NO952111D0 - Hepatobiliære magnetisk resonans-kontrast midler - Google Patents

Hepatobiliære magnetisk resonans-kontrast midler

Info

Publication number
NO952111D0
NO952111D0 NO952111A NO952111A NO952111D0 NO 952111 D0 NO952111 D0 NO 952111D0 NO 952111 A NO952111 A NO 952111A NO 952111 A NO952111 A NO 952111A NO 952111 D0 NO952111 D0 NO 952111D0
Authority
NO
Norway
Prior art keywords
alkyl
branched
straight
hepatobiliary
magnetic resonance
Prior art date
Application number
NO952111A
Other languages
English (en)
Other versions
NO300131B1 (no
NO952111L (no
Inventor
Jean-Francois Desreux
Michael F Tweedle
Peter C Ratsep
Thomas R Wagler
Edmund R Marinelli
Original Assignee
Bracco Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Int Bv filed Critical Bracco Int Bv
Publication of NO952111L publication Critical patent/NO952111L/no
Publication of NO952111D0 publication Critical patent/NO952111D0/no
Publication of NO300131B1 publication Critical patent/NO300131B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/10—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Soft Magnetic Materials (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO952111A 1993-09-30 1995-05-29 Nye tetraazacyklododecan makrocykelforbindelser, metallchelat og farmasöytisk sammensetning NO300131B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/129,870 US5358704A (en) 1993-09-30 1993-09-30 Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
PCT/IB1994/000298 WO1995009161A1 (en) 1993-09-30 1994-09-29 Hepatobiliary magnetic resonance contrast agents

Publications (3)

Publication Number Publication Date
NO952111L NO952111L (no) 1995-05-29
NO952111D0 true NO952111D0 (no) 1995-05-29
NO300131B1 NO300131B1 (no) 1997-04-14

Family

ID=22441998

Family Applications (1)

Application Number Title Priority Date Filing Date
NO952111A NO300131B1 (no) 1993-09-30 1995-05-29 Nye tetraazacyklododecan makrocykelforbindelser, metallchelat og farmasöytisk sammensetning

Country Status (14)

