FI943233A - Ihmisen Kunitz-tyyppisen proteaasiestäjän muunnos - Google Patents
Ihmisen Kunitz-tyyppisen proteaasiestäjän muunnos Download PDFInfo
- Publication number
- FI943233A FI943233A FI943233A FI943233A FI943233A FI 943233 A FI943233 A FI 943233A FI 943233 A FI943233 A FI 943233A FI 943233 A FI943233 A FI 943233A FI 943233 A FI943233 A FI 943233A
- Authority
- FI
- Finland
- Prior art keywords
- amino acid
- xaa
- naturally occurring
- variant
- occurring amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
- Prostheses (AREA)
- Amplifiers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK9200001 | 1992-01-07 | ||
| PCT/DK1993/000004 WO1993014121A1 (en) | 1992-01-07 | 1993-01-07 | A human kunitz-type protease inhibitor variant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI943233A0 FI943233A0 (fi) | 1994-07-06 |
| FI943233A true FI943233A (fi) | 1994-07-06 |
Family
ID=8153770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI943233A FI943233A (fi) | 1992-01-07 | 1994-07-06 | Ihmisen Kunitz-tyyppisen proteaasiestäjän muunnos |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5576294A (fi) |
| EP (1) | EP0621871B1 (fi) |
| JP (1) | JP3350549B2 (fi) |
| KR (1) | KR100278036B1 (fi) |
| AT (1) | ATE154938T1 (fi) |
| AU (1) | AU676145B2 (fi) |
| CA (1) | CA2127249A1 (fi) |
| CZ (1) | CZ284911B6 (fi) |
| DE (1) | DE69311893T2 (fi) |
| ES (1) | ES2104121T3 (fi) |
| FI (1) | FI943233A (fi) |
| HU (1) | HU218104B (fi) |
| IL (1) | IL104325A (fi) |
| NO (1) | NO942550L (fi) |
| NZ (1) | NZ246569A (fi) |
| PL (1) | PL175422B1 (fi) |
| WO (1) | WO1993014121A1 (fi) |
| ZA (1) | ZA9395B (fi) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060134087A1 (en) * | 1988-09-02 | 2006-06-22 | Dyax Corp. | ITI-D1 Kunitz domain mutants as hNE inhibitors |
| US5455338A (en) * | 1993-11-05 | 1995-10-03 | Zymogenetics, Inc. | DNA encoding novel human kunitz-type inhibitors and methods relating thereto |
| US6057287A (en) * | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| PT739355E (pt) * | 1994-01-11 | 2005-01-31 | Dyax Corp | Proteinas de 'dominio de kunitz' inibidoras de calicreina e seus analogos |
| DE69533544T2 (de) | 1994-01-11 | 2006-02-23 | Dyax Corp., Cambridge | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
| US5795954A (en) * | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
| EP0774001B1 (en) * | 1994-08-05 | 2002-10-16 | Chiron Corporation | Production of tissue factor pathway inhibitor |
| US5589359A (en) * | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
| US5780265A (en) * | 1995-06-05 | 1998-07-14 | Genentech, Inc. | Kunitz type plasma kallikrein inhibitors |
| US5786328A (en) * | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
| US6242414B1 (en) | 1995-06-07 | 2001-06-05 | Chiron Corporation | Regulation of cytokine synthesis and release |
| US20030199450A1 (en) * | 2001-04-27 | 2003-10-23 | Chiron Corporation | Regulation of cytokine synthesis and release |
| US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
| YU8997A (sh) * | 1996-03-11 | 1999-09-27 | Bayer Corporation | Prečišćen protein koji ima serinsku proteaznu inhibitorsku aktivnost i farmaceutski preparat koji ga sadrži |
| US20070140979A1 (en) * | 1998-12-22 | 2007-06-21 | Bayer Aktiengesellschaft | Method for accelerating the rate of mucociliary clearance |
| CN1229138C (zh) * | 1998-12-22 | 2005-11-30 | 拜尔公开股份有限公司 | 加速粘液纤毛的清除速率的方法 |
| GB9916913D0 (en) * | 1999-07-19 | 1999-09-22 | Natural Enviromental Research | Inhibitor proteins |
| US20040054082A1 (en) * | 2001-12-03 | 2004-03-18 | Bank David H | Toughened polymer blends with improved surface properties |
| ATE477020T1 (de) | 2002-06-07 | 2010-08-15 | Dyax Corp | Prevention und verringerung von ischemia |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| JP2005537006A (ja) | 2002-08-28 | 2005-12-08 | ダイアックス、コープ | 臓器及び組織の保存方法 |
| ES2362424T3 (es) * | 2003-01-07 | 2011-07-05 | Dyax Corporation | Biblioteca del dominio kunitz. |
