FI943235A0 - Uusi ihmisen Kunitz-tyyppinen proteaasiestäjä ja sen muunnnoksia - Google Patents

Uusi ihmisen Kunitz-tyyppinen proteaasiestäjä ja sen muunnnoksia

Info

Publication number
FI943235A0
FI943235A0 FI943235A FI943235A FI943235A0 FI 943235 A0 FI943235 A0 FI 943235A0 FI 943235 A FI943235 A FI 943235A FI 943235 A FI943235 A FI 943235A FI 943235 A0 FI943235 A0 FI 943235A0
Authority
FI
Finland
Prior art keywords
phe
cys
gly
glu
protease inhibitor
Prior art date
Application number
FI943235A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI943235A (fi
Inventor
Fanny Norris
Kjeld Norris
Soeren Erik Bjoern
Lars Christian Petersen
Ole Hvilsted Olsen
Donald Cameron Foster
Cindy Ann Sprecher
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of FI943235A publication Critical patent/FI943235A/fi
Publication of FI943235A0 publication Critical patent/FI943235A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FI943235A 1992-01-07 1994-07-06 Uusi ihmisen Kunitz-tyyppinen proteaasiestäjä ja sen muunnnoksia FI943235A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK9200003 1992-01-07
PCT/DK1993/000006 WO1993014123A1 (en) 1992-01-07 1993-01-07 A novel human kunitz-type protease inhibitor and variants thereof

Publications (2)

Publication Number Publication Date
FI943235A FI943235A (fi) 1994-07-06
FI943235A0 true FI943235A0 (fi) 1994-07-06

Family

ID=8153772

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943235A FI943235A0 (fi) 1992-01-07 1994-07-06 Uusi ihmisen Kunitz-tyyppinen proteaasiestäjä ja sen muunnnoksia

Country Status (17)

Country Link
US (1) US5618696A (de)
EP (1) EP0621873B1 (de)
JP (1) JP3345420B2 (de)
KR (1) KR940703860A (de)
AT (1) ATE171712T1 (de)
AU (1) AU670059B2 (de)
CA (1) CA2127247A1 (de)
CZ (1) CZ164894A3 (de)
DE (1) DE69321342T2 (de)
ES (1) ES2123635T3 (de)
FI (1) FI943235A0 (de)
HU (1) HUT70291A (de)
IL (1) IL104314A0 (de)
NO (1) NO942553L (de)
NZ (1) NZ246571A (de)
WO (1) WO1993014123A1 (de)
ZA (1) ZA9394B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060134087A1 (en) * 1988-09-02 2006-06-22 Dyax Corp. ITI-D1 Kunitz domain mutants as hNE inhibitors
US5663143A (en) * 1988-09-02 1997-09-02 Dyax Corp. Engineered human-derived kunitz domains that inhibit human neutrophil elastase
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
US6242414B1 (en) 1995-06-07 2001-06-05 Chiron Corporation Regulation of cytokine synthesis and release
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
EP2298278B1 (de) 2002-06-07 2015-11-11 Dyax Corp. Verhinderung und Reduzierung von Blutverlust und Entzündungsreaktion
DK1587907T3 (da) * 2003-01-07 2011-04-04 Dyax Corp Kunitz-domænebibliotek
KR20070041749A (ko) * 2004-07-13 2007-04-19 바이엘 파마슈티칼스 코포레이션 개선된 아프로티닌 변이체
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
ES2663497T3 (es) 2005-12-29 2018-04-13 Dyax Corp. Inhibición de proteasas
CA2696208A1 (en) * 2007-08-21 2009-02-26 Genzyme Corporation Treatment with kallikrein inhibitors
EP2231702A1 (de) * 2007-12-21 2010-09-29 Ifxa A/s Proteasehemmer
KR101792032B1 (ko) 2008-12-19 2017-11-02 백스터 인터내셔널 인코포레이티드 Ｔｆｐｉ 억제제 및 사용 방법
WO2010080833A1 (en) * 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
EP3459564B1 (de) 2010-01-06 2021-10-27 Takeda Pharmaceutical Company Limited Plasmakallikreinbindende proteine
AU2011227714B2 (en) 2010-03-19 2014-09-04 Takeda Pharmaceutical Company Limited TFPI inhibitors and methods of use
KR102169651B1 (ko) 2011-01-06 2020-10-23 다이액스 코포레이션 혈장 칼리크레인 결합 단백질
CN109111505A (zh) 2012-03-21 2019-01-01 百深有限责任公司 Tfpi抑制剂及其使用方法
IL247942B (en) 2014-03-27 2022-09-01 Dyax Corp Compositions and methods for drops in macular edema as a result of diabetes
IL311156A (en) 2015-12-11 2024-04-01 Takeda Pharmaceuticals Co Plasma kallikrein inhibitors and their uses in the treatment of hereditary angioedema attack
JP7034951B2 (ja) * 2016-06-08 2022-03-14 プレジデント アンド フェローズ オブ ハーバード カレッジ 操作されたウイルスベクターは炎症および免疫応答の誘導を低減する
CN111511918A (zh) 2017-11-08 2020-08-07 哈佛学院院长及董事 抑制病毒载体诱导的炎症反应的组合物和方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2199582A (en) * 1987-01-07 1988-07-13 Bayer Ag Analogues of pancreatic secretory trypsin inhibitor
DE3724570A1 (de) * 1987-06-27 1989-01-05 Bayer Ag Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist
US4966852A (en) * 1987-07-23 1990-10-30 Monsanto Company DNA clone of human tissue factor inhibitor
US5106833A (en) * 1987-07-23 1992-04-21 Washington University Coagulation inhibitors
DK225488D0 (da) * 1988-04-26 1988-04-26 Novo Industri As Polypeptid
JPH07102137B2 (ja) * 1988-07-19 1995-11-08 塩野義製薬株式会社 修飾ヒトｐｓｔｉ

Also Published As

Publication number Publication date
DE69321342T2 (de) 1999-04-01
ZA9394B (en) 1993-08-10
CZ164894A3 (en) 1994-12-15
NO942553L (no) 1994-09-07
KR940703860A (ko) 1994-12-12
EP0621873A1 (de) 1994-11-02
ATE171712T1 (de) 1998-10-15
FI943235A (fi) 1994-07-06
US5618696A (en) 1997-04-08
AU670059B2 (en) 1996-07-04
JPH07504652A (ja) 1995-05-25
EP0621873B1 (de) 1998-09-30
AU3346193A (en) 1993-08-03
CA2127247A1 (en) 1993-07-22
WO1993014123A1 (en) 1993-07-22
NO942553D0 (no) 1994-07-06
NZ246571A (en) 1996-09-25
JP3345420B2 (ja) 2002-11-18
HU9401989D0 (en) 1994-09-28
DE69321342D1 (de) 1998-11-05
ES2123635T3 (es) 1999-01-16
HUT70291A (en) 1995-09-28
IL104314A0 (en) 1993-05-13

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