NO335256B1 - Krystall form (form A og C) av N-(3-cyano-4-metyl-1H-indol-7-yl)-3-cyanobenzensulfonamid og fremgangsmåte for fremstilling derav - Google Patents
Krystall form (form A og C) av N-(3-cyano-4-metyl-1H-indol-7-yl)-3-cyanobenzensulfonamid og fremgangsmåte for fremstilling derav Download PDFInfo
- Publication number
- NO335256B1 NO335256B1 NO20061545A NO20061545A NO335256B1 NO 335256 B1 NO335256 B1 NO 335256B1 NO 20061545 A NO20061545 A NO 20061545A NO 20061545 A NO20061545 A NO 20061545A NO 335256 B1 NO335256 B1 NO 335256B1
- Authority
- NO
- Norway
- Prior art keywords
- crystals
- cyano
- methyl
- indol
- cyanobenzenesulfonamide
- Prior art date
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- 238000005384 cross polarization magic-angle spinning Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 229960000735 docosanol Drugs 0.000 description 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000013583 drug formulation Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- UBHWBODXJBSFLH-UHFFFAOYSA-N hexadecan-1-ol;octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO.CCCCCCCCCCCCCCCCCCO UBHWBODXJBSFLH-UHFFFAOYSA-N 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
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- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
- 150000002475 indoles Chemical class 0.000 description 1
- 239000003410 keratolytic agent Substances 0.000 description 1
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- 229940057995 liquid paraffin Drugs 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229960003194 meglumine Drugs 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- UKVIEHSSVKSQBA-UHFFFAOYSA-N methane;palladium Chemical compound C.[Pd] UKVIEHSSVKSQBA-UHFFFAOYSA-N 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 229940073665 octyldodecyl myristate Drugs 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 229940056211 paraffin Drugs 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920001289 polyvinyl ether Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229920002050 silicone resin Polymers 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
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- 238000009495 sugar coating Methods 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003318953 | 2003-09-10 | ||
| PCT/JP2004/012649 WO2005026118A1 (ja) | 2003-09-10 | 2004-09-01 | スルホンアミド含有インドール化合物の結晶およびその製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20061545L NO20061545L (no) | 2006-06-09 |
| NO335256B1 true NO335256B1 (no) | 2014-10-27 |
Family
ID=34308544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20061545A NO335256B1 (no) | 2003-09-10 | 2006-04-05 | Krystall form (form A og C) av N-(3-cyano-4-metyl-1H-indol-7-yl)-3-cyanobenzensulfonamid og fremgangsmåte for fremstilling derav |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7754894B2 (https=) |
| EP (1) | EP1666463B1 (https=) |
| JP (1) | JP4435090B2 (https=) |
| KR (1) | KR20060120644A (https=) |
| CN (2) | CN101165049A (https=) |
| AT (1) | ATE486849T1 (https=) |
| AU (1) | AU2004272400B2 (https=) |
| BR (1) | BRPI0414314A (https=) |
| CA (1) | CA2536995C (https=) |
| CY (1) | CY1110975T1 (https=) |
| DE (1) | DE602004029907D1 (https=) |
| DK (1) | DK1666463T3 (https=) |
| ES (1) | ES2354286T3 (https=) |
| HR (1) | HRP20100631T1 (https=) |
| IL (2) | IL174059A0 (https=) |
| MX (1) | MXPA06002732A (https=) |
| NO (1) | NO335256B1 (https=) |
| NZ (1) | NZ546111A (https=) |
| PL (1) | PL1666463T3 (https=) |
| PT (1) | PT1666463E (https=) |
| RU (1) | RU2336269C2 (https=) |
| SI (1) | SI1666463T1 (https=) |
| TW (1) | TW200514770A (https=) |
| WO (1) | WO2005026118A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1666463T3 (da) * | 2003-09-10 | 2010-12-20 | Eisai R&D Man Co Ltd | Krystal af sulfonamidholdig indolforbindelse og fremgangsmåde til fremstilling deraf |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3868534B2 (ja) | 1996-05-24 | 2007-01-17 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド誘導体の製造法および中間体 |
| JP2000247949A (ja) | 1999-02-26 | 2000-09-12 | Eisai Co Ltd | スルホンアミド含有インドール化合物 |
| WO2001056607A1 (en) * | 2000-02-03 | 2001-08-09 | Eisai Co., Ltd. | Integrin expression inhibitors |
| TWI283575B (en) * | 2000-10-31 | 2007-07-11 | Eisai Co Ltd | Medicinal compositions for concomitant use as anticancer agent |
| DK1666463T3 (da) * | 2003-09-10 | 2010-12-20 | Eisai R&D Man Co Ltd | Krystal af sulfonamidholdig indolforbindelse og fremgangsmåde til fremstilling deraf |
-
2004
- 2004-09-01 DK DK04772605.4T patent/DK1666463T3/da active
- 2004-09-01 ES ES04772605T patent/ES2354286T3/es not_active Expired - Lifetime
- 2004-09-01 RU RU2006111454/04A patent/RU2336269C2/ru not_active IP Right Cessation
- 2004-09-01 KR KR1020067004877A patent/KR20060120644A/ko not_active Ceased
- 2004-09-01 MX MXPA06002732A patent/MXPA06002732A/es active IP Right Grant
- 2004-09-01 CN CNA2007101667949A patent/CN101165049A/zh active Pending
- 2004-09-01 WO PCT/JP2004/012649 patent/WO2005026118A1/ja not_active Ceased
- 2004-09-01 PT PT04772605T patent/PT1666463E/pt unknown
- 2004-09-01 CA CA2536995A patent/CA2536995C/en not_active Expired - Fee Related
- 2004-09-01 BR BRPI0414314-0A patent/BRPI0414314A/pt not_active IP Right Cessation
- 2004-09-01 CN CNB2004800260696A patent/CN100406440C/zh not_active Expired - Fee Related
- 2004-09-01 NZ NZ546111A patent/NZ546111A/en not_active IP Right Cessation
- 2004-09-01 AU AU2004272400A patent/AU2004272400B2/en not_active Ceased
- 2004-09-01 DE DE602004029907T patent/DE602004029907D1/de not_active Expired - Lifetime
- 2004-09-01 US US10/571,279 patent/US7754894B2/en not_active Expired - Lifetime
- 2004-09-01 PL PL04772605T patent/PL1666463T3/pl unknown
- 2004-09-01 HR HR20100631T patent/HRP20100631T1/hr unknown
- 2004-09-01 JP JP2005513843A patent/JP4435090B2/ja not_active Expired - Fee Related
- 2004-09-01 EP EP04772605A patent/EP1666463B1/en not_active Expired - Lifetime
- 2004-09-01 SI SI200431578T patent/SI1666463T1/sl unknown
- 2004-09-01 AT AT04772605T patent/ATE486849T1/de active
- 2004-09-06 TW TW093126889A patent/TW200514770A/zh not_active IP Right Cessation
-
2006
- 2006-03-02 IL IL174059A patent/IL174059A0/en not_active IP Right Cessation
- 2006-04-05 NO NO20061545A patent/NO335256B1/no not_active IP Right Cessation
-
2009
- 2009-01-18 IL IL196569A patent/IL196569A0/en unknown
- 2009-06-09 US US12/480,959 patent/US20090247768A1/en not_active Abandoned
-
2010
- 2010-12-10 CY CY20101101136T patent/CY1110975T1/el unknown
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| Date | Code | Title | Description |
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| MM1K | Lapsed by not paying the annual fees |