NO942550L - Humanproteaseinhibitorvariant av Kunitz-type - Google Patents
Humanproteaseinhibitorvariant av Kunitz-typeInfo
- Publication number
- NO942550L NO942550L NO942550A NO942550A NO942550L NO 942550 L NO942550 L NO 942550L NO 942550 A NO942550 A NO 942550A NO 942550 A NO942550 A NO 942550A NO 942550 L NO942550 L NO 942550L
- Authority
- NO
- Norway
- Prior art keywords
- amino acid
- xaa
- naturally occurring
- occurring amino
- image
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Prostheses (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
- Amplifiers (AREA)
Abstract
Variant av humanprotease- inhibitorområde II av Kunitz-type fra vevsfaktorreaksj onsveiinhibitor (TFPI), hvor varianten omfatter den følgende aminosyresekvens X1 Asp Phe Cys Phe Leu Glu Glu Asp X2 Gly X3 Cys X4 X5 X6 Xr X8 X9 Tyr Phe Tyr Asn Asn Gin Thr Lys Gin Cys Glu Arg Phe X10 Tyr Gly Gly Cys X11 X12 X13 Met Asn Asn Phe Xu Thr Leu Glu Glu Cys Lys Asn Ile Cys Glu Asp X15 (sekvensidentitet nr. 1), hvor X1 er H eller 1-5 naturlig forekommende aminosyrerester bortsett fra Cys, X2-X14 er hver uavhengig av hverandre en naturlig forekommende aminosyrerest, og X15 er OH eller 1-5 naturlig forekommende aminosyrerester bortsett fra Cys, med det forbehold at minst en av aminosyrerestene X1-X15 er forskjellig fra den tilsvarende amino- syrerest i den naturlig forekommende sekvens.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK9200001 | 1992-01-07 | ||
PCT/DK1993/000004 WO1993014121A1 (en) | 1992-01-07 | 1993-01-07 | A human kunitz-type protease inhibitor variant |
Publications (2)
Publication Number | Publication Date |
---|---|
NO942550D0 NO942550D0 (no) | 1994-07-06 |
NO942550L true NO942550L (no) | 1994-09-07 |
Family
ID=8153770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO942550A NO942550L (no) | 1992-01-07 | 1994-07-06 | Humanproteaseinhibitorvariant av Kunitz-type |
Country Status (18)
Country | Link |
---|---|
US (1) | US5576294A (no) |
EP (1) | EP0621871B1 (no) |
JP (1) | JP3350549B2 (no) |
KR (1) | KR100278036B1 (no) |
AT (1) | ATE154938T1 (no) |
AU (1) | AU676145B2 (no) |
CA (1) | CA2127249A1 (no) |
CZ (1) | CZ284911B6 (no) |
DE (1) | DE69311893T2 (no) |
ES (1) | ES2104121T3 (no) |
FI (1) | FI943233A (no) |
HU (1) | HU218104B (no) |
IL (1) | IL104325A (no) |
NO (1) | NO942550L (no) |
NZ (1) | NZ246569A (no) |
PL (1) | PL175422B1 (no) |
WO (1) | WO1993014121A1 (no) |
ZA (1) | ZA9395B (no) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060134087A1 (en) * | 1988-09-02 | 2006-06-22 | Dyax Corp. | ITI-D1 Kunitz domain mutants as hNE inhibitors |
US5455338A (en) * | 1993-11-05 | 1995-10-03 | Zymogenetics, Inc. | DNA encoding novel human kunitz-type inhibitors and methods relating thereto |
US6057287A (en) * | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
PT739355E (pt) * | 1994-01-11 | 2005-01-31 | Dyax Corp | Proteinas de 'dominio de kunitz' inibidoras de calicreina e seus analogos |
DE69533544T2 (de) | 1994-01-11 | 2006-02-23 | Dyax Corp., Cambridge | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
US5795954A (en) * | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
EP0774001B1 (en) * | 1994-08-05 | 2002-10-16 | Chiron Corporation | Production of tissue factor pathway inhibitor |
US5589359A (en) * | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
US5780265A (en) * | 1995-06-05 | 1998-07-14 | Genentech, Inc. | Kunitz type plasma kallikrein inhibitors |
US5786328A (en) * | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
US6242414B1 (en) | 1995-06-07 | 2001-06-05 | Chiron Corporation | Regulation of cytokine synthesis and release |
US20030199450A1 (en) * | 2001-04-27 | 2003-10-23 | Chiron Corporation | Regulation of cytokine synthesis and release |
US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
YU8997A (sh) * | 1996-03-11 | 1999-09-27 | Bayer Corporation | Prečišćen protein koji ima serinsku proteaznu inhibitorsku aktivnost i farmaceutski preparat koji ga sadrži |
US20070140979A1 (en) * | 1998-12-22 | 2007-06-21 | Bayer Aktiengesellschaft | Method for accelerating the rate of mucociliary clearance |
CN1229138C (zh) * | 1998-12-22 | 2005-11-30 | 拜尔公开股份有限公司 | 加速粘液纤毛的清除速率的方法 |
GB9916913D0 (en) * | 1999-07-19 | 1999-09-22 | Natural Enviromental Research | Inhibitor proteins |
