NO942550L - Humanproteaseinhibitorvariant av Kunitz-type - Google Patents
Humanproteaseinhibitorvariant av Kunitz-typeInfo
- Publication number
- NO942550L NO942550L NO942550A NO942550A NO942550L NO 942550 L NO942550 L NO 942550L NO 942550 A NO942550 A NO 942550A NO 942550 A NO942550 A NO 942550A NO 942550 L NO942550 L NO 942550L
- Authority
- NO
- Norway
- Prior art keywords
- amino acid
- xaa
- naturally occurring
- occurring amino
- image
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Prostheses (AREA)
- Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Amplifiers (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK9200001 | 1992-01-07 | ||
PCT/DK1993/000004 WO1993014121A1 (en) | 1992-01-07 | 1993-01-07 | A human kunitz-type protease inhibitor variant |
Publications (2)
Publication Number | Publication Date |
---|---|
NO942550D0 NO942550D0 (no) | 1994-07-06 |
NO942550L true NO942550L (no) | 1994-09-07 |
Family
ID=8153770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO942550A NO942550L (no) | 1992-01-07 | 1994-07-06 | Humanproteaseinhibitorvariant av Kunitz-type |
Country Status (18)
Country | Link |
---|---|
US (1) | US5576294A (ja) |
EP (1) | EP0621871B1 (ja) |
JP (1) | JP3350549B2 (ja) |
KR (1) | KR100278036B1 (ja) |
AT (1) | ATE154938T1 (ja) |
AU (1) | AU676145B2 (ja) |
CA (1) | CA2127249A1 (ja) |
CZ (1) | CZ284911B6 (ja) |
DE (1) | DE69311893T2 (ja) |
ES (1) | ES2104121T3 (ja) |
FI (1) | FI943233A (ja) |
HU (1) | HU218104B (ja) |
IL (1) | IL104325A (ja) |
NO (1) | NO942550L (ja) |
NZ (1) | NZ246569A (ja) |
PL (1) | PL175422B1 (ja) |
WO (1) | WO1993014121A1 (ja) |
ZA (1) | ZA9395B (ja) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060134087A1 (en) * | 1988-09-02 | 2006-06-22 | Dyax Corp. | ITI-D1 Kunitz domain mutants as hNE inhibitors |
US5455338A (en) * | 1993-11-05 | 1995-10-03 | Zymogenetics, Inc. | DNA encoding novel human kunitz-type inhibitors and methods relating thereto |
US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
WO1995018830A2 (en) * | 1994-01-11 | 1995-07-13 | Protein Engineering Corporation | Inhibitors of human plasmin derived from the kunitz domains |
ATE275583T1 (de) * | 1994-01-11 | 2004-09-15 | Dyax Corp | KALLIKREINHEMMENDE ßKUNITZ-DOMÄNEß-PROTEINE UND DERIVATEN DAVON |
US5795954A (en) * | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
US5589359A (en) * | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
ATE226249T1 (de) * | 1994-08-05 | 2002-11-15 | Chiron Corp | Herstellung des inhibitors fuer die komplexbildung des gewebefaktors |
US5786328A (en) * | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
US5780265A (en) * | 1995-06-05 | 1998-07-14 | Genentech, Inc. | Kunitz type plasma kallikrein inhibitors |
US20030199450A1 (en) * | 2001-04-27 | 2003-10-23 | Chiron Corporation | Regulation of cytokine synthesis and release |
US6242414B1 (en) | 1995-06-07 | 2001-06-05 | Chiron Corporation | Regulation of cytokine synthesis and release |
US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
JP3469584B2 (ja) * | 1996-03-11 | 2003-11-25 | バイエル コーポレイション | ヒト ビクニン |
ES2318075T3 (es) * | 1998-12-22 | 2009-05-01 | Bayer Aktiengesellschaft | Metodo para acelerar la velocidad de eliminacion mucociliar. |
US20070140979A1 (en) * | 1998-12-22 | 2007-06-21 | Bayer Aktiengesellschaft | Method for accelerating the rate of mucociliary clearance |
GB9916913D0 (en) * | 1999-07-19 | 1999-09-22 | Natural Enviromental Research | Inhibitor proteins |
US20040054082A1 (en) * | 2001-12-03 | 2004-03-18 | Bank David H | Toughened polymer blends with improved surface properties |
EP2298278B1 (en) | 2002-06-07 | 2015-11-11 | Dyax Corp. | Prevention and reduction of blood loss and inflammatory response |
US7153829B2 (en) * | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
TR201900937T4 (tr) | 2002-08-28 | 2019-02-21 | Dyax Corp | Organların ve dokuların muhafaza edilmesine yönelik yöntem. |
DK1587907T3 (da) * | 2003-01-07 | 2011-04-04 | Dyax Corp | Kunitz-domænebibliotek |
