NO942549L - Humanproteaseinhibitorvariant av Kunitz-type - Google Patents

Humanproteaseinhibitorvariant av Kunitz-type

Info

Publication number
NO942549L
NO942549L NO942549A NO942549A NO942549L NO 942549 L NO942549 L NO 942549L NO 942549 A NO942549 A NO 942549A NO 942549 A NO942549 A NO 942549A NO 942549 L NO942549 L NO 942549L
Authority
NO
Norway
Prior art keywords
cys
amino acid
phe
naturally occurring
variant
Prior art date
Application number
NO942549A
Other languages
English (en)
Other versions
NO942549D0 (no
Inventor
Fanny Norris
Kjeld Norris
Soeren Erik Bjoern
Lars Christian Petersen
Ole Hvilsted Olsen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of NO942549D0 publication Critical patent/NO942549D0/no
Publication of NO942549L publication Critical patent/NO942549L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Variant av humanprotease- inhibitorområde I av Kunitz-type fra vevsfaktorreaksjonsveiinhibitor (TFPI), hvor varianten omfatter den følgende aminosyresekvens X1 Cys Ala Phe Lys Ala Asp X2 Gly X3 Cys X4 X5 X6 X7 X8 X9 Phe Phe Phe Asn Ile Phe Thr Arg Gin Cys Glu Glu Phe X10 Tyr Gly Gly Cys X11 X12 X13 Gin Asn Arg Phe X14 Ser Leu Glu Glu Cys X15 X16 Met Cys Thr Arg X17 (sekvens- identitet nr. 1), hvor X1 er H eller 1-7 naturlig forekommende aminosyre- rester bortsett fra Cys, X2-x" hver uavhengig av hverandre er en naturlig forekommende aminosyrerest, og X17 er OH eller 1-5 naturlig forekommende amino- syrerester bortsett fra Cys, med det forbehold at minst en av aminosyreres- tene X^X17 er forskjellig fra den til- svarende aminosyrerest i den naturlig forekommende sekvens.
NO942549A 1992-01-07 1994-07-06 Humanproteaseinhibitorvariant av Kunitz-type NO942549L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK9200002 1992-01-07
DK9200340 1992-11-16
PCT/DK1993/000005 WO1993014122A1 (en) 1992-01-07 1993-01-07 A human kunitz-type protease inhibitor variant

Publications (2)

Publication Number Publication Date
NO942549D0 NO942549D0 (no) 1994-07-06
NO942549L true NO942549L (no) 1994-09-07

Family

ID=26068350

Family Applications (1)

Application Number Title Priority Date Filing Date
NO942549A NO942549L (no) 1992-01-07 1994-07-06 Humanproteaseinhibitorvariant av Kunitz-type

Country Status (13)

Country Link
EP (1) EP0621872A1 (no)
JP (1) JPH07504891A (no)
AU (1) AU675926B2 (no)
CA (1) CA2127246A1 (no)
CZ (1) CZ164494A3 (no)
FI (1) FI943234A0 (no)
HU (1) HUT70293A (no)
IL (1) IL104324A0 (no)
NO (1) NO942549L (no)
NZ (1) NZ246570A (no)
RU (1) RU94036773A (no)
WO (1) WO1993014122A1 (no)
ZA (1) ZA9396B (no)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455338A (en) * 1993-11-05 1995-10-03 Zymogenetics, Inc. DNA encoding novel human kunitz-type inhibitors and methods relating thereto
PT737207E (pt) * 1994-01-11 2005-02-28 Dyax Corp Inibidores de plasmina humana derivados de dominios kunitz
DK0739355T3 (da) * 1994-01-11 2005-01-24 Dyax Corp Kallikrein-inhiberende "Kunitz-domæne"-proteiner og analoger deraf
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
ATE226249T1 (de) * 1994-08-05 2002-11-15 Chiron Corp Herstellung des inhibitors fuer die komplexbildung des gewebefaktors
US5589359A (en) * 1994-08-05 1996-12-31 Chiron Corporation Chimeric proteins
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
ATE239501T1 (de) * 1995-06-07 2003-05-15 Chiron Corp Regulierung der neutrophil elastase synthese und freisetzung
US6242414B1 (en) 1995-06-07 2001-06-05 Chiron Corporation Regulation of cytokine synthesis and release
EP1105423B1 (en) * 1998-08-25 2004-06-16 Kleesiek, Knut, Prof. Dr. A mutant of tissue factor pathway inhibitor, dna sequence and use for detecting thrombotic disorders
CN1325889A (zh) * 2000-05-26 2001-12-12 上海博德基因开发有限公司 一种新的多肽——人Kazal型抑制因子11和编码这种多肽的多核苷酸
JP2005534647A (ja) 2002-06-07 2005-11-17 ダイアックス、コープ 失血の予防及び軽減
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
US7166576B2 (en) * 2002-08-28 2007-01-23 Dyax Corp. Methods for preserving organs and tissues
US6989369B2 (en) 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
CA2536873C (en) 2003-08-29 2019-09-10 Dyax Corp. Poly-pegylated protease inhibitors
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US7276480B1 (en) 2005-12-30 2007-10-02 Dyax Corp. Prevention and reduction of blood loss
SI2379096T1 (sl) 2008-12-19 2020-03-31 Baxalta GmbH Zaviralci TFPI in postopki uporabe
AU2010203712A1 (en) 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
SI2521568T1 (sl) 2010-01-06 2019-01-31 Dyax Corp. Proteini, ki vežejo plazemski kalikrein
EP3146977A1 (en) 2010-03-19 2017-03-29 Baxalta GmbH Tfpi inhibitors and methods of use
CN103635489B (zh) 2011-01-06 2016-04-13 戴埃克斯有限公司 血浆前激肽释放酶结合蛋白
NZ629130A (en) 2012-03-21 2016-10-28 Baxalta Inc Tfpi inhibitors and methods of use
EA201891388A1 (ru) 2015-12-11 2018-11-30 Дайэкс Корп. Ингибиторы калликреина плазмы и их применение для лечения обострения наследственного ангионевротического отека

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106833A (en) * 1987-07-23 1992-04-21 Washington University Coagulation inhibitors
DK408089D0 (da) * 1989-08-18 1989-08-18 Novo Nordisk As Proteiner

Also Published As

Publication number Publication date
CZ164494A3 (en) 1994-12-15
JPH07504891A (ja) 1995-06-01
NO942549D0 (no) 1994-07-06
WO1993014122A1 (en) 1993-07-22
HU9401990D0 (en) 1994-09-28
EP0621872A1 (en) 1994-11-02
ZA9396B (en) 1993-08-10
IL104324A0 (en) 1993-05-13
NZ246570A (en) 1996-09-25
CA2127246A1 (en) 1993-07-22
AU3346093A (en) 1993-08-03
RU94036773A (ru) 1996-09-27
FI943234A (fi) 1994-07-06
AU675926B2 (en) 1997-02-27
FI943234A0 (fi) 1994-07-06
HUT70293A (en) 1995-09-28

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