ZA952362B - Separation of the enantiomers of amlodipine - Google Patents
Separation of the enantiomers of amlodipineInfo
- Publication number
- ZA952362B ZA952362B ZA952362A ZA952362A ZA952362B ZA 952362 B ZA952362 B ZA 952362B ZA 952362 A ZA952362 A ZA 952362A ZA 952362 A ZA952362 A ZA 952362A ZA 952362 B ZA952362 B ZA 952362B
- Authority
- ZA
- South Africa
- Prior art keywords
- amlodipine
- separation
- dmso
- enantiomers
- isomers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9405833A GB9405833D0 (en) | 1994-03-24 | 1994-03-24 | Separation of the enantiomers of amlodipine |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA952362B true ZA952362B (en) | 1996-09-23 |
Family
ID=10752425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA952362A ZA952362B (en) | 1994-03-24 | 1995-03-23 | Separation of the enantiomers of amlodipine |
Country Status (27)
Country | Link |
---|---|
US (2) | US5750707A (no) |
EP (1) | EP0751938B1 (no) |
JP (1) | JP2843681B2 (no) |
KR (1) | KR100188980B1 (no) |
CN (1) | CN1067055C (no) |
AT (1) | ATE166050T1 (no) |
AU (1) | AU677765B2 (no) |
BR (1) | BR9507137A (no) |
CA (1) | CA2186263C (no) |
CO (1) | CO4230248A1 (no) |
CZ (1) | CZ287324B6 (no) |
DE (1) | DE69502486T2 (no) |
DK (1) | DK0751938T3 (no) |
ES (1) | ES2116737T3 (no) |
FI (1) | FI113646B (no) |
GB (1) | GB9405833D0 (no) |
HU (1) | HU214720B (no) |
IL (1) | IL113008A (no) |
MY (1) | MY111979A (no) |
NO (1) | NO306110B1 (no) |
NZ (1) | NZ282404A (no) |
PE (1) | PE48895A1 (no) |
PL (1) | PL180085B1 (no) |
RU (1) | RU2132845C1 (no) |
TW (1) | TW448156B (no) |
WO (1) | WO1995025722A1 (no) |
ZA (1) | ZA952362B (no) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9317773D0 (en) * | 1993-08-26 | 1993-10-13 | Pfizer Ltd | Therapeutic compound |
US20050158408A1 (en) * | 1998-07-24 | 2005-07-21 | Yoo Seo H. | Dried forms of aqueous solubilized bile acid dosage formulation: preparation and uses thereof |
US7303768B2 (en) * | 1998-07-24 | 2007-12-04 | Seo Hong Yoo | Preparation of aqueous clear solution dosage forms with bile acids |
US20070072828A1 (en) * | 1998-07-24 | 2007-03-29 | Yoo Seo H | Bile preparations for colorectal disorders |
US7772220B2 (en) * | 2004-10-15 | 2010-08-10 | Seo Hong Yoo | Methods and compositions for reducing toxicity of a pharmaceutical compound |
US6333342B1 (en) | 1998-11-04 | 2001-12-25 | Isotechnika, Inc | Methods of pharmacological treatment using S(−) amlodipine |
CN1100038C (zh) * | 2000-02-21 | 2003-01-29 | 张喜田 | 氨氯地平对映体的拆分 |
GB0020842D0 (en) * | 2000-08-23 | 2000-10-11 | Pfizer Ltd | Therapeutic compositions |
US6737430B2 (en) | 2000-11-09 | 2004-05-18 | Pfizer, Inc. | Mutual prodrug of amlodipine and atorvastatin |
JP2005509637A (ja) * | 2001-10-24 | 2005-04-14 | セプラコア インク. | アムロジピンラセミ体の分離方法 |
CN1152013C (zh) * | 2001-11-22 | 2004-06-02 | 张喜田 | 一类左旋氨氯地平盐的水合物及其制剂 |
US20030176706A1 (en) * | 2002-03-18 | 2003-09-18 | Joshi Rohini Ramesh | Process for the preparation of [S(-) amlodipine - L (+)- hemitartarate] |
EP1348697A1 (en) * | 2002-03-28 | 2003-10-01 | Council Of Scientific & Industrial Research | Process for the preparation of S(-)-amlodipine-L(+)-hemitartrate |
KR100476636B1 (ko) * | 2002-09-11 | 2005-03-17 | 한림제약(주) | 엘-(+)-타르트레이트를 이용한 에스-(-)-암로디핀의 제조방법 |
US20040072879A1 (en) * | 2002-10-10 | 2004-04-15 | Dr. Reddy's Laboratories Limited | Crystalline 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine maleate salt (Amlodipine) |
KR101194453B1 (ko) * | 2003-01-31 | 2012-10-24 | 다이이찌 산쿄 가부시키가이샤 | 동맥 경화 및 고혈압증의 예방 및 치료를 위한 의약 |
US7145125B2 (en) | 2003-06-23 | 2006-12-05 | Advanced Optical Technologies, Llc | Integrating chamber cone light using LED sources |
US6846932B1 (en) * | 2003-11-20 | 2005-01-25 | Council Of Scientific And Industrial Research | Process for preparation of chiral amlodipine salts |
WO2005049571A1 (en) * | 2003-11-20 | 2005-06-02 | Council Of Scientific And Industrial Research | Process for preparation of chiral amlodipine salts |
CN1231469C (zh) * | 2003-12-05 | 2005-12-14 | 石家庄制药集团欧意药业有限公司 | 一种光学活性氨氯地平的拆分方法 |
WO2005089353A2 (en) * | 2004-03-16 | 2005-09-29 | Sepracor Inc. | (s)-amlodipine malate |
AU2005279961B2 (en) * | 2004-08-30 | 2010-05-13 | Seo Hong Yoo | Neuroprotective effect of solubilized UDCA in focal ischemic model |
WO2006044771A2 (en) * | 2004-10-15 | 2006-04-27 | Seo Hong Yoo | Methods and compositions for reducing toxicity of a pharmaceutical compound |
DE602005007763D1 (de) * | 2004-10-20 | 2008-08-07 | Emcure Pharmaceuticals Ltd | Verfahren zur herstellung eines enantiomers von amlodipin in hoher optischer reinheit |
JP2008518935A (ja) * | 2004-11-01 | 2008-06-05 | セオ ホン ユー | 筋萎縮性側索硬化症の神経退行を減少させるための方法及び組成物 |
KR101152608B1 (ko) * | 2004-12-02 | 2012-06-07 | 에스케이케미칼주식회사 | (r,s)-암로디핀으로부터 암로디핀 이성질체의 분리방법 |
WO2006059886A1 (en) * | 2004-12-02 | 2006-06-08 | Sk Chemicals, Co., Ltd. | Optical resolution method of amlodipine |
HUP0500570A3 (en) * | 2005-06-08 | 2008-03-28 | Richter Gedeon Nyrt | Process for the preparation of (s)-(-)-amlodipine |
TWI405580B (zh) * | 2005-06-27 | 2013-08-21 | Sankyo Co | 含有血管收縮素ii接受器拮抗劑及鈣通道阻斷劑之醫藥調配物 |
KR101235116B1 (ko) * | 2005-10-17 | 2013-02-20 | 에스케이케미칼주식회사 | 광학활성 암로디핀 겐티세이트 염의 제조방법 |
CN100436417C (zh) * | 2006-04-11 | 2008-11-26 | 石药集团中奇制药技术(石家庄)有限公司 | 一种光学活性氨氯地平的拆分方法 |
KR100913791B1 (ko) | 2006-07-21 | 2009-08-26 | 한미약품 주식회사 | (s)-(-)-암로디핀 캠실레이트 또는 이의 수화물 및 이를함유하는 약학적 조성물 |
TWI399223B (zh) * | 2006-09-15 | 2013-06-21 | Daiichi Sankyo Co Ltd | 奧美沙坦酯及氨氯地平之固體劑型 |
KR100828883B1 (ko) * | 2006-10-27 | 2008-05-09 | 씨제이제일제당 (주) | 라세믹 암로디핀으로부터 s-(-)-암로디핀의 분리방법 |
KR100830003B1 (ko) * | 2006-10-31 | 2008-05-15 | 씨제이제일제당 (주) | 결정성 s-(-)-암로디핀 아디핀산 염 무수물 및 이의 제조방법 |
KR100868160B1 (ko) | 2007-02-14 | 2008-11-12 | 한미약품 주식회사 | S-(-)-암로디핀 또는 이의 염의 제조방법 및 이에사용되는 중간체 |
KR100979772B1 (ko) | 2008-06-12 | 2010-09-02 | 에이치 엘 지노믹스(주) | 광학적으로 순수한 에스-(-)-암로디핀 벤젠술폰산염의제조방법 |
KR100989970B1 (ko) | 2008-07-01 | 2010-10-26 | 미래파인켐 주식회사 | (s)-(-)-암로디핀의 분리방법 |
KR101085169B1 (ko) | 2009-03-25 | 2011-11-18 | (주)켐트로스 | 암로디핀 광학 이성질체의 분리방법 |
KR101705535B1 (ko) * | 2009-04-01 | 2017-02-28 | 주식회사 씨트리 | 광학활성을 갖는 1-(3-히드록시페닐)에틸아민의 제조방법 |
RU2537361C1 (ru) * | 2013-07-18 | 2015-01-10 | Общество С Ограниченной Ответственностью "Синтегал" | Оптические изомеры (+) и (-)-бензгидрилмочевин и (+) и (-)-1-[(3-хлорфенил)-фенил-метил]мочевины, фармацевтическая композиция на их основе и способ их получения |
CN110882249B (zh) | 2019-11-08 | 2021-04-30 | 北京吾为尔创科技有限公司 | 含苯磺酸左氨氯地平水合物的组合物及其制备方法 |
CN111100064B (zh) * | 2020-01-08 | 2024-01-02 | 湖南理工学院 | 一种从废液中富集、回收和拆分碱性手性药物氨氯地平的方法 |
CN111777547B (zh) * | 2020-07-17 | 2021-10-08 | 江西施美药业股份有限公司 | 一种诱导析晶拆分左旋氨氯地平的方法 |
US11452690B1 (en) | 2021-01-27 | 2022-09-27 | ECI Pharmaceuticals, LLC | Oral liquid compositions comprising amlodipine besylate and methods of using the same |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5364872A (en) * | 1984-04-16 | 1994-11-15 | Yamanouchi Pharmaceutical Co., Ltd. | Dihydropyridine-3,5-dicarboxylic acid ester derivatives |
