DK1976985T3 - Fremgangsmåder og præparater relateret til mutant Kunitz-domæne I af TFPI-2 - Google Patents
Fremgangsmåder og præparater relateret til mutant Kunitz-domæne I af TFPI-2Info
- Publication number
- DK1976985T3 DK1976985T3 DK06848474.0T DK06848474T DK1976985T3 DK 1976985 T3 DK1976985 T3 DK 1976985T3 DK 06848474 T DK06848474 T DK 06848474T DK 1976985 T3 DK1976985 T3 DK 1976985T3
- Authority
- DK
- Denmark
- Prior art keywords
- tfpi
- methods
- kunitz domain
- preparations related
- mutant
- Prior art date
Links
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 102000055046 tissue-factor-pathway inhibitor 2 Human genes 0.000 title 1
- 108010016054 tissue-factor-pathway inhibitor 2 Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0375—Animal model for cardiovascular diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Surgery (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75473105P | 2005-12-29 | 2005-12-29 | |
| PCT/US2006/062723 WO2007076537A2 (en) | 2005-12-29 | 2006-12-29 | Methods and compositions related to mutant kunitz domain i of tfpi-2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1976985T3 true DK1976985T3 (da) | 2013-10-21 |
Family
ID=38218885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06848474.0T DK1976985T3 (da) | 2005-12-29 | 2006-12-29 | Fremgangsmåder og præparater relateret til mutant Kunitz-domæne I af TFPI-2 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8993719B2 (da) |
| EP (3) | EP1976985B1 (da) |
| JP (4) | JP5770966B2 (da) |
| AU (1) | AU2006330424B2 (da) |
| CA (2) | CA2635726C (da) |
| DK (1) | DK1976985T3 (da) |
| ES (3) | ES2594607T3 (da) |
| HK (1) | HK1190753A1 (da) |
| PL (1) | PL1976985T3 (da) |
| PT (1) | PT1976985E (da) |
| WO (1) | WO2007076537A2 (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1976985T3 (da) | 2005-12-29 | 2013-10-21 | Univ California | Fremgangsmåder og præparater relateret til mutant Kunitz-domæne I af TFPI-2 |
| US8088599B2 (en) * | 2009-02-06 | 2012-01-03 | Fudan University | Nucleic acids encoding genetically modified tissue factor pathway inhibitor (TFPI) and method of making the same |
| GB0916578D0 (en) * | 2009-09-22 | 2009-10-28 | Malmsten Nils M | Polypeptides and uses thereof |
| US20140288000A1 (en) * | 2013-03-15 | 2014-09-25 | The Regents Of The University Of California | Dual reactivity potent kunitz inhibitor of fibrinolysis |
| CN105377888A (zh) * | 2013-03-15 | 2016-03-02 | 加利福尼亚大学董事会 | 纤维蛋白溶解的双反应性的有效的Kunitz抑制剂 |
| US20170322218A1 (en) * | 2014-11-27 | 2017-11-09 | Public University Corporation Yokohama City University | Method and reagent for detecting ovarian clear cell adenocarcinoma |
| US20230331817A1 (en) * | 2020-09-10 | 2023-10-19 | The Regents Of The University Of California | Improved highly potent specific human kunitz inhibitor of fibrinolytic enzyme plasmin |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1601438A (da) | 1968-10-17 | 1970-08-24 | ||
| NO812612L (no) | 1980-08-06 | 1982-02-08 | Ferring Pharma Ltd | Enzym-inhibitorer. |
| AU560584B2 (en) | 1983-07-28 | 1987-04-09 | Bayer Aktiengesellschaft | Homologues of aprotinin |
| US4609725A (en) | 1984-10-09 | 1986-09-02 | Merck & Co., Inc. | Cardiac atrial peptides |
| GB2188322A (en) | 1986-03-26 | 1987-09-30 | Bayer Ag | Aprotinin and analogues thereof produced by a recombinant host |
| US5032573A (en) | 1987-03-23 | 1991-07-16 | Bayer Aktiengesellschaft | Homologs of aprotinin produced from a recombinant host, process, expression vector and recombinant host therefor and pharmaceutical use thereof |
| US5663143A (en) | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
| US7078383B2 (en) | 1988-09-02 | 2006-07-18 | Dyax Corp. | ITI-D1 Kunitz domain mutants as HNE inhibitors |
| IL104326A0 (en) * | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Variant of human kunitz-type protease inhibitor |
| US5455338A (en) | 1993-11-05 | 1995-10-03 | Zymogenetics, Inc. | DNA encoding novel human kunitz-type inhibitors and methods relating thereto |
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| PT739355E (pt) | 1994-01-11 | 2005-01-31 | Dyax Corp | Proteinas de 'dominio de kunitz' inibidoras de calicreina e seus analogos |
| PT1489097E (pt) | 1994-01-11 | 2012-01-04 | Dyax Corp | Inibidores de plasmina humana derivados de domínios kunitz e ácidos nucleicos codificando os mesmos |
| US5981471A (en) | 1997-02-06 | 1999-11-09 | Entremed, Inc. | Compositions and methods for inhibiting cellular proliferation |
| AUPP345098A0 (en) | 1998-05-11 | 1998-06-04 | National Institute Of Biological Standards And Control, United Kingdom | Novel anti-fibrinolytic agents |
| US20050222023A1 (en) * | 2002-02-07 | 2005-10-06 | Hans-Peter Hauser | Albumin-fused kunitz domain peptides |
| AU2003212249A1 (en) * | 2002-02-21 | 2003-09-09 | Geneprot, Inc. | Engineered human kunitz-type protease inhibitor |
| US7585842B2 (en) * | 2004-04-16 | 2009-09-08 | The Reagents Of The University Of California | Human kunitz-type inhibitor with enhanced antifibrinolytic activity |
| US7432238B2 (en) | 2004-04-16 | 2008-10-07 | Stc.Unm | Human Kunitz-type inhibitor with enhanced antifibrinolytic activity |
| CN1634986A (zh) * | 2004-11-18 | 2005-07-06 | 复旦大学 | 一种新型Kunin型多肽及其制备方法 |
| DK1976985T3 (da) | 2005-12-29 | 2013-10-21 | Univ California | Fremgangsmåder og præparater relateret til mutant Kunitz-domæne I af TFPI-2 |
-
2006
- 2006-12-29 DK DK06848474.0T patent/DK1976985T3/da active
- 2006-12-29 ES ES13157687.8T patent/ES2594607T3/es active Active
- 2006-12-29 ES ES06848474T patent/ES2431526T3/es active Active
- 2006-12-29 CA CA2635726A patent/CA2635726C/en not_active Expired - Fee Related
- 2006-12-29 US US12/087,296 patent/US8993719B2/en active Active
- 2006-12-29 JP JP2008548869A patent/JP5770966B2/ja not_active Expired - Fee Related
- 2006-12-29 EP EP06848474.0A patent/EP1976985B1/en not_active Not-in-force
- 2006-12-29 CA CA2924836A patent/CA2924836A1/en not_active Abandoned
- 2006-12-29 EP EP13157687.8A patent/EP2653542B1/en not_active Not-in-force
- 2006-12-29 PL PL06848474T patent/PL1976985T3/pl unknown
- 2006-12-29 PT PT68484740T patent/PT1976985E/pt unknown
- 2006-12-29 AU AU2006330424A patent/AU2006330424B2/en not_active Ceased
- 2006-12-29 EP EP16160326.1A patent/EP3088522B1/en not_active Not-in-force
- 2006-12-29 ES ES16160326.1T patent/ES2661002T3/es active Active
- 2006-12-29 WO PCT/US2006/062723 patent/WO2007076537A2/en active Application Filing
-
2012
- 2012-12-10 JP JP2012269496A patent/JP2013063086A/ja active Pending
-
2014
- 2014-04-22 HK HK14103786.6A patent/HK1190753A1/zh not_active IP Right Cessation
-
2015
- 2015-02-05 US US14/615,355 patent/US20150191528A1/en not_active Abandoned
- 2015-04-27 JP JP2015090192A patent/JP2015157840A/ja not_active Withdrawn
-
2018
- 2018-02-05 JP JP2018018361A patent/JP2018093882A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES2661002T3 (es) | 2018-03-27 |
| PT1976985E (pt) | 2013-10-24 |
| EP2653542A1 (en) | 2013-10-23 |
| EP1976985A4 (en) | 2009-04-29 |
| PL1976985T3 (pl) | 2014-03-31 |
| EP3088522B1 (en) | 2017-11-29 |
| EP1976985A2 (en) | 2008-10-08 |
| JP2018093882A (ja) | 2018-06-21 |
| US20090018069A1 (en) | 2009-01-15 |
| US8993719B2 (en) | 2015-03-31 |
| US20150191528A1 (en) | 2015-07-09 |
| CA2635726C (en) | 2016-10-11 |
| AU2006330424B2 (en) | 2013-11-14 |
| JP2013063086A (ja) | 2013-04-11 |
| ES2594607T3 (es) | 2016-12-21 |
| EP2653542B1 (en) | 2016-06-29 |
| EP1976985B1 (en) | 2013-07-17 |
| JP5770966B2 (ja) | 2015-08-26 |
| JP2015157840A (ja) | 2015-09-03 |
| JP2009521935A (ja) | 2009-06-11 |
| AU2006330424A1 (en) | 2007-07-05 |
| WO2007076537A2 (en) | 2007-07-05 |
| WO2007076537A3 (en) | 2008-02-14 |
| HK1190753A1 (zh) | 2014-07-11 |
| CA2635726A1 (en) | 2007-07-05 |
| EP3088522A1 (en) | 2016-11-02 |
| ES2431526T3 (es) | 2013-11-26 |
| CA2924836A1 (en) | 2007-07-05 |
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