DE69124132D1 - Tetra-aza-makrozyklen, Verfahren zu ihrer Herstellung und ihre Anwendung in NMR-Bildformung - Google Patents

Tetra-aza-makrozyklen, Verfahren zu ihrer Herstellung und ihre Anwendung in NMR-Bildformung

Info

Publication number
DE69124132D1
DE69124132D1 DE69124132T DE69124132T DE69124132D1 DE 69124132 D1 DE69124132 D1 DE 69124132D1 DE 69124132 T DE69124132 T DE 69124132T DE 69124132 T DE69124132 T DE 69124132T DE 69124132 D1 DE69124132 D1 DE 69124132D1
Authority
DE
Germany
Prior art keywords
group
alk
hydrogen atom
different
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69124132T
Other languages
English (en)
Other versions
DE69124132T2 (de
Inventor
David Parker
Nigel Robert Arnold Beeley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Celltech Ltd
Original Assignee
Celltech R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909008724A external-priority patent/GB9008724D0/en
Priority claimed from GB909008720A external-priority patent/GB9008720D0/en
Priority claimed from GB909017148A external-priority patent/GB9017148D0/en
Priority claimed from GB919104391A external-priority patent/GB9104391D0/en
Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd
Publication of DE69124132D1 publication Critical patent/DE69124132D1/de
Application granted granted Critical
Publication of DE69124132T2 publication Critical patent/DE69124132T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
DE69124132T 1990-04-18 1991-04-18 Tetra-aza-makrozyklen, Verfahren zu ihrer Herstellung und ihre Anwendung in NMR-Bildformung Expired - Fee Related DE69124132T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB909008724A GB9008724D0 (en) 1990-04-18 1990-04-18 Chemical compounds
GB909008720A GB9008720D0 (en) 1990-04-18 1990-04-18 Diagnostic agents
GB909017148A GB9017148D0 (en) 1990-08-03 1990-08-03 Diagnostic agents
GB919104391A GB9104391D0 (en) 1991-03-01 1991-03-01 Diagnostic agents

Publications (2)

Publication Number Publication Date
DE69124132D1 true DE69124132D1 (de) 1997-02-27
DE69124132T2 DE69124132T2 (de) 1997-06-05

Family

ID=27450496

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69124132T Expired - Fee Related DE69124132T2 (de) 1990-04-18 1991-04-18 Tetra-aza-makrozyklen, Verfahren zu ihrer Herstellung und ihre Anwendung in NMR-Bildformung

Country Status (15)

Country Link
US (1) US5653960A (de)
EP (1) EP0455380B1 (de)
JP (1) JPH05500969A (de)
AT (1) ATE147635T1 (de)
AU (1) AU654951B2 (de)
CA (1) CA2057868A1 (de)
DE (1) DE69124132T2 (de)
DK (1) DK0455380T3 (de)
FI (1) FI915916A0 (de)
GB (1) GB2250198B (de)
IE (1) IE911297A1 (de)
IL (1) IL97902A (de)
NO (1) NO914979D0 (de)
NZ (1) NZ237868A (de)
WO (1) WO1991016081A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5342606A (en) * 1984-10-18 1994-08-30 Board Of Regents, The University Of Texas System Polyazamacrocyclic compounds for complexation of metal ions
AU654951B2 (en) * 1990-04-18 1994-12-01 Celltech Limited Tetra-aza macrocycles, processes for their preparation and their use in magnetic resonance imaging
US5409689A (en) * 1993-08-13 1995-04-25 Concat, Ltd. MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms
TW319763B (de) 1995-02-01 1997-11-11 Epix Medical Inc
EP0841951A2 (de) * 1995-06-26 1998-05-20 Concat Ltd. Verbindungen mit chelatbildungs- und spezifizitätseigenschaften für elemente der ersten übergangsgruppe sowie deren verwendung in der medizinischen therapie und diagnostik
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
AU3225900A (en) * 1999-02-09 2000-08-29 Board Of Regents, The University Of Texas System Ph sensitive mri contrast agents
EP1191948A2 (de) 1999-06-11 2002-04-03 Neorx Corporation Hochdosierte radionuklide komplexe zur knochenmark-unterdrückung
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
RU2311413C2 (ru) * 2000-09-29 2007-11-27 Анормед, Инк. Циклические полиамины, содержащие в кольце n атомов азота, защищенных по принципу "все, кроме одного (n-1)", и способы их получения
JP2004536034A (ja) * 2001-01-08 2004-12-02 ネオルクス コーポレイション 治療的および診断的化合物、組成物および方法
EP1778699A4 (de) * 2004-08-10 2009-02-25 Dow Global Technologies Inc Targeting von chelanten und chelaten
WO2006045546A1 (en) * 2004-10-20 2006-05-04 Therapharm Gmbh Method of preparing or synthesizing polyazamacrocycle derivatives

