NO914859L - 3'-(2')-amino- eller tiolmodifiserte, fluorescensfarvestoffkoblede nukleosider, nukleotider og oligonukleotider, samt fremgangsmaate for fremstilling og anvendelse derav - Google Patents
3'-(2')-amino- eller tiolmodifiserte, fluorescensfarvestoffkoblede nukleosider, nukleotider og oligonukleotider, samt fremgangsmaate for fremstilling og anvendelse deravInfo
- Publication number
- NO914859L NO914859L NO91914859A NO914859A NO914859L NO 914859 L NO914859 L NO 914859L NO 91914859 A NO91914859 A NO 91914859A NO 914859 A NO914859 A NO 914859A NO 914859 L NO914859 L NO 914859L
- Authority
- NO
- Norway
- Prior art keywords
- amino
- nucleotides
- oigonucleotides
- fluorescense
- procedures
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000002773 nucleotide Substances 0.000 title abstract 3
- 239000002777 nucleoside Substances 0.000 title abstract 2
- 150000003573 thiols Chemical class 0.000 title 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 4
- 238000003786 synthesis reaction Methods 0.000 abstract 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 238000001514 detection method Methods 0.000 abstract 1
- 239000007850 fluorescent dye Substances 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000002372 labelling Methods 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 125000003835 nucleoside group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
- 235000011178 triphosphate Nutrition 0.000 abstract 1
- 239000001226 triphosphate Substances 0.000 abstract 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4039488 | 1990-12-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO914859D0 NO914859D0 (no) | 1991-12-10 |
| NO914859L true NO914859L (no) | 1992-06-12 |
Family
ID=6420050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO91914859A NO914859L (no) | 1990-12-11 | 1991-12-10 | 3'-(2')-amino- eller tiolmodifiserte, fluorescensfarvestoffkoblede nukleosider, nukleotider og oligonukleotider, samt fremgangsmaate for fremstilling og anvendelse derav |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US5679785A (xx) |
| EP (1) | EP0490281B1 (xx) |
| JP (1) | JP3140127B2 (xx) |
| KR (1) | KR920012107A (xx) |
| AT (1) | ATE142222T1 (xx) |
| AU (1) | AU643856B2 (xx) |
| BG (1) | BG61484B1 (xx) |
| BR (1) | BR9105335A (xx) |
| CA (1) | CA2057475A1 (xx) |
| CS (1) | CS374391A3 (xx) |
| DE (1) | DE59108143D1 (xx) |
| DK (1) | DK0490281T3 (xx) |
| ES (1) | ES2093671T3 (xx) |
| FI (1) | FI915779A (xx) |
| GR (1) | GR3021041T3 (xx) |
| HU (1) | HUT60505A (xx) |
| IE (1) | IE75726B1 (xx) |
| IL (1) | IL100298A (xx) |
| MX (1) | MX9102468A (xx) |
| NO (1) | NO914859L (xx) |
| NZ (1) | NZ240900A (xx) |
| PL (1) | PL168874B1 (xx) |
| PT (1) | PT99747A (xx) |
| RO (1) | RO111575B1 (xx) |
| RU (1) | RU2073682C1 (xx) |
| TR (1) | TR27715A (xx) |
| YU (1) | YU187991A (xx) |
Families Citing this family (55)
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| US5599922A (en) | 1994-03-18 | 1997-02-04 | Lynx Therapeutics, Inc. | Oligonucleotide N3'-P5' phosphoramidates: hybridization and nuclease resistance properties |
| US5726297A (en) * | 1994-03-18 | 1998-03-10 | Lynx Therapeutics, Inc. | Oligodeoxyribonucleotide N3' P5' phosphoramidates |
| HUT76094A (en) * | 1994-03-18 | 1997-06-30 | Lynx Therapeutics | Oligonucleotide n3'-p5' phosphoramidates: synthesis and compounds; hybridization and nuclease resistance properties |
| DE4418691A1 (de) * | 1994-05-28 | 1996-02-22 | Boehringer Mannheim Gmbh | 3'-(4'-) nicht-radioaktiv markierte Nukleoside und Nukleotide mit Aminocarbonsäure-, Peptid- oder Carbonsäure-Spacer |
| US5962271A (en) * | 1996-01-03 | 1999-10-05 | Cloutech Laboratories, Inc. | Methods and compositions for generating full-length cDNA having arbitrary nucleotide sequence at the 3'-end |
| US5859233A (en) * | 1996-02-21 | 1999-01-12 | Lynx Therapeutics, Inc. | Synthons for synthesis of oligonucleotide N3-P5 phosphoramidates |
| US5684143A (en) * | 1996-02-21 | 1997-11-04 | Lynx Therapeutics, Inc. | Oligo-2'-fluoronucleotide N3'->P5' phosphoramidates |
| US6017702A (en) * | 1996-12-05 | 2000-01-25 | The Perkin-Elmer Corporation | Chain-termination type nucleic acid sequencing method including 2'-deoxyuridine-5'-triphosphate |
| DE19741084A1 (de) * | 1997-09-18 | 1999-03-25 | Knoell Hans Forschung Ev | Hochaffine Nukleinsäuremoleküle mit funktionellen Gruppen zur spezifischen Erkennung von Zielmolekülen, ihre Herstellung und Verwendung |
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| US7563618B2 (en) * | 2001-03-23 | 2009-07-21 | Geron Corporation | Oligonucleotide conjugates |
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| MXPA05010429A (es) | 2003-03-31 | 2005-11-04 | Hoffmann La Roche | Composiciones y metodos para detectar ciertos flavivirus que incluyen miembros del serogrupo del virus de la encefalitis japonesa. |
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| US7160537B2 (en) * | 2003-12-15 | 2007-01-09 | Siemens Medical Solutions Usa, Inc. | Method for preparing radiolabeled thymidine having low chromophoric byproducts |
| US7939251B2 (en) | 2004-05-06 | 2011-05-10 | Roche Molecular Systems, Inc. | SENP1 as a marker for cancer |
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| ATE556126T1 (de) * | 2004-10-29 | 2012-05-15 | Life Technologies Corp | Funktionalisierte fluoreszierende nanokristalle und verfahren zu deren herstellung und verwendung |
| EP1809765A2 (en) * | 2004-11-04 | 2007-07-25 | Roche Diagnostics GmbH | Classification of acute myeloid leukemia |
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| WO2008070749A2 (en) * | 2006-12-05 | 2008-06-12 | Lasergen, Inc. | Photocleavable labeled nucleotides and nucleosides and labeled nucleotides and nucleosides and methods for their use in dna sequencing |
| US8420315B2 (en) | 2007-08-06 | 2013-04-16 | Orion Genomics Llc | Single nucleotide polymorphisms and combinations of novel and known polymorphisms for determining the allele-specific expression of the IGF2 gene |
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| WO2011128096A1 (en) | 2010-04-16 | 2011-10-20 | Roche Diagnostics Gmbh | Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment |
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| ES2729554T3 (es) | 2011-10-21 | 2019-11-04 | Chronix Biomedical | Biomarcadores de ácidos nucleicos en circulación asociados al cáncer colorrectal |
| ES2413566B1 (es) | 2011-12-14 | 2014-05-20 | Fundación Pública Andaluza Progreso Y Salud | Método de obtención de datos útiles para el diagnóstico y pronóstico de la hipoacusia neurosensorial. |
| GB2518078B (en) | 2012-06-18 | 2015-04-29 | Nugen Technologies Inc | Compositions and methods for negative selection of non-desired nucleic acid sequences |
| WO2014093825A1 (en) | 2012-12-14 | 2014-06-19 | Chronix Biomedical | Personalized biomarkers for cancer |
| HRP20190209T4 (hr) | 2013-05-29 | 2023-09-15 | Chronix Biomedical | Detekcija i kvantifikacija acelularne dnk darivatelja u krvotoku primatelja presađivanja organa |
| EP3201361B1 (en) | 2014-10-01 | 2020-02-12 | Chronix Biomedical | Methods of quantifying cell-free dna |
