DE69430730D1 - Hepatobillianische magnetische resonanz-kontrastmittel - Google Patents

Hepatobillianische magnetische resonanz-kontrastmittel

Info

Publication number
DE69430730D1
DE69430730D1 DE69430730T DE69430730T DE69430730D1 DE 69430730 D1 DE69430730 D1 DE 69430730D1 DE 69430730 T DE69430730 T DE 69430730T DE 69430730 T DE69430730 T DE 69430730T DE 69430730 D1 DE69430730 D1 DE 69430730D1
Authority
DE
Germany
Prior art keywords
alkyl
branched
straight
hepatobillian
magnetic resonance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69430730T
Other languages
English (en)
Other versions
DE69430730T2 (de
Inventor
Jean-Francois Desreux
F Tweedle
C Ratsep
R Wagler
R Marinelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco International BV filed Critical Bracco International BV
Publication of DE69430730D1 publication Critical patent/DE69430730D1/de
Application granted granted Critical
Publication of DE69430730T2 publication Critical patent/DE69430730T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/10—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
DE69430730T 1993-09-30 1994-09-29 Hepatobillianische magnetische resonanz-kontrastmittel Expired - Fee Related DE69430730T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/129,870 US5358704A (en) 1993-09-30 1993-09-30 Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
PCT/IB1994/000298 WO1995009161A1 (en) 1993-09-30 1994-09-29 Hepatobiliary magnetic resonance contrast agents

Publications (2)

Publication Number Publication Date
DE69430730D1 true DE69430730D1 (de) 2002-07-11
DE69430730T2 DE69430730T2 (de) 2003-02-06

Family

ID=22441998

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69430730T Expired - Fee Related DE69430730T2 (de) 1993-09-30 1994-09-29 Hepatobillianische magnetische resonanz-kontrastmittel
DE69434260T Expired - Fee Related DE69434260T2 (de) 1993-09-30 1994-09-29 Hepatobillianische magnetische Resonanz-Kontrastmittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69434260T Expired - Fee Related DE69434260T2 (de) 1993-09-30 1994-09-29 Hepatobillianische magnetische Resonanz-Kontrastmittel

Country Status (14)

Country Link
US (1) US5358704A (de)
EP (2) EP1184377B1 (de)
JP (1) JP3949714B2 (de)
KR (1) KR960702447A (de)
CN (1) CN1115180A (de)
AT (2) ATE288422T1 (de)
AU (1) AU7623494A (de)
CA (1) CA2150452A1 (de)
CZ (1) CZ136995A3 (de)
DE (2) DE69430730T2 (de)
HK (1) HK1046131A1 (de)
IL (1) IL111083A0 (de)
NO (1) NO300131B1 (de)
WO (1) WO1995009161A1 (de)

