IL104314A0 - Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them - Google Patents
Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing themInfo
- Publication number
- IL104314A0 IL104314A0 IL104314A IL10431493A IL104314A0 IL 104314 A0 IL104314 A0 IL 104314A0 IL 104314 A IL104314 A IL 104314A IL 10431493 A IL10431493 A IL 10431493A IL 104314 A0 IL104314 A0 IL 104314A0
- Authority
- IL
- Israel
- Prior art keywords
- phe
- cys
- gly
- glu
- protease inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Detergent Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK9200003 | 1992-01-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL104314A0 true IL104314A0 (en) | 1993-05-13 |
Family
ID=8153772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL104314A IL104314A0 (en) | 1992-01-07 | 1993-01-06 | Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them |
Country Status (17)
Country | Link |
---|---|
US (1) | US5618696A (de) |
EP (1) | EP0621873B1 (de) |
JP (1) | JP3345420B2 (de) |
KR (1) | KR940703860A (de) |
AT (1) | ATE171712T1 (de) |
AU (1) | AU670059B2 (de) |
CA (1) | CA2127247A1 (de) |
CZ (1) | CZ164894A3 (de) |
DE (1) | DE69321342T2 (de) |
ES (1) | ES2123635T3 (de) |
FI (1) | FI943235A0 (de) |
HU (1) | HUT70291A (de) |
IL (1) | IL104314A0 (de) |
NO (1) | NO942553L (de) |
NZ (1) | NZ246571A (de) |
WO (1) | WO1993014123A1 (de) |
ZA (1) | ZA9394B (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060134087A1 (en) * | 1988-09-02 | 2006-06-22 | Dyax Corp. | ITI-D1 Kunitz domain mutants as hNE inhibitors |
US5663143A (en) * | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
US5795954A (en) * | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
US5780265A (en) * | 1995-06-05 | 1998-07-14 | Genentech, Inc. | Kunitz type plasma kallikrein inhibitors |
US5786328A (en) * | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
US6242414B1 (en) | 1995-06-07 | 2001-06-05 | Chiron Corporation | Regulation of cytokine synthesis and release |
US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
PT2311432E (pt) | 2002-06-07 | 2015-02-09 | Dyax Corp | Polipeptídeos de domínio kunitz modificado e sua utilização para a redução de isquemia ou aparecimento de uma resposta inflamatória sistémica associada a um procedimento cirúrgico |
AU2004204095B2 (en) * | 2003-01-07 | 2009-07-30 | Dyax Corporation | Kunitz domain library |
CA2573368A1 (en) * | 2004-07-13 | 2006-02-16 | Bayer Pharmaceuticals Corporation | Improved aprotinin variants |
US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
SI1981519T1 (en) | 2005-12-29 | 2018-05-31 | Dyax Corp. | INHIBITION PROTEAZE |
WO2009026334A2 (en) * | 2007-08-21 | 2009-02-26 | Genzyme Corporation | Treatment with kallikrein inhibitors |
CN101952309A (zh) * | 2007-12-21 | 2011-01-19 | Ifxa有限公司 | 蛋白酶抑制剂 |
ES2773766T3 (es) | 2008-12-19 | 2020-07-14 | Baxalta GmbH | Inhibidores de TFPI y métodos de uso |
AU2010203712A1 (en) * | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
LT2521568T (lt) * | 2010-01-06 | 2018-12-10 | Dyax Corp. | Plazmos kalikreiną surišantys baltymai |
AU2011227714B2 (en) | 2010-03-19 | 2014-09-04 | Takeda Pharmaceutical Company Limited | TFPI inhibitors and methods of use |
CN105713092B (zh) | 2011-01-06 | 2019-09-10 | 戴埃克斯有限公司 | 血浆前激肽释放酶结合蛋白 |
CA2867363C (en) | 2012-03-21 | 2023-02-28 | Baxter International Inc. | Tfpi inhibitors and methods of use |
KR102555955B1 (ko) | 2014-03-27 | 2023-07-18 | 다케다 파머수티컬 컴패니 리미티드 | 당뇨병성 황반 부종의 치료를 위한 조성물 및 방법 |
AU2016366557B2 (en) | 2015-12-11 | 2024-01-25 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
EP3468605A4 (de) | 2016-06-08 | 2020-01-08 | President and Fellows of Harvard College | Manipulierter viraler vektor zur reduzierung von induktion von entzündungs- und immunreaktionen |
WO2019094548A1 (en) | 2017-11-08 | 2019-05-16 | President And Fellows Of Harvard College | Compositions and methods for inhibiting viral vector-induced inflammatory responses |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2199582A (en) * | 1987-01-07 | 1988-07-13 | Bayer Ag | Analogues of pancreatic secretory trypsin inhibitor |
DE3724570A1 (de) * | 1987-06-27 | 1989-01-05 | Bayer Ag | Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist |
US5106833A (en) * | 1987-07-23 | 1992-04-21 | Washington University | Coagulation inhibitors |
US4966852A (en) * | 1987-07-23 | 1990-10-30 | Monsanto Company | DNA clone of human tissue factor inhibitor |
DK225488D0 (da) * | 1988-04-26 | 1988-04-26 | Novo Industri As | Polypeptid |
JPH07102137B2 (ja) * | 1988-07-19 | 1995-11-08 | 塩野義製薬株式会社 | 修飾ヒトpsti |
-
1993
- 1993-01-06 IL IL104314A patent/IL104314A0/xx unknown
- 1993-01-07 ZA ZA9394A patent/ZA9394B/xx unknown
- 1993-01-07 HU HU9401989A patent/HUT70291A/hu unknown
- 1993-01-07 JP JP51208493A patent/JP3345420B2/ja not_active Expired - Fee Related
- 1993-01-07 EP EP93902107A patent/EP0621873B1/de not_active Expired - Lifetime
- 1993-01-07 CA CA002127247A patent/CA2127247A1/en not_active Abandoned
- 1993-01-07 WO PCT/DK1993/000006 patent/WO1993014123A1/en not_active Application Discontinuation
- 1993-01-07 AT AT93902107T patent/ATE171712T1/de not_active IP Right Cessation
- 1993-01-07 KR KR1019940702349A patent/KR940703860A/ko not_active Application Discontinuation
- 1993-01-07 DE DE69321342T patent/DE69321342T2/de not_active Expired - Fee Related
- 1993-01-07 CZ CZ941648A patent/CZ164894A3/cs unknown
- 1993-01-07 ES ES93902107T patent/ES2123635T3/es not_active Expired - Lifetime
- 1993-01-07 NZ NZ246571A patent/NZ246571A/en unknown
- 1993-01-07 AU AU33461/93A patent/AU670059B2/en not_active Ceased
-
1994
- 1994-07-06 FI FI943235A patent/FI943235A0/fi unknown
- 1994-07-06 NO NO942553A patent/NO942553L/no unknown
-
1995
- 1995-02-06 US US08/384,489 patent/US5618696A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NZ246571A (en) | 1996-09-25 |
WO1993014123A1 (en) | 1993-07-22 |
KR940703860A (ko) | 1994-12-12 |
ZA9394B (en) | 1993-08-10 |
CA2127247A1 (en) | 1993-07-22 |
CZ164894A3 (en) | 1994-12-15 |
AU3346193A (en) | 1993-08-03 |
NO942553D0 (no) | 1994-07-06 |
JP3345420B2 (ja) | 2002-11-18 |
HU9401989D0 (en) | 1994-09-28 |
ES2123635T3 (es) | 1999-01-16 |
AU670059B2 (en) | 1996-07-04 |
US5618696A (en) | 1997-04-08 |
DE69321342T2 (de) | 1999-04-01 |
EP0621873B1 (de) | 1998-09-30 |
ATE171712T1 (de) | 1998-10-15 |
HUT70291A (en) | 1995-09-28 |
DE69321342D1 (de) | 1998-11-05 |
FI943235A (fi) | 1994-07-06 |
NO942553L (no) | 1994-09-07 |
EP0621873A1 (de) | 1994-11-02 |
JPH07504652A (ja) | 1995-05-25 |
FI943235A0 (fi) | 1994-07-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL104314A0 (en) | Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them | |
EP1531791A4 (de) | PRûVENTION UND VERRINGERUNG VON BLUTVERLUST | |
UA35636C2 (uk) | Поліпептид, який має активність легеневої поверхнево-активної речовини, та фармацевтична композиція для лікування респіраторного дистрес-синдрому у ссавців | |
AU633913B2 (en) | Novel tnf-inhibit proteins and their preparation | |
HUP0003592A2 (hu) | LH-RH peptid analógok, alkalmazásuk, és ezeket tartalmazó gyógyászati készítmények | |
IL104325A (en) | Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above | |
MD1652G2 (ro) | Proteină cu activitate de tip citochină, ADN recombinant, codificator pentru această proteină, celule şi microorganisme transformate, vector de expresie, procedeu de obţinere a proteinei şi remediu care conţine această proteină | |
AU5963290A (en) | Inhibition of the n-end rule pathway in living cells | |
YU29596A (sh) | Genski proizvodi koji regulišu gojaznost | |
CA2002924A1 (en) | Anti-Thrombins | |
CA2083837A1 (en) | Recombinant dna coding for a novel protein having .beta.-1,3 glucanase activity, bacteria containing this dna, transformed plant cells and plants | |
NZ334714A (en) | Liver proteins as agents against autoimmune diseases | |
CA2077590A1 (en) | Recombinant dna coding for a protein with endochitinase activity | |
AU585167B2 (en) | Novel substrate peptides | |
AU8302791A (en) | Recombinant gene coding for a protein having an endochitinase activity | |
RU94036002A (ru) | Ингибитор протеазы, днк, вектор, клетка, способ получения ингибитора, фармацевтическая композиция | |
WO1999057262A3 (de) | An metallionen bindendes peptid | |
EP1225184A4 (de) | Menschliche antithrombin-varianten | |
PT100299A (pt) | Analogo de hirudina, metodo para a sua producao e anti-coagulante contendo-o, e vector de secrecao , microorganismos transformados com o referido vector e metodo para a producao de produtos a partir dos referidos microorganismos |