NO841627L - Fremgangsmaate for fremstilling av hydantoinderivater - Google Patents
Fremgangsmaate for fremstilling av hydantoinderivaterInfo
- Publication number
- NO841627L NO841627L NO841627A NO841627A NO841627L NO 841627 L NO841627 L NO 841627L NO 841627 A NO841627 A NO 841627A NO 841627 A NO841627 A NO 841627A NO 841627 L NO841627 L NO 841627L
- Authority
- NO
- Norway
- Prior art keywords
- spiro
- fluoro
- dione
- tritium
- imidazolidine
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 19
- 238000002360 preparation method Methods 0.000 title description 7
- 229940053195 antiepileptics hydantoin derivative Drugs 0.000 title 1
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical class O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 21
- 229910052722 tritium Inorganic materials 0.000 claims description 14
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical group CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 12
- 229910052805 deuterium Inorganic materials 0.000 claims description 12
- 239000003054 catalyst Substances 0.000 claims description 11
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical group CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 9
- WRYCSMQKUKOKBP-UHFFFAOYSA-N Imidazolidine Chemical compound C1CNCN1 WRYCSMQKUKOKBP-UHFFFAOYSA-N 0.000 claims description 9
- YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical group [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 claims description 9
- -1 spiro-hydantoin compound Chemical class 0.000 claims description 9
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical group [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 8
- 229910052736 halogen Chemical group 0.000 claims description 8
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical group [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 7
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- 150000001768 cations Chemical class 0.000 claims description 4
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- 239000003960 organic solvent Substances 0.000 claims description 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 3
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- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
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- 231100000252 nontoxic Toxicity 0.000 description 3
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- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- FEONEKOZSGPOFN-UHFFFAOYSA-K tribromoiron Chemical compound Br[Fe](Br)Br FEONEKOZSGPOFN-UHFFFAOYSA-K 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/488,947 US4474967A (en) | 1983-04-27 | 1983-04-27 | 8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO841627L true NO841627L (no) | 1984-10-29 |
Family
ID=23941785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO841627A NO841627L (no) | 1983-04-27 | 1984-04-25 | Fremgangsmaate for fremstilling av hydantoinderivater |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4474967A (de) |
| EP (1) | EP0124327A3 (de) |
| JP (1) | JPS59205384A (de) |
| KR (1) | KR860000915B1 (de) |
| AU (1) | AU542142B2 (de) |
| CA (1) | CA1226866A (de) |
| CS (1) | CS250661B2 (de) |
| DD (1) | DD219772A5 (de) |
| DK (1) | DK208284A (de) |
| ES (1) | ES8607312A1 (de) |
| FI (1) | FI841657A (de) |
| GR (1) | GR81491B (de) |
| HU (1) | HU191755B (de) |
| IL (1) | IL71656A (de) |
| NO (1) | NO841627L (de) |
| NZ (1) | NZ207959A (de) |
| PH (1) | PH22869A (de) |
| PL (1) | PL142759B1 (de) |
| PT (1) | PT78476B (de) |
| SU (1) | SU1240362A3 (de) |
| YU (1) | YU43358B (de) |
| ZA (1) | ZA843091B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3565105D1 (en) * | 1984-08-20 | 1988-10-27 | Pfizer | Process for the production as asymmetric hydantoins |
