NO335462B1 - Derivater av N-heterocyklylmetylbenzamider, medikament og farmasøytisk preparat inneholdende en slik forbindelse samt anvendelse av forbindelsen - Google Patents

Derivater av N-heterocyklylmetylbenzamider, medikament og farmasøytisk preparat inneholdende en slik forbindelse samt anvendelse av forbindelsen

Info

Publication number
NO335462B1
NO335462B1 NO20062030A NO20062030A NO335462B1 NO 335462 B1 NO335462 B1 NO 335462B1 NO 20062030 A NO20062030 A NO 20062030A NO 20062030 A NO20062030 A NO 20062030A NO 335462 B1 NO335462 B1 NO 335462B1
Authority
NO
Norway
Prior art keywords
alkoxy
alkyl
compound
nhso
halo
Prior art date
Application number
NO20062030A
Other languages
English (en)
Norwegian (no)
Other versions
NO20062030L (no
Inventor
Pierre Roger
Pascale Magat
Gihad Dargazanli
Benoit Marabout
Geneviève ESTENNE-BOUHTOU
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NO20062030L publication Critical patent/NO20062030L/no
Publication of NO335462B1 publication Critical patent/NO335462B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
NO20062030A 2003-10-17 2006-05-05 Derivater av N-heterocyklylmetylbenzamider, medikament og farmasøytisk preparat inneholdende en slik forbindelse samt anvendelse av forbindelsen NO335462B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0312165A FR2861076B1 (fr) 2003-10-17 2003-10-17 Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
PCT/FR2004/002643 WO2005037783A2 (fr) 2003-10-17 2004-10-15 Composes tricycliques comme inhibiteurs de transport de glycine

Publications (2)

Publication Number Publication Date
NO20062030L NO20062030L (no) 2006-07-07
NO335462B1 true NO335462B1 (no) 2014-12-15

Family

ID=34385252

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20062030A NO335462B1 (no) 2003-10-17 2006-05-05 Derivater av N-heterocyklylmetylbenzamider, medikament og farmasøytisk preparat inneholdende en slik forbindelse samt anvendelse av forbindelsen

Country Status (32)

Country Link
US (3) US7288656B2 (enExample)
EP (1) EP1680421B1 (enExample)
JP (1) JP4853918B2 (enExample)
KR (1) KR101125305B1 (enExample)
CN (2) CN1882587B (enExample)
AT (1) ATE386036T1 (enExample)
AU (1) AU2004281217B2 (enExample)
BR (1) BRPI0415489A (enExample)
CA (1) CA2542647C (enExample)
CR (1) CR8342A (enExample)
CY (1) CY1108925T1 (enExample)
DE (1) DE602004011806T2 (enExample)
DK (1) DK1680421T3 (enExample)
EC (1) ECSP066511A (enExample)
ES (1) ES2300837T3 (enExample)
FR (1) FR2861076B1 (enExample)
HR (1) HRP20080186T3 (enExample)
IL (1) IL174940A (enExample)
MA (1) MA28099A1 (enExample)
ME (1) ME00111B (enExample)
NO (1) NO335462B1 (enExample)
NZ (1) NZ547163A (enExample)
OA (1) OA13317A (enExample)
PL (1) PL1680421T3 (enExample)
PT (1) PT1680421E (enExample)
RS (2) RS20060314A (enExample)
RU (1) RU2346945C2 (enExample)
SG (1) SG147435A1 (enExample)
TN (1) TNSN06110A1 (enExample)
UA (1) UA81186C2 (enExample)
WO (1) WO2005037783A2 (enExample)
ZA (1) ZA200603861B (enExample)