US20040054082A1 (en) * | 2001-12-03 | 2004-03-18 | Bank David H | Toughened polymer blends with improved surface properties |
ATE477020T1 (de) | 2002-06-07 | 2010-08-15 | Dyax Corp | Prevention und verringerung von ischemia |
US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
JP2005537006A (ja) | 2002-08-28 | 2005-12-08 | ダイアックス、コープ | 臓器及び組織の保存方法 |
ES2362424T3 (es) * | 2003-01-07 | 2011-07-05 | Dyax Corporation | Biblioteca del dominio kunitz. |
US6989369B2 (en) | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
US20050089515A1 (en) * | 2003-08-29 | 2005-04-28 | Dyax Corp. | Poly-pegylated protease inhibitors |
US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
US7276480B1 (en) | 2005-12-30 | 2007-10-02 | Dyax Corp. | Prevention and reduction of blood loss |
CA2643693A1 (en) * | 2006-03-10 | 2007-09-20 | Dyax Corp. | Formulations for ecallantide |
SI2379096T1 (sl) | 2008-12-19 | 2020-03-31 | Baxalta GmbH | Zaviralci TFPI in postopki uporabe |
EP2385843A4 (en) | 2009-01-06 | 2013-02-27 | Dyax Corp | TREATMENT OF MUZOSITIS WITH CALLICINE INHIBITORS |
CN101798346B (zh) * | 2009-02-06 | 2013-05-29 | 复旦大学 | 一种酵母表达的长效重组人组织因子途径抑制物 |
CA3168591A1 (en) | 2010-01-06 | 2011-07-14 | Takeda Pharmaceutical Company Limited | Plasma kallikrein binding proteins |
WO2011115712A2 (en) | 2010-03-19 | 2011-09-22 | Baxter International Inc | Tfpi inhibitors and methods of use |
JP2014506257A (ja) | 2011-01-06 | 2014-03-13 | ダイアックス コーポレーション | 血漿カリクレイン結合タンパク質 |
KR101391988B1 (ko) | 2011-11-04 | 2014-05-08 | 동아대학교 산학협력단 | 항섬유소용해 기능을 가진 호박벌 독액의 쿠니츠 타입 세린 프로테아제 저해 폴리펩티드 및 이를 코딩하는 염기서열 |
DK2827883T3 (da) | 2012-03-21 | 2019-07-29 | Baxalta GmbH | Tfpi-inhibitorer og fremgangsmåder til anvendelse |
KR102555955B1 (ko) | 2014-03-27 | 2023-07-18 | 다케다 파머수티컬 컴패니 리미티드 | 당뇨병성 황반 부종의 치료를 위한 조성물 및 방법 |
EP3387018A1 (en) | 2015-12-11 | 2018-10-17 | Dyax Corp. | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5106833A (en) * | 1987-07-23 | 1992-04-21 | Washington University | Coagulation inhibitors |
DK408089D0 (da) * | 1989-08-18 | 1989-08-18 | Novo Nordisk As | Proteiner |
-
1993
- 1993-01-06 IL IL10432593A patent/IL104325A/xx not_active IP Right Cessation
- 1993-01-07 JP JP51199293A patent/JP3350549B2/ja not_active Expired - Fee Related
- 1993-01-07 HU HU9401991A patent/HU218104B/hu not_active IP Right Cessation
- 1993-01-07 KR KR1019940702351A patent/KR100278036B1/ko not_active IP Right Cessation
- 1993-01-07 CA CA002127249A patent/CA2127249A1/en not_active Abandoned
- 1993-01-07 DE DE69311893T patent/DE69311893T2/de not_active Expired - Fee Related
- 1993-01-07 NZ NZ246569A patent/NZ246569A/en unknown
- 1993-01-07 CZ CZ941649A patent/CZ284911B6/cs not_active IP Right Cessation
- 1993-01-07 WO PCT/DK1993/000004 patent/WO1993014121A1/en active IP Right Grant
- 1993-01-07 ZA ZA9395A patent/ZA9395B/xx unknown
- 1993-01-07 AU AU33459/93A patent/AU676145B2/en not_active Ceased
- 1993-01-07 PL PL93304468A patent/PL175422B1/pl unknown
- 1993-01-07 EP EP93902105A patent/EP0621871B1/en not_active Expired - Lifetime
- 1993-01-07 AT AT93902105T patent/ATE154938T1/de not_active IP Right Cessation
- 1993-01-07 ES ES93902105T patent/ES2104121T3/es not_active Expired - Lifetime
-
1994
- 1994-07-06 NO NO942550A patent/NO942550L/no not_active Application Discontinuation
- 1994-07-06 FI FI943233A patent/FI943233A/fi unknown
- 1994-10-12 US US08/321,658 patent/US5576294A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69311893T2 (de) | 1998-02-05 |
HU218104B (hu) | 2000-06-28 |
EP0621871B1 (en) | 1997-07-02 |
FI943233A0 (fi) | 1994-07-06 |
NO942550D0 (no) | 1994-07-06 |
WO1993014121A1 (en) | 1993-07-22 |
IL104325A (en) | 2000-10-31 |
CA2127249A1 (en) | 1993-07-22 |
ES2104121T3 (es) | 1997-10-01 |
NZ246569A (en) | 1996-05-28 |
AU3345993A (en) | 1993-08-03 |
AU676145B2 (en) | 1997-03-06 |
ATE154938T1 (de) | 1997-07-15 |
EP0621871A1 (en) | 1994-11-02 |
FI943233A (fi) | 1994-07-06 |
HUT70295A (en) | 1995-09-28 |
ZA9395B (en) | 1993-08-20 |
IL104325A0 (en) | 1993-05-13 |
DE69311893D1 (de) | 1997-08-07 |
CZ284911B6 (cs) | 1999-04-14 |
PL175422B1 (pl) | 1998-12-31 |
HU9401991D0 (en) | 1994-09-28 |
CZ164994A3 (en) | 1994-12-15 |
US5576294A (en) | 1996-11-19 |
JP3350549B2 (ja) | 2002-11-25 |
KR100278036B1 (ko) | 2001-01-15 |
KR940703854A (ko) | 1994-12-12 |
JPH07506335A (ja) | 1995-07-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |