NO20061545L - Krystall av sulfonamid-inneholdende indolforbindelse og fremgangsmate for fremstilling derav - Google Patents

Krystall av sulfonamid-inneholdende indolforbindelse og fremgangsmate for fremstilling derav

Info

Publication number
NO20061545L
NO20061545L NO20061545A NO20061545A NO20061545L NO 20061545 L NO20061545 L NO 20061545L NO 20061545 A NO20061545 A NO 20061545A NO 20061545 A NO20061545 A NO 20061545A NO 20061545 L NO20061545 L NO 20061545L
Authority
NO
Norway
Prior art keywords
sulfonamide
crystal
preparation
indole compound
containing indole
Prior art date
Application number
NO20061545A
Other languages
English (en)
Other versions
NO335256B1 (no
Inventor
Keiko Takahashi
Kenji Hayashi
Taichi Abe
Takao Omae
Takashi Kato
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of NO20061545L publication Critical patent/NO20061545L/no
Publication of NO335256B1 publication Critical patent/NO335256B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Krystaller av N-(3-cyano-4-metyl-lH-indol-7-yl)-3-cyanobenzensulfonamid som, når undersøkt ved røntgen-pulverdiffraktometri, har en diffraksjonstopp ved en diffraksjonsvinkel (29 ± 0,2°) på 19,1°.
NO20061545A 2003-09-10 2006-04-05 Krystall form (form A og C) av N-(3-cyano-4-metyl-1H-indol-7-yl)-3-cyanobenzensulfonamid og fremgangsmåte for fremstilling derav NO335256B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003318953 2003-09-10
PCT/JP2004/012649 WO2005026118A1 (ja) 2003-09-10 2004-09-01 スルホンアミド含有インドール化合物の結晶およびその製造方法

Publications (2)

Publication Number Publication Date
NO20061545L true NO20061545L (no) 2006-06-09
NO335256B1 NO335256B1 (no) 2014-10-27

Family

ID=34308544

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20061545A NO335256B1 (no) 2003-09-10 2006-04-05 Krystall form (form A og C) av N-(3-cyano-4-metyl-1H-indol-7-yl)-3-cyanobenzensulfonamid og fremgangsmåte for fremstilling derav

Country Status (25)

Country Link
US (2) US7754894B2 (no)
EP (1) EP1666463B1 (no)
JP (1) JP4435090B2 (no)
KR (1) KR20060120644A (no)
CN (2) CN101165049A (no)
AT (1) ATE486849T1 (no)
AU (1) AU2004272400B2 (no)
BR (1) BRPI0414314A (no)
CA (1) CA2536995C (no)
CY (1) CY1110975T1 (no)
DE (1) DE602004029907D1 (no)
DK (1) DK1666463T3 (no)
ES (1) ES2354286T3 (no)
HK (1) HK1092796A1 (no)
HR (1) HRP20100631T1 (no)
IL (2) IL174059A0 (no)
MX (1) MXPA06002732A (no)
NO (1) NO335256B1 (no)
NZ (1) NZ546111A (no)
PL (1) PL1666463T3 (no)
PT (1) PT1666463E (no)
RU (1) RU2336269C2 (no)
SI (1) SI1666463T1 (no)
TW (1) TW200514770A (no)
WO (1) WO2005026118A1 (no)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004029907D1 (de) * 2003-09-10 2010-12-16 Eisai R&D Man Co Ltd Kristall einer sulfonamidhaltigen indolverbindung und verfahren zu dessen herstellung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3868534B2 (ja) * 1996-05-24 2007-01-17 エーザイ・アール・アンド・ディー・マネジメント株式会社 スルホンアミド誘導体の製造法および中間体
JP2000247949A (ja) * 1999-02-26 2000-09-12 Eisai Co Ltd スルホンアミド含有インドール化合物
JP4039856B2 (ja) * 2000-02-03 2008-01-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 インテグリン発現阻害剤
TWI283575B (en) * 2000-10-31 2007-07-11 Eisai Co Ltd Medicinal compositions for concomitant use as anticancer agent
DE602004029907D1 (de) * 2003-09-10 2010-12-16 Eisai R&D Man Co Ltd Kristall einer sulfonamidhaltigen indolverbindung und verfahren zu dessen herstellung

