ES2104121T3 - Variante de un inhibidor de proteasas, de tipo kunitz, de origen humano. - Google Patents
Variante de un inhibidor de proteasas, de tipo kunitz, de origen humano.Info
- Publication number
- ES2104121T3 ES2104121T3 ES93902105T ES93902105T ES2104121T3 ES 2104121 T3 ES2104121 T3 ES 2104121T3 ES 93902105 T ES93902105 T ES 93902105T ES 93902105 T ES93902105 T ES 93902105T ES 2104121 T3 ES2104121 T3 ES 2104121T3
- Authority
- ES
- Spain
- Prior art keywords
- amino acid
- xaa
- naturally occurring
- variant
- occurring amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Prostheses (AREA)
- Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Amplifiers (AREA)
Abstract
UNA VARIANTE DEL CAMPO INHIBIDOR DE PROTEASA DE TIPO KUNITZ HUMANO II DE INHIBIDOR DE PASO DE FACTOR DE TEJIDO (TFPI), COMPRENDIENDO LA VARIANTE LA SIGUIENTE SECUENCIA AMINOACIDA X1 ASP PHE CYS PHE GLU GLU ASP X2 GLY X3 CYS X4 X5 X6 X7 X8 X9 TYR PHE TYR ASN AS GLN THR LYS GLN CYS GLU ARG PHE X10 TYR GLY GLY CYS X11 X12 X13 MET ASN PHE X14 THR LEU GLU GLU CYS -LYS ASN ILE CYS GLU ASP X15(SEQ ID NO 1) EN LA QUE X1 REPRESENTA H O 1-5 RESIDUOS AMINOACIDOS PRODUCIDOS NATURALMENTE EXCEPTO CYS, X2-X14 CADA UNO INDEPENDIENTEMENTE REPRESENTA UN RESIDUO AMINOACIDO PRODUCIDO NATURALMENTE, Y X15 REPRESENTA OH, O 1-5 RESIDUOS AMINOACIDOS PRODUCIDOS NATURALMENTE EXCEPTO CYS, SIEMPRE QUE UNO DE LOS RESIDUOS AMINOACIDOS X1-X15 SEA DIFERENTE DEL RESIDUO AMINOACIDO CORRESPONDIENTE DE LA SECUENCIA NATIVA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK9200001 | 1992-01-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2104121T3 true ES2104121T3 (es) | 1997-10-01 |
Family
ID=8153770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93902105T Expired - Lifetime ES2104121T3 (es) | 1992-01-07 | 1993-01-07 | Variante de un inhibidor de proteasas, de tipo kunitz, de origen humano. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5576294A (es) |
| EP (1) | EP0621871B1 (es) |
| JP (1) | JP3350549B2 (es) |
| KR (1) | KR100278036B1 (es) |
| AT (1) | ATE154938T1 (es) |
| AU (1) | AU676145B2 (es) |
| CA (1) | CA2127249A1 (es) |
| CZ (1) | CZ284911B6 (es) |
| DE (1) | DE69311893T2 (es) |
| ES (1) | ES2104121T3 (es) |
| FI (1) | FI943233A0 (es) |
| HU (1) | HU218104B (es) |
| IL (1) | IL104325A (es) |
| NO (1) | NO942550L (es) |
| NZ (1) | NZ246569A (es) |
| PL (1) | PL175422B1 (es) |
| WO (1) | WO1993014121A1 (es) |
| ZA (1) | ZA9395B (es) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060134087A1 (en) * | 1988-09-02 | 2006-06-22 | Dyax Corp. | ITI-D1 Kunitz domain mutants as hNE inhibitors |
| US5455338A (en) | 1993-11-05 | 1995-10-03 | Zymogenetics, Inc. | DNA encoding novel human kunitz-type inhibitors and methods relating thereto |
| US6057287A (en) * | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| ATE277081T1 (de) * | 1994-01-11 | 2004-10-15 | Dyax Corp | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
| ATE275583T1 (de) * | 1994-01-11 | 2004-09-15 | Dyax Corp | KALLIKREINHEMMENDE ßKUNITZ-DOMÄNEß-PROTEINE UND DERIVATEN DAVON |
| US5795954A (en) * | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
| AU707762B2 (en) * | 1994-08-05 | 1999-07-22 | Novartis Vaccines And Diagnostics, Inc. | Production of tissue factor pathway inhibitor |
| US5589359A (en) | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
| US5786328A (en) * | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
| US5780265A (en) * | 1995-06-05 | 1998-07-14 | Genentech, Inc. | Kunitz type plasma kallikrein inhibitors |
| US6242414B1 (en) | 1995-06-07 | 2001-06-05 | Chiron Corporation | Regulation of cytokine synthesis and release |
| US20030199450A1 (en) * | 2001-04-27 | 2003-10-23 | Chiron Corporation | Regulation of cytokine synthesis and release |
| US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
| BR9708021A (pt) * | 1996-03-11 | 1999-07-27 | Bayer Ag | Proteína substancialmente purificada composição farmacêutica sequência de ácido nucleico isolada vetor de express o de protéina auto-replicante e processos para inibir a atividade de protéinas de serina tratar uma condição e preparar um medicamento de uma proteína |
| CA2356404C (en) * | 1998-12-22 | 2010-03-30 | Bayer Aktiengesellschaft | Method for accelerating the rate of mucociliary clearance |
| US20070140979A1 (en) * | 1998-12-22 | 2007-06-21 | Bayer Aktiengesellschaft | Method for accelerating the rate of mucociliary clearance |
| GB9916913D0 (en) * | 1999-07-19 | 1999-09-22 | Natural Enviromental Research | Inhibitor proteins |
| US20040054082A1 (en) * | 2001-12-03 | 2004-03-18 | Bank David H | Toughened polymer blends with improved surface properties |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| ATE528014T1 (de) * | 2002-06-07 | 2011-10-15 | Dyax Corp | Polypeptid mit modifizierten kunitz domains |
| SI2386310T1 (sl) * | 2002-08-28 | 2019-03-29 | Dyax Corp. | Metode za ohranjanje organov in tkiv |
| DE602004031589D1 (de) * | 2003-01-07 | 2011-04-14 | Dyax Corp | Kunitz-domäne-bibliothek |
| US6989369B2 (en) | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
| AU2004268145B2 (en) | 2003-08-29 | 2010-09-16 | Takeda Pharmaceutical Company Limited | Poly-PEGylated protease inhibitors |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| US7276480B1 (en) | 2005-12-30 | 2007-10-02 | Dyax Corp. | Prevention and reduction of blood loss |
| WO2007106746A2 (en) * | 2006-03-10 | 2007-09-20 | Dyax Corp. | Formulations for ecallantide |
| KR102165021B1 (ko) | 2008-12-19 | 2020-10-14 | 박스알타 인코퍼레이티드 | Tfpi 억제제 및 사용 방법 |
| WO2010080833A1 (en) | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
| CN101798346B (zh) * | 2009-02-06 | 2013-05-29 | 复旦大学 | 一种酵母表达的长效重组人组织因子途径抑制物 |
| HUE057244T2 (hu) | 2010-01-06 | 2022-04-28 | Takeda Pharmaceuticals Co | Plazma kallikreint kötõ fehérjék |
| JP5730983B2 (ja) | 2010-03-19 | 2015-06-10 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | Ｔｆｐｉ阻害剤および使用方法 |
| JP2014506257A (ja) | 2011-01-06 | 2014-03-13 | ダイアックス コーポレーション | 血漿カリクレイン結合タンパク質 |
| KR101391988B1 (ko) | 2011-11-04 | 2014-05-08 | 동아대학교 산학협력단 | 항섬유소용해 기능을 가진 호박벌 독액의 쿠니츠 타입 세린 프로테아제 저해 폴리펩티드 및 이를 코딩하는 염기서열 |
| SI2827883T1 (sl) | 2012-03-21 | 2019-08-30 | Baxalta GmbH | Inhibitorji TFPI in postopki uporabe |
| JP6719384B2 (ja) | 2014-03-27 | 2020-07-15 | ダイアックス コーポレーション | 糖尿病黄斑浮腫の治療のための組成物および方法 |
| US11286307B2 (en) | 2015-12-11 | 2022-03-29 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5106833A (en) * | 1987-07-23 | 1992-04-21 | Washington University | Coagulation inhibitors |
| DK408089D0 (da) * | 1989-08-18 | 1989-08-18 | Novo Nordisk As | Proteiner |
-
1993
- 1993-01-06 IL IL10432593A patent/IL104325A/xx not_active IP Right Cessation
- 1993-01-07 CA CA002127249A patent/CA2127249A1/en not_active Abandoned
- 1993-01-07 AT AT93902105T patent/ATE154938T1/de not_active IP Right Cessation
- 1993-01-07 DE DE69311893T patent/DE69311893T2/de not_active Expired - Fee Related
- 1993-01-07 ES ES93902105T patent/ES2104121T3/es not_active Expired - Lifetime
- 1993-01-07 NZ NZ246569A patent/NZ246569A/en unknown
- 1993-01-07 PL PL93304468A patent/PL175422B1/pl unknown
- 1993-01-07 JP JP51199293A patent/JP3350549B2/ja not_active Expired - Fee Related
- 1993-01-07 ZA ZA9395A patent/ZA9395B/xx unknown
- 1993-01-07 EP EP93902105A patent/EP0621871B1/en not_active Expired - Lifetime
- 1993-01-07 KR KR1019940702351A patent/KR100278036B1/ko not_active IP Right Cessation
- 1993-01-07 CZ CZ941649A patent/CZ284911B6/cs not_active IP Right Cessation
- 1993-01-07 WO PCT/DK1993/000004 patent/WO1993014121A1/en active IP Right Grant
- 1993-01-07 AU AU33459/93A patent/AU676145B2/en not_active Ceased
- 1993-01-07 HU HU9401991A patent/HU218104B/hu not_active IP Right Cessation
-
1994
- 1994-07-06 NO NO942550A patent/NO942550L/no not_active Application Discontinuation
- 1994-07-06 FI FI943233A patent/FI943233A0/fi unknown
- 1994-10-12 US US08/321,658 patent/US5576294A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1993014121A1 (en) | 1993-07-22 |
| ATE154938T1 (de) | 1997-07-15 |
| ZA9395B (en) | 1993-08-20 |
| HU9401991D0 (en) | 1994-09-28 |
| NO942550L (no) | 1994-09-07 |
| EP0621871A1 (en) | 1994-11-02 |
| FI943233A (fi) | 1994-07-06 |
| KR100278036B1 (ko) | 2001-01-15 |
| DE69311893D1 (de) | 1997-08-07 |
| DE69311893T2 (de) | 1998-02-05 |
| US5576294A (en) | 1996-11-19 |
| JPH07506335A (ja) | 1995-07-13 |
| HU218104B (hu) | 2000-06-28 |
| CA2127249A1 (en) | 1993-07-22 |
| CZ164994A3 (en) | 1994-12-15 |
| CZ284911B6 (cs) | 1999-04-14 |
| PL175422B1 (pl) | 1998-12-31 |
| AU676145B2 (en) | 1997-03-06 |
| JP3350549B2 (ja) | 2002-11-25 |
| HUT70295A (en) | 1995-09-28 |
| NZ246569A (en) | 1996-05-28 |
| IL104325A (en) | 2000-10-31 |
| FI943233A0 (fi) | 1994-07-06 |
| NO942550D0 (no) | 1994-07-06 |
| AU3345993A (en) | 1993-08-03 |
| KR940703854A (ko) | 1994-12-12 |
| EP0621871B1 (en) | 1997-07-02 |
| IL104325A0 (en) | 1993-05-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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