NO942551L - Humanproteaseinhibitorvariant av Kunitz-type - Google Patents

Humanproteaseinhibitorvariant av Kunitz-type

Info

Publication number
NO942551L
NO942551L NO942551A NO942551A NO942551L NO 942551 L NO942551 L NO 942551L NO 942551 A NO942551 A NO 942551A NO 942551 A NO942551 A NO 942551A NO 942551 L NO942551 L NO 942551L
Authority
NO
Norway
Prior art keywords
amino acid
protease inhibitor
variant
type human
naturally occurring
Prior art date
Application number
NO942551A
Other languages
English (en)
Other versions
NO942551D0 (no
Inventor
Fanny Norris
Kjeld Norris
Soeren Erik Bjoern
Lars Christian Petersen
Ole Hvilsted Olsen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of NO942551D0 publication Critical patent/NO942551D0/no
Publication of NO942551L publication Critical patent/NO942551L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Prostheses (AREA)

Abstract

Variant av humanprotease-inhibitorområde III av Kunitz-type i vevsfaktorproteaseinhibitor (TFPI>, hvor varianten omfatter aminosyresek-vensen (I) XSer Trp Cys Leu Thr Pro Ala Asp" XGlyCys567Phe Tyr Tyr Asn Ser Val Ile Gly Lys Cys Arg Pro Phe XTyr XGly Cys X13Glu Asn Asn Phe XSer Lys- Gin Glu Cys Leu Arg Ala Cys Lys Lys X, hvor Xer H eller 1-5 naturlig forekommende aminosyrerester bortsett fra Cys,er hver uavhengig av hverandre en naturlig forekommende aminosyrerest, og Xer OH eller 1-5 naturlig forekommende aminosyrerester bortsett fra Cys, med det forbehold at minst én av amino-syrerestene XXer forskjellig fra den tilsvarende aminosyrerest i den naturlig forekommende sekvens.
NO942551A 1992-01-07 1994-07-06 Humanproteaseinhibitorvariant av Kunitz-type NO942551L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK9200004 1992-01-07
PCT/DK1993/000003 WO1993014120A1 (en) 1992-01-07 1993-01-07 A human kunitz-type protease inhibitor variant

Publications (2)

Publication Number Publication Date
NO942551D0 NO942551D0 (no) 1994-07-06
NO942551L true NO942551L (no) 1994-09-07

Family

ID=8153774

Family Applications (1)

Application Number Title Priority Date Filing Date
NO942551A NO942551L (no) 1992-01-07 1994-07-06 Humanproteaseinhibitorvariant av Kunitz-type

Country Status (15)

Country Link
EP (1) EP0621870B1 (no)
JP (1) JPH07506241A (no)
AT (1) ATE152735T1 (no)
AU (1) AU675925B2 (no)
CA (1) CA2127250A1 (no)
CZ (1) CZ164594A3 (no)
DE (1) DE69310499D1 (no)
FI (1) FI943232A0 (no)
HU (1) HUT70294A (no)
IL (1) IL104326A0 (no)
NO (1) NO942551L (no)
NZ (1) NZ246568A (no)
RU (1) RU94045952A (no)
WO (1) WO1993014120A1 (no)
ZA (1) ZA9397B (no)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE529444T1 (de) 1994-01-11 2011-11-15 Dyax Corp Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
WO1995021601A2 (en) * 1994-01-11 1995-08-17 Protein Engineering Corporation Kallikrein-inhibiting 'kunitz domain' proteins and analogues thereof
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
US5589359A (en) 1994-08-05 1996-12-31 Chiron Corporation Chimeric proteins
DE69528591T2 (de) * 1994-08-05 2003-02-20 Chiron Corp Herstellung des inhibitors fuer die komplexbildung des gewebefaktors
ZA963619B (en) 1995-05-08 1996-11-22 Scios Inc Protease inhibitor peptides
AU5854096A (en) * 1995-05-08 1996-11-29 Scios Inc. Kunitz type protease inhibitors
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
US6242414B1 (en) 1995-06-07 2001-06-05 Chiron Corporation Regulation of cytokine synthesis and release
HU226419B1 (en) 1996-03-11 2008-12-29 Aerovance Human bikunin
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
PT2311432E (pt) 2002-06-07 2015-02-09 Dyax Corp Polipeptídeos de domínio kunitz modificado e sua utilização para a redução de isquemia ou aparecimento de uma resposta inflamatória sistémica associada a um procedimento cirúrgico
DK1542710T3 (da) * 2002-08-28 2012-10-15 Dyax Corp Fremgangsmåde til konservering af organer og væv
US6989369B2 (en) 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
WO2005021557A2 (en) 2003-08-29 2005-03-10 Dyax Corp. Poly-pegylated protease inhibitors
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
ES2661002T3 (es) * 2005-12-29 2018-03-27 The Regents Of The University Of California Procedimientos y composiciones relacionadas con el dominio Kunitz I mutante de TFPI-2
US7276480B1 (en) 2005-12-30 2007-10-02 Dyax Corp. Prevention and reduction of blood loss
ES2773766T3 (es) 2008-12-19 2020-07-14 Baxalta GmbH Inhibidores de TFPI y métodos de uso
AU2010203712A1 (en) 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
CN101798346B (zh) * 2009-02-06 2013-05-29 复旦大学 一种酵母表达的长效重组人组织因子途径抑制物
LT2521568T (lt) 2010-01-06 2018-12-10 Dyax Corp. Plazmos kalikreiną surišantys baltymai
AU2011227714B2 (en) 2010-03-19 2014-09-04 Takeda Pharmaceutical Company Limited TFPI inhibitors and methods of use
CN105713092B (zh) 2011-01-06 2019-09-10 戴埃克斯有限公司 血浆前激肽释放酶结合蛋白
CA2867363C (en) 2012-03-21 2023-02-28 Baxter International Inc. Tfpi inhibitors and methods of use
AU2016366557B2 (en) 2015-12-11 2024-01-25 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106833A (en) * 1987-07-23 1992-04-21 Washington University Coagulation inhibitors
DK408089D0 (da) * 1989-08-18 1989-08-18 Novo Nordisk As Proteiner

Also Published As

Publication number Publication date
ATE152735T1 (de) 1997-05-15
NZ246568A (en) 1996-02-27
FI943232A (fi) 1994-07-06
WO1993014120A1 (en) 1993-07-22
CA2127250A1 (en) 1993-07-22
IL104326A0 (en) 1993-05-13
FI943232A0 (fi) 1994-07-06
NO942551D0 (no) 1994-07-06
EP0621870B1 (en) 1997-05-07
HUT70294A (en) 1995-09-28
RU94045952A (ru) 1996-10-10
JPH07506241A (ja) 1995-07-13
DE69310499D1 (de) 1997-06-12
CZ164594A3 (en) 1994-12-15
AU3345893A (en) 1993-08-03
EP0621870A1 (en) 1994-11-02
ZA9397B (en) 1993-08-10
AU675925B2 (en) 1997-02-27
HU9401992D0 (en) 1994-09-28

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