ATE288422T1 - Hepatobillianische magnetische resonanz- kontrastmittel - Google Patents

Hepatobillianische magnetische resonanz- kontrastmittel

Info

Publication number
ATE288422T1
ATE288422T1 AT01127327T AT01127327T ATE288422T1 AT E288422 T1 ATE288422 T1 AT E288422T1 AT 01127327 T AT01127327 T AT 01127327T AT 01127327 T AT01127327 T AT 01127327T AT E288422 T1 ATE288422 T1 AT E288422T1
Authority
AT
Austria
Prior art keywords
alkyl
branched
straight
hepatobillian
magnetic resonance
Prior art date
Application number
AT01127327T
Other languages
English (en)
Inventor
Jean-Francois Desreux
Michael F Tweedle
Peter C Ratsep
Thomas R Wagler
Edmund R Marinelli
Original Assignee
Bracco Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Int Bv filed Critical Bracco Int Bv
Application granted granted Critical
Publication of ATE288422T1 publication Critical patent/ATE288422T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/10—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Soft Magnetic Materials (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT01127327T 1993-09-30 1994-09-29 Hepatobillianische magnetische resonanz- kontrastmittel ATE288422T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/129,870 US5358704A (en) 1993-09-30 1993-09-30 Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents

Publications (1)

Publication Number Publication Date
ATE288422T1 true ATE288422T1 (de) 2005-02-15

Family

ID=22441998

Family Applications (2)

Application Number Title Priority Date Filing Date
AT01127327T ATE288422T1 (de) 1993-09-30 1994-09-29 Hepatobillianische magnetische resonanz- kontrastmittel
AT94926365T ATE218554T1 (de) 1993-09-30 1994-09-29 Hepatobillianische magnetische resonanz- kontrastmittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT94926365T ATE218554T1 (de) 1993-09-30 1994-09-29 Hepatobillianische magnetische resonanz- kontrastmittel

Country Status (14)

Country Link
US (1) US5358704A (de)
EP (2) EP0670832B1 (de)
JP (1) JP3949714B2 (de)
KR (1) KR960702447A (de)
CN (1) CN1115180A (de)
AT (2) ATE288422T1 (de)
AU (1) AU7623494A (de)
CA (1) CA2150452A1 (de)
CZ (1) CZ136995A3 (de)
DE (2) DE69430730T2 (de)
HK (1) HK1046131A1 (de)
IL (1) IL111083A0 (de)
NO (1) NO300131B1 (de)
WO (1) WO1995009161A1 (de)

