ECSP066511A - Derivados de n-heterociclilmetilbenzamidas, su preparación y su aplicación en terapeutica - Google Patents

Derivados de n-heterociclilmetilbenzamidas, su preparación y su aplicación en terapeutica

Info

Publication number
ECSP066511A
ECSP066511A EC2006006511A ECSP066511A ECSP066511A EC SP066511 A ECSP066511 A EC SP066511A EC 2006006511 A EC2006006511 A EC 2006006511A EC SP066511 A ECSP066511 A EC SP066511A EC SP066511 A ECSP066511 A EC SP066511A
Authority
EC
Ecuador
Prior art keywords
alkoxy
alkyl
nhso
halo
optionally substituted
Prior art date
Application number
EC2006006511A
Other languages
English (en)
Inventor
Gihad Dargazanli
Genevieve Estenne-Bouhtou
Pascale Magat
Benoit Marabout
Pierre Pierre Roger
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of ECSP066511A publication Critical patent/ECSP066511A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compuesto de fórmula general (I) en la que R representa un átomo de hidrógeno o un grupo vinilo; n representa 0, 1 ó 2; X representa un grupo de fórmula CH o un átomo de nitrógeno; R1 representa bien un grupo fenilo o naftilo, bien un grupo ciclohexilo, bien un grupo heteroarilo; R2 representa bien un átomo de hidrógeno, bien uno o varios sustituyentes elegidos entre los átomos de halógeno y los grupos trifluorometilo, alquilo, alcoxi, tienilo, feniloxi, hidroxi, mercapto, tioalquilo, ciano o un grupo de fórmula general ?NR4R5, SO2NR4R5, -SO2?alquilo, -SO2?fenilo, ?CONR4R5, -COOR7, -CO?alquilo, -CO?fenilo, -NHCOR8, ?NHSO2?alquilo, -NHSO2-fenilo y -NHSO2NR4R5 o un grupo divalente de fórmula ?OCF2O? ; R4 y R5 representan cada uno un átomo de hidrógeno o un grupo alquilo o R4 y R5 forman con el átomo de nitrógeno que los soporta un ciclo pirrolidinio, piperidinio o morfolinio. Los compuestos de fórmula (I) presentan una actividad particular como inhibidores específicos de los transportadores glyt1 y/o glyt2.
EC2006006511A 2003-10-17 2006-04-17 Derivados de n-heterociclilmetilbenzamidas, su preparación y su aplicación en terapeutica ECSP066511A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0312165A FR2861076B1 (fr) 2003-10-17 2003-10-17 Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ECSP066511A true ECSP066511A (es) 2006-10-10

Family

ID=34385252

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006511A ECSP066511A (es) 2003-10-17 2006-04-17 Derivados de n-heterociclilmetilbenzamidas, su preparación y su aplicación en terapeutica

Country Status (33)

