NO963991L - Fremgangsmåte ved separasjon av enantiomerer av amlodipin via deres diastereomere tartrater - Google Patents

Fremgangsmåte ved separasjon av enantiomerer av amlodipin via deres diastereomere tartrater

Info

Publication number
NO963991L
NO963991L NO963991A NO963991A NO963991L NO 963991 L NO963991 L NO 963991L NO 963991 A NO963991 A NO 963991A NO 963991 A NO963991 A NO 963991A NO 963991 L NO963991 L NO 963991L
Authority
NO
Norway
Prior art keywords
amlodipine
separation
enantiomers
dmso
tartrates
Prior art date
Application number
NO963991A
Other languages
English (en)
Other versions
NO963991D0 (no
NO306110B1 (no
Inventor
Peter Lionel Spargo
Original Assignee
Pfizer Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev
Publication of NO963991D0 publication Critical patent/NO963991D0/no
Publication of NO963991L publication Critical patent/NO963991L/no
Publication of NO306110B1 publication Critical patent/NO306110B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
NO963991A 1994-03-24 1996-09-23 Fremgangsmåte ved separasjon av enantiomerer av amlodipin via deres diastereomere tartrater NO306110B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9405833A GB9405833D0 (en) 1994-03-24 1994-03-24 Separation of the enantiomers of amlodipine
PCT/EP1995/000847 WO1995025722A1 (en) 1994-03-24 1995-03-06 Separation of the enantiomers of amlodipine via their diastereomeric tartrates

Publications (3)

Publication Number Publication Date
NO963991D0 NO963991D0 (no) 1996-09-23
NO963991L true NO963991L (no) 1996-11-19
NO306110B1 NO306110B1 (no) 1999-09-20

Family

ID=10752425

Family Applications (1)

Application Number Title Priority Date Filing Date
NO963991A NO306110B1 (no) 1994-03-24 1996-09-23 Fremgangsmåte ved separasjon av enantiomerer av amlodipin via deres diastereomere tartrater

Country Status (27)

Country Link
US (2) US5750707A (no)
EP (1) EP0751938B1 (no)
JP (1) JP2843681B2 (no)
KR (1) KR100188980B1 (no)
CN (1) CN1067055C (no)
AT (1) ATE166050T1 (no)
AU (1) AU677765B2 (no)
BR (1) BR9507137A (no)
CA (1) CA2186263C (no)
CO (1) CO4230248A1 (no)
CZ (1) CZ287324B6 (no)
DE (1) DE69502486T2 (no)
DK (1) DK0751938T3 (no)
ES (1) ES2116737T3 (no)
FI (1) FI113646B (no)
GB (1) GB9405833D0 (no)
HU (1) HU214720B (no)
IL (1) IL113008A (no)
MY (1) MY111979A (no)
NO (1) NO306110B1 (no)
NZ (1) NZ282404A (no)
PE (1) PE48895A1 (no)
PL (1) PL180085B1 (no)
RU (1) RU2132845C1 (no)
TW (1) TW448156B (no)
WO (1) WO1995025722A1 (no)
ZA (1) ZA952362B (no)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9317773D0 (en) * 1993-08-26 1993-10-13 Pfizer Ltd Therapeutic compound
US20050158408A1 (en) * 1998-07-24 2005-07-21 Yoo Seo H. Dried forms of aqueous solubilized bile acid dosage formulation: preparation and uses thereof
US7303768B2 (en) * 1998-07-24 2007-12-04 Seo Hong Yoo Preparation of aqueous clear solution dosage forms with bile acids
US20070072828A1 (en) * 1998-07-24 2007-03-29 Yoo Seo H Bile preparations for colorectal disorders
US7772220B2 (en) * 2004-10-15 2010-08-10 Seo Hong Yoo Methods and compositions for reducing toxicity of a pharmaceutical compound
US6333342B1 (en) 1998-11-04 2001-12-25 Isotechnika, Inc Methods of pharmacological treatment using S(−) amlodipine
CN1100038C (zh) * 2000-02-21 2003-01-29 张喜田 氨氯地平对映体的拆分
GB0020842D0 (en) * 2000-08-23 2000-10-11 Pfizer Ltd Therapeutic compositions
US6737430B2 (en) 2000-11-09 2004-05-18 Pfizer, Inc. Mutual prodrug of amlodipine and atorvastatin
JP2005509637A (ja) * 2001-10-24 2005-04-14 セプラコア インク． アムロジピンラセミ体の分離方法
CN1152013C (zh) * 2001-11-22 2004-06-02 张喜田 一类左旋氨氯地平盐的水合物及其制剂
US20030176706A1 (en) * 2002-03-18 2003-09-18 Joshi Rohini Ramesh Process for the preparation of [S(-) amlodipine - L (+)- hemitartarate]
EP1348697A1 (en) * 2002-03-28 2003-10-01 Council Of Scientific & Industrial Research Process for the preparation of S(-)-amlodipine-L(+)-hemitartrate
KR100476636B1 (ko) * 2002-09-11 2005-03-17 한림제약(주) 엘-(+)-타르트레이트를 이용한 에스-(-)-암로디핀의 제조방법
US20040072879A1 (en) * 2002-10-10 2004-04-15 Dr. Reddy's Laboratories Limited Crystalline 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine maleate salt (Amlodipine)
KR101194453B1 (ko) * 2003-01-31 2012-10-24 다이이찌 산쿄 가부시키가이샤 동맥 경화 및 고혈압증의 예방 및 치료를 위한 의약
US7145125B2 (en) 2003-06-23 2006-12-05 Advanced Optical Technologies, Llc Integrating chamber cone light using LED sources
US6846932B1 (en) * 2003-11-20 2005-01-25 Council Of Scientific And Industrial Research Process for preparation of chiral amlodipine salts
WO2005049571A1 (en) * 2003-11-20 2005-06-02 Council Of Scientific And Industrial Research Process for preparation of chiral amlodipine salts
CN1231469C (zh) * 2003-12-05 2005-12-14 石家庄制药集团欧意药业有限公司 一种光学活性氨氯地平的拆分方法
WO2005089353A2 (en) * 2004-03-16 2005-09-29 Sepracor Inc. (s)-amlodipine malate
AU2005279961B2 (en) * 2004-08-30 2010-05-13 Seo Hong Yoo Neuroprotective effect of solubilized UDCA in focal ischemic model
WO2006044771A2 (en) * 2004-10-15 2006-04-27 Seo Hong Yoo Methods and compositions for reducing toxicity of a pharmaceutical compound
DE602005007763D1 (de) * 2004-10-20 2008-08-07 Emcure Pharmaceuticals Ltd Verfahren zur herstellung eines enantiomers von amlodipin in hoher optischer reinheit
JP2008518935A (ja) * 2004-11-01 2008-06-05 セオ ホン ユー 筋萎縮性側索硬化症の神経退行を減少させるための方法及び組成物
KR101152608B1 (ko) * 2004-12-02 2012-06-07 에스케이케미칼주식회사 (ｒ,ｓ)-암로디핀으로부터 암로디핀 이성질체의 분리방법
WO2006059886A1 (en) * 2004-12-02 2006-06-08 Sk Chemicals, Co., Ltd. Optical resolution method of amlodipine
HUP0500570A3 (en) * 2005-06-08 2008-03-28 Richter Gedeon Nyrt Process for the preparation of (s)-(-)-amlodipine
TWI405580B (zh) * 2005-06-27 2013-08-21 Sankyo Co 含有血管收縮素ｉｉ接受器拮抗劑及鈣通道阻斷劑之醫藥調配物
KR101235116B1 (ko) * 2005-10-17 2013-02-20 에스케이케미칼주식회사 광학활성 암로디핀 겐티세이트 염의 제조방법
CN100436417C (zh) * 2006-04-11 2008-11-26 石药集团中奇制药技术（石家庄）有限公司 一种光学活性氨氯地平的拆分方法
KR100913791B1 (ko) 2006-07-21 2009-08-26 한미약품 주식회사 (ｓ)-(-)-암로디핀 캠실레이트 또는 이의 수화물 및 이를함유하는 약학적 조성물
TWI399223B (zh) * 2006-09-15 2013-06-21 Daiichi Sankyo Co Ltd 奧美沙坦酯及氨氯地平之固體劑型
KR100828883B1 (ko) * 2006-10-27 2008-05-09 씨제이제일제당 (주) 라세믹 암로디핀으로부터 ｓ-(-)-암로디핀의 분리방법
KR100830003B1 (ko) * 2006-10-31 2008-05-15 씨제이제일제당 (주) 결정성 ｓ-(-)-암로디핀 아디핀산 염 무수물 및 이의 제조방법
KR100868160B1 (ko) 2007-02-14 2008-11-12 한미약품 주식회사 Ｓ-(-)-암로디핀 또는 이의 염의 제조방법 및 이에사용되는 중간체
KR100979772B1 (ko) 2008-06-12 2010-09-02 에이치 엘 지노믹스(주) 광학적으로 순수한 에스-(-)-암로디핀 벤젠술폰산염의제조방법
KR100989970B1 (ko) 2008-07-01 2010-10-26 미래파인켐 주식회사 (ｓ)-(-)-암로디핀의 분리방법
KR101085169B1 (ko) 2009-03-25 2011-11-18 (주)켐트로스 암로디핀 광학 이성질체의 분리방법
KR101705535B1 (ko) * 2009-04-01 2017-02-28 주식회사 씨트리 광학활성을 갖는 1-(3-히드록시페닐)에틸아민의 제조방법
RU2537361C1 (ru) * 2013-07-18 2015-01-10 Общество С Ограниченной Ответственностью "Синтегал" Оптические изомеры (+) и (-)-бензгидрилмочевин и (+) и (-)-1-[(3-хлорфенил)-фенил-метил]мочевины, фармацевтическая композиция на их основе и способ их получения
CN110882249B (zh) 2019-11-08 2021-04-30 北京吾为尔创科技有限公司 含苯磺酸左氨氯地平水合物的组合物及其制备方法
CN111100064B (zh) * 2020-01-08 2024-01-02 湖南理工学院 一种从废液中富集、回收和拆分碱性手性药物氨氯地平的方法
CN111777547B (zh) * 2020-07-17 2021-10-08 江西施美药业股份有限公司 一种诱导析晶拆分左旋氨氯地平的方法
US11452690B1 (en) 2021-01-27 2022-09-27 ECI Pharmaceuticals, LLC Oral liquid compositions comprising amlodipine besylate and methods of using the same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5364872A (en) * 1984-04-16 1994-11-15 Yamanouchi Pharmaceutical Co., Ltd. Dihydropyridine-3,5-dicarboxylic acid ester derivatives
GR850872B (no) * 1984-04-16 1985-11-25 Yamanouchi Pharma Co Ltd
US5326772A (en) * 1984-09-28 1994-07-05 Byk Gulden Lomberg Chemische Fabrik Gmbh Diaryl compounds for their use
GB2181127B (en) * 1985-08-21 1989-08-02 Glaxo Spa 4-phenyl-dihydropyridine carboxylic acid derivatives
DK142287A (da) * 1986-03-27 1987-09-28 Byk Gulden Lomberg Chem Fab Optisk aktive 1,4-dihydropyridinderivater
NZ220022A (en) * 1986-04-22 1990-04-26 Byk Gulden Lomberg Chem Fab 1,4-dihydropyridine derivatives and pharmaceutical compositions
AU2614288A (en) * 1987-10-27 1989-05-23 Byk Gulden Lomberg Chemische Fabrik Gmbh New pyrrolidines
GB8804630D0 (en) * 1988-02-27 1988-03-30 Pfizer Ltd Preparation of r-& s-amlodipine
GB8822170D0 (en) * 1988-09-21 1988-10-26 Pfizer Ltd Therapeutic agents
IT1230752B (it) * 1989-02-17 1991-10-29 Boehringer Biochemia Srl Processo per la preparazione di 1,4 diidropiridine polisostituite in forma enantiomericamente pura.
DE3906460C1 (no) * 1989-03-01 1990-11-15 Goedecke Ag, 1000 Berlin, De