| US4841079A (en) * | 1987-08-07 | 1989-06-20 | Pfizer, Inc. | Process for the production of asymmetric hydantoins |
| US5059693A (en) * | 1989-10-06 | 1991-10-22 | Pfizer Inc. | Process for making 3-aroyl-2-oxindole-1-carboxamides |
| GB9317764D0 (en) * | 1993-08-26 | 1993-10-13 | Pfizer Ltd | Therapeutic compound |
| IL137128A0 (en) * | 1998-01-30 | 2001-07-24 | R Tech Ueno Ltd | Ophthalmic compositions containing tetrahydroquinazoline derivatives |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3821383A (en) * | 1972-07-10 | 1974-06-28 | Ayerst Mckenna & Harrison | Compositions for and a method of treating diabetic complications |
| CA1088945A (en) * | 1976-10-18 | 1980-11-04 | Pfizer Limited | Hydantoin derivatives as therapeutic agents |
| US4117230A (en) * | 1976-10-18 | 1978-09-26 | Pfizer Inc. | Hydantoin derivatives as therapeutic agents |
| US4130714A (en) * | 1977-05-23 | 1978-12-19 | Pfizer Inc. | Hydantoin therapeutic agents |
| US4248882A (en) * | 1980-02-12 | 1981-02-03 | Pfizer Inc. | Treating diabetes-associated complications with hydantoin amines |
| JPS5745185A (en) * | 1980-07-21 | 1982-03-13 | Eisai Co Ltd | Hydantoin derivative and its preparation |
-
1983
- 1983-04-27 US US06/488,947 patent/US4474967A/en not_active Expired - Fee Related
-
1984
- 1984-04-19 EP EP84302667A patent/EP0124327A3/de not_active Withdrawn
- 1984-04-24 PL PL1984247379A patent/PL142759B1/pl unknown
- 1984-04-24 PT PT78476A patent/PT78476B/pt unknown
- 1984-04-24 DD DD84262257A patent/DD219772A5/de not_active IP Right Cessation
- 1984-04-25 SU SU843732823A patent/SU1240362A3/ru active
- 1984-04-25 ES ES531873A patent/ES8607312A1/es not_active Expired
- 1984-04-25 CA CA000452774A patent/CA1226866A/en not_active Expired
- 1984-04-25 NO NO841627A patent/NO841627L/no unknown
- 1984-04-26 GR GR74517A patent/GR81491B/el unknown
- 1984-04-26 DK DK208284A patent/DK208284A/da not_active Application Discontinuation
- 1984-04-26 KR KR1019840002240A patent/KR860000915B1/ko active IP Right Grant
- 1984-04-26 YU YU741/84A patent/YU43358B/xx unknown
- 1984-04-26 ZA ZA843091A patent/ZA843091B/xx unknown
- 1984-04-26 FI FI841657A patent/FI841657A/fi not_active Application Discontinuation
- 1984-04-26 PH PH30605A patent/PH22869A/en unknown
- 1984-04-26 IL IL71656A patent/IL71656A/xx not_active IP Right Cessation
- 1984-04-26 NZ NZ207959A patent/NZ207959A/en unknown
- 1984-04-26 CS CS843101A patent/CS250661B2/cs unknown
- 1984-04-26 HU HU841622A patent/HU191755B/hu not_active IP Right Cessation
- 1984-04-26 AU AU27263/84A patent/AU542142B2/en not_active Ceased
- 1984-04-27 JP JP59086040A patent/JPS59205384A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DK208284A (da) | 1984-10-28 |
| KR860000915B1 (ko) | 1986-07-18 |
| HU191755B (en) | 1987-04-28 |
| AU2726384A (en) | 1984-11-01 |
| ZA843091B (en) | 1985-12-24 |
| PH22869A (en) | 1989-01-19 |
| JPS59205384A (ja) | 1984-11-20 |
| PL142759B1 (en) | 1987-11-30 |
| PL247379A1 (en) | 1985-03-26 |
| PT78476B (en) | 1986-08-28 |
| CA1226866A (en) | 1987-09-15 |
| FI841657A (fi) | 1984-10-28 |
| SU1240362A3 (ru) | 1986-06-23 |
| DD219772A5 (de) | 1985-03-13 |
| US4474967A (en) | 1984-10-02 |
| IL71656A0 (en) | 1984-07-31 |
| GR81491B (de) | 1984-12-11 |
| YU43358B (en) | 1989-06-30 |
| IL71656A (en) | 1987-10-20 |
| DK208284D0 (da) | 1984-04-26 |
| ES8607312A1 (es) | 1986-06-01 |
| HUT34197A (en) | 1985-02-28 |
| KR840008355A (ko) | 1984-12-14 |
| CS250661B2 (en) | 1987-05-14 |
| NZ207959A (en) | 1987-04-30 |
| FI841657A0 (fi) | 1984-04-26 |
| YU74184A (en) | 1986-10-31 |
| PT78476A (en) | 1984-05-01 |
| EP0124327A3 (de) | 1985-07-31 |
| AU542142B2 (en) | 1985-02-07 |
| EP0124327A2 (de) | 1984-11-07 |
| ES531873A0 (es) | 1986-06-01 |
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