FI943232A - Ihmisen Kunitz-tyyppisen proteaasiestäjän muunnos - Google Patents
Ihmisen Kunitz-tyyppisen proteaasiestäjän muunnos Download PDFInfo
- Publication number
- FI943232A FI943232A FI943232A FI943232A FI943232A FI 943232 A FI943232 A FI 943232A FI 943232 A FI943232 A FI 943232A FI 943232 A FI943232 A FI 943232A FI 943232 A FI943232 A FI 943232A
- Authority
- FI
- Finland
- Prior art keywords
- amino acid
- variant
- protease inhibitor
- type protease
- naturally occurring
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Prostheses (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK9200004 | 1992-01-07 | ||
PCT/DK1993/000003 WO1993014120A1 (en) | 1992-01-07 | 1993-01-07 | A human kunitz-type protease inhibitor variant |
Publications (2)
Publication Number | Publication Date |
---|---|
FI943232A true FI943232A (fi) | 1994-07-06 |
FI943232A0 FI943232A0 (fi) | 1994-07-06 |
Family
ID=8153774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI943232A FI943232A0 (fi) | 1992-01-07 | 1994-07-06 | Ihmisen Kunitz-tyyppisen proteaasiestäjän muunnos |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0621870B1 (fi) |
JP (1) | JPH07506241A (fi) |
AT (1) | ATE152735T1 (fi) |
AU (1) | AU675925B2 (fi) |
CA (1) | CA2127250A1 (fi) |
CZ (1) | CZ164594A3 (fi) |
DE (1) | DE69310499D1 (fi) |
FI (1) | FI943232A0 (fi) |
HU (1) | HUT70294A (fi) |
IL (1) | IL104326A0 (fi) |
NO (1) | NO942551L (fi) |
NZ (1) | NZ246568A (fi) |
RU (1) | RU94045952A (fi) |
WO (1) | WO1993014120A1 (fi) |
ZA (1) | ZA9397B (fi) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6057287A (en) * | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
PT739355E (pt) * | 1994-01-11 | 2005-01-31 | Dyax Corp | Proteinas de 'dominio de kunitz' inibidoras de calicreina e seus analogos |
DE69533544T2 (de) | 1994-01-11 | 2006-02-23 | Dyax Corp., Cambridge | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
US5795954A (en) * | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
EP0774001B1 (en) * | 1994-08-05 | 2002-10-16 | Chiron Corporation | Production of tissue factor pathway inhibitor |
US5589359A (en) * | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
ZA963619B (en) | 1995-05-08 | 1996-11-22 | Scios Inc | Protease inhibitor peptides |
CA2220497A1 (en) * | 1995-05-08 | 1996-11-14 | Scios, Inc. | Kunitz type protease inhibitors |
US5780265A (en) * | 1995-06-05 | 1998-07-14 | Genentech, Inc. | Kunitz type plasma kallikrein inhibitors |
US5786328A (en) * | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
US6242414B1 (en) | 1995-06-07 | 2001-06-05 | Chiron Corporation | Regulation of cytokine synthesis and release |
YU8997A (sh) | 1996-03-11 | 1999-09-27 | Bayer Corporation | Prečišćen protein koji ima serinsku proteaznu inhibitorsku aktivnost i farmaceutski preparat koji ga sadrži |
US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
ATE477020T1 (de) | 2002-06-07 | 2010-08-15 | Dyax Corp | Prevention und verringerung von ischemia |
JP2005537006A (ja) | 2002-08-28 | 2005-12-08 | ダイアックス、コープ | 臓器及び組織の保存方法 |
US6989369B2 (en) | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
US20050089515A1 (en) | 2003-08-29 | 2005-04-28 | Dyax Corp. | Poly-pegylated protease inhibitors |
US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
US8993719B2 (en) * | 2005-12-29 | 2015-03-31 | The Regents Of The University Of California | Methods and compositions related to mutant Kunitz domain I of TFPI-2 |
US7276480B1 (en) | 2005-12-30 | 2007-10-02 | Dyax Corp. | Prevention and reduction of blood loss |
SI2379096T1 (sl) | 2008-12-19 | 2020-03-31 | Baxalta GmbH | Zaviralci TFPI in postopki uporabe |
