DE602005007763D1 - Verfahren zur herstellung eines enantiomers von amlodipin in hoher optischer reinheit - Google Patents

Verfahren zur herstellung eines enantiomers von amlodipin in hoher optischer reinheit

Info

Publication number
DE602005007763D1
DE602005007763D1 DE602005007763T DE602005007763T DE602005007763D1 DE 602005007763 D1 DE602005007763 D1 DE 602005007763D1 DE 602005007763 T DE602005007763 T DE 602005007763T DE 602005007763 T DE602005007763 T DE 602005007763T DE 602005007763 D1 DE602005007763 D1 DE 602005007763D1
Authority
DE
Germany
Prior art keywords
amlodipin
enantiomer
preparing
optical purity
highly optical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005007763T
Other languages
English (en)
Inventor
Milind Moreshwar Gharpure
Baburao Manikrao Bhawal
Prasad Vasudeo Ranade
Rajendra Dagadu Deshmukh
Satish Ramanlal Mehta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emcure Pharmaceuticals Ltd
Original Assignee
Emcure Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emcure Pharmaceuticals Ltd filed Critical Emcure Pharmaceuticals Ltd
Publication of DE602005007763D1 publication Critical patent/DE602005007763D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE602005007763T 2004-10-20 2005-10-17 Verfahren zur herstellung eines enantiomers von amlodipin in hoher optischer reinheit Active DE602005007763D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1123MU2004 2004-10-20
PCT/IB2005/003108 WO2006043148A1 (en) 2004-10-20 2005-10-17 Process for producing enantiomer of amlodipine in high optical purity

Publications (1)

Publication Number Publication Date
DE602005007763D1 true DE602005007763D1 (de) 2008-08-07

Family

ID=35708803

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005007763T Active DE602005007763D1 (de) 2004-10-20 2005-10-17 Verfahren zur herstellung eines enantiomers von amlodipin in hoher optischer reinheit

Country Status (11)

Country Link
US (2) US7858801B2 (de)
EP (1) EP1802576B1 (de)
JP (1) JP4932728B2 (de)
KR (1) KR101130622B1 (de)
AT (1) ATE399154T1 (de)
BR (1) BRPI0511095B8 (de)
DE (1) DE602005007763D1 (de)
ES (1) ES2307209T3 (de)
PT (1) PT1802576E (de)
RU (1) RU2376288C2 (de)
WO (1) WO2006043148A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0500570A3 (en) * 2005-06-08 2008-03-28 Richter Gedeon Nyrt Process for the preparation of (s)-(-)-amlodipine
KR100913791B1 (ko) * 2006-07-21 2009-08-26 한미약품 주식회사 (ｓ)-(-)-암로디핀 캠실레이트 또는 이의 수화물 및 이를함유하는 약학적 조성물
KR101088488B1 (ko) 2006-08-30 2011-11-30 주식회사 씨트리 광학활성을 갖는 암로디핀의 제조방법
KR100828883B1 (ko) * 2006-10-27 2008-05-09 씨제이제일제당 (주) 라세믹 암로디핀으로부터 ｓ-(-)-암로디핀의 분리방법
CN101766611B (zh) * 2010-02-09 2011-10-12 施慧达药业集团(吉林)有限公司 一种左旋氨氯地平或其可药用盐和β受体阻滞剂的药物组合物及其应用
CN101773500B (zh) * 2010-02-09 2012-05-23 施慧达药业集团(吉林)有限公司 抗高血压的药物组合物
KR101313842B1 (ko) * 2010-09-15 2013-10-01 대화제약 주식회사 에스-암로디핀 베실레이트 및 그 수화물의 제조방법
CN111689894B (zh) * 2019-03-13 2023-05-02 鲁南制药集团股份有限公司 一种苯磺酸左旋氨氯地平晶型
CN112110850B (zh) * 2019-06-20 2023-05-02 鲁南制药集团股份有限公司 一种苯磺酸左旋氨氯地平新晶型
CN110882249B (zh) 2019-11-08 2021-04-30 北京吾为尔创科技有限公司 含苯磺酸左氨氯地平水合物的组合物及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8804630D0 (en) 1988-02-27 1988-03-30 Pfizer Ltd Preparation of r-& s-amlodipine
WO1993010779A1 (en) * 1991-11-26 1993-06-10 Sepracor, Inc. Methods and compositions for treating hypertension, angina and other disorders using optically pure (-) amlodipine
US6057344A (en) 1991-11-26 2000-05-02 Sepracor, Inc. Methods for treating hypertension, and angina using optically pure (-) amlodipine
GB9317773D0 (en) 1993-08-26 1993-10-13 Pfizer Ltd Therapeutic compound
GB9405833D0 (en) 1994-03-24 1994-05-11 Pfizer Ltd Separation of the enantiomers of amlodipine
CN1100038C (zh) 2000-02-21 2003-01-29 张喜田 氨氯地平对映体的拆分
KR20040062575A (ko) 2001-10-24 2004-07-07 세프라코 아이엔시. 암로디핀 라셈체의 분리 방법
US20030176706A1 (en) 2002-03-18 2003-09-18 Joshi Rohini Ramesh Process for the preparation of [S(-) amlodipine - L (+)- hemitartarate]
EP1348697A1 (de) 2002-03-28 2003-10-01 Council Of Scientific & Industrial Research Verfahren zur Herstellung von S(-)-amlodipine-L(+)-hemitartrate
KR100476636B1 (ko) 2002-09-11 2005-03-17 한림제약(주) 엘-(+)-타르트레이트를 이용한 에스-(-)-암로디핀의 제조방법
EP1407773A1 (de) 2002-10-08 2004-04-14 Council of Scientific and Industrial Research Verfahren zur Herstellung von s(-)Amlodipin-Salzen
US6608206B1 (en) * 2002-10-30 2003-08-19 Council Of Scientific & Industrial Research Process for making S(-) Amlodipine salts
BRPI0416648A2 (pt) * 2003-11-20 2009-01-13 Council Scient Ind Res processo para a preparaÇço de sais quirais farmaceuticamente aceitÁveis de amlodipina

Also Published As

Publication number Publication date
WO2006043148A1 (en) 2006-04-27
US20080262239A1 (en) 2008-10-23
US7858801B2 (en) 2010-12-28
JP2008517050A (ja) 2008-05-22
ES2307209T3 (es) 2008-11-16
US8445688B2 (en) 2013-05-21
JP4932728B2 (ja) 2012-05-16
PT1802576E (pt) 2008-09-15
EP1802576B1 (de) 2008-06-25
RU2376288C2 (ru) 2009-12-20
WO2006043148B1 (en) 2006-06-08
ATE399154T1 (de) 2008-07-15
RU2006138705A (ru) 2008-05-10
BRPI0511095A (pt) 2007-12-26
BRPI0511095B1 (pt) 2021-01-19
EP1802576A1 (de) 2007-07-04
US20110021783A1 (en) 2011-01-27
BRPI0511095B8 (pt) 2021-05-25
KR101130622B1 (ko) 2012-04-02
KR20070062946A (ko) 2007-06-18

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Legal Events

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8364 No opposition during term of opposition