NO963506L - 4-Heterocyklyl-substituerte kinazolin-derivater, fremgangsmåte for fremstilling derav og deres anvendelse som anti-kreftmidler - Google Patents
4-Heterocyklyl-substituerte kinazolin-derivater, fremgangsmåte for fremstilling derav og deres anvendelse som anti-kreftmidlerInfo
- Publication number
- NO963506L NO963506L NO963506A NO963506A NO963506L NO 963506 L NO963506 L NO 963506L NO 963506 A NO963506 A NO 963506A NO 963506 A NO963506 A NO 963506A NO 963506 L NO963506 L NO 963506L
- Authority
- NO
- Norway
- Prior art keywords
- formula
- cancer agents
- oxy
- heterocyclyl
- preparation
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 abstract 3
- -1 methylene, thio Chemical group 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 125000004149 thio group Chemical group *S* 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- DRYRBWIFRVMRPV-UHFFFAOYSA-N quinazolin-4-amine Chemical class C1=CC=C2C(N)=NC=NC2=C1 DRYRBWIFRVMRPV-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20025994A | 1994-02-23 | 1994-02-23 | |
| PCT/IB1995/000061 WO1995023141A1 (fr) | 1994-02-23 | 1995-01-27 | Derives de la quinazoline a substitution 4-heterocyclyle, procedes d'elaboration et utilisations correspondantes comme agents anticancereux |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO963506D0 NO963506D0 (no) | 1996-08-22 |
| NO963506L true NO963506L (no) | 1996-10-22 |
Family
ID=22740969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO963506A NO963506L (no) | 1994-02-23 | 1996-08-22 | 4-Heterocyklyl-substituerte kinazolin-derivater, fremgangsmåte for fremstilling derav og deres anvendelse som anti-kreftmidler |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5736534A (fr) |
| EP (1) | EP0746554A1 (fr) |
| JP (1) | JP2890267B2 (fr) |
| KR (1) | KR100225721B1 (fr) |
| CN (1) | CN1141633A (fr) |
| AU (1) | AU686843B2 (fr) |
| BR (1) | BR9506936A (fr) |
| CA (1) | CA2183655C (fr) |
| CO (1) | CO4340688A1 (fr) |
| CZ (1) | CZ288955B6 (fr) |
| FI (1) | FI963283A (fr) |
| HU (1) | HUT76291A (fr) |
| IL (1) | IL112673A0 (fr) |
| MX (1) | MX9603593A (fr) |
| NO (1) | NO963506L (fr) |
| NZ (1) | NZ278135A (fr) |
| PE (1) | PE4896A1 (fr) |
| PL (1) | PL315941A1 (fr) |
| RU (1) | RU2137762C1 (fr) |
| TW (1) | TW404946B (fr) |
| WO (1) | WO1995023141A1 (fr) |
| ZA (1) | ZA951458B (fr) |
Families Citing this family (129)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5714493A (en) * | 1991-05-10 | 1998-02-03 | Rhone-Poulenc Rorer Pharmaceuticals, Inc. | Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase |
| US6645969B1 (en) | 1991-05-10 | 2003-11-11 | Aventis Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase |
| USRE37650E1 (en) | 1991-05-10 | 2002-04-09 | Aventis Pharmacetical Products, Inc. | Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase |
| US5710158A (en) * | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| TW321649B (fr) * | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
| GB9424233D0 (en) * | 1994-11-30 | 1995-01-18 | Zeneca Ltd | Quinazoline derivatives |
| WO1996033977A1 (fr) * | 1995-04-27 | 1996-10-31 | Zeneca Limited | Derives de quinazoline |
| GB9508535D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivative |
| GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| GB9508565D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
| GB9508537D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| US7060808B1 (en) * | 1995-06-07 | 2006-06-13 | Imclone Systems Incorporated | Humanized anti-EGF receptor monoclonal antibody |
| GB9624482D0 (en) * | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| EP0888349B1 (fr) * | 1996-01-23 | 2002-05-22 | Novartis AG | Pyrrolopyrimidines et leurs procedes de preparation |
