH09505607A (ja) 1997-06-03
JP2899418B2 (ja) 1999-06-02
DK0756596T3 (da) 2002-12-23
US5736556A (en) 1998-04-07
KR100210417B1 (ko) 1999-07-15
RU2134264C1 (ru) 1999-08-10

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