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US5900228A (en) 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
US6495118B1 (en) 1997-09-26 2002-12-17 Schering Aktiengesellschaft Lipophilic metal complexes for necrosis and infarction imaging
DE19744004C1 (de) * 1997-09-26 1999-07-22 Schering Ag Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
US6713046B1 (en) 1997-10-27 2004-03-30 Research Corporation Technologies Magnetic resonance imaging agents for the delivery of therapeutic agents
CA2309749A1 (en) 1997-11-17 1999-05-27 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
IT1297035B1 (it) 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
US6093382A (en) 1998-05-16 2000-07-25 Bracco Research Usa Inc. Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
US6056939A (en) * 1998-08-28 2000-05-02 Desreux; Jean F. Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals
AU2001276956A1 (en) 2000-07-17 2002-01-30 California Institute Of Technology Macrocyclic mri contrast agents
AU2002211517A1 (en) 2000-10-04 2002-04-15 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
US20030004236A1 (en) * 2001-04-20 2003-01-02 Meade Thomas J. Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances
US20020197648A1 (en) * 2001-05-02 2002-12-26 Silva Robin M. High throughput screening methods using magnetic resonance imaging agents
US20030135108A1 (en) * 2001-05-02 2003-07-17 Silva Robin M. High throughput screening methods using magnetic resonance imaging agents
US20040038303A1 (en) * 2002-04-08 2004-02-26 Unger Gretchen M. Biologic modulations with nanoparticles
WO2004021996A2 (en) * 2002-09-06 2004-03-18 The Government Of The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services Backbone-substituted bifunctional dota ligands, complexes and compositions thereof, and methods of using same
EP1587547A2 (de) * 2003-01-22 2005-10-26 The General Hospital Corporation Amyloid-bindung, metallchelat-bildner
US7012140B1 (en) * 2003-07-14 2006-03-14 Board Of Regents, The University Of Texas System Selection of coordination geometry to adjust water exchange rates of paramagnetic metal ion-based macrocyclic contrast agents
WO2005115105A2 (en) * 2004-05-10 2005-12-08 Northwestern University Self-immolative magnetic resonance imaging contrast agents sensitive to beta-glucuronidase
AU2005253962A1 (en) 2004-06-09 2005-12-29 Kereos, Inc. Lipophilic derivatives of chelate monoamides
EP1836239B1 (de) 2005-01-13 2008-10-29 Cinvention Ag Kohlenstoffnanopartikel enthaltende verbundwerkstoffe
EA200801110A1 (ru) * 2005-10-18 2008-10-30 Синвеншен Аг Частицы на основе термореактивных смол и способы их получения
US20090317335A1 (en) * 2006-04-20 2009-12-24 Wenbin Lin Hybrid Nanomaterials as Multimodal Imaging Contrast Agents
CA2670061A1 (en) * 2006-11-21 2008-06-12 Barnes-Jewish Hospital Methods of imaging employing chelating agents
CN100459932C (zh) * 2007-01-15 2009-02-11 北京大学人民医院 一种mri分子影像探针及其制备方法
AU2008206953A1 (en) * 2007-01-19 2008-07-24 Cinvention Ag Porous, non-degradable implant made by powder molding
AU2008220793A1 (en) * 2007-02-28 2008-09-04 Cinvention Ag High surface cultivation system
WO2008104599A1 (en) * 2007-02-28 2008-09-04 Cinvention Ag High surface cultivation system bag
EP2072060A1 (de) 2007-12-18 2009-06-24 Institut Curie Verfahren und Zusammensetzungen zur Herstellung und Verwendung von Toxinkonjugaten
US20100029909A1 (en) * 2008-05-23 2010-02-04 Northwestern University Compositions and methods comprising magnetic resonance contrast agents
US8580231B2 (en) 2008-05-23 2013-11-12 Northwestern University Compositions and methods comprising magnetic resonance contrast agents
WO2009148554A1 (en) 2008-05-30 2009-12-10 Siemens Medical Solutions Usa, Inc. Achievement of high therapeutic index through molecular imaging guided targeted drug treatment
JP2012523403A (ja) 2009-04-10 2012-10-04 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 変性病変の診断のためのリガンドとしてのフコイダン
EP2646058A1 (de) 2010-12-03 2013-10-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Mittel zur molekularen bildgebung von serin-protease bei menschlichen pathologien
US9598499B2 (en) 2010-12-30 2017-03-21 Institut National De La Santé Et De La Recherche Médicale (Inserm) Antigen binding formats for use in therapeutic treatments or diagnostic assays
WO2013153138A1 (en) 2012-04-11 2013-10-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Matrix metalloproteinase 9 (mmp-9) aptamer and uses thereof
EP2733153A1 (de) 2012-11-15 2014-05-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur Herstellung von Immunkonjugaten und Verwendungen davon
US10987308B2 (en) 2014-09-03 2021-04-27 Genesegues, Inc. Therapeutic nanoparticles and related compositions, methods and systems
KR102395523B1 (ko) 2016-09-27 2022-05-10 바이엘 파마 악티엔게젤샤프트 칼코부트롤의 변형체 a의 결정형의 제조 방법
US10093741B1 (en) 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
AU2018261890A1 (en) 2017-05-05 2019-11-28 Centre For Probe Development And Commercialization IGF-1R monoclonal antibodies and uses thereof
BR112019023246B1 (pt) 2017-05-05 2023-11-14 Centre For Probe Development And Commercialization Compostos compreendendo uma fração quelante, métodos para produção dos mesmos e usos dos mesmos
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DE3276165D1 (de) * 1982-11-03 1987-06-04 Ciba Geigy Ag Dibenzo(b,i)-1,4,8,11-tetraaza(14)annulenocobalt(iii) iodide
DE3562917D1 (en) * 1984-04-18 1988-06-30 Ciba Geigy Ag Substituted dibenzotetraaza-û14¨-annulene metal complexes, process for their preparation and their use
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DE4001655A1 (de) * 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
JP3131219B2 (ja) * 1990-01-19 2001-01-31 ニユコメド・イメージング・アクシエセルカペト キレート化合物

Also Published As

Publication number Publication date
US5358704A (en) 1994-10-25
CN1115180A (zh) 1996-01-17
DE69434260T2 (de) 2006-01-19
JPH08503967A (ja) 1996-04-30
NO952111D0 (no) 1995-05-29
EP0670832A1 (de) 1995-09-13
JP3949714B2 (ja) 2007-07-25
EP1184377A1 (de) 2002-03-06
ATE218554T1 (de) 2002-06-15
AU7623494A (en) 1995-04-18
KR960702447A (ko) 1996-04-27
DE69434260D1 (de) 2005-03-10
EP0670832B1 (de) 2002-06-05
CA2150452A1 (en) 1995-04-06
NO952111L (no) 1995-05-29
NO300131B1 (no) 1997-04-14
WO1995009161A1 (en) 1995-04-06
DE69430730T2 (de) 2003-02-06
CZ136995A3 (en) 1995-12-13
DE69430730D1 (de) 2002-07-11
IL111083A0 (en) 1994-11-28
EP1184377B1 (de) 2005-02-02
HK1046131A1 (zh) 2002-12-27

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