ATE218554T1 - Hepatobillianische magnetische resonanz- kontrastmittel - Google Patents

Hepatobillianische magnetische resonanz- kontrastmittel

Info

Publication number
ATE218554T1
ATE218554T1 AT94926365T AT94926365T ATE218554T1 AT E218554 T1 ATE218554 T1 AT E218554T1 AT 94926365 T AT94926365 T AT 94926365T AT 94926365 T AT94926365 T AT 94926365T AT E218554 T1 ATE218554 T1 AT E218554T1
Authority
AT
Austria
Prior art keywords
alkyl
branched
straight
hepatobillian
magnetic resonance
Prior art date
Application number
AT94926365T
Other languages
English (en)
Inventor
Jean-Francois Desreux
Michael F Tweedle
Peter C Ratsep
Thomas R Wagler
Edmund R Marinelli
Original Assignee
Bracco Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Int Bv filed Critical Bracco Int Bv
Application granted granted Critical
Publication of ATE218554T1 publication Critical patent/ATE218554T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/10—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Soft Magnetic Materials (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT94926365T 1993-09-30 1994-09-29 Hepatobillianische magnetische resonanz- kontrastmittel ATE218554T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/129,870 US5358704A (en) 1993-09-30 1993-09-30 Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
PCT/IB1994/000298 WO1995009161A1 (en) 1993-09-30 1994-09-29 Hepatobiliary magnetic resonance contrast agents

Publications (1)

Publication Number Publication Date
ATE218554T1 true ATE218554T1 (de) 2002-06-15

Family

ID=22441998

Family Applications (2)

Application Number Title Priority Date Filing Date
AT01127327T ATE288422T1 (de) 1993-09-30 1994-09-29 Hepatobillianische magnetische resonanz- kontrastmittel
AT94926365T ATE218554T1 (de) 1993-09-30 1994-09-29 Hepatobillianische magnetische resonanz- kontrastmittel

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT01127327T ATE288422T1 (de) 1993-09-30 1994-09-29 Hepatobillianische magnetische resonanz- kontrastmittel

Country Status (14)

Country Link
US (1) US5358704A (de)
EP (2) EP1184377B1 (de)
JP (1) JP3949714B2 (de)
KR (1) KR960702447A (de)
CN (1) CN1115180A (de)
AT (2) ATE288422T1 (de)
AU (1) AU7623494A (de)
CA (1) CA2150452A1 (de)
CZ (1) CZ136995A3 (de)
DE (2) DE69430730T2 (de)
HK (1) HK1046131A1 (de)
IL (1) IL111083A0 (de)
NO (1) NO300131B1 (de)
WO (1) WO1995009161A1 (de)

