CZ164494A3 - Human variant of kunitz-type protease inhibitor - Google Patents

Human variant of kunitz-type protease inhibitor Download PDF

Info

Publication number
CZ164494A3
CZ164494A3 CZ941644A CZ164494A CZ164494A3 CZ 164494 A3 CZ164494 A3 CZ 164494A3 CZ 941644 A CZ941644 A CZ 941644A CZ 164494 A CZ164494 A CZ 164494A CZ 164494 A3 CZ164494 A3 CZ 164494A3
Authority
CZ
Czechia
Prior art keywords
phe
amino acid
arg
variant
lys
Prior art date
Application number
CZ941644A
Other languages
Czech (cs)
English (en)
Inventor
Fanny Norris
Kjeld Norris
Soren Erik Bjorn
Lars Christian Petersen
Ole Hvilsted Olsen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of CZ164494A3 publication Critical patent/CZ164494A3/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CZ941644A 1992-01-07 1993-01-07 Human variant of kunitz-type protease inhibitor CZ164494A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK9200002 1992-01-07
DK9200340 1992-11-16

Publications (1)

Publication Number Publication Date
CZ164494A3 true CZ164494A3 (en) 1994-12-15

Family

ID=26068350

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ941644A CZ164494A3 (en) 1992-01-07 1993-01-07 Human variant of kunitz-type protease inhibitor

Country Status (13)

Country Link
EP (1) EP0621872A1 (no)
JP (1) JPH07504891A (no)
AU (1) AU675926B2 (no)
CA (1) CA2127246A1 (no)
CZ (1) CZ164494A3 (no)
FI (1) FI943234A (no)
HU (1) HUT70293A (no)
IL (1) IL104324A0 (no)
NO (1) NO942549L (no)
NZ (1) NZ246570A (no)
RU (1) RU94036773A (no)
WO (1) WO1993014122A1 (no)
ZA (1) ZA9396B (no)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455338A (en) * 1993-11-05 1995-10-03 Zymogenetics, Inc. DNA encoding novel human kunitz-type inhibitors and methods relating thereto
US6057287A (en) * 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
DE69533544T2 (de) * 1994-01-11 2006-02-23 Dyax Corp., Cambridge Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten
PT739355E (pt) * 1994-01-11 2005-01-31 Dyax Corp Proteinas de 'dominio de kunitz' inibidoras de calicreina e seus analogos
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
EP0774001B1 (en) * 1994-08-05 2002-10-16 Chiron Corporation Production of tissue factor pathway inhibitor
US5589359A (en) * 1994-08-05 1996-12-31 Chiron Corporation Chimeric proteins
US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
US6242414B1 (en) 1995-06-07 2001-06-05 Chiron Corporation Regulation of cytokine synthesis and release
AU708394B2 (en) * 1995-06-07 1999-08-05 Novartis Vaccines And Diagnostics, Inc. Regulation of cytokine synthesis and release
US6521410B1 (en) * 1998-08-25 2003-02-18 Knut Kleesiek Mutant of tissue factor pathway inhibitor, DNA sequence and use for detecting thrombotic disorders
CN1325889A (zh) * 2000-05-26 2001-12-12 上海博德基因开发有限公司 一种新的多肽——人Kazal型抑制因子11和编码这种多肽的多核苷酸
ATE477020T1 (de) 2002-06-07 2010-08-15 Dyax Corp Prevention und verringerung von ischemia
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
JP2005537006A (ja) * 2002-08-28 2005-12-08 ダイアックス、コープ 臓器及び組織の保存方法
US6989369B2 (en) 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
US20050089515A1 (en) 2003-08-29 2005-04-28 Dyax Corp. Poly-pegylated protease inhibitors
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US7276480B1 (en) 2005-12-30 2007-10-02 Dyax Corp. Prevention and reduction of blood loss
SI2379096T1 (sl) 2008-12-19 2020-03-31 Baxalta GmbH Zaviralci TFPI in postopki uporabe
EP2385843A4 (en) 2009-01-06 2013-02-27 Dyax Corp TREATMENT OF MUZOSITIS WITH CALLICINE INHIBITORS
CA3168591A1 (en) 2010-01-06 2011-07-14 Takeda Pharmaceutical Company Limited Plasma kallikrein binding proteins
WO2011115712A2 (en) 2010-03-19 2011-09-22 Baxter International Inc Tfpi inhibitors and methods of use
JP2014506257A (ja) 2011-01-06 2014-03-13 ダイアックス コーポレーション 血漿カリクレイン結合タンパク質
DK2827883T3 (da) 2012-03-21 2019-07-29 Baxalta GmbH Tfpi-inhibitorer og fremgangsmåder til anvendelse
EP3387018A1 (en) 2015-12-11 2018-10-17 Dyax Corp. Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106833A (en) * 1987-07-23 1992-04-21 Washington University Coagulation inhibitors
DK408089D0 (da) * 1989-08-18 1989-08-18 Novo Nordisk As Proteiner

Also Published As

Publication number Publication date
FI943234A0 (fi) 1994-07-06
NO942549L (no) 1994-09-07
NZ246570A (en) 1996-09-25
JPH07504891A (ja) 1995-06-01
FI943234A (fi) 1994-07-06
EP0621872A1 (en) 1994-11-02
CA2127246A1 (en) 1993-07-22
RU94036773A (ru) 1996-09-27
AU675926B2 (en) 1997-02-27
IL104324A0 (en) 1993-05-13
WO1993014122A1 (en) 1993-07-22
NO942549D0 (no) 1994-07-06
HUT70293A (en) 1995-09-28
HU9401990D0 (en) 1994-09-28
AU3346093A (en) 1993-08-03
ZA9396B (en) 1993-08-10

Similar Documents

Publication Publication Date Title
JP3350549B2 (ja) ヒトＫｕｎｉｔｚ型プロテアーゼ阻害剤変異体
CZ164494A3 (en) Human variant of kunitz-type protease inhibitor
AU675925B2 (en) A human kunitz-type protease inhibitor variant
AU671611B2 (en) Human kunitz-type protease inhibitor variants
JP3345420B2 (ja) 新規のヒトクニツ型プロテアーゼインヒビター及びその変異体