ZA927205B - Acylals of imidazole-5-carboxylic acid derivatives, process for their preparation and their use. - Google Patents

Acylals of imidazole-5-carboxylic acid derivatives, process for their preparation and their use.

Info

Publication number
ZA927205B
ZA927205B ZA927205A ZA927205A ZA927205B ZA 927205 B ZA927205 B ZA 927205B ZA 927205 A ZA927205 A ZA 927205A ZA 927205 A ZA927205 A ZA 927205A ZA 927205 B ZA927205 B ZA 927205B
Authority
ZA
South Africa
Prior art keywords
acylals
imidazole
preparation
carboxylic acid
acid derivatives
Prior art date
Application number
ZA927205A
Other languages
English (en)
Inventor
Dieter Binder
Josef Weinberger
Original Assignee
Chem Pharm Forsch Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Pharm Forsch Gmbh filed Critical Chem Pharm Forsch Gmbh
Publication of ZA927205B publication Critical patent/ZA927205B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA927205A 1991-10-04 1992-09-21 Acylals of imidazole-5-carboxylic acid derivatives, process for their preparation and their use. ZA927205B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0198791A AT398202B (de) 1991-10-04 1991-10-04 Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung

Publications (1)

Publication Number Publication Date
ZA927205B true ZA927205B (en) 1993-03-23

Family

ID=3525398

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA927205A ZA927205B (en) 1991-10-04 1992-09-21 Acylals of imidazole-5-carboxylic acid derivatives, process for their preparation and their use.

Country Status (22)

Country Link
US (1) US5298519A (xx)
EP (1) EP0535420A1 (xx)
JP (1) JP2544565B2 (xx)
CN (1) CN1032856C (xx)
AT (1) AT398202B (xx)
AU (1) AU649357B2 (xx)
CA (1) CA2079735A1 (xx)
CZ (1) CZ301992A3 (xx)
FI (1) FI924353A (xx)
HR (1) HRP920817A2 (xx)
HU (1) HUT62291A (xx)
IL (1) IL103329A (xx)
LV (1) LV10256B (xx)
MY (1) MY108350A (xx)
NO (1) NO923798L (xx)
NZ (1) NZ244320A (xx)
RU (1) RU2105764C1 (xx)
SI (1) SI9200240A (xx)
SK (1) SK301992A3 (xx)
TW (1) TW223073B (xx)
YU (1) YU48290B (xx)
ZA (1) ZA927205B (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2105939B1 (es) * 1994-08-02 1998-07-01 Uriach & Cia Sa J Nuevos pirazoles con actividad antagonista de la angiotensina ii.
CN101024643A (zh) * 2006-02-20 2007-08-29 上海艾力斯医药科技有限公司 咪唑－5－羧酸类衍生物、制备方法及其应用
ATE525371T1 (de) * 2006-12-06 2011-10-15 Shanghai Allist Pharmaceutical Inc Salze von imidazol-5-carbonsäure-derivaten, herstellungsverfahren und verwendung davon
CN101195615B (zh) * 2006-12-06 2013-03-27 深圳市信立泰资产管理有限公司 咪唑-5-羧酸衍生物的盐、制备方法及其药物组合物
CN101214242A (zh) * 2007-01-05 2008-07-09 上海艾力斯医药科技有限公司 新的药用组合物
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US8034782B2 (en) 2008-07-16 2011-10-11 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CN101317842A (zh) 2007-06-07 2008-12-10 上海艾力斯医药科技有限公司 一种咪唑-5-羧酸衍生物的治疗用途
CN101367795B (zh) * 2007-08-17 2012-05-02 上海艾力斯生物医药有限公司 一种咪唑-5-羧酸衍生物及其制备方法
CN101407511B (zh) * 2007-10-11 2013-01-09 上海艾力斯生物医药有限公司 一种结晶型的咪唑-5-羧酸衍生物
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN103012377A (zh) * 2011-09-27 2013-04-03 江苏艾力斯生物医药有限公司 一种咪唑-5-羧酸酯的重结晶方法
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
AU2014274812B2 (en) 2013-06-05 2018-09-27 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase C, method of making and using same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US5064825A (en) * 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
HU215834B (hu) * 1989-06-30 1999-04-28 E. I. Du Pont De Nemours And Co. Eljárás aromás csoporttal szubsztituált imidazolszármazékok, valamint ezeket hatóanyagként tartalmazó gyógyszerkészítmények előállítására
EP0411507B1 (en) * 1989-08-02 1994-10-26 Takeda Chemical Industries, Ltd. Pyrazole derivatives, their production and use
DE4132631A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Imidazolyl-propensaeurederivate
DE4132632A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Substituierte imidazolyl-propensaeurederivate
PT573218E (pt) * 1992-06-02 2001-06-29 Sankyo Co 4-carbonilimidazoles como antagonistas de angiotensina ii e sua utilizacao terapeutica

Also Published As

Publication number Publication date
CA2079735A1 (en) 1993-04-05
FI924353A (fi) 1993-04-05
AT398202B (de) 1994-10-25
SI9200240A (en) 1993-06-30
AU2617692A (en) 1993-04-08
EP0535420A1 (de) 1993-04-07
JP2544565B2 (ja) 1996-10-16
YU87592A (sh) 1995-10-03
AU649357B2 (en) 1994-05-19
NO923798L (no) 1993-04-05
NZ244320A (en) 1995-01-27
HRP920817A2 (en) 1996-08-31
CZ301992A3 (en) 1993-08-11
LV10256B (en) 1995-04-20
JPH05310731A (ja) 1993-11-22
HUT62291A (en) 1993-04-28
NO923798D0 (no) 1992-09-30
ATA198791A (de) 1994-02-15
CN1032856C (zh) 1996-09-25
US5298519A (en) 1994-03-29
SK301992A3 (en) 1995-10-11
TW223073B (xx) 1994-05-01
LV10256A (lv) 1994-10-20
RU2105764C1 (ru) 1998-02-27
CN1071426A (zh) 1993-04-28
IL103329A (en) 1996-10-31
YU48290B (sh) 1998-05-15
IL103329A0 (en) 1993-03-15
FI924353A0 (fi) 1992-09-29
HU9203149D0 (en) 1992-12-28
MY108350A (en) 1996-09-30

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