Also Published As

Publication number Publication date
EP1666463A4 (en) 2007-12-12
JPWO2005026118A1 (ja) 2007-11-08
AU2004272400A1 (en) 2005-03-24
SI1666463T1 (sl) 2011-02-28
MXPA06002732A (es) 2006-06-05
PT1666463E (pt) 2011-01-17
PL1666463T3 (pl) 2011-04-29
BRPI0414314A (pt) 2006-10-31
IL196569A0 (en) 2011-07-31
ATE486849T1 (de) 2010-11-15
CY1110975T1 (el) 2015-06-11
NZ546111A (en) 2008-11-28
KR20060120644A (ko) 2006-11-27
ES2354286T3 (es) 2011-03-11
US20090247768A1 (en) 2009-10-01
US20070082941A1 (en) 2007-04-12
HK1092796A1 (en) 2007-02-16
DK1666463T3 (da) 2010-12-20
CA2536995A1 (en) 2005-03-24
CN100406440C (zh) 2008-07-30
DE602004029907D1 (de) 2010-12-16
US7754894B2 (en) 2010-07-13
TWI349663B (no) 2011-10-01
WO2005026118A1 (ja) 2005-03-24
CA2536995C (en) 2013-12-17
IL174059A0 (en) 2006-08-01
EP1666463B1 (en) 2010-11-03
HRP20100631T1 (hr) 2010-12-31
NO335256B1 (no) 2014-10-27
CN101165049A (zh) 2008-04-23
AU2004272400B2 (en) 2010-03-04
RU2336269C2 (ru) 2008-10-20
CN1849305A (zh) 2006-10-18
EP1666463A1 (en) 2006-06-07
RU2006111454A (ru) 2006-08-27
TW200514770A (en) 2005-05-01
JP4435090B2 (ja) 2010-03-17

Similar Documents

Publication Publication Date Title
NO20065503L (no) Indolyderivater som lever-X-resptormodulatorer.
NO20062599L (no) Fremgangsmate for syntese av perindopril og farmasoytisk akseptable salter derav
GEP20053600B (en) 3-(4-Amidopyrrol-2-Ylmethlidene)-2- Indolinone Derivatives as Protein Kinase Inhibitors
NZ543722A (en) Novel substituted 3-sulfur indoles
DK0711280T3 (da) Perhydroisoindolderivater, fremstilling af disse forbindelser og farmaceutiske præparater indeholdende disse forbindelser
NO20050664L (no) 2,4 substituerte indoler og anvendelse derav som 5-HT6 modulatorer
NO20022558L (no) 4-karboksyamino-2-etyl-1,2,3,4-tetrahydrokinolinkrystall som CETP inhibitor
NO20055257L (no) Ny fremgangsmate for syntesen av s-indolin-2-karboksylsyre og anvendelse derav i syntesen av perindopril
AU2003274462A1 (en) N-(indole-2-carbonyl) amides as anti-diabetic agents
DK1333026T3 (da) Fremgangsmåde til fremstilling af perindopril med höj renhed og nyttige mellemforbindelser til syntesen
NO20061545L (no) Krystall av sulfonamid-inneholdende indolforbindelse og fremgangsmate for fremstilling derav
CY1108238T1 (el) Μεθοδος συνθεσης της περινδοπριλης και των φαρμακευτικως αποδεκτων αλατων της
DK1367061T3 (da) Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1371659T3 (da) Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
MY135359A (en) New process for the synthesis of perindopril and pharmaceutically acceptable salts thereof
DK1380591T3 (da) Fremgangsmåde til syntese af perindopril og farmaceutiske acceptable salte heraf
CY1106543T1 (el) Μεθοδος συνθεσεως υπερινδοπριλης και τα φαρμακευτικως αποδεκτα αλατα αυτης
DK1367063T3 (da) Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
WO2005012328A3 (fr) Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
DE60332851D1 (de) Indolinverbindung und deren medizinische verwendung
MY137288A (en) New process for the synthesis of n-[(s)-1-ethoxycarbonylbutyl]-(s)-alanine and application in the synthesis of perindopril
NO20063027L (no) Fremgangsmaten for syntesen av derivater av (2S,3aS,7aS)-1-[(S)-alkanyl]-oktahydro-lH-indol-2-karboksylsyre og anvendelse derav i syntesen av perindopril
MY137391A (en) New process for the synthesis of n-[(s)-1-ethoxycarbonylbutyl]-(s)-alanine and application in the synthesis of perindopril
DK1567519T3 (da) Krystallinske derivater af 2-(5-chlorthien-2-yl)-N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl)ethensulfonamid
TH112057B (th) พอลิมอร์ฟของ n-ไฮดรอกซี่-3-[4-[[[2-(2-เมธิล-1h-อินดอล-3-อิล)เอธิล]อะมิโน[เมธิล]ฟีนิล]-2e-2-โพลพีนาไมด์

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees