ZA9394B - A novel human kunitz-type inhibitor and variants thereof - Google Patents

A novel human kunitz-type inhibitor and variants thereof

Info

Publication number
ZA9394B
ZA9394B ZA9394A ZA9394A ZA9394B ZA 9394 B ZA9394 B ZA 9394B ZA 9394 A ZA9394 A ZA 9394A ZA 9394 A ZA9394 A ZA 9394A ZA 9394 B ZA9394 B ZA 9394B
Authority
ZA
South Africa
Prior art keywords
phe
cys
gly
glu
asn
Prior art date
Application number
ZA9394A
Other languages
English (en)
Inventor
Fanny Norris
Kjeld Norris
Soeren Erik Bjoern
Lars Christian Petersen
Ole Hvilsted Olsen
Donald Cameron Foster
Cindy Ann Sprecher
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of ZA9394B publication Critical patent/ZA9394B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA9394A 1992-01-07 1993-01-07 A novel human kunitz-type inhibitor and variants thereof ZA9394B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK9200003 1992-01-07

Publications (1)

Publication Number Publication Date
ZA9394B true ZA9394B (en) 1993-08-10

Family

ID=8153772

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9394A ZA9394B (en) 1992-01-07 1993-01-07 A novel human kunitz-type inhibitor and variants thereof

Country Status (17)

Country Link
US (1) US5618696A (es)
EP (1) EP0621873B1 (es)
JP (1) JP3345420B2 (es)
KR (1) KR940703860A (es)
AT (1) ATE171712T1 (es)
AU (1) AU670059B2 (es)
CA (1) CA2127247A1 (es)
CZ (1) CZ164894A3 (es)
DE (1) DE69321342T2 (es)
ES (1) ES2123635T3 (es)
FI (1) FI943235A (es)
HU (1) HUT70291A (es)
IL (1) IL104314A0 (es)
NO (1) NO942553L (es)
NZ (1) NZ246571A (es)
WO (1) WO1993014123A1 (es)
ZA (1) ZA9394B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060134087A1 (en) * 1988-09-02 2006-06-22 Dyax Corp. ITI-D1 Kunitz domain mutants as hNE inhibitors
US5663143A (en) * 1988-09-02 1997-09-02 Dyax Corp. Engineered human-derived kunitz domains that inhibit human neutrophil elastase
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
US6242414B1 (en) 1995-06-07 2001-06-05 Chiron Corporation Regulation of cytokine synthesis and release
EP2298278B1 (en) * 2002-06-07 2015-11-11 Dyax Corp. Prevention and reduction of blood loss and inflammatory response
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
EP1587907B1 (en) * 2003-01-07 2011-03-02 Dyax Corporation Kunitz domain library
US20090005297A1 (en) * 2004-07-13 2009-01-01 Kevin Lumb Aprotinin Variants
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US8828703B2 (en) 2005-12-29 2014-09-09 Dyax Corp. Protease inhibition
US20090075887A1 (en) * 2007-08-21 2009-03-19 Genzyme Corporation Treatment with Kallikrein Inhibitors
WO2009080054A1 (en) * 2007-12-21 2009-07-02 Ifxa A/S Protease inhibitor
BR122021014783B1 (pt) 2008-12-19 2023-03-14 Baxalta GmbH Peptídeo que se liga a tfpi, uso do peptídeo, composição farmacêutica e método para purificação de tfpi
AU2010203712A1 (en) * 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
RS62853B1 (sr) 2010-01-06 2022-02-28 Takeda Pharmaceuticals Co Proteini koji vezuju kalikrein plazme
CN103025345B (zh) 2010-03-19 2016-01-20 巴克斯特国际公司 Tfpi抑制剂及使用方法
AU2012204202A1 (en) 2011-01-06 2013-07-11 Dyax Corp. Plasma kallikrein binding proteins
AU2013235741C1 (en) 2012-03-21 2017-12-21 Takeda Pharmaceutical Company Limited TFPI inhibitors and methods of use
CN106459210A (zh) 2014-03-27 2017-02-22 戴埃克斯有限公司 用于治疗糖尿病黄斑性水肿的组合物和方法
US11286307B2 (en) 2015-12-11 2022-03-29 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
US11339396B2 (en) 2016-06-08 2022-05-24 President And Fellows Of Harvard College Engineered viral vector reduces induction of inflammatory and immune responses
WO2019094548A1 (en) 2017-11-08 2019-05-16 President And Fellows Of Harvard College Compositions and methods for inhibiting viral vector-induced inflammatory responses

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2199582A (en) * 1987-01-07 1988-07-13 Bayer Ag Analogues of pancreatic secretory trypsin inhibitor
DE3724570A1 (de) * 1987-06-27 1989-01-05 Bayer Ag Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist
US5106833A (en) * 1987-07-23 1992-04-21 Washington University Coagulation inhibitors
US4966852A (en) * 1987-07-23 1990-10-30 Monsanto Company DNA clone of human tissue factor inhibitor
DK225488D0 (da) * 1988-04-26 1988-04-26 Novo Industri As Polypeptid
JPH07102137B2 (ja) * 1988-07-19 1995-11-08 塩野義製薬株式会社 修飾ヒトｐｓｔｉ

Also Published As

Publication number Publication date
FI943235A0 (fi) 1994-07-06
AU3346193A (en) 1993-08-03
AU670059B2 (en) 1996-07-04
IL104314A0 (en) 1993-05-13
KR940703860A (ko) 1994-12-12
CZ164894A3 (en) 1994-12-15
EP0621873B1 (en) 1998-09-30
JP3345420B2 (ja) 2002-11-18
FI943235A (fi) 1994-07-06
HU9401989D0 (en) 1994-09-28
EP0621873A1 (en) 1994-11-02
DE69321342T2 (de) 1999-04-01
NO942553D0 (no) 1994-07-06
CA2127247A1 (en) 1993-07-22
ES2123635T3 (es) 1999-01-16
US5618696A (en) 1997-04-08
NO942553L (no) 1994-09-07
WO1993014123A1 (en) 1993-07-22
JPH07504652A (ja) 1995-05-25
ATE171712T1 (de) 1998-10-15
DE69321342D1 (de) 1998-11-05
NZ246571A (en) 1996-09-25
HUT70291A (en) 1995-09-28

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