Country Link
US (3) US7288656B2 (es)
EP (1) EP1680421B1 (es)
JP (1) JP4853918B2 (es)
KR (1) KR101125305B1 (es)
CN (2) CN1882587B (es)
AT (1) ATE386036T1 (es)
AU (1) AU2004281217B2 (es)
BR (1) BRPI0415489A (es)
CA (1) CA2542647C (es)
CR (1) CR8342A (es)
CY (1) CY1108925T1 (es)
DE (1) DE602004011806T2 (es)
DK (1) DK1680421T3 (es)
EC (1) ECSP066511A (es)
ES (1) ES2300837T3 (es)
FR (1) FR2861076B1 (es)
HK (2) HK1142887A1 (es)
HR (1) HRP20080186T3 (es)
IL (1) IL174940A (es)
MA (1) MA28099A1 (es)
ME (1) ME00111B (es)
NO (1) NO335462B1 (es)
NZ (1) NZ547163A (es)
OA (1) OA13317A (es)
PL (1) PL1680421T3 (es)
PT (1) PT1680421E (es)
RS (2) RS51587B (es)
RU (1) RU2346945C2 (es)
SG (1) SG147435A1 (es)
TN (1) TNSN06110A1 (es)
UA (1) UA81186C2 (es)
WO (1) WO2005037783A2 (es)
ZA (1) ZA200603861B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2842804B1 (fr) 2002-07-29 2004-09-03 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861076B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
FR2861071B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique
FR2861074B1 (fr) * 2003-10-17 2006-04-07 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
WO2006038070A2 (en) * 2004-03-30 2006-04-13 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
FR2906251B1 (fr) * 2006-09-22 2008-11-07 Sanofi Aventis Sa Derives de pyrrolizine, indolizine et quinolizine, leur preparation et leur application en therapeutique
US9582981B2 (en) 2014-10-08 2017-02-28 Rfmicron, Inc. Radio frequency identification (RFID) moisture tag(s) and sensors with extended sensing via capillaries
US11817637B2 (en) 2006-11-18 2023-11-14 Rfmicron, Inc. Radio frequency identification (RFID) moisture tag(s) and sensors with extended sensing via capillaries
WO2009013535A1 (en) * 2007-07-23 2009-01-29 Astrazeneca Ab 2-azabicyclo(2.2.2)octane derivatives as modulators of the glycine transporter i receptor
CN101784533B (zh) 2007-08-22 2013-08-21 艾博特股份有限两合公司 4-苄基氨基喹啉、含有它们的药物组合物和它们在治疗中的用途
JP5554319B2 (ja) 2008-04-01 2014-07-23 アボット ゲーエムベーハー ウント カンパニー カーゲー テトラヒドロイソキノリン類、それを含む医薬組成物および治療におけるそれの使用
EP2373651A1 (en) * 2008-12-04 2011-10-12 Sanofi Novel polymorphic forms of an azabicyclo-trifluoromethyl benzamide derivative
AR075182A1 (es) * 2009-01-28 2011-03-16 Astrazeneca Ab Compuestos 2-aza-biciclo (2.2.2) octano y sus usos
CN102405222A (zh) * 2009-01-28 2012-04-04 阿斯利康(瑞典)有限公司 2-氮杂-二环[2.2.1]庚烷化合物及其用途
FR2941954B1 (fr) * 2009-02-10 2011-04-08 Sanofi Aventis Derives de n-°(6-aza-bicyclo°3.2.1!oct-1-yl)-aryl-methyl! benzamide, leur preparation et leur application en therapeutique
FR2941953B1 (fr) * 2009-02-10 2011-04-08 Sanofi Aventis Derives de n-°(2-aza-bicyclo°2.1.1!hex-1-yl)-benzamide, leur preparation et leur application en therapeutique
AR075442A1 (es) 2009-02-16 2011-03-30 Abbott Gmbh & Co Kg Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia
TW201038569A (en) 2009-02-16 2010-11-01 Abbott Gmbh & Co Kg Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
CA2755526A1 (fr) * 2009-03-16 2010-09-23 Sanofi Derives de n-[(2-aza-bicyclo[2.1.1]hex-1-yl)-aryl-methyl]-heterobenzamide, leur preparation et leur application en therapeutique
FR2943056A1 (fr) * 2009-03-16 2010-09-17 Sanofi Aventis Derives de n-°2-aza-bicyclo°2.1.1!hex-1-yl)-aryl-methyl!- heterobenzamide, leur preparation et leur application en therapeutique
FR2943059A1 (fr) * 2009-03-16 2010-09-17 Sanofi Aventis Derives de n-°6-aza-bicyclo°3.2.1!oct-5-yl)-aryl-methyl!- heterobenzamide,leur preparation et leur application en therapeutique
FR2944284A1 (fr) * 2009-04-14 2010-10-15 Sanofi Aventis Derives de n-°7-aza-bicyclo°2.2.1!hept-1-yl)-aryl-methyl! -benzamide, leur preparation et leur application en therapeutique
US8153653B2 (en) * 2010-06-22 2012-04-10 Hoffmann-La Roche Inc. Amido-tropane derivatives
US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9045459B2 (en) 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8853196B2 (en) 2011-08-05 2014-10-07 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846741B2 (en) 2011-11-18 2014-09-30 Abbvie Inc. N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
CN103958477B (zh) * 2011-11-29 2017-03-29 (株)威沃尊 苯甲酰胺衍生物及其用途
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
KR20160062165A (ko) 2013-10-17 2016-06-01 아비에 도이치란트 게엠베하 운트 콤파니 카게 아미노테트랄린 및 아미노인단 유도체, 이들을 포함하는 약제학적 조성물, 및 치료에서 이들의 용도
WO2015055770A1 (en) 2013-10-17 2015-04-23 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9550754B2 (en) 2014-09-11 2017-01-24 AbbVie Deutschland GmbH & Co. KG 4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy
JP6906227B2 (ja) * 2017-08-18 2021-07-21 国立大学法人千葉大学 ハロゲン結合ドナー／有機塩基複合型化合物及び酸塩基複合触媒

