NO923798L - Fremgangsmaate for fremstilling og anvendelse av nye acylaler av imidazol-5-karboksylsyrederivater - Google Patents

Fremgangsmaate for fremstilling og anvendelse av nye acylaler av imidazol-5-karboksylsyrederivater

Info

Publication number
NO923798L
NO923798L NO92923798A NO923798A NO923798L NO 923798 L NO923798 L NO 923798L NO 92923798 A NO92923798 A NO 92923798A NO 923798 A NO923798 A NO 923798A NO 923798 L NO923798 L NO 923798L
Authority
NO
Norway
Prior art keywords
carboxylic acid
imidazole
acylals
procedure
preparation
Prior art date
Application number
NO92923798A
Other languages
English (en)
Other versions
NO923798D0 (no
Inventor
Dieter Binder
Josef Weinberger
Original Assignee
Chem Pharm Forsch Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Pharm Forsch Gmbh filed Critical Chem Pharm Forsch Gmbh
Publication of NO923798D0 publication Critical patent/NO923798D0/no
Publication of NO923798L publication Critical patent/NO923798L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Nye imidazol-5-karboksylsyreacylaler med generell formel R2 N-/ . «S der RI betyr en eventuelt umettet, rettkjedet alkyl- gruppe med 1-6 karbonatomer og R2 betyr hydrogen, klor, brom, Jod eller CT^ og RS betyr Ci-Cio-alkyl, C3-C7~ cykloalkyl eller benzyl og deres farmasøytisk godtag- bare salter. Det beskrives fremgangsmåte for fremstilling av forbindelsene og deres anvendelse som blodtrykksenkende midler.
NO92923798A 1991-10-04 1992-09-30 Fremgangsmaate for fremstilling og anvendelse av nye acylaler av imidazol-5-karboksylsyrederivater NO923798L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0198791A AT398202B (de) 1991-10-04 1991-10-04 Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung

Publications (2)

Publication Number Publication Date
NO923798D0 NO923798D0 (no) 1992-09-30
NO923798L true NO923798L (no) 1993-04-05

Family

ID=3525398

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92923798A NO923798L (no) 1991-10-04 1992-09-30 Fremgangsmaate for fremstilling og anvendelse av nye acylaler av imidazol-5-karboksylsyrederivater

Country Status (22)

Country Link
US (1) US5298519A (no)
EP (1) EP0535420A1 (no)
JP (1) JP2544565B2 (no)
CN (1) CN1032856C (no)
AT (1) AT398202B (no)
AU (1) AU649357B2 (no)
CA (1) CA2079735A1 (no)
CZ (1) CZ301992A3 (no)
FI (1) FI924353A (no)
HR (1) HRP920817A2 (no)
HU (1) HUT62291A (no)
IL (1) IL103329A (no)
LV (1) LV10256B (no)
MY (1) MY108350A (no)
NO (1) NO923798L (no)
NZ (1) NZ244320A (no)
RU (1) RU2105764C1 (no)
SI (1) SI9200240A (no)
SK (1) SK301992A3 (no)
TW (1) TW223073B (no)
YU (1) YU48290B (no)
ZA (1) ZA927205B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2105939B1 (es) * 1994-08-02 1998-07-01 Uriach & Cia Sa J Nuevos pirazoles con actividad antagonista de la angiotensina ii.
CN101024643A (zh) * 2006-02-20 2007-08-29 上海艾力斯医药科技有限公司 咪唑－5－羧酸类衍生物、制备方法及其应用
JP5290190B2 (ja) * 2006-12-06 2013-09-18 サルブリス・アセット・マネイジメント・カンパニー・リミテッド イミダゾール−５−カルボン酸誘導体の塩、製造方法及びその医薬組成物
CN101195615B (zh) * 2006-12-06 2013-03-27 深圳市信立泰资产管理有限公司 咪唑-5-羧酸衍生物的盐、制备方法及其药物组合物
CN101214242A (zh) * 2007-01-05 2008-07-09 上海艾力斯医药科技有限公司 新的药用组合物
DK2170930T3 (da) 2007-06-04 2012-11-05 Synergy Pharmaceuticals Inc Agonister af guanylatcyclase, anvendelige til behandlingen af gastrointestinale sygdomme, inflammation, cancer og andre sygdomme
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN101317842A (zh) 2007-06-07 2008-12-10 上海艾力斯医药科技有限公司 一种咪唑-5-羧酸衍生物的治疗用途
CN101367795B (zh) * 2007-08-17 2012-05-02 上海艾力斯生物医药有限公司 一种咪唑-5-羧酸衍生物及其制备方法
CN101407511B (zh) * 2007-10-11 2013-01-09 上海艾力斯生物医药有限公司 一种结晶型的咪唑-5-羧酸衍生物
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN103012377A (zh) * 2011-09-27 2013-04-03 江苏艾力斯生物医药有限公司 一种咪唑-5-羧酸酯的重结晶方法
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
KR102272746B1 (ko) 2013-06-05 2021-07-08 보슈 헬스 아일랜드 리미티드 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US5064825A (en) * 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
KR950009860B1 (ko) * 1989-06-30 1995-08-29 이. 아이. 듀퐁 드 네모아 앤드 캄파니 융합된 환 아릴 치환된 이미다졸과 약제학적으로 허용되는 이의 염, 이들의 제조방법 및 이들을 함유하는 약제학적 조성물
EP0411507B1 (en) * 1989-08-02 1994-10-26 Takeda Chemical Industries, Ltd. Pyrazole derivatives, their production and use
DE4132631A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Imidazolyl-propensaeurederivate
DE4132632A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Substituierte imidazolyl-propensaeurederivate
PT573218E (pt) * 1992-06-02 2001-06-29 Sankyo Co 4-carbonilimidazoles como antagonistas de angiotensina ii e sua utilizacao terapeutica

Also Published As

Publication number Publication date
AT398202B (de) 1994-10-25
IL103329A (en) 1996-10-31
YU87592A (sh) 1995-10-03
HU9203149D0 (en) 1992-12-28
TW223073B (no) 1994-05-01
MY108350A (en) 1996-09-30
CZ301992A3 (en) 1993-08-11
EP0535420A1 (de) 1993-04-07
YU48290B (sh) 1998-05-15
HUT62291A (en) 1993-04-28
AU649357B2 (en) 1994-05-19
JP2544565B2 (ja) 1996-10-16
LV10256A (lv) 1994-10-20
ATA198791A (de) 1994-02-15
HRP920817A2 (en) 1996-08-31
IL103329A0 (en) 1993-03-15
NZ244320A (en) 1995-01-27
SK301992A3 (en) 1995-10-11
FI924353A (fi) 1993-04-05
RU2105764C1 (ru) 1998-02-27
SI9200240A (en) 1993-06-30
JPH05310731A (ja) 1993-11-22
AU2617692A (en) 1993-04-08
US5298519A (en) 1994-03-29
CA2079735A1 (en) 1993-04-05
ZA927205B (en) 1993-03-23
NO923798D0 (no) 1992-09-30
FI924353A0 (fi) 1992-09-29
CN1032856C (zh) 1996-09-25
CN1071426A (zh) 1993-04-28
LV10256B (en) 1995-04-20

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