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US6495118B1 (en) 1997-09-26 2002-12-17 Schering Aktiengesellschaft Lipophilic metal complexes for necrosis and infarction imaging
DE19744004C1 (de) * 1997-09-26 1999-07-22 Schering Ag Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
US6713046B1 (en) 1997-10-27 2004-03-30 Research Corporation Technologies Magnetic resonance imaging agents for the delivery of therapeutic agents
AU752812B2 (en) 1997-11-17 2002-10-03 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
IT1297035B1 (it) * 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
US6093382A (en) 1998-05-16 2000-07-25 Bracco Research Usa Inc. Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
US6056939A (en) * 1998-08-28 2000-05-02 Desreux; Jean F. Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals
WO2002006287A2 (en) 2000-07-17 2002-01-24 California Institute Of Technology Macrocyclic mri contrast agents
WO2002028441A2 (en) 2000-10-04 2002-04-11 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
US20030004236A1 (en) * 2001-04-20 2003-01-02 Meade Thomas J. Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances
US20020197648A1 (en) * 2001-05-02 2002-12-26 Silva Robin M. High throughput screening methods using magnetic resonance imaging agents
US20030135108A1 (en) * 2001-05-02 2003-07-17 Silva Robin M. High throughput screening methods using magnetic resonance imaging agents
US20040038303A1 (en) * 2002-04-08 2004-02-26 Unger Gretchen M. Biologic modulations with nanoparticles
EP1545498A4 (de) * 2002-09-06 2006-09-06 Us Gov Health & Human Serv Gerüst-substituierte bifunktionale dota-liganden, ihre komplexe und zusammensetzungen und ihre anwendungsverfahren
AU2004206956A1 (en) * 2003-01-22 2004-08-05 The General Hospital Corporation Amyloid-binding, metal-chelating agents
US7012140B1 (en) * 2003-07-14 2006-03-14 Board Of Regents, The University Of Texas System Selection of coordination geometry to adjust water exchange rates of paramagnetic metal ion-based macrocyclic contrast agents
US20060088475A1 (en) * 2004-05-10 2006-04-27 Northwestern University Self-immolative magnetic resonance imaging contrast agents sensitive to beta-glucuronidase
EP1768558A4 (de) 2004-06-09 2009-11-25 Kereos Inc Lipophile derivate von chelat-monoamiden
EP2014708A1 (de) 2005-01-13 2009-01-14 Cinvention Ag Geformter Körper aus einem Verbundstoffmaterial
AU2006303324A1 (en) * 2005-10-18 2007-04-26 Cinvention Ag Thermoset particles and methods for production thereof
US20090317335A1 (en) * 2006-04-20 2009-12-24 Wenbin Lin Hybrid Nanomaterials as Multimodal Imaging Contrast Agents
WO2008070464A2 (en) * 2006-11-21 2008-06-12 Barnes-Jewish Hospital Methods of imaging employing chelating agents
CN100459932C (zh) * 2007-01-15 2009-02-11 北京大学人民医院 一种mri分子影像探针及其制备方法
US20080213611A1 (en) * 2007-01-19 2008-09-04 Cinvention Ag Porous, non-degradable implant made by powder molding
WO2008104588A1 (en) * 2007-02-28 2008-09-04 Cinvention Ag High surface cultivation system
WO2008104599A1 (en) * 2007-02-28 2008-09-04 Cinvention Ag High surface cultivation system bag
EP2072060A1 (de) 2007-12-18 2009-06-24 Institut Curie Verfahren und Zusammensetzungen zur Herstellung und Verwendung von Toxinkonjugaten
US20100029909A1 (en) * 2008-05-23 2010-02-04 Northwestern University Compositions and methods comprising magnetic resonance contrast agents
US8580231B2 (en) 2008-05-23 2013-11-12 Northwestern University Compositions and methods comprising magnetic resonance contrast agents
JP5681102B2 (ja) 2008-05-30 2015-03-04 シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッドＳｉｅｍｅｎｓ Ｍｅｄｉｃａｌ Ｓｏｌｕｔｉｏｎｓ ＵＳＡ，Ｉｎｃ． 分子イメージング手法のための化合物
EP3156078B1 (de) 2009-04-10 2020-03-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Fucoidane als liganden zur diagnose degenerativer pathologien
WO2012072819A1 (en) 2010-12-03 2012-06-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Agents for the molecular imaging of serine-protease in human pathologies
US9598499B2 (en) 2010-12-30 2017-03-21 Institut National De La Santé Et De La Recherche Médicale (Inserm) Antigen binding formats for use in therapeutic treatments or diagnostic assays
WO2013153138A1 (en) 2012-04-11 2013-10-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Matrix metalloproteinase 9 (mmp-9) aptamer and uses thereof
EP2733153A1 (de) 2012-11-15 2014-05-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur Herstellung von Immunkonjugaten und Verwendungen davon
SG10201902499VA (en) 2014-09-03 2019-04-29 Genesegues Inc Therapeutic nanoparticles and related compositions, methods and systems
DK3519394T3 (da) 2016-09-27 2020-08-17 Bayer Pharma AG Fremgangsmåde til fremstilling af den krystallinske form af modifikation a af calcobutrol
AU2018261888B2 (en) 2017-05-05 2022-06-30 Centre For Probe Development And Commercialization Pharmacokinetic enhancements of bifunctional chelates and uses thereof
US10093741B1 (en) 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
WO2018204872A2 (en) 2017-05-05 2018-11-08 Fusion Pharmaceuticals Inc. Igf-1r monoclonal antibodies and uses thereof
US11607462B2 (en) 2017-05-16 2023-03-21 Northwestern University Systems and methods for minimally-invasive assessment of toxicity-induced tissue injury
MX2023004299A (es) 2020-10-13 2023-07-07 Univ Pennsylvania Direccionamiento de células t cd4+ in vivo para terapeuticos de arnm.

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DE3276165D1 (de) * 1982-11-03 1987-06-04 Ciba Geigy Ag Dibenzo(b,i)-1,4,8,11-tetraaza(14)annulenocobalt(iii) iodide
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DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
DE4001655A1 (de) * 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
JP3131219B2 (ja) * 1990-01-19 2001-01-31 ニユコメド・イメージング・アクシエセルカペト キレート化合物

Also Published As

Publication number Publication date
EP0670832A1 (de) 1995-09-13
NO300131B1 (no) 1997-04-14
NO952111D0 (no) 1995-05-29
EP1184377B1 (de) 2005-02-02
KR960702447A (ko) 1996-04-27
HK1046131A1 (en) 2002-12-27
EP0670832B1 (de) 2002-06-05
WO1995009161A1 (en) 1995-04-06
JPH08503967A (ja) 1996-04-30
JP3949714B2 (ja) 2007-07-25
CZ136995A3 (en) 1995-12-13
ATE288422T1 (de) 2005-02-15
DE69434260D1 (de) 2005-03-10
EP1184377A1 (de) 2002-03-06
US5358704A (en) 1994-10-25
DE69430730T2 (de) 2003-02-06
NO952111L (no) 1995-05-29
DE69430730D1 (de) 2002-07-11
CN1115180A (zh) 1996-01-17
DE69434260T2 (de) 2006-01-19
IL111083A0 (en) 1994-11-28
CA2150452A1 (en) 1995-04-06
AU7623494A (en) 1995-04-18

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