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FR2842804B1 (fr) 2002-07-29 2004-09-03 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861074B1 (fr) * 2003-10-17 2006-04-07 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861071B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique
FR2861076B1 (fr) 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
EP1734962A4 (en) * 2004-03-30 2010-07-14 Painceptor Pharma Corp COMPOSITIONS AND METHOD FOR MODULATING CONTROLLED ION CHANNELS
FR2906251B1 (fr) * 2006-09-22 2008-11-07 Sanofi Aventis Sa Derives de pyrrolizine, indolizine et quinolizine, leur preparation et leur application en therapeutique
US11817637B2 (en) 2006-11-18 2023-11-14 Rfmicron, Inc. Radio frequency identification (RFID) moisture tag(s) and sensors with extended sensing via capillaries
WO2009013535A1 (en) * 2007-07-23 2009-01-29 Astrazeneca Ab 2-azabicyclo(2.2.2)octane derivatives as modulators of the glycine transporter i receptor
US8420670B2 (en) 2007-08-22 2013-04-16 Abbott Laboratories 4-benzylaminoquinolines, pharmaceutical compositions containing them, and their use in therapy
MX2010010773A (es) 2008-04-01 2011-04-11 Abbott Gmbh & Co Kg Tetrahidroisoquinolinas, composiciones farmaceuticas que las contienen y su uso en terapia.
CA2745690A1 (en) * 2008-12-04 2010-06-10 Evgeny Zlotinikov Novel polymorphic forms of an azabicyclo-trifluoromethyl benzamide derivative
AR075182A1 (es) * 2009-01-28 2011-03-16 Astrazeneca Ab Compuestos 2-aza-biciclo (2.2.2) octano y sus usos
EP2391628A4 (en) * 2009-01-28 2012-10-10 Astrazeneca Ab 2-AZA-BICYCLOÝ2.2.1¨HEPTANE COMPOUNDS AND USES THEREOF
FR2941953B1 (fr) * 2009-02-10 2011-04-08 Sanofi Aventis Derives de n-°(2-aza-bicyclo°2.1.1!hex-1-yl)-benzamide, leur preparation et leur application en therapeutique
FR2941954B1 (fr) * 2009-02-10 2011-04-08 Sanofi Aventis Derives de n-°(6-aza-bicyclo°3.2.1!oct-1-yl)-aryl-methyl! benzamide, leur preparation et leur application en therapeutique
TW201038569A (en) 2009-02-16 2010-11-01 Abbott Gmbh & Co Kg Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
AR075442A1 (es) 2009-02-16 2011-03-30 Abbott Gmbh & Co Kg Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia
FR2943056A1 (fr) * 2009-03-16 2010-09-17 Sanofi Aventis Derives de n-°2-aza-bicyclo°2.1.1!hex-1-yl)-aryl-methyl!- heterobenzamide, leur preparation et leur application en therapeutique
FR2943059A1 (fr) * 2009-03-16 2010-09-17 Sanofi Aventis Derives de n-°6-aza-bicyclo°3.2.1!oct-5-yl)-aryl-methyl!- heterobenzamide,leur preparation et leur application en therapeutique
RU2011141778A (ru) * 2009-03-16 2013-04-27 Санофи Производные n-[(2-азабицикло[2.1.1]гекс-1-ил)арилметил]гетеробензамида, их получение и их применение в терапии
FR2944284A1 (fr) * 2009-04-14 2010-10-15 Sanofi Aventis Derives de n-°7-aza-bicyclo°2.2.1!hept-1-yl)-aryl-methyl! -benzamide, leur preparation et leur application en therapeutique
US8153653B2 (en) * 2010-06-22 2012-04-10 Hoffmann-La Roche Inc. Amido-tropane derivatives
US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9045459B2 (en) * 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8853196B2 (en) 2011-08-05 2014-10-07 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
MX2014006004A (es) 2011-11-18 2015-04-16 Abbvie Deutschland Derivados de aminobenzociclohepteno, aminotetralina, aminoindano y fenalcilamina n-sustituidas, composiciones farmaceuticas que los contienen, y su uso en terapia.
PL2786986T3 (pl) * 2011-11-29 2018-08-31 Vivozon, Inc. Nowa pochodna benzamidu i jej zastosowanie
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
EP3057960B1 (en) 2013-10-17 2019-02-27 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
MX2016004934A (es) 2013-10-17 2016-12-20 Abbvie Deutschland Derivados de aminotetralina y aminoindano, composiciones farmaceuticas que los contienen, y su uso en terapia.
US9550754B2 (en) 2014-09-11 2017-01-24 AbbVie Deutschland GmbH & Co. KG 4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2016060938A2 (en) 2014-10-08 2016-04-21 RF Micron, Inc. Radio frequency identification (rfid) moisture tag(s) and sensors with extended sensing via capillaries
JP6906227B2 (ja) * 2017-08-18 2021-07-21 国立大学法人千葉大学 ハロゲン結合ドナー／有機塩基複合型化合物及び酸塩基複合触媒