Also Published As

Publication number Publication date
US5750707A (en) 1998-05-12
EP0751938B1 (en) 1998-05-13
JP2843681B2 (ja) 1999-01-06
EP0751938A1 (en) 1997-01-08
PE48895A1 (es) 1996-01-06
CN1067055C (zh) 2001-06-13
CA2186263C (en) 1999-05-11
IL113008A (en) 1999-07-14
IL113008A0 (en) 1995-06-29
HU9602597D0 (en) 1996-11-28
TW448156B (en) 2001-08-01
US6046338A (en) 2000-04-04
NO963991D0 (no) 1996-09-23
FI963775A0 (fi) 1996-09-23
DE69502486D1 (de) 1998-06-18
ATE166050T1 (de) 1998-05-15
HU214720B (hu) 1998-05-28
ZA952362B (en) 1996-09-23
AU677765B2 (en) 1997-05-01
FI113646B (fi) 2004-05-31
CO4230248A1 (es) 1995-10-19
GB9405833D0 (en) 1994-05-11
JPH09510707A (ja) 1997-10-28
RU2132845C1 (ru) 1999-07-10
DE69502486T2 (de) 1998-09-10
ES2116737T3 (es) 1998-07-16
MY111979A (en) 2001-03-31
WO1995025722A1 (en) 1995-09-28
CN1144523A (zh) 1997-03-05
AU1949395A (en) 1995-10-09
MX9604299A (es) 1998-05-31
BR9507137A (pt) 1997-09-30
HUT76290A (en) 1997-07-28
NO306110B1 (no) 1999-09-20
CA2186263A1 (en) 1995-09-28
KR970701697A (ko) 1997-04-12
CZ278496A3 (en) 1997-03-12
NZ282404A (en) 1997-11-24
FI963775A (fi) 1996-09-23
CZ287324B6 (en) 2000-10-11
PL180085B1 (pl) 2000-12-29
DK0751938T3 (da) 1998-10-07
KR100188980B1 (ko) 1999-06-01
PL316535A1 (en) 1997-01-20

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