AU675926B2 - A human kunitz-type protease inhibitor variant - Google Patents

A human kunitz-type protease inhibitor variant

Info

Publication number
AU675926B2
AU675926B2 AU33460/93A AU3346093A AU675926B2 AU 675926 B2 AU675926 B2 AU 675926B2 AU 33460/93 A AU33460/93 A AU 33460/93A AU 3346093 A AU3346093 A AU 3346093A AU 675926 B2 AU675926 B2 AU 675926B2
Authority
AU
Australia
Prior art keywords
phe
arg
variant according
lys
glu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU33460/93A
Other languages
English (en)
Other versions
AU3346093A (en
Inventor
Soren Erik Bjorn
Fanny Norris
Kjeld Norris
Ole Hvilsted Olsen
Lars Christian Petersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of AU3346093A publication Critical patent/AU3346093A/en
Application granted granted Critical
Publication of AU675926B2 publication Critical patent/AU675926B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AU33460/93A 1992-01-07 1993-01-07 A human kunitz-type protease inhibitor variant Ceased AU675926B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
WODK9200002 1992-01-07
DK9200002 1992-01-07
DK9200340 1992-11-16
WODK9200340 1992-11-16
PCT/DK1993/000005 WO1993014122A1 (en) 1992-01-07 1993-01-07 A human kunitz-type protease inhibitor variant

Publications (2)

Publication Number Publication Date
AU3346093A AU3346093A (en) 1993-08-03
AU675926B2 true AU675926B2 (en) 1997-02-27

Family

ID=26068350

Family Applications (1)

Application Number Title Priority Date Filing Date
AU33460/93A Ceased AU675926B2 (en) 1992-01-07 1993-01-07 A human kunitz-type protease inhibitor variant

Country Status (13)

Country Link
EP (1) EP0621872A1 (no)
JP (1) JPH07504891A (no)
AU (1) AU675926B2 (no)
CA (1) CA2127246A1 (no)
CZ (1) CZ164494A3 (no)
FI (1) FI943234A (no)
HU (1) HUT70293A (no)
IL (1) IL104324A0 (no)
NO (1) NO942549L (no)
NZ (1) NZ246570A (no)
RU (1) RU94036773A (no)
WO (1) WO1993014122A1 (no)
ZA (1) ZA9396B (no)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455338A (en) * 1993-11-05 1995-10-03 Zymogenetics, Inc. DNA encoding novel human kunitz-type inhibitors and methods relating thereto
US6057287A (en) * 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
DE69533544T2 (de) * 1994-01-11 2006-02-23 Dyax Corp., Cambridge Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten
PT739355E (pt) * 1994-01-11 2005-01-31 Dyax Corp Proteinas de 'dominio de kunitz' inibidoras de calicreina e seus analogos
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
EP0774001B1 (en) * 1994-08-05 2002-10-16 Chiron Corporation Production of tissue factor pathway inhibitor
US5589359A (en) * 1994-08-05 1996-12-31 Chiron Corporation Chimeric proteins
US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
US6242414B1 (en) 1995-06-07 2001-06-05 Chiron Corporation Regulation of cytokine synthesis and release
AU708394B2 (en) * 1995-06-07 1999-08-05 Novartis Vaccines And Diagnostics, Inc. Regulation of cytokine synthesis and release
US6521410B1 (en) * 1998-08-25 2003-02-18 Knut Kleesiek Mutant of tissue factor pathway inhibitor, DNA sequence and use for detecting thrombotic disorders
CN1325889A (zh) * 2000-05-26 2001-12-12 上海博德基因开发有限公司 一种新的多肽——人Kazal型抑制因子11和编码这种多肽的多核苷酸
ATE477020T1 (de) 2002-06-07 2010-08-15 Dyax Corp Prevention und verringerung von ischemia
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
JP2005537006A (ja) * 2002-08-28 2005-12-08 ダイアックス、コープ 臓器及び組織の保存方法
US6989369B2 (en) 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
US20050089515A1 (en) 2003-08-29 2005-04-28 Dyax Corp. Poly-pegylated protease inhibitors
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US7276480B1 (en) 2005-12-30 2007-10-02 Dyax Corp. Prevention and reduction of blood loss
SI2379096T1 (sl) 2008-12-19 2020-03-31 Baxalta GmbH Zaviralci TFPI in postopki uporabe
EP2385843A4 (en) 2009-01-06 2013-02-27 Dyax Corp TREATMENT OF MUZOSITIS WITH CALLICINE INHIBITORS
CA3168591A1 (en) 2010-01-06 2011-07-14 Takeda Pharmaceutical Company Limited Plasma kallikrein binding proteins
WO2011115712A2 (en) 2010-03-19 2011-09-22 Baxter International Inc Tfpi inhibitors and methods of use
JP2014506257A (ja) 2011-01-06 2014-03-13 ダイアックス コーポレーション 血漿カリクレイン結合タンパク質
DK2827883T3 (da) 2012-03-21 2019-07-29 Baxalta GmbH Tfpi-inhibitorer og fremgangsmåder til anvendelse
EP3387018A1 (en) 2015-12-11 2018-10-17 Dyax Corp. Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6285290A (en) * 1989-08-18 1991-04-03 Novo Nordisk A/S Anticoagulant protein

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106833A (en) * 1987-07-23 1992-04-21 Washington University Coagulation inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6285290A (en) * 1989-08-18 1991-04-03 Novo Nordisk A/S Anticoagulant protein

Also Published As

Publication number Publication date
FI943234A0 (fi) 1994-07-06
NO942549L (no) 1994-09-07
NZ246570A (en) 1996-09-25
JPH07504891A (ja) 1995-06-01
FI943234A (fi) 1994-07-06
EP0621872A1 (en) 1994-11-02
CA2127246A1 (en) 1993-07-22
CZ164494A3 (en) 1994-12-15
RU94036773A (ru) 1996-09-27
IL104324A0 (en) 1993-05-13
WO1993014122A1 (en) 1993-07-22
NO942549D0 (no) 1994-07-06
HUT70293A (en) 1995-09-28
HU9401990D0 (en) 1994-09-28
AU3346093A (en) 1993-08-03
ZA9396B (en) 1993-08-10

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired