BRPI0415489A - derivados de n-heterociclilmetilbenzamidas, sua preparação e sua aplicação em terapêutica - Google Patents

derivados de n-heterociclilmetilbenzamidas, sua preparação e sua aplicação em terapêutica

Info

Publication number
BRPI0415489A
BRPI0415489A BRPI0415489-4A BRPI0415489A BRPI0415489A BR PI0415489 A BRPI0415489 A BR PI0415489A BR PI0415489 A BRPI0415489 A BR PI0415489A BR PI0415489 A BRPI0415489 A BR PI0415489A
Authority
BR
Brazil
Prior art keywords
alkoxy
alkyl
nhso
halo
optionally substituted
Prior art date
Application number
BRPI0415489-4A
Other languages
English (en)
Inventor
Gihad Dargazanli
Genevieve Estenne-Bouhtou
Pascale Magat
Benoit Marabout
Pierre Roger
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of BRPI0415489A publication Critical patent/BRPI0415489A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

"DERIVADOS DE N-HETEROCICLILMETILBENZAMIDAS, SUA PREPARAçãO E SUA APLICAçãO EM TERAPêUTICA". Composto de fórmula geral (I) na qual R representa ou um átomo de hidrogênio ou um grupo vinila; n representa 0 ou 1 ou 2; X representa um grupo de fórmula CH ou um átomo de nitrogênio; R, representa ou um grupo fenila ou naftila, ou um grupo ciclohexila, ou um grupo heteroarila; R~ 2~ representa ou um átomo de hidrogênio, ou um ou vários substituintes escolhidos entre os átomos de halogênio e os grupos trifluormetila, alquila, alcóxi, tienila, fenilóxi, hidróxi, mercapto, tioalquila, ciano ou um grupo de fórmula geral -NR~ 4~R~ 5~, SO~ 2~NR~ 4~R~ 5~, SO~ 2~-alquila, -SO~ 2~-fenila, -CONR~ 4~R~ 5~, -COOR~ 7~-, -CO-alquila, -CO-fenila, NHCOR~ 8~, -NHSO~ 2~-alquila, -NHSO~ 2~-fenila e -NHSO~ 2~ NR~ 4~R~ 5~ ou um grupo divalente de fórmula -OCF~ 2~O-; R~ 4~ e R~ 5~ representam cada um deles um átomo de hidrogênio ou um grupo alquila ou R~ 4~ e R~ 5~ formam com o átomo de nitrogênio que os porta um ciclo pirrolidina, um ciclo piperidina ou um ciclo morfolina. Aplicação em terapêutica.
BRPI0415489-4A 2003-10-17 2004-10-15 derivados de n-heterociclilmetilbenzamidas, sua preparação e sua aplicação em terapêutica BRPI0415489A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0312165A FR2861076B1 (fr) 2003-10-17 2003-10-17 Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
PCT/FR2004/002643 WO2005037783A2 (fr) 2003-10-17 2004-10-15 Composes tricycliques comme inhibiteurs de transport de glycine

Publications (1)

Publication Number Publication Date
BRPI0415489A true BRPI0415489A (pt) 2006-12-26

Family

ID=34385252

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415489-4A BRPI0415489A (pt) 2003-10-17 2004-10-15 derivados de n-heterociclilmetilbenzamidas, sua preparação e sua aplicação em terapêutica

Country Status (33)

Country Link
US (3) US7288656B2 (pt)
EP (1) EP1680421B1 (pt)
JP (1) JP4853918B2 (pt)
KR (1) KR101125305B1 (pt)
CN (2) CN1882587B (pt)
AT (1) ATE386036T1 (pt)
AU (1) AU2004281217B2 (pt)
BR (1) BRPI0415489A (pt)
CA (1) CA2542647C (pt)
CR (1) CR8342A (pt)
CY (1) CY1108925T1 (pt)
DE (1) DE602004011806T2 (pt)
DK (1) DK1680421T3 (pt)
EC (1) ECSP066511A (pt)
ES (1) ES2300837T3 (pt)
FR (1) FR2861076B1 (pt)
HK (2) HK1142887A1 (pt)
HR (1) HRP20080186T3 (pt)
IL (1) IL174940A (pt)
MA (1) MA28099A1 (pt)
ME (1) ME00111B (pt)
NO (1) NO335462B1 (pt)
NZ (1) NZ547163A (pt)
OA (1) OA13317A (pt)
PL (1) PL1680421T3 (pt)
PT (1) PT1680421E (pt)
RS (2) RS20060314A (pt)
RU (1) RU2346945C2 (pt)
SG (1) SG147435A1 (pt)
TN (1) TNSN06110A1 (pt)
UA (1) UA81186C2 (pt)
WO (1) WO2005037783A2 (pt)
ZA (1) ZA200603861B (pt)