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2803528C2 (de) * 1977-03-09 1984-10-18 Tabushi, Iwao, Kyoto Schwermetallionen-Adsorbens und dessen Verwendung zum Adsorbieren von Schwermetallionen
JPS53144592A (en) * 1977-05-19 1978-12-15 Tabuse Iwao 122alkyll1*4*7*100tetrazacyclotridecane
US4432907A (en) * 1979-09-10 1984-02-21 Analytical Radiation Corporation Diamine acid fluorescent chelates
US4671958A (en) * 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
SU1098937A1 (ru) * 1983-03-25 1984-06-23 Ордена Ленина институт элементоорганических соединений им.А.Н.Несмеянова 1,4,7,10-Тетра/диоксифосфорилметил/-1,4,7,10-тетраазациклододекан в качестве комплексона дл св зывани катионов меди /п/,кобальта /п/,кадми /п/,свинца /п/ и лантана /ш/
CA1260827A (en) * 1984-08-31 1989-09-26 Richard C. Siegel Antibody-metal ion complexes
US4659839A (en) * 1984-10-10 1987-04-21 Mallinckrodt, Inc. Coupling agents for radiolabeled antibody fragments
US5342606A (en) * 1984-10-18 1994-08-30 Board Of Regents, The University Of Texas System Polyazamacrocyclic compounds for complexation of metal ions
DE3680924D1 (de) * 1985-01-14 1991-09-26 Neorx Corp Metall-radionuklid markiertes protein fuer diagnose und therapie.
JPS61226751A (ja) * 1985-03-30 1986-10-08 Konishiroku Photo Ind Co Ltd ハロゲン化銀写真感光材料用処理液及びその処理方法
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
DE3772785D1 (de) * 1986-01-23 1991-10-17 Squibb & Sons Inc 1-substituiertes-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecan und analoga.
FR2596992B1 (fr) * 1986-04-11 1988-12-16 Guerbet Sa Sel de lysine du complexe gadolinium-dota et ses applications au diagnostic
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
US5049667A (en) * 1987-04-14 1991-09-17 Guerbet S.A. Nitrogen-containing cyclic ligands
DE3713842A1 (de) * 1987-04-22 1988-11-17 Schering Ag Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
GB8719042D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
CA2004798A1 (en) * 1988-12-09 1990-06-09 Jacques Banville 6-aminoalkyl carbapenems
GB8903023D0 (en) * 1989-02-10 1989-03-30 Parker David Chemical compounds
US5053503A (en) * 1989-02-17 1991-10-01 Centocor Chelating agents
AU654951B2 (en) * 1990-04-18 1994-12-01 Celltech Limited Tetra-aza macrocycles, processes for their preparation and their use in magnetic resonance imaging

Also Published As

Publication number Publication date
NO914979L (no) 1991-12-17
GB2250198A (en) 1992-06-03
EP0455380A2 (de) 1991-11-06
ATE147635T1 (de) 1997-02-15
GB2250198B (en) 1994-06-22
NZ237868A (en) 1994-04-27
US5653960A (en) 1997-08-05
IE911297A1 (en) 1991-10-23
NO914979D0 (no) 1991-12-17
AU7673091A (en) 1991-11-11
IL97902A0 (en) 1992-06-21
JPH05500969A (ja) 1993-02-25
IL97902A (en) 1996-03-31
GB9126303D0 (en) 1992-02-12
EP0455380A3 (de) 1991-11-27
CA2057868A1 (en) 1991-10-19
FI915916A0 (fi) 1991-12-16
EP0455380B1 (de) 1997-01-15
AU654951B2 (en) 1994-12-01
DK0455380T3 (da) 1997-02-03
DE69124132T2 (de) 1997-06-05
WO1991016081A1 (en) 1991-10-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee