HK1046131A1 - 肝膽磁性共振對比劑 - Google Patents

肝膽磁性共振對比劑

Info

Publication number
HK1046131A1
HK1046131A1 HK02106580.1A HK02106580A HK1046131A1 HK 1046131 A1 HK1046131 A1 HK 1046131A1 HK 02106580 A HK02106580 A HK 02106580A HK 1046131 A1 HK1046131 A1 HK 1046131A1
Authority
HK
Hong Kong
Prior art keywords
alkyl
branched
straight
hepatobiliary
magnetic resonance
Prior art date
Application number
HK02106580.1A
Other languages
English (en)
Inventor
Desreux Jean-Francois
F Tweedle Michael
C Ratsep Peter
R Wagler Thomas
R Marinelli Edmund
Original Assignee
Bracco Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Int Bv filed Critical Bracco Int Bv
Publication of HK1046131A1 publication Critical patent/HK1046131A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/10—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Soft Magnetic Materials (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK02106580.1A 1993-09-30 2002-09-06 肝膽磁性共振對比劑 HK1046131A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/129,870 US5358704A (en) 1993-09-30 1993-09-30 Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents

Publications (1)

Publication Number Publication Date
HK1046131A1 true HK1046131A1 (zh) 2002-12-27

Family

ID=22441998

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02106580.1A HK1046131A1 (zh) 1993-09-30 2002-09-06 肝膽磁性共振對比劑

Country Status (14)

Country Link
US (1) US5358704A (zh)
EP (2) EP0670832B1 (zh)
JP (1) JP3949714B2 (zh)
KR (1) KR960702447A (zh)
CN (1) CN1115180A (zh)
AT (2) ATE288422T1 (zh)
AU (1) AU7623494A (zh)
CA (1) CA2150452A1 (zh)
CZ (1) CZ136995A3 (zh)
DE (2) DE69434260T2 (zh)
HK (1) HK1046131A1 (zh)
IL (1) IL111083A0 (zh)
NO (1) NO300131B1 (zh)
WO (1) WO1995009161A1 (zh)

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US5980862A (en) * 1995-06-02 1999-11-09 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
EP0846003A1 (en) * 1995-08-17 1998-06-10 Monsanto Company Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands
US5900228A (en) 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
US6495118B1 (en) * 1997-09-26 2002-12-17 Schering Aktiengesellschaft Lipophilic metal complexes for necrosis and infarction imaging
DE19744004C1 (de) * 1997-09-26 1999-07-22 Schering Ag Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
US6713046B1 (en) 1997-10-27 2004-03-30 Research Corporation Technologies Magnetic resonance imaging agents for the delivery of therapeutic agents
AU752812B2 (en) 1997-11-17 2002-10-03 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
IT1297035B1 (it) 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
US6093382A (en) * 1998-05-16 2000-07-25 Bracco Research Usa Inc. Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
US6056939A (en) * 1998-08-28 2000-05-02 Desreux; Jean F. Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals
AU2001276956A1 (en) 2000-07-17 2002-01-30 California Institute Of Technology Macrocyclic mri contrast agents
WO2002028441A2 (en) 2000-10-04 2002-04-11 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
US20030004236A1 (en) * 2001-04-20 2003-01-02 Meade Thomas J. Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances
US20030135108A1 (en) * 2001-05-02 2003-07-17 Silva Robin M. High throughput screening methods using magnetic resonance imaging agents
WO2002087632A1 (en) * 2001-05-02 2002-11-07 Metaprobe, Inc. High throughput screening methods using magnetic resonance imaging agents
US20040038303A1 (en) * 2002-04-08 2004-02-26 Unger Gretchen M. Biologic modulations with nanoparticles
WO2004021996A2 (en) * 2002-09-06 2004-03-18 The Government Of The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services Backbone-substituted bifunctional dota ligands, complexes and compositions thereof, and methods of using same
WO2004064869A2 (en) * 2003-01-22 2004-08-05 The General Hospital Corporation Amyloid-binding, metal-chelating agents
US7012140B1 (en) * 2003-07-14 2006-03-14 Board Of Regents, The University Of Texas System Selection of coordination geometry to adjust water exchange rates of paramagnetic metal ion-based macrocyclic contrast agents
WO2005115105A2 (en) * 2004-05-10 2005-12-08 Northwestern University Self-immolative magnetic resonance imaging contrast agents sensitive to beta-glucuronidase
EP1768558A4 (en) 2004-06-09 2009-11-25 Kereos Inc LIPOPHILES DERIVATIVES OF CHELATE MONOAMIDES
EA011516B1 (ru) 2005-01-13 2009-04-28 Синвеншен Аг Композиционный материал и способ его изготовления
EP1937753A1 (en) * 2005-10-18 2008-07-02 Cinvention Ag Thermoset particles and methods for production thereof
US20090317335A1 (en) * 2006-04-20 2009-12-24 Wenbin Lin Hybrid Nanomaterials as Multimodal Imaging Contrast Agents
AU2007329592A1 (en) * 2006-11-21 2008-06-12 Barnes-Jewish Hospital Methods of imaging employing chelating agents
CN100459932C (zh) * 2007-01-15 2009-02-11 北京大学人民医院 一种mri分子影像探针及其制备方法
AU2008206953A1 (en) * 2007-01-19 2008-07-24 Cinvention Ag Porous, non-degradable implant made by powder molding
EP2126040A1 (en) * 2007-02-28 2009-12-02 Cinvention Ag High surface cultivation system
US20080206862A1 (en) * 2007-02-28 2008-08-28 Cinvention Ag High surface cultivation system bag
EP2072060A1 (en) 2007-12-18 2009-06-24 Institut Curie Methods and compositions for the preparation and use of toxin conjugates.
US20100029909A1 (en) * 2008-05-23 2010-02-04 Northwestern University Compositions and methods comprising magnetic resonance contrast agents
US8580231B2 (en) 2008-05-23 2013-11-12 Northwestern University Compositions and methods comprising magnetic resonance contrast agents
US8293206B2 (en) 2008-05-30 2012-10-23 Siemens Medical Solutions Usa, Inc. Achievement of a high therapeutic index through molecular imaging guided targeted drug treatment
ES2617741T3 (es) 2009-04-10 2017-06-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Fucoidanos como ligandos para el diagnóstico de patologías degenerativas
US9272054B2 (en) 2010-12-03 2016-03-01 Institut National De La Sante Et De La Recherche Medicale (Inserm) Agents for the molecular imaging of serine-protease in human pathologies
EP2658869B1 (en) 2010-12-30 2019-06-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Antigen binding formats for use in therapeutic treatments or diagnostic assays
US20150337308A1 (en) 2012-04-11 2015-11-26 Chu De Bordeaux Matrix metalloproteinase 9 (mmp-9) aptamer and uses thereof
EP2733153A1 (en) 2012-11-15 2014-05-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the preparation of immunoconjugates and uses thereof
KR20170054429A (ko) 2014-09-03 2017-05-17 제네세규스 인코포레이티드 치료용 나노입자 및 관련 조성물, 방법, 및 시스템
IL265536B (en) 2016-09-27 2022-07-01 Bayer Pharma AG A method for the production of a crystalline form of the a modification of calcobuterol
JP7191938B2 (ja) 2017-05-05 2022-12-19 センター・フォー・プローブ・デベロップメント・アンド・コマーシャライゼイション Ｉｇｆ－１ｒモノクローナル抗体及びその使用
RU2019139432A (ru) 2017-05-05 2021-06-07 Сентр фор Проуб Девелопмент энд Коммерсиализэйшн Фармакокинетическая оптимизация бифункциональных хелатов и их применение
US10093741B1 (en) 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
US11607462B2 (en) 2017-05-16 2023-03-21 Northwestern University Systems and methods for minimally-invasive assessment of toxicity-induced tissue injury

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EP0073456B1 (en) * 1981-08-24 1985-11-27 Asahi Kasei Kogyo Kabushiki Kaisha Tetraazaannulene cobalt complex compounds and method for preparation thereof
EP0108181B1 (de) * 1982-11-03 1987-04-29 Ciba-Geigy Ag Dibenzo(b,i)-1,4,8,11-tetraaza(14)annulenkobalt(III)jodid
EP0162804B1 (de) * 1984-04-18 1988-05-25 Ciba-Geigy Ag Substituierte Dibenzotetraaza-[14]-annulenmetallkomplexe, Verfahren zu ihrer Herstellung und ihre Verwendung
US4899755A (en) * 1985-05-08 1990-02-13 The General Hospital Corporation Hepatobiliary NMR contrast agents
US4880008A (en) * 1985-05-08 1989-11-14 The General Hospital Corporation Vivo enhancement of NMR relaxivity
GB8603537D0 (en) * 1986-02-13 1986-03-19 Parker D Conjugate compound
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
DE4001655A1 (de) * 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
EP0511275A1 (en) * 1990-01-19 1992-11-04 Nycomed Imaging As Chelating compounds

Also Published As

Publication number Publication date
CZ136995A3 (en) 1995-12-13
DE69430730T2 (de) 2003-02-06
DE69434260D1 (de) 2005-03-10
ATE288422T1 (de) 2005-02-15
NO952111L (no) 1995-05-29
CN1115180A (zh) 1996-01-17
DE69434260T2 (de) 2006-01-19
NO952111D0 (no) 1995-05-29
CA2150452A1 (en) 1995-04-06
AU7623494A (en) 1995-04-18
ATE218554T1 (de) 2002-06-15
JP3949714B2 (ja) 2007-07-25
EP0670832B1 (en) 2002-06-05
EP0670832A1 (en) 1995-09-13
DE69430730D1 (de) 2002-07-11
IL111083A0 (en) 1994-11-28
JPH08503967A (ja) 1996-04-30
KR960702447A (ko) 1996-04-27
EP1184377A1 (en) 2002-03-06
NO300131B1 (no) 1997-04-14
WO1995009161A1 (en) 1995-04-06
US5358704A (en) 1994-10-25
EP1184377B1 (en) 2005-02-02

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