| US6989369B2 (en) | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
| US20050089515A1 (en) * | 2003-08-29 | 2005-04-28 | Dyax Corp. | Poly-pegylated protease inhibitors |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| US7276480B1 (en) | 2005-12-30 | 2007-10-02 | Dyax Corp. | Prevention and reduction of blood loss |
| CA2643693A1 (en) * | 2006-03-10 | 2007-09-20 | Dyax Corp. | Formulations for ecallantide |
| SI2379096T1 (sl) | 2008-12-19 | 2020-03-31 | Baxalta GmbH | Zaviralci TFPI in postopki uporabe |
| EP2385843A4 (en) | 2009-01-06 | 2013-02-27 | Dyax Corp | TREATMENT OF MUZOSITIS WITH CALLICINE INHIBITORS |
| CN101798346B (zh) * | 2009-02-06 | 2013-05-29 | 复旦大学 | 一种酵母表达的长效重组人组织因子途径抑制物 |
| CA3168591A1 (en) | 2010-01-06 | 2011-07-14 | Takeda Pharmaceutical Company Limited | Plasma kallikrein binding proteins |
| WO2011115712A2 (en) | 2010-03-19 | 2011-09-22 | Baxter International Inc | Tfpi inhibitors and methods of use |
| JP2014506257A (ja) | 2011-01-06 | 2014-03-13 | ダイアックス コーポレーション | 血漿カリクレイン結合タンパク質 |
| KR101391988B1 (ko) | 2011-11-04 | 2014-05-08 | 동아대학교 산학협력단 | 항섬유소용해 기능을 가진 호박벌 독액의 쿠니츠 타입 세린 프로테아제 저해 폴리펩티드 및 이를 코딩하는 염기서열 |
| DK2827883T3 (da) | 2012-03-21 | 2019-07-29 | Baxalta GmbH | Tfpi-inhibitorer og fremgangsmåder til anvendelse |
| KR102555955B1 (ko) | 2014-03-27 | 2023-07-18 | 다케다 파머수티컬 컴패니 리미티드 | 당뇨병성 황반 부종의 치료를 위한 조성물 및 방법 |
| EP3387018A1 (en) | 2015-12-11 | 2018-10-17 | Dyax Corp. | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5106833A (en) * | 1987-07-23 | 1992-04-21 | Washington University | Coagulation inhibitors |
| DK408089D0 (da) * | 1989-08-18 | 1989-08-18 | Novo Nordisk As | Proteiner |
-
1993
- 1993-01-06 IL IL10432593A patent/IL104325A/xx not_active IP Right Cessation
- 1993-01-07 JP JP51199293A patent/JP3350549B2/ja not_active Expired - Fee Related
- 1993-01-07 HU HU9401991A patent/HU218104B/hu not_active IP Right Cessation
- 1993-01-07 KR KR1019940702351A patent/KR100278036B1/ko not_active IP Right Cessation
- 1993-01-07 CA CA002127249A patent/CA2127249A1/en not_active Abandoned
- 1993-01-07 DE DE69311893T patent/DE69311893T2/de not_active Expired - Fee Related
- 1993-01-07 NZ NZ246569A patent/NZ246569A/en unknown
- 1993-01-07 CZ CZ941649A patent/CZ284911B6/cs not_active IP Right Cessation
- 1993-01-07 WO PCT/DK1993/000004 patent/WO1993014121A1/en active IP Right Grant
- 1993-01-07 ZA ZA9395A patent/ZA9395B/xx unknown
- 1993-01-07 AU AU33459/93A patent/AU676145B2/en not_active Ceased
- 1993-01-07 PL PL93304468A patent/PL175422B1/pl unknown
- 1993-01-07 EP EP93902105A patent/EP0621871B1/en not_active Expired - Lifetime
- 1993-01-07 AT AT93902105T patent/ATE154938T1/de not_active IP Right Cessation
- 1993-01-07 ES ES93902105T patent/ES2104121T3/es not_active Expired - Lifetime
-
1994
- 1994-07-06 NO NO942550A patent/NO942550L/no not_active Application Discontinuation
- 1994-07-06 FI FI943233A patent/FI943233A/fi unknown
- 1994-10-12 US US08/321,658 patent/US5576294A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69311893T2 (de) | 1998-02-05 |
| HU218104B (hu) | 2000-06-28 |
| EP0621871B1 (en) | 1997-07-02 |
| FI943233A0 (fi) | 1994-07-06 |
| NO942550D0 (no) | 1994-07-06 |
| WO1993014121A1 (en) | 1993-07-22 |
| IL104325A (en) | 2000-10-31 |
| CA2127249A1 (en) | 1993-07-22 |
| ES2104121T3 (es) | 1997-10-01 |
| NZ246569A (en) | 1996-05-28 |
| AU3345993A (en) | 1993-08-03 |
| NO942550L (no) | 1994-09-07 |
| AU676145B2 (en) | 1997-03-06 |
| ATE154938T1 (de) | 1997-07-15 |
| EP0621871A1 (en) | 1994-11-02 |
| HUT70295A (en) | 1995-09-28 |
| ZA9395B (en) | 1993-08-20 |
| IL104325A0 (en) | 1993-05-13 |
| DE69311893D1 (de) | 1997-08-07 |
| CZ284911B6 (cs) | 1999-04-14 |
| PL175422B1 (pl) | 1998-12-31 |
| HU9401991D0 (en) | 1994-09-28 |
| CZ164994A3 (en) | 1994-12-15 |
| US5576294A (en) | 1996-11-19 |
| JP3350549B2 (ja) | 2002-11-25 |
| KR100278036B1 (ko) | 2001-01-15 |
| KR940703854A (ko) | 1994-12-12 |
| JPH07506335A (ja) | 1995-07-13 |
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