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US5980862A (en) * 1995-06-02 1999-11-09 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
US6713045B1 (en) 1995-06-02 2004-03-30 Research Corporation Technologies, Inc. Targeted magnetic resonance imaging agents for the detection of physiological processes
BR9610241A (pt) * 1995-08-17 1999-06-29 Monsanto Co Processos para análise de imagem de diagnóstico utilizando bioconjgados de complexos de metal de ligandos macrocíclicos contendo nitrogênio
US5900228A (en) 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
DE19744004C1 (de) * 1997-09-26 1999-07-22 Schering Ag Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
US6495118B1 (en) 1997-09-26 2002-12-17 Schering Aktiengesellschaft Lipophilic metal complexes for necrosis and infarction imaging
US6713046B1 (en) 1997-10-27 2004-03-30 Research Corporation Technologies Magnetic resonance imaging agents for the delivery of therapeutic agents
CA2309749A1 (en) 1997-11-17 1999-05-27 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
IT1297035B1 (it) 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
US6093382A (en) 1998-05-16 2000-07-25 Bracco Research Usa Inc. Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
US6056939A (en) * 1998-08-28 2000-05-02 Desreux; Jean F. Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals
WO2002006287A2 (en) 2000-07-17 2002-01-24 California Institute Of Technology Macrocyclic mri contrast agents
WO2002028441A2 (en) 2000-10-04 2002-04-11 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
US20030004236A1 (en) * 2001-04-20 2003-01-02 Meade Thomas J. Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances
US20030135108A1 (en) * 2001-05-02 2003-07-17 Silva Robin M. High throughput screening methods using magnetic resonance imaging agents
US20020197648A1 (en) * 2001-05-02 2002-12-26 Silva Robin M. High throughput screening methods using magnetic resonance imaging agents
US20040038303A1 (en) * 2002-04-08 2004-02-26 Unger Gretchen M. Biologic modulations with nanoparticles
WO2004021996A2 (en) * 2002-09-06 2004-03-18 The Government Of The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services Backbone-substituted bifunctional dota ligands, complexes and compositions thereof, and methods of using same
JP2006515630A (ja) * 2003-01-22 2006-06-01 ザ ジェネラル ホスピタル コーポレイション アミロイド結合性金属キレート剤
US7012140B1 (en) * 2003-07-14 2006-03-14 Board Of Regents, The University Of Texas System Selection of coordination geometry to adjust water exchange rates of paramagnetic metal ion-based macrocyclic contrast agents
US20060088475A1 (en) * 2004-05-10 2006-04-27 Northwestern University Self-immolative magnetic resonance imaging contrast agents sensitive to beta-glucuronidase
JP2008502726A (ja) 2004-06-09 2008-01-31 ケレオス インコーポレーティッド キレートモノアミドの親油性誘導体
EP2014728A1 (de) 2005-01-13 2009-01-14 Cinvention Ag Verbundstoffmaterialbeschichtungen
WO2007045616A1 (en) * 2005-10-18 2007-04-26 Cinvention Ag Thermoset particles and methods for production thereof
WO2007124131A2 (en) * 2006-04-20 2007-11-01 The University Of North Carolina At Chapel Hill Hybrid nanomaterials as multimodal imaging contrast agents
US20080241061A1 (en) * 2006-11-21 2008-10-02 Lanza Gregory M Methods of imaging employing chelating agents
CN100459932C (zh) * 2007-01-15 2009-02-11 北京大学人民医院 一种mri分子影像探针及其制备方法
EP2104473A1 (de) * 2007-01-19 2009-09-30 Cinvention Ag Durch pulverformung hergestelltes poröses und nicht abbaubares implantat
WO2008104599A1 (en) * 2007-02-28 2008-09-04 Cinvention Ag High surface cultivation system bag
AU2008220793A1 (en) * 2007-02-28 2008-09-04 Cinvention Ag High surface cultivation system
EP2072060A1 (de) 2007-12-18 2009-06-24 Institut Curie Verfahren und Zusammensetzungen zur Herstellung und Verwendung von Toxinkonjugaten
US20100029909A1 (en) * 2008-05-23 2010-02-04 Northwestern University Compositions and methods comprising magnetic resonance contrast agents
US8580231B2 (en) 2008-05-23 2013-11-12 Northwestern University Compositions and methods comprising magnetic resonance contrast agents
US8293206B2 (en) 2008-05-30 2012-10-23 Siemens Medical Solutions Usa, Inc. Achievement of a high therapeutic index through molecular imaging guided targeted drug treatment
US20120093725A1 (en) 2009-04-10 2012-04-19 Inserm (Institut National De La Sante Et De La Recherche Medicale Fucoidans as Ligands for the Diagnosis of Degenerative Pathologies
US9272054B2 (en) 2010-12-03 2016-03-01 Institut National De La Sante Et De La Recherche Medicale (Inserm) Agents for the molecular imaging of serine-protease in human pathologies
WO2012089814A1 (en) 2010-12-30 2012-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Antigen binding formats for use in therapeutic treatments or diagnostic assays
US20150337308A1 (en) 2012-04-11 2015-11-26 Chu De Bordeaux Matrix metalloproteinase 9 (mmp-9) aptamer and uses thereof
EP2733153A1 (de) 2012-11-15 2014-05-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur Herstellung von Immunkonjugaten und Verwendungen davon
CN107072963B (zh) 2014-09-03 2020-07-07 吉倪塞思公司 治疗性纳米粒子和相关的组合物、方法和系统
PL3519394T3 (pl) 2016-09-27 2020-11-30 Bayer Pharma Aktiengesellschaft Sposób wytwarzania krystalicznej postaci o modyfikacji a kalkobutrolu
EA201992595A1 (ru) 2017-05-05 2020-04-21 Фьюжн Фармасьютикалс Инк. Усиление фармакокинетики бифункциональных хелатов и их применения
US10093741B1 (en) 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
KR20200004861A (ko) 2017-05-05 2020-01-14 퓨전 파마슈티칼즈 인크. Igf-1r 모노클로날 항체 및 그의 용도
US11607462B2 (en) 2017-05-16 2023-03-21 Northwestern University Systems and methods for minimally-invasive assessment of toxicity-induced tissue injury

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EP0073456B1 (de) * 1981-08-24 1985-11-27 Asahi Kasei Kogyo Kabushiki Kaisha Tetraazaannulen-Cobalt-Complexe und Verfahren zu ihrer Herstellung
DE3276165D1 (de) * 1982-11-03 1987-06-04 Ciba Geigy Ag Dibenzo(b,i)-1,4,8,11-tetraaza(14)annulenocobalt(iii) iodide
DE3562917D1 (en) * 1984-04-18 1988-06-30 Ciba Geigy Ag Substituted dibenzotetraaza-û14¨-annulene metal complexes, process for their preparation and their use
US4899755A (en) * 1985-05-08 1990-02-13 The General Hospital Corporation Hepatobiliary NMR contrast agents
US4880008A (en) * 1985-05-08 1989-11-14 The General Hospital Corporation Vivo enhancement of NMR relaxivity
GB8603537D0 (en) * 1986-02-13 1986-03-19 Parker D Conjugate compound
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
DE4001655A1 (de) * 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
CA2072080A1 (en) * 1990-01-19 1991-07-20 Jo Klaveness Chelating compounds

Also Published As

Publication number Publication date
NO952111L (no) 1995-05-29
DE69434260T2 (de) 2006-01-19
EP1184377A1 (de) 2002-03-06
CN1115180A (zh) 1996-01-17
ATE288422T1 (de) 2005-02-15
AU7623494A (en) 1995-04-18
JP3949714B2 (ja) 2007-07-25
NO300131B1 (no) 1997-04-14
EP0670832B1 (de) 2002-06-05
EP0670832A1 (de) 1995-09-13
CZ136995A3 (en) 1995-12-13
ATE218554T1 (de) 2002-06-15
KR960702447A (ko) 1996-04-27
EP1184377B1 (de) 2005-02-02
CA2150452A1 (en) 1995-04-06
JPH08503967A (ja) 1996-04-30
IL111083A0 (en) 1994-11-28
DE69434260D1 (de) 2005-03-10
NO952111D0 (no) 1995-05-29
WO1995009161A1 (en) 1995-04-06
HK1046131A1 (zh) 2002-12-27
US5358704A (en) 1994-10-25
DE69430730T2 (de) 2003-02-06

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee