ATE171712T1 - Neuartiger menschlicher proteaseinhibitor vom kunitz-typ und entsprechende varianten - Google Patents

Neuartiger menschlicher proteaseinhibitor vom kunitz-typ und entsprechende varianten

Info

Publication number
ATE171712T1
ATE171712T1 AT93902107T AT93902107T ATE171712T1 AT E171712 T1 ATE171712 T1 AT E171712T1 AT 93902107 T AT93902107 T AT 93902107T AT 93902107 T AT93902107 T AT 93902107T AT E171712 T1 ATE171712 T1 AT E171712T1
Authority
AT
Austria
Prior art keywords
phe
cys
gly
glu
asn
Prior art date
Application number
AT93902107T
Other languages
English (en)
Inventor
Fanny Norris
Kjeld Norris
Rn S Ren Erik Bj
Lars Christian Petersen
Ole Hvilsted Olsen
Donald Cameron Foster
Cindy Ann Sprecher
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE171712T1 publication Critical patent/ATE171712T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Detergent Compositions (AREA)
AT93902107T 1992-01-07 1993-01-07 Neuartiger menschlicher proteaseinhibitor vom kunitz-typ und entsprechende varianten ATE171712T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK9200003 1992-01-07

Publications (1)

Publication Number Publication Date
ATE171712T1 true ATE171712T1 (de) 1998-10-15

Family

ID=8153772

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93902107T ATE171712T1 (de) 1992-01-07 1993-01-07 Neuartiger menschlicher proteaseinhibitor vom kunitz-typ und entsprechende varianten

Country Status (17)

Country Link
US (1) US5618696A (de)
EP (1) EP0621873B1 (de)
JP (1) JP3345420B2 (de)
KR (1) KR940703860A (de)
AT (1) ATE171712T1 (de)
AU (1) AU670059B2 (de)
CA (1) CA2127247A1 (de)
CZ (1) CZ164894A3 (de)
DE (1) DE69321342T2 (de)
ES (1) ES2123635T3 (de)
FI (1) FI943235A0 (de)
HU (1) HUT70291A (de)
IL (1) IL104314A0 (de)
NO (1) NO942553L (de)
NZ (1) NZ246571A (de)
WO (1) WO1993014123A1 (de)
ZA (1) ZA9394B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060134087A1 (en) * 1988-09-02 2006-06-22 Dyax Corp. ITI-D1 Kunitz domain mutants as hNE inhibitors
US5663143A (en) * 1988-09-02 1997-09-02 Dyax Corp. Engineered human-derived kunitz domains that inhibit human neutrophil elastase
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
US6242414B1 (en) 1995-06-07 2001-06-05 Chiron Corporation Regulation of cytokine synthesis and release
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
PT2311432E (pt) 2002-06-07 2015-02-09 Dyax Corp Polipeptídeos de domínio kunitz modificado e sua utilização para a redução de isquemia ou aparecimento de uma resposta inflamatória sistémica associada a um procedimento cirúrgico
AU2004204095B2 (en) * 2003-01-07 2009-07-30 Dyax Corporation Kunitz domain library
CA2573368A1 (en) * 2004-07-13 2006-02-16 Bayer Pharmaceuticals Corporation Improved aprotinin variants
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
SI1981519T1 (en) 2005-12-29 2018-05-31 Dyax Corp. INHIBITION PROTEAZE
WO2009026334A2 (en) * 2007-08-21 2009-02-26 Genzyme Corporation Treatment with kallikrein inhibitors
CN101952309A (zh) * 2007-12-21 2011-01-19 Ifxa有限公司 蛋白酶抑制剂
ES2773766T3 (es) 2008-12-19 2020-07-14 Baxalta GmbH Inhibidores de TFPI y métodos de uso
AU2010203712A1 (en) * 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
LT2521568T (lt) * 2010-01-06 2018-12-10 Dyax Corp. Plazmos kalikreiną surišantys baltymai
AU2011227714B2 (en) 2010-03-19 2014-09-04 Takeda Pharmaceutical Company Limited TFPI inhibitors and methods of use
CN105713092B (zh) 2011-01-06 2019-09-10 戴埃克斯有限公司 血浆前激肽释放酶结合蛋白
CA2867363C (en) 2012-03-21 2023-02-28 Baxter International Inc. Tfpi inhibitors and methods of use
KR102555955B1 (ko) 2014-03-27 2023-07-18 다케다 파머수티컬 컴패니 리미티드 당뇨병성 황반 부종의 치료를 위한 조성물 및 방법
AU2016366557B2 (en) 2015-12-11 2024-01-25 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
EP3468605A4 (de) 2016-06-08 2020-01-08 President and Fellows of Harvard College Manipulierter viraler vektor zur reduzierung von induktion von entzündungs- und immunreaktionen
WO2019094548A1 (en) 2017-11-08 2019-05-16 President And Fellows Of Harvard College Compositions and methods for inhibiting viral vector-induced inflammatory responses

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2199582A (en) * 1987-01-07 1988-07-13 Bayer Ag Analogues of pancreatic secretory trypsin inhibitor
DE3724570A1 (de) * 1987-06-27 1989-01-05 Bayer Ag Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist
US5106833A (en) * 1987-07-23 1992-04-21 Washington University Coagulation inhibitors
US4966852A (en) * 1987-07-23 1990-10-30 Monsanto Company DNA clone of human tissue factor inhibitor
DK225488D0 (da) * 1988-04-26 1988-04-26 Novo Industri As Polypeptid
JPH07102137B2 (ja) * 1988-07-19 1995-11-08 塩野義製薬株式会社 修飾ヒトｐｓｔｉ

Also Published As

Publication number Publication date
NZ246571A (en) 1996-09-25
WO1993014123A1 (en) 1993-07-22
KR940703860A (ko) 1994-12-12
ZA9394B (en) 1993-08-10
CA2127247A1 (en) 1993-07-22
CZ164894A3 (en) 1994-12-15
AU3346193A (en) 1993-08-03
NO942553D0 (no) 1994-07-06
JP3345420B2 (ja) 2002-11-18
HU9401989D0 (en) 1994-09-28
ES2123635T3 (es) 1999-01-16
IL104314A0 (en) 1993-05-13
AU670059B2 (en) 1996-07-04
US5618696A (en) 1997-04-08
DE69321342T2 (de) 1999-04-01
EP0621873B1 (de) 1998-09-30
HUT70291A (en) 1995-09-28
DE69321342D1 (de) 1998-11-05
FI943235A (fi) 1994-07-06
NO942553L (no) 1994-09-07
EP0621873A1 (de) 1994-11-02
JPH07504652A (ja) 1995-05-25
FI943235A0 (fi) 1994-07-06

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