GR850872B (no) * | 1984-04-16 | 1985-11-25 | Yamanouchi Pharma Co Ltd | |
US5326772A (en) * | 1984-09-28 | 1994-07-05 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Diaryl compounds for their use |
GB2181127B (en) * | 1985-08-21 | 1989-08-02 | Glaxo Spa | 4-phenyl-dihydropyridine carboxylic acid derivatives |
DK142287A (da) * | 1986-03-27 | 1987-09-28 | Byk Gulden Lomberg Chem Fab | Optisk aktive 1,4-dihydropyridinderivater |
NZ220022A (en) * | 1986-04-22 | 1990-04-26 | Byk Gulden Lomberg Chem Fab | 1,4-dihydropyridine derivatives and pharmaceutical compositions |
AU2614288A (en) * | 1987-10-27 | 1989-05-23 | Byk Gulden Lomberg Chemische Fabrik Gmbh | New pyrrolidines |
GB8804630D0 (en) * | 1988-02-27 | 1988-03-30 | Pfizer Ltd | Preparation of r-& s-amlodipine |
GB8822170D0 (en) * | 1988-09-21 | 1988-10-26 | Pfizer Ltd | Therapeutic agents |
IT1230752B (it) * | 1989-02-17 | 1991-10-29 | Boehringer Biochemia Srl | Processo per la preparazione di 1,4 diidropiridine polisostituite in forma enantiomericamente pura. |
DE3906460C1 (no) * | 1989-03-01 | 1990-11-15 | Goedecke Ag, 1000 Berlin, De |
-
1994
- 1994-03-24 GB GB9405833A patent/GB9405833D0/en active Pending
-
1995
- 1995-02-08 TW TW084101060A patent/TW448156B/zh not_active IP Right Cessation
- 1995-03-06 AT AT95912222T patent/ATE166050T1/de not_active IP Right Cessation
- 1995-03-06 CZ CZ19962784A patent/CZ287324B6/cs not_active IP Right Cessation
- 1995-03-06 KR KR1019960705266A patent/KR100188980B1/ko not_active IP Right Cessation
- 1995-03-06 EP EP95912222A patent/EP0751938B1/en not_active Expired - Lifetime
- 1995-03-06 CN CN95192238A patent/CN1067055C/zh not_active Expired - Fee Related
- 1995-03-06 CA CA002186263A patent/CA2186263C/en not_active Expired - Fee Related
- 1995-03-06 NZ NZ282404A patent/NZ282404A/en unknown
- 1995-03-06 BR BR9507137A patent/BR9507137A/pt not_active IP Right Cessation
- 1995-03-06 PL PL95316535A patent/PL180085B1/pl not_active IP Right Cessation
- 1995-03-06 DE DE69502486T patent/DE69502486T2/de not_active Expired - Fee Related
- 1995-03-06 JP JP7524336A patent/JP2843681B2/ja not_active Expired - Fee Related
- 1995-03-06 ES ES95912222T patent/ES2116737T3/es not_active Expired - Lifetime
- 1995-03-06 WO PCT/EP1995/000847 patent/WO1995025722A1/en active IP Right Grant
- 1995-03-06 DK DK95912222T patent/DK0751938T3/da active
- 1995-03-06 HU HU9602597A patent/HU214720B/hu not_active IP Right Cessation
- 1995-03-06 RU RU96119351A patent/RU2132845C1/ru not_active IP Right Cessation
- 1995-03-06 US US08/704,612 patent/US5750707A/en not_active Expired - Fee Related
- 1995-03-06 AU AU19493/95A patent/AU677765B2/en not_active Ceased
- 1995-03-13 CO CO95009744A patent/CO4230248A1/es unknown
- 1995-03-16 PE PE1995264250A patent/PE48895A1/es not_active Application Discontinuation
- 1995-03-16 IL IL11300895A patent/IL113008A/xx not_active IP Right Cessation
- 1995-03-20 MY MYPI95000696A patent/MY111979A/en unknown
- 1995-03-23 ZA ZA952362A patent/ZA952362B/xx unknown
-
1996
- 1996-09-23 FI FI963775A patent/FI113646B/fi active
- 1996-09-23 NO NO963991A patent/NO306110B1/no unknown
-
1998
- 1998-05-05 US US09/071,810 patent/US6046338A/en not_active Expired - Fee Related
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