ES2123635T3 - Nuevo inhibidor de la proteasa humana de tipo kunitz y sus variantes. - Google Patents
Nuevo inhibidor de la proteasa humana de tipo kunitz y sus variantes.Info
- Publication number
- ES2123635T3 ES2123635T3 ES93902107T ES93902107T ES2123635T3 ES 2123635 T3 ES2123635 T3 ES 2123635T3 ES 93902107 T ES93902107 T ES 93902107T ES 93902107 T ES93902107 T ES 93902107T ES 2123635 T3 ES2123635 T3 ES 2123635T3
- Authority
- ES
- Spain
- Prior art keywords
- phe
- cys
- gly
- glu
- protease inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Detergent Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
UNA INHIBIDOR DE PROTEASA DE TIPO KUNITZ HUMANO QUE COMPRENDE LA SIGUIENTE SECUENCIA AMINOACIDA LEU PRO ASN CYSALA PHE PRO MET GLU LYS PRO CYS GLN THRM TYR MET THR ARG TRP PHE PHE ASN PHE THR GLY GLU CYS GLU LEU PHE ALA TYR GLY GLY CYS GLY GLY ASN SER ASN ASN PHE LEU ARG LYS GLU LYS CYS GLU LYS PHE CYS PHE THR (SEQ ID NO 1) O UNA VARIANTE DE ESTA CON PROPIEDADES DE INHIBIDOR DE PROTEASA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK9200003 | 1992-01-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2123635T3 true ES2123635T3 (es) | 1999-01-16 |
Family
ID=8153772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93902107T Expired - Lifetime ES2123635T3 (es) | 1992-01-07 | 1993-01-07 | Nuevo inhibidor de la proteasa humana de tipo kunitz y sus variantes. |
Country Status (17)
Country | Link |
---|---|
US (1) | US5618696A (es) |
EP (1) | EP0621873B1 (es) |
JP (1) | JP3345420B2 (es) |
KR (1) | KR940703860A (es) |
AT (1) | ATE171712T1 (es) |
AU (1) | AU670059B2 (es) |
CA (1) | CA2127247A1 (es) |
CZ (1) | CZ164894A3 (es) |
DE (1) | DE69321342T2 (es) |
ES (1) | ES2123635T3 (es) |
FI (1) | FI943235A (es) |
HU (1) | HUT70291A (es) |
IL (1) | IL104314A0 (es) |
NO (1) | NO942553L (es) |
NZ (1) | NZ246571A (es) |
WO (1) | WO1993014123A1 (es) |
ZA (1) | ZA9394B (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060134087A1 (en) * | 1988-09-02 | 2006-06-22 | Dyax Corp. | ITI-D1 Kunitz domain mutants as hNE inhibitors |
US5663143A (en) * | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
US5795954A (en) * | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
US5786328A (en) * | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
US5780265A (en) * | 1995-06-05 | 1998-07-14 | Genentech, Inc. | Kunitz type plasma kallikrein inhibitors |
US6242414B1 (en) | 1995-06-07 | 2001-06-05 | Chiron Corporation | Regulation of cytokine synthesis and release |
US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
ATE528014T1 (de) | 2002-06-07 | 2011-10-15 | Dyax Corp | Polypeptid mit modifizierten kunitz domains |
DE602004031589D1 (de) * | 2003-01-07 | 2011-04-14 | Dyax Corp | Kunitz-domäne-bibliothek |
MX2007000473A (es) * | 2004-07-13 | 2007-03-29 | Bayer Pharmaceuticals Corp | Variantes mejoradas de la aprotinina. |
US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
LT1981519T (lt) | 2005-12-29 | 2018-04-25 | Dyax Corp. | Proteazės slopinimas |
AU2008289005A1 (en) * | 2007-08-21 | 2009-02-26 | Genzyme Corporation | Treatment with kallikrein inhibitors |
CN101952309A (zh) * | 2007-12-21 | 2011-01-19 | Ifxa有限公司 | 蛋白酶抑制剂 |
KR102165021B1 (ko) | 2008-12-19 | 2020-10-14 | 박스알타 인코퍼레이티드 | Tfpi 억제제 및 사용 방법 |
WO2010080833A1 (en) * | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
HUE057244T2 (hu) | 2010-01-06 | 2022-04-28 | Takeda Pharmaceuticals Co | Plazma kallikreint kötõ fehérjék |
JP5730983B2 (ja) | 2010-03-19 | 2015-06-10 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | Tfpi阻害剤および使用方法 |
JP2014506257A (ja) | 2011-01-06 | 2014-03-13 | ダイアックス コーポレーション | 血漿カリクレイン結合タンパク質 |
SI2827883T1 (sl) | 2012-03-21 | 2019-08-30 | Baxalta GmbH | Inhibitorji TFPI in postopki uporabe |
JP6719384B2 (ja) | 2014-03-27 | 2020-07-15 | ダイアックス コーポレーション | 糖尿病黄斑浮腫の治療のための組成物および方法 |
US11286307B2 (en) | 2015-12-11 | 2022-03-29 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
EP3468605A4 (en) * | 2016-06-08 | 2020-01-08 | President and Fellows of Harvard College | MODIFIED VIRAL VECTOR REDUCING THE INDUCTION OF INFLAMMATORY AND IMMUNE RESPONSES |
US11981911B2 (en) | 2017-11-08 | 2024-05-14 | President And Fellows Of Harvard College | Compositions and methods for inhibiting viral vector-induced inflammatory responses |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2199582A (en) * | 1987-01-07 | 1988-07-13 | Bayer Ag | Analogues of pancreatic secretory trypsin inhibitor |
DE3724570A1 (de) * | 1987-06-27 | 1989-01-05 | Bayer Ag | Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist |
US5106833A (en) * | 1987-07-23 | 1992-04-21 | Washington University | Coagulation inhibitors |
US4966852A (en) * | 1987-07-23 | 1990-10-30 | Monsanto Company | DNA clone of human tissue factor inhibitor |
DK225488D0 (da) * | 1988-04-26 | 1988-04-26 | Novo Industri As | Polypeptid |
JPH07102137B2 (ja) * | 1988-07-19 | 1995-11-08 | 塩野義製薬株式会社 | 修飾ヒトpsti |
-
1993
- 1993-01-06 IL IL104314A patent/IL104314A0/xx unknown
- 1993-01-07 WO PCT/DK1993/000006 patent/WO1993014123A1/en not_active Application Discontinuation
- 1993-01-07 AU AU33461/93A patent/AU670059B2/en not_active Ceased
- 1993-01-07 KR KR1019940702349A patent/KR940703860A/ko not_active Application Discontinuation
- 1993-01-07 CA CA002127247A patent/CA2127247A1/en not_active Abandoned
- 1993-01-07 HU HU9401989A patent/HUT70291A/hu unknown
- 1993-01-07 ZA ZA9394A patent/ZA9394B/xx unknown
- 1993-01-07 EP EP93902107A patent/EP0621873B1/en not_active Expired - Lifetime
- 1993-01-07 NZ NZ246571A patent/NZ246571A/en unknown
- 1993-01-07 CZ CZ941648A patent/CZ164894A3/cs unknown
- 1993-01-07 ES ES93902107T patent/ES2123635T3/es not_active Expired - Lifetime
- 1993-01-07 JP JP51208493A patent/JP3345420B2/ja not_active Expired - Fee Related
- 1993-01-07 DE DE69321342T patent/DE69321342T2/de not_active Expired - Fee Related
- 1993-01-07 AT AT93902107T patent/ATE171712T1/de not_active IP Right Cessation
-
1994
- 1994-07-06 NO NO942553A patent/NO942553L/no unknown
- 1994-07-06 FI FI943235A patent/FI943235A/fi unknown
-
1995
- 1995-02-06 US US08/384,489 patent/US5618696A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CZ164894A3 (en) | 1994-12-15 |
NZ246571A (en) | 1996-09-25 |
NO942553L (no) | 1994-09-07 |
US5618696A (en) | 1997-04-08 |
AU670059B2 (en) | 1996-07-04 |
KR940703860A (ko) | 1994-12-12 |
FI943235A0 (fi) | 1994-07-06 |
FI943235A (fi) | 1994-07-06 |
ZA9394B (en) | 1993-08-10 |
EP0621873B1 (en) | 1998-09-30 |
AU3346193A (en) | 1993-08-03 |
NO942553D0 (no) | 1994-07-06 |
CA2127247A1 (en) | 1993-07-22 |
WO1993014123A1 (en) | 1993-07-22 |
JP3345420B2 (ja) | 2002-11-18 |
JPH07504652A (ja) | 1995-05-25 |
HUT70291A (en) | 1995-09-28 |
DE69321342D1 (de) | 1998-11-05 |
EP0621873A1 (en) | 1994-11-02 |
ATE171712T1 (de) | 1998-10-15 |
DE69321342T2 (de) | 1999-04-01 |
HU9401989D0 (en) | 1994-09-28 |
IL104314A0 (en) | 1993-05-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA2A | Application withdrawn |
Effective date: 19940525 |
|
FG2A | Definitive protection |
Ref document number: 621873 Country of ref document: ES |