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US4066662A (en) 1973-12-14 1978-01-03 Science Union Et Cie., Societe Francaise De Recherche Medicale N-substituted-2-aminomethyl-3-azabicyclo(3,3,0)octane compounds
CA1223873A (en) 1982-04-14 1987-07-07 Francis D. King Pharmaceutically active compounds
PH23937A (en) 1986-12-16 1990-01-23 Robins Co Inc A H Anxiolytic-n-(1-azabicyclo(2.2.2.)oct-3-yl)benzamides and thiobenzamides
GB8720805D0 (en) 1987-09-04 1987-10-14 Naylor R J 2-alkoxy-n-(1-azabicyclo(2 2 2)oct-3-yl)benzamides & thiobenzamides
SE9600683D0 (sv) * 1996-02-23 1996-02-23 Astra Ab Azabicyclic esters of carbamic acids useful in therapy
PL342818A1 (en) * 1998-03-06 2001-07-02 Janssen Pharmaceutica Nv Glycin transport inhibitors
FR2861076B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
PT1680421E (pt) 2008-05-13
HK1098465A1 (en) 2007-07-20
HRP20080186T3 (en) 2008-05-31
CA2542647A1 (fr) 2005-04-28
US20060264441A1 (en) 2006-11-23
CN101684118A (zh) 2010-03-31
NZ547163A (en) 2010-01-29
CR8342A (es) 2006-10-04
OA13317A (fr) 2007-04-13
CY1108925T1 (el) 2014-07-02
US7619089B2 (en) 2009-11-17
CN1882587B (zh) 2012-06-27
DK1680421T3 (da) 2008-06-09
ECSP066511A (es) 2006-10-10
IL174940A0 (en) 2006-08-20
RS20060314A (sr) 2008-08-07
ATE386036T1 (de) 2008-03-15
MA28099A1 (fr) 2006-08-01
CA2542647C (fr) 2012-07-10
DE602004011806D1 (de) 2008-03-27
HK1142887A1 (en) 2010-12-17
RU2006116889A (ru) 2007-11-27
US20100022548A1 (en) 2010-01-28
WO2005037783A3 (fr) 2005-07-07
KR20060109432A (ko) 2006-10-20
TNSN06110A1 (fr) 2007-11-15
SG147435A1 (en) 2008-11-28
RU2346945C2 (ru) 2009-02-20
CN1882587A (zh) 2006-12-20
WO2005037783A2 (fr) 2005-04-28
ME00111B (me) 2010-10-10
AU2004281217B2 (en) 2010-07-22
BRPI0415489A (pt) 2006-12-26
FR2861076B1 (fr) 2006-01-06
ZA200603861B (en) 2007-12-27
US7288656B2 (en) 2007-10-30
PL1680421T3 (pl) 2008-07-31
CN101684118B (zh) 2013-04-10
RS51587B (sr) 2011-08-31
NO20062030L (no) 2006-07-07
AU2004281217A1 (en) 2005-04-28
KR101125305B1 (ko) 2012-03-27
JP4853918B2 (ja) 2012-01-11
US20080070941A1 (en) 2008-03-20
US8513246B2 (en) 2013-08-20
EP1680421A2 (fr) 2006-07-19
UA81186C2 (en) 2007-12-10
ES2300837T3 (es) 2008-06-16
JP2007508361A (ja) 2007-04-05
FR2861076A1 (fr) 2005-04-22
IL174940A (en) 2010-11-30
MEP12208A (en) 2010-06-10
DE602004011806T2 (de) 2009-02-05
EP1680421B1 (fr) 2008-02-13

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