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FR2861076B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
FR2861074B1 (fr) * 2003-10-17 2006-04-07 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861071B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique
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FR2906251B1 (fr) * 2006-09-22 2008-11-07 Sanofi Aventis Sa Derives de pyrrolizine, indolizine et quinolizine, leur preparation et leur application en therapeutique
US11817637B2 (en) 2006-11-18 2023-11-14 Rfmicron, Inc. Radio frequency identification (RFID) moisture tag(s) and sensors with extended sensing via capillaries
US9582981B2 (en) 2014-10-08 2017-02-28 Rfmicron, Inc. Radio frequency identification (RFID) moisture tag(s) and sensors with extended sensing via capillaries
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EP2271625B1 (en) 2008-04-01 2012-09-12 Abbott GmbH & Co. KG Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy
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WO2010087762A1 (en) * 2009-01-28 2010-08-05 Astrazeneca Ab 2-aza-bicyclo[2.2.1]heptane compounds and uses thereof
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US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
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US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
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Also Published As

Publication number Publication date
MA28099A1 (fr) 2006-08-01
EP1680421B1 (fr) 2008-02-13
US20080070941A1 (en) 2008-03-20
KR101125305B1 (ko) 2012-03-27
KR20060109432A (ko) 2006-10-20
SG147435A1 (en) 2008-11-28
IL174940A (en) 2010-11-30
IL174940A0 (en) 2006-08-20
ATE386036T1 (de) 2008-03-15
CN101684118A (zh) 2010-03-31
CA2542647C (fr) 2012-07-10
RU2006116889A (ru) 2007-11-27
TNSN06110A1 (fr) 2007-11-15
DE602004011806T2 (de) 2009-02-05
DE602004011806D1 (de) 2008-03-27
UA81186C2 (en) 2007-12-10
WO2005037783A2 (fr) 2005-04-28
JP2007508361A (ja) 2007-04-05
AU2004281217A1 (en) 2005-04-28
US7619089B2 (en) 2009-11-17
NO335462B1 (no) 2014-12-15
CN1882587A (zh) 2006-12-20
CR8342A (es) 2006-10-04
US20060264441A1 (en) 2006-11-23
PL1680421T3 (pl) 2008-07-31
CY1108925T1 (el) 2014-07-02
US7288656B2 (en) 2007-10-30
PT1680421E (pt) 2008-05-13
MEP12208A (en) 2010-06-10
US8513246B2 (en) 2013-08-20
RS20060314A (en) 2008-08-07
HK1142887A1 (en) 2010-12-17
NZ547163A (en) 2010-01-29
CN101684118B (zh) 2013-04-10
ME00111B (me) 2010-10-10
RS51587B (en) 2011-08-31
OA13317A (fr) 2007-04-13
EP1680421A2 (fr) 2006-07-19
AU2004281217B2 (en) 2010-07-22
ZA200603861B (en) 2007-12-27
WO2005037783A3 (fr) 2005-07-07
ES2300837T3 (es) 2008-06-16
FR2861076B1 (fr) 2006-01-06
CN1882587B (zh) 2012-06-27
DK1680421T3 (da) 2008-06-09
FR2861076A1 (fr) 2005-04-22
RU2346945C2 (ru) 2009-02-20
ECSP066511A (es) 2006-10-10
US20100022548A1 (en) 2010-01-28
NO20062030L (no) 2006-07-07
CA2542647A1 (fr) 2005-04-28
HK1098465A1 (en) 2007-07-20
HRP20080186T3 (en) 2008-05-31
JP4853918B2 (ja) 2012-01-11

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2483 DE 07-08-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.