CN101684118B - 三环化合物作为甘氨酸转运抑制剂的用途 - Google Patents
三环化合物作为甘氨酸转运抑制剂的用途 Download PDFInfo
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- CN101684118B CN101684118B CN2009101638818A CN200910163881A CN101684118B CN 101684118 B CN101684118 B CN 101684118B CN 2009101638818 A CN2009101638818 A CN 2009101638818A CN 200910163881 A CN200910163881 A CN 200910163881A CN 101684118 B CN101684118 B CN 101684118B
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- Prior art keywords
- azabicyclo
- oct
- threo
- group
- hydrochloride
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 77
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- 238000000034 method Methods 0.000 claims abstract description 33
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- -1 1-azabicyclo[2.2.2]oct-2-yl Chemical group 0.000 claims description 21
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- 239000002253 acid Substances 0.000 claims description 12
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- 125000005843 halogen group Chemical group 0.000 claims description 8
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
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Landscapes
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| FR0312165 | 2003-10-17 | ||
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| FR2861076B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique |
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| FR2861071B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique |
| CA2561993A1 (en) * | 2004-03-30 | 2006-04-13 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| FR2906251B1 (fr) | 2006-09-22 | 2008-11-07 | Sanofi Aventis Sa | Derives de pyrrolizine, indolizine et quinolizine, leur preparation et leur application en therapeutique |
| US11817637B2 (en) | 2006-11-18 | 2023-11-14 | Rfmicron, Inc. | Radio frequency identification (RFID) moisture tag(s) and sensors with extended sensing via capillaries |
| WO2009013535A1 (en) * | 2007-07-23 | 2009-01-29 | Astrazeneca Ab | 2-azabicyclo(2.2.2)octane derivatives as modulators of the glycine transporter i receptor |
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