| US9896538B2 (en) | 2016-03-28 | 2018-02-20 | Aat Bioquest, Inc. | Polyfluoreno[4,5-cde]oxepine polymers and conjugates thereof |
| US11220628B2 (en) | 2019-02-20 | 2022-01-11 | Aat Bioquest, Inc. | Condensed polycyclic conjugated polymers and their use for biological detection |
| WO2021154933A1 (en) | 2020-01-30 | 2021-08-05 | Aat Bioquest, Inc. | Uv excitable polyfluorene based conjugates and their use in methods of analyte detection |
| WO2023147355A2 (en) * | 2022-01-25 | 2023-08-03 | Oregon Health & Science University | Methods and systems for increasing capture potential of a spatial array |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5015733A (en) * | 1983-12-20 | 1991-05-14 | California Institute Of Technology | Nucleosides possessing blocked aliphatic amino groups |
| US4849513A (en) * | 1983-12-20 | 1989-07-18 | California Institute Of Technology | Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups |
| EP0267996A1 (en) * | 1986-11-20 | 1988-05-25 | Tamir Biotechnology Ltd. | New nucleotide derivatives |
| GB2236852B (en) * | 1989-09-25 | 1994-04-06 | Scotgen Ltd | DNA probe based assays and intermediates useful in the synthesis of cleavable nucleic acids for use in such assays |
| US5227487A (en) * | 1990-04-16 | 1993-07-13 | Molecular Probes, Inc. | Certain tricyclic and pentacyclic-hetero nitrogen rhodol dyes |
| US5541307A (en) * | 1990-07-27 | 1996-07-30 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs and solid phase synthesis thereof |
-
1991
- 1991-12-02 YU YU187991A patent/YU187991A/sh unknown
- 1991-12-04 BG BG95575A patent/BG61484B1/bg unknown
- 1991-12-06 DE DE59108143T patent/DE59108143D1/de not_active Expired - Fee Related
- 1991-12-06 DK DK91120935.1T patent/DK0490281T3/da active
- 1991-12-06 ES ES91120935T patent/ES2093671T3/es not_active Expired - Lifetime
- 1991-12-06 EP EP91120935A patent/EP0490281B1/de not_active Expired - Lifetime
- 1991-12-06 AT AT91120935T patent/ATE142222T1/de not_active IP Right Cessation
- 1991-12-09 FI FI915779A patent/FI915779A/fi unknown
- 1991-12-09 NZ NZ24090091A patent/NZ240900A/en unknown
- 1991-12-09 IL IL100298A patent/IL100298A/xx not_active IP Right Cessation
- 1991-12-09 TR TR01195/91A patent/TR27715A/xx unknown
- 1991-12-09 RO RO148926A patent/RO111575B1/ro unknown
- 1991-12-10 HU HU913885A patent/HUT60505A/hu unknown
- 1991-12-10 PT PT99747A patent/PT99747A/pt not_active Application Discontinuation
- 1991-12-10 RU SU915010267A patent/RU2073682C1/ru active
- 1991-12-10 CA CA002057475A patent/CA2057475A1/en not_active Abandoned
- 1991-12-10 CS CS913743A patent/CS374391A3/cs unknown
- 1991-12-10 AU AU88927/91A patent/AU643856B2/en not_active Ceased
- 1991-12-10 PL PL91292701A patent/PL168874B1/pl unknown
- 1991-12-10 NO NO91914859A patent/NO914859L/no unknown
- 1991-12-10 IE IE430191A patent/IE75726B1/en not_active IP Right Cessation
- 1991-12-10 MX MX9102468A patent/MX9102468A/es unknown
- 1991-12-11 KR KR1019910022614A patent/KR920012107A/ko not_active Application Discontinuation
- 1991-12-11 JP JP03350821A patent/JP3140127B2/ja not_active Expired - Fee Related
- 1991-12-11 BR BR919105335A patent/BR9105335A/pt unknown
-
1994
- 1994-01-18 US US08/184,759 patent/US5679785A/en not_active Expired - Fee Related
-
1995
- 1995-06-01 US US08/457,377 patent/US5659025A/en not_active Expired - Fee Related
- 1995-06-01 US US08/456,734 patent/US5668269A/en not_active Expired - Fee Related
-
1996
- 1996-09-13 GR GR960402400T patent/GR3021041T3/el unknown
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