Country Link
US (1) US5358704A (no)
EP (2) EP0670832B1 (no)
JP (1) JP3949714B2 (no)
KR (1) KR960702447A (no)
CN (1) CN1115180A (no)
AT (2) ATE288422T1 (no)
AU (1) AU7623494A (no)
CA (1) CA2150452A1 (no)
CZ (1) CZ136995A3 (no)
DE (2) DE69434260T2 (no)
HK (1) HK1046131A1 (no)
IL (1) IL111083A0 (no)
NO (1) NO300131B1 (no)
WO (1) WO1995009161A1 (no)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
JPH0797340A (ja) * 1993-06-03 1995-04-11 Terumo Corp Ｍｒｉ造影剤組成物
IT1269839B (it) * 1994-05-26 1997-04-15 Bracco Spa Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi
US6962686B2 (en) * 1994-10-12 2005-11-08 California Institute Of Technology Cell-specific gene delivery vehicles
US5672335A (en) * 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents
TW319763B (no) 1995-02-01 1997-11-11 Epix Medical Inc
US6770261B2 (en) 1995-06-02 2004-08-03 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
US5707605A (en) * 1995-06-02 1998-01-13 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
US6713045B1 (en) 1995-06-02 2004-03-30 Research Corporation Technologies, Inc. Targeted magnetic resonance imaging agents for the detection of physiological processes
US5980862A (en) * 1995-06-02 1999-11-09 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
JPH11511168A (ja) * 1995-08-17 1999-09-28 モンサント カンパニー 窒素含有大環状リガンドの金属錯体の生体分子結合体を使用する診断造影検査方法
US5900228A (en) 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
US6495118B1 (en) * 1997-09-26 2002-12-17 Schering Aktiengesellschaft Lipophilic metal complexes for necrosis and infarction imaging
DE19744004C1 (de) * 1997-09-26 1999-07-22 Schering Ag Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
US6713046B1 (en) 1997-10-27 2004-03-30 Research Corporation Technologies Magnetic resonance imaging agents for the delivery of therapeutic agents
JP4163381B2 (ja) 1997-11-17 2008-10-08 カリフォルニア・インスティテュート・オブ・テクノロジー 生理学的薬剤の検出のための磁気共鳴造影剤
IT1297035B1 (it) * 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
US6093382A (en) 1998-05-16 2000-07-25 Bracco Research Usa Inc. Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
US6056939A (en) * 1998-08-28 2000-05-02 Desreux; Jean F. Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals
US6656450B2 (en) 2000-07-17 2003-12-02 California Institute Of Technology, Inc. Macrocyclic magnetic resonance imaging contrast agents
US7029655B2 (en) 2000-10-04 2006-04-18 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
US20030004236A1 (en) * 2001-04-20 2003-01-02 Meade Thomas J. Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances
US20020197648A1 (en) * 2001-05-02 2002-12-26 Silva Robin M. High throughput screening methods using magnetic resonance imaging agents
US20030135108A1 (en) * 2001-05-02 2003-07-17 Silva Robin M. High throughput screening methods using magnetic resonance imaging agents
US20040038303A1 (en) * 2002-04-08 2004-02-26 Unger Gretchen M. Biologic modulations with nanoparticles
EP1545498A4 (en) * 2002-09-06 2006-09-06 Us Gov Health & Human Serv BIFUNCTIONAL DOTA LIGANDS SUBSTITUTED ON THE SKELETON, COMPLEXES AND COMPOSITIONS THEREOF AND METHODS OF USE THEREOF
WO2004064869A2 (en) * 2003-01-22 2004-08-05 The General Hospital Corporation Amyloid-binding, metal-chelating agents
US7012140B1 (en) * 2003-07-14 2006-03-14 Board Of Regents, The University Of Texas System Selection of coordination geometry to adjust water exchange rates of paramagnetic metal ion-based macrocyclic contrast agents
US20060088475A1 (en) * 2004-05-10 2006-04-27 Northwestern University Self-immolative magnetic resonance imaging contrast agents sensitive to beta-glucuronidase
JP2008502726A (ja) 2004-06-09 2008-01-31 ケレオス インコーポレーティッド キレートモノアミドの親油性誘導体
SI1836239T1 (sl) 2005-01-13 2009-04-30 Cinv Ag Kompozitni materiali, ki vsebujejo ogljikove nanodelce
BRPI0617450A2 (pt) * 2005-10-18 2011-07-26 Cinv Ag partÍculas de termocura e mÉtodos para produÇço das mesmas
WO2007124131A2 (en) * 2006-04-20 2007-11-01 The University Of North Carolina At Chapel Hill Hybrid nanomaterials as multimodal imaging contrast agents
JP2010510252A (ja) * 2006-11-21 2010-04-02 バーンズ ジューイッシュ ホスピタル キレート剤を用いるイメージング法
CN100459932C (zh) * 2007-01-15 2009-02-11 北京大学人民医院 一种mri分子影像探针及其制备方法
CN101646402A (zh) * 2007-01-19 2010-02-10 金文申有限公司 用粉末模塑法制成的多孔、不可降解植入物
US20080206862A1 (en) * 2007-02-28 2008-08-28 Cinvention Ag High surface cultivation system bag
BRPI0807993A2 (pt) * 2007-02-28 2014-06-17 Cinv Ag Sistema de cultivo de alta superfície.
EP2072060A1 (en) 2007-12-18 2009-06-24 Institut Curie Methods and compositions for the preparation and use of toxin conjugates.
US8580231B2 (en) 2008-05-23 2013-11-12 Northwestern University Compositions and methods comprising magnetic resonance contrast agents
US20100029909A1 (en) * 2008-05-23 2010-02-04 Northwestern University Compositions and methods comprising magnetic resonance contrast agents
WO2009148554A1 (en) 2008-05-30 2009-12-10 Siemens Medical Solutions Usa, Inc. Achievement of high therapeutic index through molecular imaging guided targeted drug treatment
US20120093725A1 (en) 2009-04-10 2012-04-19 Inserm (Institut National De La Sante Et De La Recherche Medicale Fucoidans as Ligands for the Diagnosis of Degenerative Pathologies
US9272054B2 (en) 2010-12-03 2016-03-01 Institut National De La Sante Et De La Recherche Medicale (Inserm) Agents for the molecular imaging of serine-protease in human pathologies
US9598499B2 (en) 2010-12-30 2017-03-21 Institut National De La Santé Et De La Recherche Médicale (Inserm) Antigen binding formats for use in therapeutic treatments or diagnostic assays
WO2013153138A1 (en) 2012-04-11 2013-10-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Matrix metalloproteinase 9 (mmp-9) aptamer and uses thereof
EP2733153A1 (en) 2012-11-15 2014-05-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the preparation of immunoconjugates and uses thereof
US10987308B2 (en) 2014-09-03 2021-04-27 Genesegues, Inc. Therapeutic nanoparticles and related compositions, methods and systems
SI3519394T1 (sl) 2016-09-27 2020-08-31 Bayer Pharma Aktiengesellschaft Postopek izdelave kristalinične oblike modifikacije kalkobutrola
AU2018261890A1 (en) 2017-05-05 2019-11-28 Centre For Probe Development And Commercialization IGF-1R monoclonal antibodies and uses thereof
AU2018261888B2 (en) 2017-05-05 2022-06-30 Centre For Probe Development And Commercialization Pharmacokinetic enhancements of bifunctional chelates and uses thereof
US10093741B1 (en) 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
US11607462B2 (en) 2017-05-16 2023-03-21 Northwestern University Systems and methods for minimally-invasive assessment of toxicity-induced tissue injury

