NO952111D0 - Hepatobiliære magnetisk resonans-kontrast midler - Google Patents

Hepatobiliære magnetisk resonans-kontrast midler

Info

Publication number
NO952111D0
NO952111D0 NO952111A NO952111A NO952111D0 NO 952111 D0 NO952111 D0 NO 952111D0 NO 952111 A NO952111 A NO 952111A NO 952111 A NO952111 A NO 952111A NO 952111 D0 NO952111 D0 NO 952111D0
Authority
NO
Norway
Prior art keywords
alkyl
branched
straight
hepatobiliary
magnetic resonance
Prior art date
Application number
NO952111A
Other languages
English (en)
Other versions
NO952111L (no
NO300131B1 (no
Inventor
Jean-Francois Desreux
Michael F Tweedle
Peter C Ratsep
Thomas R Wagler
Edmund R Marinelli
Original Assignee
Bracco Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Int Bv filed Critical Bracco Int Bv
Publication of NO952111L publication Critical patent/NO952111L/no
Publication of NO952111D0 publication Critical patent/NO952111D0/no
Publication of NO300131B1 publication Critical patent/NO300131B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/10—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Soft Magnetic Materials (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO952111A 1993-09-30 1995-05-29 Nye tetraazacyklododecan makrocykelforbindelser, metallchelat og farmasöytisk sammensetning NO300131B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/129,870 US5358704A (en) 1993-09-30 1993-09-30 Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
PCT/IB1994/000298 WO1995009161A1 (en) 1993-09-30 1994-09-29 Hepatobiliary magnetic resonance contrast agents

Publications (3)

Publication Number Publication Date
NO952111L NO952111L (no) 1995-05-29
NO952111D0 true NO952111D0 (no) 1995-05-29
NO300131B1 NO300131B1 (no) 1997-04-14

Family

ID=22441998

Family Applications (1)

Application Number Title Priority Date Filing Date
NO952111A NO300131B1 (no) 1993-09-30 1995-05-29 Nye tetraazacyklododecan makrocykelforbindelser, metallchelat og farmasöytisk sammensetning

Country Status (14)

Country Link
US (1) US5358704A (no)
EP (2) EP1184377B1 (no)
JP (1) JP3949714B2 (no)
KR (1) KR960702447A (no)
CN (1) CN1115180A (no)
AT (2) ATE218554T1 (no)
AU (1) AU7623494A (no)
CA (1) CA2150452A1 (no)
CZ (1) CZ136995A3 (no)
DE (2) DE69434260T2 (no)
HK (1) HK1046131A1 (no)
IL (1) IL111083A0 (no)
NO (1) NO300131B1 (no)
WO (1) WO1995009161A1 (no)

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US5980862A (en) * 1995-06-02 1999-11-09 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
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EP0846003A1 (en) * 1995-08-17 1998-06-10 Monsanto Company Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands
US5900228A (en) 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
US6495118B1 (en) 1997-09-26 2002-12-17 Schering Aktiengesellschaft Lipophilic metal complexes for necrosis and infarction imaging
DE19744004C1 (de) * 1997-09-26 1999-07-22 Schering Ag Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
US6713046B1 (en) 1997-10-27 2004-03-30 Research Corporation Technologies Magnetic resonance imaging agents for the delivery of therapeutic agents
WO1999025389A2 (en) 1997-11-17 1999-05-27 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
IT1297035B1 (it) 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
US6093382A (en) 1998-05-16 2000-07-25 Bracco Research Usa Inc. Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
US6056939A (en) * 1998-08-28 2000-05-02 Desreux; Jean F. Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals
US6656450B2 (en) 2000-07-17 2003-12-02 California Institute Of Technology, Inc. Macrocyclic magnetic resonance imaging contrast agents
AU2002211517A1 (en) 2000-10-04 2002-04-15 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
US20030004236A1 (en) * 2001-04-20 2003-01-02 Meade Thomas J. Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances
WO2002087632A1 (en) * 2001-05-02 2002-11-07 Metaprobe, Inc. High throughput screening methods using magnetic resonance imaging agents
US20030135108A1 (en) * 2001-05-02 2003-07-17 Silva Robin M. High throughput screening methods using magnetic resonance imaging agents
US20040038303A1 (en) * 2002-04-08 2004-02-26 Unger Gretchen M. Biologic modulations with nanoparticles
CA2495442C (en) * 2002-09-06 2013-12-10 Martin W. Brechbiel Backbone-substituted bifunctional dota ligands, complexes and compositions thereof, and methods of using same
WO2004064869A2 (en) * 2003-01-22 2004-08-05 The General Hospital Corporation Amyloid-binding, metal-chelating agents
US7012140B1 (en) * 2003-07-14 2006-03-14 Board Of Regents, The University Of Texas System Selection of coordination geometry to adjust water exchange rates of paramagnetic metal ion-based macrocyclic contrast agents
WO2005115105A2 (en) * 2004-05-10 2005-12-08 Northwestern University Self-immolative magnetic resonance imaging contrast agents sensitive to beta-glucuronidase
US7504088B2 (en) 2004-06-09 2009-03-17 Kereos, Inc. Lipophilic derivatives of chelate monoamides
EP2014728A1 (en) 2005-01-13 2009-01-14 Cinvention Ag Composite material coatings
EP1937753A1 (en) * 2005-10-18 2008-07-02 Cinvention Ag Thermoset particles and methods for production thereof
US20090317335A1 (en) * 2006-04-20 2009-12-24 Wenbin Lin Hybrid Nanomaterials as Multimodal Imaging Contrast Agents
AU2007329592A1 (en) * 2006-11-21 2008-06-12 Barnes-Jewish Hospital Methods of imaging employing chelating agents
CN100459932C (zh) * 2007-01-15 2009-02-11 北京大学人民医院 一种mri分子影像探针及其制备方法
BRPI0806916A2 (pt) * 2007-01-19 2014-04-29 Cinv Ag Implante poroso, não degradável feito por moldagem de pó
BRPI0807993A2 (pt) * 2007-02-28 2014-06-17 Cinv Ag Sistema de cultivo de alta superfície.
WO2008104599A1 (en) * 2007-02-28 2008-09-04 Cinvention Ag High surface cultivation system bag
EP2072060A1 (en) 2007-12-18 2009-06-24 Institut Curie Methods and compositions for the preparation and use of toxin conjugates.
US20100029909A1 (en) * 2008-05-23 2010-02-04 Northwestern University Compositions and methods comprising magnetic resonance contrast agents
US8580231B2 (en) 2008-05-23 2013-11-12 Northwestern University Compositions and methods comprising magnetic resonance contrast agents
JP5681102B2 (ja) 2008-05-30 2015-03-04 シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッドＳｉｅｍｅｎｓ Ｍｅｄｉｃａｌ Ｓｏｌｕｔｉｏｎｓ ＵＳＡ，Ｉｎｃ． 分子イメージング手法のための化合物
US20120093725A1 (en) 2009-04-10 2012-04-19 Inserm (Institut National De La Sante Et De La Recherche Medicale Fucoidans as Ligands for the Diagnosis of Degenerative Pathologies
WO2012072819A1 (en) 2010-12-03 2012-06-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Agents for the molecular imaging of serine-protease in human pathologies
US9598499B2 (en) 2010-12-30 2017-03-21 Institut National De La Santé Et De La Recherche Médicale (Inserm) Antigen binding formats for use in therapeutic treatments or diagnostic assays
EP2836597A1 (en) 2012-04-11 2015-02-18 Institut National de la Santé et de la Recherche Médicale (INSERM) Matrix metalloproteinase 9 (mmp-9) aptamer and uses thereof
EP2733153A1 (en) 2012-11-15 2014-05-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the preparation of immunoconjugates and uses thereof
CN111700877A (zh) 2014-09-03 2020-09-25 吉倪塞思公司 治疗性纳米粒子和相关的组合物、方法和系统
ES2809736T3 (es) 2016-09-27 2021-03-05 Bayer Pharma AG Método para producir la forma cristalina de modificación a de calcobutrol
CA3062553C (en) 2017-05-05 2024-02-06 Fusion Pharmaceuticals Inc. Pharmacokinetic enhancements of bifunctional chelates and uses thereof
US10093741B1 (en) 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
AU2018261890A1 (en) 2017-05-05 2019-11-28 Centre For Probe Development And Commercialization IGF-1R monoclonal antibodies and uses thereof
US11607462B2 (en) 2017-05-16 2023-03-21 Northwestern University Systems and methods for minimally-invasive assessment of toxicity-induced tissue injury

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DE3267697D1 (en) * 1981-08-24 1986-01-09 Asahi Chemical Ind Tetraazaannulene cobalt complex compounds and method for preparation thereof
DE3276165D1 (de) * 1982-11-03 1987-06-04 Ciba Geigy Ag Dibenzo(b,i)-1,4,8,11-tetraaza(14)annulenocobalt(iii) iodide
DE3562917D1 (en) * 1984-04-18 1988-06-30 Ciba Geigy Ag Substituted dibenzotetraaza-û14¨-annulene metal complexes, process for their preparation and their use
US4880008A (en) * 1985-05-08 1989-11-14 The General Hospital Corporation Vivo enhancement of NMR relaxivity
US4899755A (en) * 1985-05-08 1990-02-13 The General Hospital Corporation Hepatobiliary NMR contrast agents
GB8603537D0 (en) * 1986-02-13 1986-03-19 Parker D Conjugate compound
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
DE4001655A1 (de) * 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
WO1991010669A1 (en) * 1990-01-19 1991-07-25 Cockbain, Julian, Roderick, Michaelson Chelating compounds

Also Published As

Publication number Publication date
CN1115180A (zh) 1996-01-17
DE69434260T2 (de) 2006-01-19
EP0670832B1 (en) 2002-06-05
JPH08503967A (ja) 1996-04-30
EP1184377B1 (en) 2005-02-02
CZ136995A3 (en) 1995-12-13
CA2150452A1 (en) 1995-04-06
DE69430730T2 (de) 2003-02-06
ATE218554T1 (de) 2002-06-15
DE69434260D1 (de) 2005-03-10
WO1995009161A1 (en) 1995-04-06
ATE288422T1 (de) 2005-02-15
EP1184377A1 (en) 2002-03-06
EP0670832A1 (en) 1995-09-13
KR960702447A (ko) 1996-04-27
IL111083A0 (en) 1994-11-28
AU7623494A (en) 1995-04-18
NO952111L (no) 1995-05-29
DE69430730D1 (de) 2002-07-11
JP3949714B2 (ja) 2007-07-25
HK1046131A1 (zh) 2002-12-27
NO300131B1 (no) 1997-04-14
US5358704A (en) 1994-10-25

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