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4066662A (en) 1973-12-14 1978-01-03 Science Union Et Cie., Societe Francaise De Recherche Medicale N-substituted-2-aminomethyl-3-azabicyclo(3,3,0)octane compounds
IE56226B1 (en) 1982-04-14 1991-05-22 Beecham Group Plc Substituted azabicyclo compounds,process for their preparation and pharmaceutical compositions containing them
DE3780276T2 (de) 1986-12-16 1993-02-25 Robins Co Inc A H Angstloesende n-(1-azabicyclo(2.2.2)oct-3-yl)benzamide und -thiobenzamide.
GB8720805D0 (en) 1987-09-04 1987-10-14 Naylor R J 2-alkoxy-n-(1-azabicyclo(2 2 2)oct-3-yl)benzamides & thiobenzamides
SK13092000A3 (sk) * 1998-03-06 2001-03-12 Janssen Pharmaceutica N. V. Inhibítory prenosu glycínu, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie
FR2861076B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
JP2007508361A (ja) 2007-04-05
US7288656B2 (en) 2007-10-30
PL1680421T3 (pl) 2008-07-31
MEP12208A (en) 2010-06-10
CN101684118A (zh) 2010-03-31
DK1680421T3 (da) 2008-06-09
WO2005037783A3 (fr) 2005-07-07
RS51587B (en) 2011-08-31
RU2006116889A (ru) 2007-11-27
WO2005037783A2 (fr) 2005-04-28
FR2861076A1 (fr) 2005-04-22
US8513246B2 (en) 2013-08-20
ES2300837T3 (es) 2008-06-16
EP1680421A2 (fr) 2006-07-19
KR101125305B1 (ko) 2012-03-27
CA2542647C (fr) 2012-07-10
MA28099A1 (fr) 2006-08-01
NO20062030L (no) 2006-07-07
TNSN06110A1 (fr) 2007-11-15
RS20060314A (en) 2008-08-07
US20060264441A1 (en) 2006-11-23
CR8342A (es) 2006-10-04
AU2004281217B2 (en) 2010-07-22
HK1098465A1 (en) 2007-07-20
HRP20080186T3 (en) 2008-05-31
AU2004281217A1 (en) 2005-04-28
SG147435A1 (en) 2008-11-28
JP4853918B2 (ja) 2012-01-11
HK1142887A1 (en) 2010-12-17
DE602004011806D1 (de) 2008-03-27
DE602004011806T2 (de) 2009-02-05
PT1680421E (pt) 2008-05-13
ME00111B (me) 2010-10-10
OA13317A (fr) 2007-04-13
CN101684118B (zh) 2013-04-10
ATE386036T1 (de) 2008-03-15
CN1882587B (zh) 2012-06-27
CA2542647A1 (fr) 2005-04-28
BRPI0415489A (pt) 2006-12-26
IL174940A0 (en) 2006-08-20
EP1680421B1 (fr) 2008-02-13
NZ547163A (en) 2010-01-29
KR20060109432A (ko) 2006-10-20
NO335462B1 (no) 2014-12-15
CN1882587A (zh) 2006-12-20
US20100022548A1 (en) 2010-01-28
CY1108925T1 (el) 2014-07-02
ZA200603861B (en) 2007-12-27
FR2861076B1 (fr) 2006-01-06
UA81186C2 (en) 2007-12-10
IL174940A (en) 2010-11-30
RU2346945C2 (ru) 2009-02-20
US20080070941A1 (en) 2008-03-20
US7619089B2 (en) 2009-11-17

Similar Documents

Publication Publication Date Title
ECSP066511A (es) Derivados de n-heterociclilmetilbenzamidas, su preparación y su aplicación en terapeutica
IL174936A0 (en) Derivatives of n-[phenyl(alkylpiperidine-2-yl) methyl] benzamide, prearation method thereof and application of same in therapeutics
HK1098456A1 (en) Derivatives of n-[heteroaryl(piperidine-2-yl)methyl]benzamide, preparation method thereof and application of same in therapeutics
NO944162D0 (no) Substituerte heterosykliske karboksylsyreamider, deres fremstilling og deres anvendelse som legemiddel
ATE464291T1 (de) Indolderivate als ppar-aktivatoren
NO324228B1 (no) 4-amino-5-cyano-2-anilino-pyrimidinderivater og deres anvendelse og fremgangsmate for fremstilling, samt farmasoytisk sammensetning
DE602006008320D1 (de) Pyrrolopyridin-derivate und deren verwendung als ppar-rezeptormodulatoren
ATE396189T1 (de) Cyanopyrrolhaltige cyclische carbamat- und thiocarbamatbiaryle und verfahren zu deren herstellung
TH93950A (th) อนุพันธ์ 1,4-เบนไซโธอีพีน 1,1- ไดออกไซด์ชนิดใหม่ ที่แทนที่โดยเบนซิลแรดิคัล, วิธีสำหรับการเตรียมสารนั้น, เภสัชภัณฑ์ซึ่งประกอบรวมด้วยสารประกอบเหล่านี้และการใช้สารนั้น