| US5760041A (en) * | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
| HUP9901155A3 (en) | 1996-02-13 | 2003-04-28 | Astrazeneca Ab | Quinazoline derivatives as vegf inhibitors |
| GB9603097D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline compounds |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| EP0886524A2 (fr) * | 1996-03-01 | 1998-12-30 | Chiron Corporation | Apport d'agents therapeutiques a la prostate |
| KR100489174B1 (ko) | 1996-03-05 | 2005-09-30 | 제네카-파마 소시에떼아노님 | 4-아닐리노퀴나졸린유도체 |
| CA2249446C (fr) | 1996-04-12 | 2008-06-17 | Warner-Lambert Company | Inhibiteurs irreversibles de tyrosine kinases |
| GB9607729D0 (en) * | 1996-04-13 | 1996-06-19 | Zeneca Ltd | Quinazoline derivatives |
| GB9707800D0 (en) | 1996-05-06 | 1997-06-04 | Zeneca Ltd | Chemical compounds |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| EP0837063A1 (fr) * | 1996-10-17 | 1998-04-22 | Pfizer Inc. | Dérivés de 4-aminoquinazoline |
| US6225318B1 (en) | 1996-10-17 | 2001-05-01 | Pfizer Inc | 4-aminoquinazolone derivatives |
| AU4718997A (en) | 1996-11-27 | 1998-06-22 | Pfizer Inc. | Fused bicyclic pyrimidine derivatives |
| US6002008A (en) * | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| US5929080A (en) * | 1997-05-06 | 1999-07-27 | American Cyanamid Company | Method of treating polycystic kidney disease |
| ZA986732B (en) * | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| ZA986729B (en) * | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| US6251912B1 (en) | 1997-08-01 | 2001-06-26 | American Cyanamid Company | Substituted quinazoline derivatives |
| DE69838172T2 (de) | 1997-08-22 | 2008-04-10 | Astrazeneca Ab | Oxindolylchinazolinderivate als angiogenesehemmer |
| US6323209B1 (en) | 1997-11-06 | 2001-11-27 | American Cyanamid Company | Method of treating or inhibiting colonic polyps |
| JPH11236333A (ja) * | 1997-12-30 | 1999-08-31 | Pfizer Prod Inc | 抗ガン剤として有用なイミダゾリン−４−オン誘導体 |
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| AU6159499A (en) | 1998-09-29 | 2000-04-17 | Wyeth Holdings Corporation | Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors |
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| US6174903B1 (en) | 1998-12-28 | 2001-01-16 | Pfizer Inc. | Imidazolidin-4-one derivatives useful as anticancer agents |
| UA71945C2 (en) | 1999-01-27 | 2005-01-17 | Pfizer Prod Inc | Substituted bicyclic derivatives being used as anticancer agents |
| JP3270834B2 (ja) | 1999-01-27 | 2002-04-02 | ファイザー・プロダクツ・インク | 抗がん剤として有用なヘテロ芳香族二環式誘導体 |
| CZ306810B6 (cs) | 1999-02-10 | 2017-07-19 | Astrazeneca Ab | Použití chinazolinového derivátu jako inhibitoru angiogeneze |
| PL365999A1 (en) * | 1999-05-14 | 2005-01-24 | Imclone Systems Incorporated | Treatment of refractory human tumors with epidermal growth factor receptor antagonists |
| US6432979B1 (en) | 1999-08-12 | 2002-08-13 | American Cyanamid Company | Method of treating or inhibiting colonic polyps and colorectal cancer |
| CN100376567C (zh) | 1999-11-05 | 2008-03-26 | 阿斯特拉曾尼卡有限公司 | 作为vegf抑制剂的喹唑啉衍生物 |
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| CN102786512A (zh) | 2012-05-31 | 2012-11-21 | 中国人民解放军军事医学科学院毒物药物研究所 | N-芳基不饱和稠环叔胺类化合物及其制备方法和抗肿瘤应用 |
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| CN108129461B (zh) * | 2018-01-24 | 2020-08-21 | 浙江工业大学 | 苯甲酰氨基苯并[d]氮杂*基喹唑啉类化合物及制备和应用 |
| CN108078992B (zh) * | 2018-01-24 | 2020-08-21 | 浙江工业大学 | 特戊酰氨基二甲氧基苯并[d]氮杂*基喹唑啉类化合物在制备治疗白血病药物中的应用 |
| CN108014113B (zh) * | 2018-01-24 | 2020-10-09 | 浙江工业大学 | 丁酰氨基二甲氧基苯并[d]氮杂*基喹唑啉类化合物在制备治疗宫颈癌药物中的应用 |
| CN108125959B (zh) * | 2018-01-24 | 2019-12-31 | 浙江工业大学 | 二甲氧基苯氨基乙酰氨基喹唑啉类化合物在制备治疗白血病药物中的应用 |
| CN108245519B (zh) * | 2018-01-24 | 2020-02-21 | 浙江工业大学 | 丁酰氨基喹唑啉类化合物在制备治疗白血病药物中的应用 |
| CN108143736B (zh) * | 2018-01-24 | 2020-08-21 | 浙江工业大学 | 丁酰氨基苯并[d]氮杂*基喹唑啉类在制备治疗肺癌药物中的应用 |