EP2385843A4 (en) | 2009-01-06 | 2013-02-27 | Dyax Corp | TREATMENT OF MUZOSITIS WITH CALLICINE INHIBITORS |
CN101798346B (zh) * | 2009-02-06 | 2013-05-29 | 复旦大学 | 一种酵母表达的长效重组人组织因子途径抑制物 |
CA3168591A1 (en) | 2010-01-06 | 2011-07-14 | Takeda Pharmaceutical Company Limited | Plasma kallikrein binding proteins |
WO2011115712A2 (en) | 2010-03-19 | 2011-09-22 | Baxter International Inc | Tfpi inhibitors and methods of use |
JP2014506257A (ja) | 2011-01-06 | 2014-03-13 | ダイアックス コーポレーション | 血漿カリクレイン結合タンパク質 |
DK2827883T3 (da) | 2012-03-21 | 2019-07-29 | Baxalta GmbH | Tfpi-inhibitorer og fremgangsmåder til anvendelse |
EP3387018A1 (en) | 2015-12-11 | 2018-10-17 | Dyax Corp. | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5106833A (en) * | 1987-07-23 | 1992-04-21 | Washington University | Coagulation inhibitors |
DK408089D0 (da) * | 1989-08-18 | 1989-08-18 | Novo Nordisk As | Proteiner |
-
1993
- 1993-01-06 IL IL104326A patent/IL104326A0/xx unknown
- 1993-01-07 AT AT93902104T patent/ATE152735T1/de not_active IP Right Cessation
- 1993-01-07 AU AU33458/93A patent/AU675925B2/en not_active Ceased
- 1993-01-07 ZA ZA9397A patent/ZA9397B/xx unknown
- 1993-01-07 CA CA002127250A patent/CA2127250A1/en not_active Abandoned
- 1993-01-07 CZ CZ941645A patent/CZ164594A3/cs unknown
- 1993-01-07 JP JP5511991A patent/JPH07506241A/ja active Pending
- 1993-01-07 HU HU9401992A patent/HUT70294A/hu unknown
- 1993-01-07 EP EP93902104A patent/EP0621870B1/en not_active Expired - Lifetime
- 1993-01-07 DE DE69310499T patent/DE69310499D1/de not_active Expired - Lifetime
- 1993-01-07 WO PCT/DK1993/000003 patent/WO1993014120A1/en not_active Application Discontinuation
- 1993-01-07 NZ NZ246568A patent/NZ246568A/en unknown
- 1993-01-07 RU RU94045952/13A patent/RU94045952A/ru unknown
-
1994
- 1994-07-06 FI FI943232A patent/FI943232A0/fi not_active Application Discontinuation
- 1994-07-06 NO NO942551A patent/NO942551L/no unknown
Also Published As
Publication number | Publication date |
---|---|
AU675925B2 (en) | 1997-02-27 |
EP0621870B1 (en) | 1997-05-07 |
WO1993014120A1 (en) | 1993-07-22 |
NO942551L (no) | 1994-09-07 |
ZA9397B (en) | 1993-08-10 |
NO942551D0 (no) | 1994-07-06 |
CZ164594A3 (en) | 1994-12-15 |
NZ246568A (en) | 1996-02-27 |
EP0621870A1 (en) | 1994-11-02 |
FI943232A0 (fi) | 1994-07-06 |
AU3345893A (en) | 1993-08-03 |
IL104326A0 (en) | 1993-05-13 |
RU94045952A (ru) | 1996-10-10 |
HU9401992D0 (en) | 1994-09-28 |
HUT70294A (en) | 1995-09-28 |
JPH07506241A (ja) | 1995-07-13 |
CA2127250A1 (en) | 1993-07-22 |
DE69310499D1 (de) | 1997-06-12 |
ATE152735T1 (de) | 1997-05-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI943232A0 (fi) | Ihmisen Kunitz-tyyppisen proteaasiestäjän muunnos | |
FI943233A (fi) | Ihmisen Kunitz-tyyppisen proteaasiestäjän muunnos | |
MX9102407A (es) | 4 arilpiperazinas y 4-arilpiperidinas novedosas. | |
DE69331586T2 (de) | Verbessertes femorales manschettenimplantat | |
MX9101788A (es) | Composiciones de tinta a base de agua | |
BR9509648A (pt) | Combinações de herbicidas de fenilsulfoniluréia e protetores | |
HU9401990D0 (en) | Human kunitz-type protease inhibitor variant | |
MD306B1 (ro) | Remediu pentru profilaxia afectiunilor vasculare determinate de actiunea peroxizilor glicoproteinfixati | |
NO901558L (no) | Vasoaktive peptider. | |
KR950701347A (ko) | 신규한 향종양성 사이토킨(A novel anti-neoplastic cytokine) | |
IT1264129B1 (it) | Peptidi ad attivita' immunomodulatoria derivati da frammenti di leucochinina | |
KR940021982U (ko) | 청소기용 사이클론의 압력 조절장치 | |
KR930016980U (ko) | Tv의 고압조기 방전회로 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application lapsed |