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0073456B1 (en) * 1981-08-24 1985-11-27 Asahi Kasei Kogyo Kabushiki Kaisha Tetraazaannulene cobalt complex compounds and method for preparation thereof
EP0108181B1 (de) * 1982-11-03 1987-04-29 Ciba-Geigy Ag Dibenzo(b,i)-1,4,8,11-tetraaza(14)annulenkobalt(III)jodid
DE3562917D1 (en) * 1984-04-18 1988-06-30 Ciba Geigy Ag Substituted dibenzotetraaza-û14¨-annulene metal complexes, process for their preparation and their use
US4880008A (en) * 1985-05-08 1989-11-14 The General Hospital Corporation Vivo enhancement of NMR relaxivity
US4899755A (en) * 1985-05-08 1990-02-13 The General Hospital Corporation Hepatobiliary NMR contrast agents
GB8603537D0 (en) * 1986-02-13 1986-03-19 Parker D Conjugate compound
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
DE4001655A1 (de) * 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
JP3131219B2 (ja) * 1990-01-19 2001-01-31 ニユコメド・イメージング・アクシエセルカペト キレート化合物

Also Published As

Publication number Publication date
DE69430730T2 (de) 2003-02-06
ATE218554T1 (de) 2002-06-15
EP0670832A1 (en) 1995-09-13
DE69434260D1 (de) 2005-03-10
DE69430730D1 (de) 2002-07-11
HK1046131A1 (zh) 2002-12-27
JPH08503967A (ja) 1996-04-30
NO300131B1 (no) 1997-04-14
ATE288422T1 (de) 2005-02-15
AU7623494A (en) 1995-04-18
CZ136995A3 (en) 1995-12-13
CN1115180A (zh) 1996-01-17
DE69434260T2 (de) 2006-01-19
NO952111L (no) 1995-05-29
EP1184377A1 (en) 2002-03-06
KR960702447A (ko) 1996-04-27
CA2150452A1 (en) 1995-04-06
WO1995009161A1 (en) 1995-04-06
IL111083A0 (en) 1994-11-28
EP0670832B1 (en) 2002-06-05
US5358704A (en) 1994-10-25
JP3949714B2 (ja) 2007-07-25
EP1184377B1 (en) 2005-02-02

Similar Documents

Publication Publication Date Title
NO952111D0 (no) Hepatobiliære magnetisk resonans-kontrast midler
PH30934A (en) Alkyl phosphonate polyazamacrocyclic chelates for mri.
HUP0103165A2 (hu) Tiazolinsavszármazékok, a vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk
NZ227421A (en) 1,4,7,10-tetraazacyclododecane derivatives and diagnosis using nmr
FI915916A0 (fi) Tetra-azamakrocykler, foerfaranden foer deras framstaellning och deras anvaendning vid magnetresonans- bildformning.
TW337985B (en) "N-(B-branched alkyl)-1, 2-benzisothiolin, 3ones, their preparation and their use as industrial biocides"
ATE161844T1 (de) Acyl-(2'-hydroxybiphenyl-2-yl)- phosphinsäuresalze, ihre herstellung und verwendung
ES2181372T3 (es) Derivados de dihidro- o tetrahidronaftaleno que tienen actividad (anti)-estrogena.
ES8206537A1 (es) Procedimiento para la obtencion de nuevos derivados de la tiazolo (3,2-a) pirimidina
WO1999032068A3 (de) Neue entwicklerkombinationen für oxidationsfärbemittel
ZA858376B (en) 3-amino-2,3-dihydro-1-benzoxepine-compounds and methods for their preparation and pharmaceutical preparations containing these compounds
ES2018407A6 (es) Procedimiento para la obtencion de 1-ariloxi-3-nitroamino-2-propanoles.