| CN108324718B (zh) * | 2018-01-24 | 2020-10-09 | 浙江工业大学 | 环己基甲氧基甲酰氨基氯代苯并氮杂*基喹唑啉类化合物在治疗白血病药物中的应用 |
| WO2024086296A1 (fr) * | 2022-10-20 | 2024-04-25 | Mekanistic Therapeutics Llc | Composés utiles dans la modulation de egfr et pi3k |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE790679A (fr) * | 1971-11-03 | 1973-04-27 | Ici Ltd | Derives de l'indole |
| US4012513A (en) * | 1971-11-03 | 1977-03-15 | Imperial Chemical Industries Limited | Indole derivatives for providing analgesic and anti-inflammatory effects |
| WO1992020642A1 (fr) * | 1991-05-10 | 1992-11-26 | Rhone-Poulenc Rorer International (Holdings) Inc. | Composes aryle et heteroaryle bis monocycliques et/ou bicycliques qui inhibent la tyrosine kinase d'un recepteur du egf et/ou du pdgf |
| NZ243082A (en) * | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
| PT100905A (pt) * | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
| AU661533B2 (en) * | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| GB9323290D0 (en) * | 1992-12-10 | 1994-01-05 | Zeneca Ltd | Quinazoline derivatives |
| GB9314893D0 (en) * | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
-
1995
- 1995-01-27 EP EP95905737A patent/EP0746554A1/fr not_active Withdrawn
- 1995-01-27 JP JP7522227A patent/JP2890267B2/ja not_active Expired - Lifetime
- 1995-01-27 CN CN95191723A patent/CN1141633A/zh active Pending
- 1995-01-27 CA CA002183655A patent/CA2183655C/fr not_active Expired - Fee Related
- 1995-01-27 PL PL95315941A patent/PL315941A1/xx unknown
- 1995-01-27 RU RU96119255A patent/RU2137762C1/ru active
- 1995-01-27 CZ CZ19962413A patent/CZ288955B6/cs not_active IP Right Cessation
- 1995-01-27 HU HU9602305A patent/HUT76291A/hu unknown
- 1995-01-27 MX MX9603593A patent/MX9603593A/es not_active IP Right Cessation
- 1995-01-27 AU AU29727/95A patent/AU686843B2/en not_active Ceased
- 1995-01-27 WO PCT/IB1995/000061 patent/WO1995023141A1/fr active IP Right Grant
- 1995-01-27 BR BR9506936A patent/BR9506936A/pt not_active Application Discontinuation
- 1995-01-27 KR KR1019960704612A patent/KR100225721B1/ko not_active IP Right Cessation
- 1995-01-27 US US08/682,565 patent/US5736534A/en not_active Expired - Fee Related
- 1995-02-06 TW TW084100928A patent/TW404946B/zh not_active IP Right Cessation
- 1995-02-16 IL IL11267395A patent/IL112673A0/xx unknown
- 1995-02-17 PE PE1995262160A patent/PE4896A1/es not_active Application Discontinuation
- 1995-02-22 CO CO95006643A patent/CO4340688A1/es unknown
- 1995-02-22 ZA ZA951458A patent/ZA951458B/xx unknown
-
1996
- 1996-08-19 NZ NZ278135A patent/NZ278135A/en unknown
- 1996-08-22 FI FI963283A patent/FI963283A/fi unknown
- 1996-08-22 NO NO963506A patent/NO963506L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| FI963283A0 (fi) | 1996-08-22 |
| CA2183655A1 (fr) | 1995-08-31 |
| FI963283A (fi) | 1996-08-22 |
| HU9602305D0 (en) | 1996-10-28 |
| EP0746554A1 (fr) | 1996-12-11 |
| PE4896A1 (es) | 1996-03-09 |
| CO4340688A1 (es) | 1996-07-30 |
| IL112673A0 (en) | 1995-05-26 |
| TW404946B (en) | 2000-09-11 |
| CZ241396A3 (en) | 1997-07-16 |
| NZ278135A (en) | 1998-03-25 |
| KR970701183A (ko) | 1997-03-17 |
| AU686843B2 (en) | 1998-02-12 |
| US5736534A (en) | 1998-04-07 |
| RU2137762C1 (ru) | 1999-09-20 |
| JPH09501953A (ja) | 1997-02-25 |
| CA2183655C (fr) | 2001-03-06 |
| JP2890267B2 (ja) | 1999-05-10 |
| ZA951458B (en) | 1996-08-22 |
| AU2972795A (en) | 1995-09-11 |
| MX9603593A (es) | 1997-03-29 |
| BR9506936A (pt) | 1997-09-09 |
| WO1995023141A1 (fr) | 1995-08-31 |
| KR100225721B1 (ko) | 1999-10-15 |
| CZ288955B6 (cs) | 2001-10-17 |
| NO963506D0 (no) | 1996-08-22 |
| CN1141633A (zh) | 1997-01-29 |
| HUT76291A (en) | 1997-07-28 |
| PL315941A1 (en) | 1996-12-09 |
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