US6989369B2 (en) | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
PT1663281E (pt) * | 2003-08-29 | 2014-03-17 | Dyax Corp | Inibidores de proteases poli-peguilados |
US7235530B2 (en) * | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
US7276480B1 (en) | 2005-12-30 | 2007-10-02 | Dyax Corp. | Prevention and reduction of blood loss |
CA2643693A1 (en) * | 2006-03-10 | 2007-09-20 | Dyax Corp. | Formulations for ecallantide |
KR101792032B1 (ko) | 2008-12-19 | 2017-11-02 | 백스터 인터내셔널 인코포레이티드 | Tfpi 억제제 및 사용 방법 |
WO2010080833A1 (en) | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
CN101798346B (zh) * | 2009-02-06 | 2013-05-29 | 复旦大学 | 一种酵母表达的长效重组人组织因子途径抑制物 |
EP3459564B1 (en) | 2010-01-06 | 2021-10-27 | Takeda Pharmaceutical Company Limited | Plasma kallikrein binding proteins |
AU2011227714B2 (en) | 2010-03-19 | 2014-09-04 | Takeda Pharmaceutical Company Limited | TFPI inhibitors and methods of use |
KR102169651B1 (ko) | 2011-01-06 | 2020-10-23 | 다이액스 코포레이션 | 혈장 칼리크레인 결합 단백질 |
KR101391988B1 (ko) | 2011-11-04 | 2014-05-08 | 동아대학교 산학협력단 | 항섬유소용해 기능을 가진 호박벌 독액의 쿠니츠 타입 세린 프로테아제 저해 폴리펩티드 및 이를 코딩하는 염기서열 |
CN109111505A (zh) | 2012-03-21 | 2019-01-01 | 百深有限责任公司 | Tfpi抑制剂及其使用方法 |
IL247942B (en) | 2014-03-27 | 2022-09-01 | Dyax Corp | Compositions and methods for drops in macular edema as a result of diabetes |
IL311156A (en) | 2015-12-11 | 2024-04-01 | Takeda Pharmaceuticals Co | Plasma kallikrein inhibitors and their uses in the treatment of hereditary angioedema attack |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5106833A (en) * | 1987-07-23 | 1992-04-21 | Washington University | Coagulation inhibitors |
DK408089D0 (da) * | 1989-08-18 | 1989-08-18 | Novo Nordisk As | Proteiner |
-
1993
- 1993-01-06 IL IL10432593A patent/IL104325A/xx not_active IP Right Cessation
- 1993-01-07 AU AU33459/93A patent/AU676145B2/en not_active Ceased
- 1993-01-07 EP EP93902105A patent/EP0621871B1/en not_active Expired - Lifetime
- 1993-01-07 JP JP51199293A patent/JP3350549B2/ja not_active Expired - Fee Related
- 1993-01-07 CZ CZ941649A patent/CZ284911B6/cs not_active IP Right Cessation
- 1993-01-07 DE DE69311893T patent/DE69311893T2/de not_active Expired - Fee Related
- 1993-01-07 ZA ZA9395A patent/ZA9395B/xx unknown
- 1993-01-07 AT AT93902105T patent/ATE154938T1/de not_active IP Right Cessation
- 1993-01-07 WO PCT/DK1993/000004 patent/WO1993014121A1/en active IP Right Grant
- 1993-01-07 HU HU9401991A patent/HU218104B/hu not_active IP Right Cessation
- 1993-01-07 NZ NZ246569A patent/NZ246569A/en unknown
- 1993-01-07 KR KR1019940702351A patent/KR100278036B1/ko not_active IP Right Cessation
- 1993-01-07 CA CA002127249A patent/CA2127249A1/en not_active Abandoned
- 1993-01-07 ES ES93902105T patent/ES2104121T3/es not_active Expired - Lifetime
- 1993-01-07 PL PL93304468A patent/PL175422B1/pl unknown
-
1994
- 1994-07-06 FI FI943233A patent/FI943233A/fi unknown
- 1994-07-06 NO NO942550A patent/NO942550L/no not_active Application Discontinuation
- 1994-10-12 US US08/321,658 patent/US5576294A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1993014121A1 (en) | 1993-07-22 |
KR100278036B1 (ko) | 2001-01-15 |
HU218104B (hu) | 2000-06-28 |
NZ246569A (en) | 1996-05-28 |
DE69311893D1 (de) | 1997-08-07 |
EP0621871B1 (en) | 1997-07-02 |
HUT70295A (en) | 1995-09-28 |
CZ284911B6 (cs) | 1999-04-14 |
KR940703854A (ko) | 1994-12-12 |
AU676145B2 (en) | 1997-03-06 |
NO942550D0 (no) | 1994-07-06 |
CA2127249A1 (en) | 1993-07-22 |
IL104325A0 (en) | 1993-05-13 |
FI943233A0 (fi) | 1994-07-06 |
JP3350549B2 (ja) | 2002-11-25 |
DE69311893T2 (de) | 1998-02-05 |
EP0621871A1 (en) | 1994-11-02 |
FI943233A (fi) | 1994-07-06 |
US5576294A (en) | 1996-11-19 |
PL175422B1 (pl) | 1998-12-31 |
JPH07506335A (ja) | 1995-07-13 |
IL104325A (en) | 2000-10-31 |
ATE154938T1 (de) | 1997-07-15 |
ZA9395B (en) | 1993-08-20 |
AU3345993A (en) | 1993-08-03 |
CZ164994A3 (en) | 1994-12-15 |
ES2104121T3 (es) | 1997-10-01 |
HU9401991D0 (en) | 1994-09-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |